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Aliases for DBNL Gene

Aliases for DBNL Gene

  • Drebrin Like 2 3 5
  • HPK1-Interacting Protein Of 55 KDa 2 3 4
  • Cervical Mucin-Associated Protein 3 4
  • SH3 Domain-Containing Protein 7 3 4
  • Actin-Binding Protein 1 2 3
  • Cervical SH3P7 3 4
  • Drebrin-F 3 4
  • HIP-55 3 4
  • SH3P7 3 4
  • Src Homology 3 Domain-Containing Protein HIP-55 3
  • Drebrin-Like Protein 3
  • Drebrin-Like 2
  • HIP55 3
  • ABP1 3
  • CMAP 4

External Ids for DBNL Gene

Previous GeneCards Identifiers for DBNL Gene

  • GC07U990153
  • GC07P043857
  • GC07P044050
  • GC07P044084
  • GC07P043969

Summaries for DBNL Gene

GeneCards Summary for DBNL Gene

DBNL (Drebrin Like) is a Protein Coding gene. Among its related pathways are JNK signaling in the CD4+ TCR pathway and Apoptotic cleavage of cellular proteins. Gene Ontology (GO) annotations related to this gene include actin binding and protein C-terminus binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot for DBNL Gene

  • Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gene Wiki entry for DBNL Gene

Additional gene information for DBNL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNL Gene

Genomics for DBNL Gene

GeneHancer (GH) Regulatory Elements for DBNL Gene

Promoters and enhancers for DBNL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J044043 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.4 +1.1 1125 4.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF213 DBNL POLM RASA4CP ENSG00000241057 ENSG00000239556 DDX56 SNHG15 TMED4 STK17A MIR6837
GH07J043903 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5.4 -139.1 -139077 3.6 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 FOS SP3 SP5 REST URGCP URGCP-MRPS24 ENSG00000239556 POLM RASA4CP DBNL MRPS24
GH07J043925 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5 -117.9 -117893 2.2 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 UBE2D4 URGCP POLM RASA4CP DBNL PIR62464
GH07J044064 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 4.7 +21.0 21003 1.6 ZNF282 PKNOX1 USF1 POLR2A RBM22 STAT5A RBPJ ENSG00000239775 PGAM2 POLM LINC00957 DBNL
GH07J043567 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -473.9 -473920 6.6 ATF1 IRF4 ZNF766 FOS ATF7 RUNX3 JUNB ZNF592 MAFF SMARCA4 COA1 LUARIS BLVRA STK17A DBNL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBNL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBNL gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • CUTL1
  • HTF
  • Pax-5
  • C/EBPalpha

Genomic Locations for DBNL Gene

Genomic Locations for DBNL Gene
chr7:44,044,640-44,069,456
(GRCh38/hg38)
Size:
24,817 bases
Orientation:
Plus strand
chr7:44,084,239-44,109,055
(GRCh37/hg19)
Size:
24,817 bases
Orientation:
Plus strand

Genomic View for DBNL Gene

Genes around DBNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNL Gene

Proteins for DBNL Gene

  • Protein details for DBNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU6-DBNL_HUMAN
    Recommended name:
    Drebrin-like protein
    Protein Accession:
    Q9UJU6
    Secondary Accessions:
    • A4D2I9
    • B4DDP6
    • B4DEM2
    • C9J7P1
    • P84070
    • Q6IAI8
    • Q96F30
    • Q96K74
    • Q9HBN8
    • Q9NR72

    Protein attributes for DBNL Gene

    Size:
    430 amino acids
    Molecular mass:
    48207 Da
    Quaternary structure:
    • Interacts with SHANK2, SHANK3 and SYN1. Interacts with FGD1 and DNM1. Interacts with ANKRD54. Interacts with COBL. Interacts with WASL and WIPF1 (By similarity). Interacts with MAP4K1 and PRAM1.

    Three dimensional structures from OCA and Proteopedia for DBNL Gene

    Alternative splice isoforms for DBNL Gene

neXtProt entry for DBNL Gene

Post-translational modifications for DBNL Gene

No data available for DME Specific Peptides for DBNL Gene

Domains & Families for DBNL Gene

Gene Families for DBNL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q9UJU6

UniProtKB/Swiss-Prot:

DBNL_HUMAN :
  • The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.
  • Belongs to the ABP1 family.
Domain:
  • The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.
Family:
  • Belongs to the ABP1 family.
genes like me logo Genes that share domains with DBNL: view

Function for DBNL Gene

Molecular function for DBNL Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
GENATLAS Biochemistry:
drebrin (actin-binding protein)-like

Gene Ontology (GO) - Molecular Function for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IEA --
GO:0008047 enzyme activator activity TAS 10567356
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with DBNL: view
genes like me logo Genes that share phenotypes with DBNL: view

Animal Models for DBNL Gene

MGI Knock Outs for DBNL:
  • Dbnl Dbnl<tm1Jwnd>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DBNL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBNL Gene

Localization for DBNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBNL Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Cell junction, synapse. Cell projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Early endosome. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250 UniProtKB:Q62418}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBNL gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 3
nucleus 3
golgi apparatus 3
endosome 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001726 ruffle ISS --
GO:0002102 podosome ISS --
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DBNL: view

Pathways & Interactions for DBNL Gene

genes like me logo Genes that share pathways with DBNL: view

SIGNOR curated interactions for DBNL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007257 activation of JUN kinase activity TAS 10567356
genes like me logo Genes that share ontologies with DBNL: view

Drugs & Compounds for DBNL Gene

No Compound Related Data Available

Transcripts for DBNL Gene

Unigene Clusters for DBNL Gene

Drebrin-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DBNL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBNL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9: - - -
SP10: -
SP11: - -

ExUns: 13c · 13d · 13e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DBNL Gene

GeneLoc Exon Structure for
DBNL
ECgene alternative splicing isoforms for
DBNL

Expression for DBNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBNL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNL Gene

This gene is overexpressed in Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for DBNL Gene

This gene is overexpressed in Lymph node (10.2), Peripheral blood mononuclear cells (10.2), and Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DBNL Gene



Protein tissue co-expression partners for DBNL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DBNL Gene:

DBNL

SOURCE GeneReport for Unigene cluster for DBNL Gene:

Hs.436500

Evidence on tissue expression from TISSUES for DBNL Gene

  • Nervous system(5)
  • Blood(4.7)
  • Eye(4.3)
  • Liver(4.2)
  • Lung(3.6)
  • Spleen(3.5)
  • Intestine(3.2)
  • Skin(3.2)
  • Kidney(2.9)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with DBNL: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBNL Gene

Orthologs for DBNL Gene

This gene was present in the common ancestor of animals.

Orthologs for DBNL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNL 34 33
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DBNL 34 33
  • 88.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
OneToMany
DBNL 33
  • 85.3 (n)
-- 34
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dbnl 33
  • 84.49 (n)
mouse
(Mus musculus)
Mammalia Dbnl 16 34 33
  • 84.06 (n)
oppossum
(Monodelphis domestica)
Mammalia DBNL 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBNL 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBNL 34 33
  • 73.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBNL 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbnl 33
  • 66.27 (n)
zebrafish
(Danio rerio)
Actinopterygii dbnlb 34 33
  • 67.15 (n)
OneToMany
dbnla 34
  • 47 (a)
OneToMany
wufb34f02 33
fruit fly
(Drosophila melanogaster)
Insecta CG10083 34 33
  • 58.24 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012240 33
  • 49.45 (n)
worm
(Caenorhabditis elegans)
Secernentea K08E3.4 34 33
  • 49.89 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3471 34
  • 35 (a)
OneToMany
Species where no ortholog for DBNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBNL Gene

ENSEMBL:
Gene Tree for DBNL (if available)
TreeFam:
Gene Tree for DBNL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBNL: view image

Paralogs for DBNL Gene

Paralogs for DBNL Gene

(6) SIMAP similar genes for DBNL Gene using alignment to 15 proteins:

  • DBNL_HUMAN
  • B4DDD6_HUMAN
  • B4DDP6_HUMAN
  • B4DEM2_HUMAN
  • C9J7P1_HUMAN
  • F2Z2V3_HUMAN
  • F2Z3E3_HUMAN
  • F8WB73_HUMAN
  • F8WBB2_HUMAN
  • F8WBG8_HUMAN
  • F8WC20_HUMAN
  • F8WCK3_HUMAN
  • F8WFE1_HUMAN
  • H0Y5J4_HUMAN
  • H7C111_HUMAN
genes like me logo Genes that share paralogs with DBNL: view

Variants for DBNL Gene

Sequence variations from dbSNP and Humsavar for DBNL Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000009538 -- 44,044,189(+) T/G upstream_transcript_variant
rs1000281497 -- 44,058,075(+) G/A intron_variant
rs1000435799 -- 44,047,242(+) T/A/C intron_variant
rs1000901391 -- 44,053,607(+) T/C intron_variant
rs1001477237 -- 44,050,759(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DBNL Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv8082 CNV gain 18304495
nsv830980 CNV loss 17160897
nsv966788 CNV duplication 23825009

Variation tolerance for DBNL Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBNL Gene

Human Gene Mutation Database (HGMD)
DBNL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBNL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNL Gene

Disorders for DBNL Gene

Additional Disease Information for DBNL

No disorders were found for DBNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBNL Gene

Publications for DBNL Gene

  1. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. (PMID: 14729663) Le Bras S … Deckert M (The Journal of biological chemistry 2004) 3 4 22 58
  2. Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. (PMID: 11689006) Chen YR … Tan TH (Biochemical and biophysical research communications 2001) 3 4 22 58
  3. NMR solution structures of actin depolymerizing factor homology domains. (PMID: 19768801) Goroncy AK … Yokoyama S (Protein science : a publication of the Protein Society 2009) 4 22 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for DBNL Gene

Sources for DBNL Gene

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