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Aliases for DBF4 Gene

Aliases for DBF4 Gene

  • DBF4 Zinc Finger 2 3 5
  • Activator Of S Phase Kinase 2 3 4
  • DBF4-Type Zinc Finger-Containing Protein 1 3 4
  • Zinc Finger, DBF-Type Containing 1 2 3
  • DBF4 Zinc Finger A 2 3
  • Chiffon Homolog A 3 4
  • DBF4A 3 4
  • ZDBF1 3 4
  • ASK 3 4
  • Chiffon Homolog (Drosophila) 2
  • DBF4 Homolog (S. Cerevisiae) 2
  • Protein DBF4 Homolog A 3
  • DBF4 Homolog 3
  • CHIF 3

External Ids for DBF4 Gene

Previous GeneCards Identifiers for DBF4 Gene

  • GC07P087151
  • GC07P087343
  • GC07P087505
  • GC07P082115

Summaries for DBF4 Gene

GeneCards Summary for DBF4 Gene

DBF4 (DBF4 Zinc Finger) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and enzyme activator activity. An important paralog of this gene is DBF4B.

UniProtKB/Swiss-Prot for DBF4 Gene

  • Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at Ser-40 and Ser-53 and then is involved in regulating the initiation of DNA replication during cell cycle.

Gene Wiki entry for DBF4 Gene

Additional gene information for DBF4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBF4 Gene

Genomics for DBF4 Gene

GeneHancer (GH) Regulatory Elements for DBF4 Gene

Promoters and enhancers for DBF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J087873 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.7 672 6.4 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B CBX5 ZNF213 SLC25A40 DBF4 PIR53232 TMEM243 RUNDC3B ABCB4 ADAM22
GH07J087343 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 14.2 -530.8 -530841 4.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B FOS SP3 TP53TG1 CROT ENSG00000273623 GC07M087343 GC07M087345 GC07P087364 ENSG00000276185 DBF4
GH07J088217 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.2 +343.3 343336 4.1 HDGF PKNOX1 CLOCK SMAD1 SIN3A ZBTB7B IRF4 YY1 ZNF766 CBX5 SRI ENSG00000228113 DBF4 LOC102723885
GH07J087151 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.7 -722.9 -722923 4.3 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 MEF2D GLIS1 DMTF1 PIR39826 TMEM243 TP53TG1 DBF4 ENSG00000200397 LOC101927420
GH07J087139 Enhancer 1 ENCODE 12.1 -735.5 -735495 2 PKNOX1 SMAD1 FOXA2 ARNT ZNF766 CBX5 E2F8 ZNF592 PPARGC1A MEF2D DMTF1 DBF4 ENSG00000200397 TMEM243 LOC101927420 PIR39826 ENSG00000261462
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DBF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBF4 gene promoter:

Genomic Locations for DBF4 Gene

Genomic Locations for DBF4 Gene
chr7:87,876,216-87,909,541
(GRCh38/hg38)
Size:
33,326 bases
Orientation:
Plus strand
chr7:87,505,531-87,538,856
(GRCh37/hg19)

Genomic View for DBF4 Gene

Genes around DBF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBF4 Gene

Proteins for DBF4 Gene

  • Protein details for DBF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU7-DBF4A_HUMAN
    Recommended name:
    Protein DBF4 homolog A
    Protein Accession:
    Q9UBU7
    Secondary Accessions:
    • A4D1D8
    • A8K954
    • O75226
    • Q75MS6
    • Q75N01
    • Q9Y2M6

    Protein attributes for DBF4 Gene

    Size:
    674 amino acids
    Molecular mass:
    76858 Da
    Quaternary structure:
    • Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6.

    Three dimensional structures from OCA and Proteopedia for DBF4 Gene

    Alternative splice isoforms for DBF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBF4 Gene

Post-translational modifications for DBF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBF4 Gene

No data available for DME Specific Peptides for DBF4 Gene

Domains & Families for DBF4 Gene

Gene Families for DBF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DBF4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DBF4: view

No data available for UniProtKB/Swiss-Prot for DBF4 Gene

Function for DBF4 Gene

Molecular function for DBF4 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at Ser-40 and Ser-53 and then is involved in regulating the initiation of DNA replication during cell cycle.
UniProtKB/Swiss-Prot Induction:
Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase.

Phenotypes From GWAS Catalog for DBF4 Gene

Gene Ontology (GO) - Molecular Function for DBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16899510
GO:0008047 enzyme activator activity TAS 10373557
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with DBF4: view
genes like me logo Genes that share phenotypes with DBF4: view

Animal Models for DBF4 Gene

MGI Knock Outs for DBF4:
  • Dbf4 Dbf4<tm1b(KOMP)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for DBF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBF4 Gene

Localization for DBF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBF4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBF4 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IDA --
GO:0031431 Dbf4-dependent protein kinase complex IBA --
genes like me logo Genes that share ontologies with DBF4: view

Pathways & Interactions for DBF4 Gene

genes like me logo Genes that share pathways with DBF4: view

Pathways by source for DBF4 Gene

1 KEGG pathway for DBF4 Gene
1 GeneGo (Thomson Reuters) pathway for DBF4 Gene

SIGNOR curated interactions for DBF4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0007049 cell cycle IEA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0045740 positive regulation of DNA replication IBA --
genes like me logo Genes that share ontologies with DBF4: view

Drugs & Compounds for DBF4 Gene

No Compound Related Data Available

Transcripts for DBF4 Gene

Unigene Clusters for DBF4 Gene

DBF4 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

  • Addgene plasmids for DBF4

Alternative Splicing Database (ASD) splice patterns (SP) for DBF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -
SP3: -
SP4: - - - - - - - -

Relevant External Links for DBF4 Gene

GeneLoc Exon Structure for
DBF4
ECgene alternative splicing isoforms for
DBF4

Expression for DBF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBF4 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for DBF4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DBF4 Gene



Protein tissue co-expression partners for DBF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DBF4 Gene:

DBF4

SOURCE GeneReport for Unigene cluster for DBF4 Gene:

Hs.485380

mRNA Expression by UniProt/SwissProt for DBF4 Gene:

Q9UBU7-DBF4A_HUMAN
Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Evidence on tissue expression from TISSUES for DBF4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with DBF4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DBF4 Gene

Orthologs for DBF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBF4 34 33
  • 99.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DBF4 34 33
  • 88.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DBF4 34 33
  • 86.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbf4 33
  • 78.03 (n)
mouse
(Mus musculus)
Mammalia Dbf4 16 34 33
  • 77.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DBF4 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBF4 34 33
  • 60.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBF4 34
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20827 33
zebrafish
(Danio rerio)
Actinopterygii dbf4 34
  • 26 (a)
OneToOne
Species where no ortholog for DBF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBF4 Gene

ENSEMBL:
Gene Tree for DBF4 (if available)
TreeFam:
Gene Tree for DBF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBF4: view image

Paralogs for DBF4 Gene

Paralogs for DBF4 Gene

Pseudogenes.org Pseudogenes for DBF4 Gene

genes like me logo Genes that share paralogs with DBF4: view

Variants for DBF4 Gene

Sequence variations from dbSNP and Humsavar for DBF4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000043358 -- 87,901,652(+) A/C/G intron_variant
rs1000203144 -- 87,876,477(+) C/T 5_prime_UTR_variant
rs1000331620 -- 87,896,912(+) A/C intron_variant
rs1000432458 -- 87,903,639(+) G/A intron_variant
rs1000569876 -- 87,904,883(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DBF4 Gene

Variant ID Type Subtype PubMed ID
nsv464622 CNV gain 19166990
nsv525073 CNV gain 19592680
nsv607725 CNV gain 21841781

Variation tolerance for DBF4 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBF4 Gene

Disorders for DBF4 Gene

Additional Disease Information for DBF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DBF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBF4 Gene

Publications for DBF4 Gene

  1. Functional interaction between tumor suppressor menin and activator of S-phase kinase. (PMID: 15374998) Schnepp RW … Hua X (Cancer research 2004) 3 4 22 58
  2. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PMID: 10373557) Kumagai H … Masai H (Molecular and cellular biology 1999) 2 3 4 58
  3. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. (PMID: 10523313) Jiang W … Hunter T (The EMBO journal 1999) 3 4 22 58
  4. The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. (PMID: 19111665) Tsuji T … Jiang W (Molecular cell 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DBF4 Gene

Sources for DBF4 Gene

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