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Aliases for DBNDD2 Gene

Aliases for DBNDD2 Gene

  • Dysbindin Domain Containing 2 2 3 5
  • Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 2 2 3
  • Casein Kinase-1 Binding Protein 3 4
  • C20orf35 3 4
  • HSMNP1 3 4
  • CK1BP 3 4
  • Dysbindin Domain-Containing Protein 2 3
  • Chromosome 20 Open Reading Frame 35 2
  • SCF Apoptosis Response Protein 1 3

External Ids for DBNDD2 Gene

Previous HGNC Symbols for DBNDD2 Gene

  • C20orf35

Previous GeneCards Identifiers for DBNDD2 Gene

  • GC20P043426
  • GC20P043468
  • GC20P044034
  • GC20P040776

Summaries for DBNDD2 Gene

GeneCards Summary for DBNDD2 Gene

DBNDD2 (Dysbindin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DTNBP1.

UniProtKB/Swiss-Prot for DBNDD2 Gene

  • May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).

Gene Wiki entry for DBNDD2 Gene

Additional gene information for DBNDD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNDD2 Gene

Genomics for DBNDD2 Gene

GeneHancer (GH) Regulatory Elements for DBNDD2 Gene

Promoters and enhancers for DBNDD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I045405 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 586.5 +1.5 1451 3.6 MLX ARID4B ZNF2 ZBTB7B ZNF48 GLIS2 KLF7 SP3 MXD4 REST DBNDD2 TP53TG5 SYS1 SYS1-DBNDD2
GH20I045415 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 38.5 +10.3 10261 1.9 PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 PIGT DBNDD2 TP53TG5 SYS1 RPS2P7 MIR6812
GH20I045372 Enhancer 1.4 FANTOM5 Ensembl ENCODE 60.3 -32.4 -32387 2 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 POLR2B E2F8 ZNF143 DEK SP5 DBNDD2 TP53TG5 PIGT SYS1 KCNS1 WFDC11 SYS1-DBNDD2 NDUFB4P10
GH20I045357 Enhancer 1.2 ENCODE dbSUPER 39.1 -46.8 -46760 4.4 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ATF7 DBNDD2 TP53TG5 SYS1 PIGT SDC4
GH20I045353 Enhancer 1.1 Ensembl ENCODE dbSUPER 39 -51.0 -51045 2 FOXA2 JUN MAX BATF FOSL1 GATA3 RBAK SCRT2 HNF4G FOSL2 DBNDD2 NCOA5 TP53TG5 PIGT SYS1 RBPJL MATN4 SDC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DBNDD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBNDD2 gene promoter:

Genomic Locations for DBNDD2 Gene

Genomic Locations for DBNDD2 Gene
chr20:45,405,993-45,410,610
(GRCh38/hg38)
Size:
4,618 bases
Orientation:
Plus strand
chr20:44,034,633-44,039,250
(GRCh37/hg19)

Genomic View for DBNDD2 Gene

Genes around DBNDD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBNDD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBNDD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNDD2 Gene

Proteins for DBNDD2 Gene

  • Protein details for DBNDD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQY9-DBND2_HUMAN
    Recommended name:
    Dysbindin domain-containing protein 2
    Protein Accession:
    Q9BQY9
    Secondary Accessions:
    • Q331S6
    • Q5QPV4
    • Q5QPV6
    • Q9BQZ0
    • Q9BVL1
    • Q9H1F6
    • Q9NWZ0
    • Q9NY07
    • Q9NZ31

    Protein attributes for DBNDD2 Gene

    Size:
    259 amino acids
    Molecular mass:
    27671 Da
    Quaternary structure:
    • Monomer. Interacts with CSNK1D and CSNK1E.

    Alternative splice isoforms for DBNDD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBNDD2 Gene

Post-translational modifications for DBNDD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DBNDD2 Gene

Domains & Families for DBNDD2 Gene

Gene Families for DBNDD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DBNDD2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BQY9

UniProtKB/Swiss-Prot:

DBND2_HUMAN :
  • Belongs to the dysbindin family.
Family:
  • Belongs to the dysbindin family.
genes like me logo Genes that share domains with DBNDD2: view

Function for DBNDD2 Gene

Molecular function for DBNDD2 Gene

UniProtKB/Swiss-Prot Function:
May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).

Phenotypes From GWAS Catalog for DBNDD2 Gene

Gene Ontology (GO) - Molecular Function for DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16618118
genes like me logo Genes that share ontologies with DBNDD2: view
genes like me logo Genes that share phenotypes with DBNDD2: view

Animal Models for DBNDD2 Gene

MGI Knock Outs for DBNDD2:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBNDD2 Gene

Localization for DBNDD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBNDD2 gene
Compartment Confidence
nucleus 2
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030672 synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with DBNDD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DBNDD2 Gene

Pathways & Interactions for DBNDD2 Gene

SuperPathways for DBNDD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 16618118
GO:0031175 neuron projection development IBA --
genes like me logo Genes that share ontologies with DBNDD2: view

No data available for Pathways by source and SIGNOR curated interactions for DBNDD2 Gene

Drugs & Compounds for DBNDD2 Gene

No Compound Related Data Available

Transcripts for DBNDD2 Gene

Unigene Clusters for DBNDD2 Gene

Dysbindin (dystrobrevin binding protein 1) domain containing 2:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD2 Gene

No ASD Table

Relevant External Links for DBNDD2 Gene

GeneLoc Exon Structure for
DBNDD2
ECgene alternative splicing isoforms for
DBNDD2

Expression for DBNDD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBNDD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNDD2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.6) and Brain - Substantia nigra (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of DBNDD2 Gene:

DBNDD2

SOURCE GeneReport for Unigene cluster for DBNDD2 Gene:

Hs.730643

mRNA Expression by UniProt/SwissProt for DBNDD2 Gene:

Q9BQY9-DBND2_HUMAN
Tissue specificity: Detected in brain.

Evidence on tissue expression from TISSUES for DBNDD2 Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Intestine(2.7)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with DBNDD2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBNDD2 Gene

Orthologs for DBNDD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBNDD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNDD2 33 34
  • 98.97 (n)
dog
(Canis familiaris)
Mammalia DBNDD2 33 34
  • 88.05 (n)
cow
(Bos Taurus)
Mammalia DBNDD2 33 34
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia Dbndd2 33 16 34
  • 80.8 (n)
rat
(Rattus norvegicus)
Mammalia Dbndd2 33
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia DBNDD2 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBNDD2 34 33
  • 60.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBNDD2 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10760 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53635 33
zebrafish
(Danio rerio)
Actinopterygii DBNDD2 34
  • 30 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.17524 33
Species where no ortholog for DBNDD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBNDD2 Gene

ENSEMBL:
Gene Tree for DBNDD2 (if available)
TreeFam:
Gene Tree for DBNDD2 (if available)

Paralogs for DBNDD2 Gene

Paralogs for DBNDD2 Gene

(1) SIMAP similar genes for DBNDD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DBNDD2: view

Variants for DBNDD2 Gene

Sequence variations from dbSNP and Humsavar for DBNDD2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000426555 -- 45,410,894(+) G/T downstream_transcript_variant
rs1000439674 -- 45,411,105(+) G/T downstream_transcript_variant
rs1000467575 -- 45,406,055(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000521153 -- 45,405,895(+) C/T upstream_transcript_variant
rs1001222018 -- 45,410,973(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DBNDD2 Gene

Variant ID Type Subtype PubMed ID
dgv4319n100 CNV gain 25217958
nsv1056102 CNV loss 25217958

Variation tolerance for DBNDD2 Gene

Gene Damage Index Score: 0.77; 16.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBNDD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBNDD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNDD2 Gene

Disorders for DBNDD2 Gene

Additional Disease Information for DBNDD2

No disorders were found for DBNDD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBNDD2 Gene

Publications for DBNDD2 Gene

  1. Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. (PMID: 16618118) Yin H … Kuret J (Biochemistry 2006) 2 3 4 58
  2. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. (PMID: 16305340) Lucas T … Jansen B (Stem cells and development 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for DBNDD2 Gene

Sources for DBNDD2 Gene

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