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Aliases for DBI Gene

Aliases for DBI Gene

  • Diazepam Binding Inhibitor, Acyl-CoA Binding Protein 2 3 5
  • Endozepine 2 3 4
  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A Binding Protein) 2 3
  • Diazepam-Binding Inhibitor 3 4
  • ACBP 3 4
  • EP 3 4
  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein) 3
  • Cholecystokinin-Releasing Peptide, Trypsin-Sensitive 3
  • Acyl-Coenzyme A Binding Domain Containing 1 3
  • Acyl Coenzyme A Binding Protein 3
  • Acyl-CoA-Binding Protein 3
  • GABA Receptor Modulator 3
  • CCK-RP 3
  • ACBD1 3

External Ids for DBI Gene

Previous GeneCards Identifiers for DBI Gene

  • GC02P117330
  • GC02P118045
  • GC02P120031
  • GC02P120219
  • GC02P120220
  • GC02P119840
  • GC02P120124
  • GC02P112449

Summaries for DBI Gene

Entrez Gene Summary for DBI Gene

  • This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

CIViC summary for DBI Gene

GeneCards Summary for DBI Gene

DBI (Diazepam Binding Inhibitor, Acyl-CoA Binding Protein) is a Protein Coding gene. Diseases associated with DBI include Hepatic Coma and Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2. Among its related pathways are PPAR Alpha Pathway and Benzodiazepine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and fatty-acyl-CoA binding. An important paralog of this gene is ACBD7.

UniProtKB/Swiss-Prot for DBI Gene

  • Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Gene Wiki entry for DBI Gene

Additional gene information for DBI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBI Gene

Genomics for DBI Gene

GeneHancer (GH) Regulatory Elements for DBI Gene

Promoters and enhancers for DBI Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J119365 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658.8 +0.0 11 3.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 DBI PIR46529 C2orf76 SCTR ENSG00000231013
GH02J119387 Enhancer 1.1 Ensembl ENCODE 20.3 +20.8 20838 1.5 YY1 ZNF766 ATF7 FOS RUNX3 RXRA JUNB MEF2D NFIL3 SMARCA4 DBI ENSG00000231013 C2orf76 TMEM37 SCTR STEAP3 PIR46529
GH02J119419 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.2 +61.2 61176 16.7 HDGF FOXA2 SMAD1 MLX ARID4B ZNF2 ZBTB7B YY1 SLC30A9 POLR2B TMEM37 SCTR ENSG00000231013 CFAP221 DBI STEAP3 PIR46529
GH02J119407 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.4 +41.5 41486 1.6 ZSCAN5A MEIS2 CTCF PKNOX1 ARID4B ZNF2 DNMT3B RAD21 TEAD3 CC2D1A ENSG00000231013 TMEM37 SCTR DBI PIR46529
GH02J119401 Enhancer 1 ENCODE dbSUPER 9.4 +36.1 36052 2.4 ELF3 FOXA2 RAD21 YY1 EGR1 THAP11 RXRA CEBPB ELF1 REST ENSG00000231013 TMEM37 STEAP3 SCTR DBI PIR46529
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBI gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for DBI Gene

Genomic Locations for DBI Gene
5,640 bases
Plus strand
5,630 bases
Plus strand

Genomic View for DBI Gene

Genes around DBI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBI Gene

Proteins for DBI Gene

  • Protein details for DBI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-CoA-binding protein
    Protein Accession:
    Secondary Accessions:
    • B8ZWD2
    • B8ZWD6
    • B8ZWD7
    • P08869
    • Q4VWZ6
    • Q53SQ7
    • Q6IB48
    • Q9UCI8

    Protein attributes for DBI Gene

    87 amino acids
    Molecular mass:
    10044 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DBI Gene

    Alternative splice isoforms for DBI Gene

neXtProt entry for DBI Gene

Post-translational modifications for DBI Gene

  • Ubiquitination at posLast=7777 and Lys55
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DBI Gene

Domains & Families for DBI Gene

Gene Families for DBI Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ACBP family.
  • Belongs to the ACBP family.
genes like me logo Genes that share domains with DBI: view

Function for DBI Gene

Molecular function for DBI Gene

UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
GENATLAS Biochemistry:
diazepam binding inhibitor (?GABA receptor modulator),endozepine

Phenotypes From GWAS Catalog for DBI Gene

Gene Ontology (GO) - Molecular Function for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0030156 benzodiazepine receptor binding TAS 3020548
GO:0036042 long-chain fatty acyl-CoA binding IDA 21079819
GO:0046983 protein dimerization activity IDA 21079819
genes like me logo Genes that share ontologies with DBI: view
genes like me logo Genes that share phenotypes with DBI: view

Animal Models for DBI Gene

MGI Knock Outs for DBI:
  • Dbi Dbi<tm1Smdp>
  • Dbi Dbi<tm2.2Smdp>
  • Dbi Dbi<tm1Kier>

Animal Model Products

  • Taconic Biosciences Mouse Models for DBI

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DBI Gene

Localization for DBI Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBI Gene

Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding (PubMed:17953517). {ECO:0000269 PubMed:17953517}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBI gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with DBI: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DBI Gene

Pathways & Interactions for DBI Gene

genes like me logo Genes that share pathways with DBI: view

SIGNOR curated interactions for DBI Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process TAS --
GO:0018345 NOT protein palmitoylation IDA 21079819
GO:0036151 phosphatidylcholine acyl-chain remodeling IDA 21079819
genes like me logo Genes that share ontologies with DBI: view

Drugs & Compounds for DBI Gene

(7) Drugs for DBI Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexadecanal Experimental Pharma Target 0
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra Target 0

(36) Additional Compounds for DBI Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
genes like me logo Genes that share compounds with DBI: view

Transcripts for DBI Gene

Unigene Clusters for DBI Gene

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8: - -

Relevant External Links for DBI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DBI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBI Gene

This gene is overexpressed in Oral epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DBI Gene

Protein tissue co-expression partners for DBI Gene

NURSA nuclear receptor signaling pathways regulating expression of DBI Gene:


SOURCE GeneReport for Unigene cluster for DBI Gene:


mRNA Expression by UniProt/SwissProt for DBI Gene:

Tissue specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.

Evidence on tissue expression from TISSUES for DBI Gene

  • Liver(4.9)
  • Nervous system(4.8)
  • Blood(4.3)
  • Kidney(3.3)
  • Intestine(3.1)
  • Heart(2.8)
  • Muscle(2.7)
  • Adrenal gland(2.6)
  • Lung(2.5)
  • Skin(2.5)
  • Spleen(2.5)
  • Gall bladder(2)
  • Lymph node(2)
  • Pancreas(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with DBI: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBI Gene

Orthologs for DBI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DBI 34 33
  • 100 (n)
(Bos Taurus)
Mammalia DBI 34 33
  • 91.57 (n)
(Mus musculus)
Mammalia Dbi 16 34 33
  • 82.38 (n)
(Rattus norvegicus)
Mammalia Dbi 33
  • 82.38 (n)
(Monodelphis domestica)
Mammalia DBI 34
  • 77 (a)
(Canis familiaris)
Mammalia DBI 34
  • 59 (a)
(Gallus gallus)
Aves DBI 34 33
  • 74.71 (n)
(Anolis carolinensis)
Reptilia DBI 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75740 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2125 33
(Danio rerio)
Actinopterygii dbi 34 33
  • 73.95 (n)
zgc77734 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3079 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007460 33
  • 63.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbi 34 33
  • 57.36 (n)
CG8498 34
  • 52 (a)
CG8629 34
  • 46 (a)
CG8628 34
  • 46 (a)
CG5804 34
  • 43 (a)
CG15829 34
  • 40 (a)
(Caenorhabditis elegans)
Secernentea acbp-1 34 33
  • 63.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACB1 36 34 33
  • 57.61 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL188W 33
  • 57.61 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05643g 33
  • 56.59 (n)
(Triticum aestivum)
Liliopsida Ta.1334 33
(Zea mays)
Liliopsida Zm.7156 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1539.06 33
  • 57.32 (n)
Species where no ortholog for DBI was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DBI Gene

Gene Tree for DBI (if available)
Gene Tree for DBI (if available)
Evolutionary constrained regions (ECRs) for DBI: view image

Paralogs for DBI Gene

Paralogs for DBI Gene

(7) SIMAP similar genes for DBI Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DBI: view

Variants for DBI Gene

Sequence variations from dbSNP and Humsavar for DBI Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000068537 -- 119,368,613(+) T/C intron_variant
rs1000201298 -- 119,366,117(+) C/A upstream_transcript_variant
rs1000445755 -- 119,371,678(+) T/C intron_variant
rs1000662734 -- 119,369,959(+) A/G intron_variant
rs1000733822 -- 119,371,420(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DBI Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV gain 19166990
nsv508862 CNV insertion 20534489
nsv582784 CNV gain 21841781

Variation tolerance for DBI Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBI Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBI Gene

Disorders for DBI Gene

MalaCards: The human disease database

(2) MalaCards diseases for DBI Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatic coma
  • hepatocerebral intoxication
abdominal obesity-metabolic syndrome quantitative trait locus 2
  • aoms2
- elite association - COSMIC cancer census association via MalaCards
Search DBI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DBI

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DBI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBI Gene

Publications for DBI Gene

  1. High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PMID: 17044054) Taskinen JP … Wierenga RK (Proteins 2007) 3 4 22 58
  2. Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations. (PMID: 17262885) Fisher E … Döring F (Molecular nutrition & food research 2007) 3 22 44 58
  3. Identification of new acyl-CoA binding protein transcripts in human and mouse. (PMID: 16055366) Nitz I … Burwinkel B (The international journal of biochemistry & cell biology 2005) 3 4 22 58
  4. Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain. (PMID: 21698759) Ludewig AH … Döring F (IUBMB life 2011) 3 4 58
  5. Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms. (PMID: 20345851) Nitz I … Döring F (Journal of cellular and molecular medicine 2011) 3 4 58

Products for DBI Gene

Sources for DBI Gene

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