Aliases for DBNL Gene
External Ids for DBNL Gene
Previous GeneCards Identifiers for DBNL Gene
GeneCards Summary for DBNL Gene
DBNL (Drebrin Like) is a Protein Coding gene. Diseases associated with DBNL include Cardiomyopathy, Dilated, 1P and Glycogen Storage Disease. Among its related pathways are JNK signaling in the CD4+ TCR pathway and Apoptotic execution phase. Gene Ontology (GO) annotations related to this gene include actin binding and protein C-terminus binding. An important paralog of this gene is DBN1.
UniProtKB/Swiss-Prot Summary for DBNL Gene
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.