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Aliases for DBNDD1 Gene

Aliases for DBNDD1 Gene

  • Dysbindin Domain Containing 1 2 3 5
  • Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 1 2

External Ids for DBNDD1 Gene

Previous GeneCards Identifiers for DBNDD1 Gene

  • GC16M088599
  • GC16M090071
  • GC16M075763

Summaries for DBNDD1 Gene

GeneCards Summary for DBNDD1 Gene

DBNDD1 (Dysbindin Domain Containing 1) is a Protein Coding gene.

Additional gene information for DBNDD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNDD1 Gene

Genomics for DBNDD1 Gene

GeneHancer (GH) Regulatory Elements for DBNDD1 Gene

Promoters and enhancers for DBNDD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I090018 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 573.4 -1.0 -974 5.3 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DBNDD1 GAS8 DEF8 PRDM7 ACSF3 ANKRD11 SNORD68 URAHP GAS8-AS1 TUBB3
GH16I089717 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.5 +299.1 299078 7.5 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 VPS9D1 ZNF276 AFG3L1P CDK10 LOC101927863 ENSG00000268218 ACSF3 ANKRD11 MC1R TCF25
GH16I089993 Enhancer 1.5 Ensembl ENCODE dbSUPER 19.4 +24.9 24884 3.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B PIR44838 ENSG00000259877 AFG3L1P ANKRD11 MC1R ACSF3 TCF25 GAS8 LOC101927863 SNORD68
GH16I089656 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.1 +362.4 362366 2.6 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 POLR2B E2F8 ZNF143 CHMP1A SPATA33 CDK10 AFG3L1P TCF25 MC1R ENSG00000259877 GAS8-AS1 ACSF3 DBNDD1
GH16I089558 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.5 +457.5 457505 7.9 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC RPL13 SNORD68 PIR32702 GC16P089561 GC16P089560 AFG3L1P ANKRD11 TCF25 ENSG00000268218 ENSG00000259877
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DBNDD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBNDD1 gene promoter:

Genomic Locations for DBNDD1 Gene

Genomic Locations for DBNDD1 Gene
chr16:90,004,865-90,020,131
(GRCh38/hg38)
Size:
15,267 bases
Orientation:
Minus strand
chr16:90,071,273-90,086,536
(GRCh37/hg19)

Genomic View for DBNDD1 Gene

Genes around DBNDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBNDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBNDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNDD1 Gene

Proteins for DBNDD1 Gene

  • Protein details for DBNDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9R9-DBND1_HUMAN
    Recommended name:
    Dysbindin domain-containing protein 1
    Protein Accession:
    Q9H9R9
    Secondary Accessions:
    • B4DQS3
    • Q69YT2
    • Q9BW25

    Protein attributes for DBNDD1 Gene

    Size:
    158 amino acids
    Molecular mass:
    17042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DBNDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBNDD1 Gene

Post-translational modifications for DBNDD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBNDD1 Gene

No data available for DME Specific Peptides for DBNDD1 Gene

Domains & Families for DBNDD1 Gene

Gene Families for DBNDD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DBNDD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DBNDD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9R9

UniProtKB/Swiss-Prot:

DBND1_HUMAN :
  • Belongs to the dysbindin family.
Family:
  • Belongs to the dysbindin family.
genes like me logo Genes that share domains with DBNDD1: view

Function for DBNDD1 Gene

Phenotypes From GWAS Catalog for DBNDD1 Gene

genes like me logo Genes that share phenotypes with DBNDD1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DBNDD1 Gene

Localization for DBNDD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBNDD1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DBNDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030672 synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with DBNDD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DBNDD1 Gene

Pathways & Interactions for DBNDD1 Gene

SuperPathways for DBNDD1 Gene

No Data Available

Interacting Proteins for DBNDD1 Gene

Gene Ontology (GO) - Biological Process for DBNDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IBA --
genes like me logo Genes that share ontologies with DBNDD1: view

No data available for Pathways by source and SIGNOR curated interactions for DBNDD1 Gene

Drugs & Compounds for DBNDD1 Gene

No Compound Related Data Available

Transcripts for DBNDD1 Gene

Unigene Clusters for DBNDD1 Gene

Dysbindin (dystrobrevin binding protein 1) domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for DBNDD1 Gene

GeneLoc Exon Structure for
DBNDD1
ECgene alternative splicing isoforms for
DBNDD1

Expression for DBNDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBNDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNDD1 Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBNDD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DBNDD1 Gene:

DBNDD1

SOURCE GeneReport for Unigene cluster for DBNDD1 Gene:

Hs.301394

Evidence on tissue expression from TISSUES for DBNDD1 Gene

  • Nervous system(4.8)
  • Eye(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DBNDD1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBNDD1 Gene

Orthologs for DBNDD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBNDD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNDD1 33 34
  • 98.08 (n)
dog
(Canis familiaris)
Mammalia DBNDD1 33 34
  • 82.43 (n)
cow
(Bos Taurus)
Mammalia DBNDD1 33 34
  • 79.39 (n)
rat
(Rattus norvegicus)
Mammalia Dbndd1 33
  • 78.18 (n)
mouse
(Mus musculus)
Mammalia Dbndd1 33 16 34
  • 72.84 (n)
oppossum
(Monodelphis domestica)
Mammalia DBNDD1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBNDD1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBNDD1 33 34
  • 69.39 (n)
lizard
(Anolis carolinensis)
Reptilia DBNDD1 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbndd1 33
  • 69.23 (n)
zebrafish
(Danio rerio)
Actinopterygii DBNDD1 34
  • 42 (a)
OneToOne
Species where no ortholog for DBNDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBNDD1 Gene

ENSEMBL:
Gene Tree for DBNDD1 (if available)
TreeFam:
Gene Tree for DBNDD1 (if available)

Paralogs for DBNDD1 Gene

(1) SIMAP similar genes for DBNDD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DBNDD1: view

No data available for Paralogs for DBNDD1 Gene

Variants for DBNDD1 Gene

Sequence variations from dbSNP and Humsavar for DBNDD1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000362619 -- 90,011,815(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000490566 -- 90,005,359(-) G/T 3_prime_UTR_variant
rs1000530300 -- 90,005,563(-) G/A 3_prime_UTR_variant
rs1000684387 -- 90,010,898(-) TCTATCT/TCT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000816639 -- 90,011,987(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DBNDD1 Gene

Variant ID Type Subtype PubMed ID
dgv3067n100 CNV gain 25217958
esv1095561 CNV deletion 17803354
esv1361959 CNV deletion 17803354
esv26767 CNV gain 19812545
esv2762221 CNV gain+loss 21179565
esv3332179 CNV duplication 20981092
esv3448710 CNV duplication 20981092
esv3582452 CNV loss 25503493
esv3639603 CNV gain 21293372
nsv1062080 CNV loss 25217958
nsv1066499 CNV loss 25217958
nsv1070787 CNV deletion 25765185
nsv428331 CNV gain+loss 18775914
nsv457626 CNV loss 19166990
nsv471119 CNV loss 18288195
nsv471120 CNV gain 18288195
nsv482951 CNV loss 15286789
nsv573799 CNV gain 21841781
nsv573810 CNV loss 21841781
nsv573841 CNV loss 21841781
nsv573842 CNV loss 21841781
nsv952080 CNV deletion 24416366

Variation tolerance for DBNDD1 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBNDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBNDD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNDD1 Gene

Disorders for DBNDD1 Gene

Additional Disease Information for DBNDD1

No disorders were found for DBNDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBNDD1 Gene

Publications for DBNDD1 Gene

  1. Genome-wide association study of tanning phenotype in a population of European ancestry. (PMID: 19340012) Nan H … Han J (The Journal of investigative dermatology 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for DBNDD1 Gene

Sources for DBNDD1 Gene

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