Aliases for DBN1 Gene
External Ids for DBN1 Gene
Previous HGNC Symbols for DBN1 Gene
Previous GeneCards Identifiers for DBN1 Gene
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DBN1 Gene
DBN1 (Drebrin 1) is a Protein Coding gene. Diseases associated with DBN1 include Alzheimer Disease and Glaucomatocyclitic Crisis. Among its related pathways are Cytoskeletal Signaling and Neuroscience. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is DBNL.
UniProtKB/Swiss-Prot Summary for DBN1 Gene
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).