Aliases for DBN1 Gene
External Ids for DBN1 Gene
Previous HGNC Symbols for DBN1 Gene
Previous GeneCards Identifiers for DBN1 Gene
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DBN1 Gene
DBN1 (Drebrin 1) is a Protein Coding gene. Diseases associated with DBN1 include Alzheimer Disease and Down Syndrome. Among its related pathways are G-Beta Gamma Signaling and Neuroscience. Gene Ontology (GO) annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is DBNL.
UniProtKB/Swiss-Prot Summary for DBN1 Gene
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).