Aliases for DBF4B Gene
External Ids for DBF4B Gene
Previous GeneCards Identifiers for DBF4B Gene
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
GeneCards Summary for DBF4B Gene
DBF4B (DBF4 Zinc Finger B) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein kinase activator activity. An important paralog of this gene is DBF4.
UniProtKB/Swiss-Prot Summary for DBF4B Gene
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.