Aliases for DBF4 Gene
External Ids for DBF4 Gene
Previous GeneCards Identifiers for DBF4 Gene
GeneCards Summary for DBF4 Gene
DBF4 (DBF4 Zinc Finger) is a Protein Coding gene. Diseases associated with DBF4 include Myasthenic Syndrome, Congenital, 6, Presynaptic and Congenital Myasthenic Syndrome. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and enzyme activator activity. An important paralog of this gene is DBF4B.
UniProtKB/Swiss-Prot Summary for DBF4 Gene
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.