This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stabili... See more...

Aliases for DAZAP2 Gene

Aliases for DAZAP2 Gene

  • DAZ Associated Protein 2 2 3 5
  • DAZ-Associated Protein 2 3 4
  • KIAA0058 2 4
  • Proline-Rich Transcript, Brain-Expressed Protein 3
  • Deleted In Azoospermia Associated Protein 2 3
  • Deleted In Azoospermia-Associated Protein 2 4
  • Proline-Rich Transcript In Brain 3
  • DAZAP2 5
  • PRTB 3

External Ids for DAZAP2 Gene

Previous GeneCards Identifiers for DAZAP2 Gene

  • GC02U990100
  • GC12P051349
  • GC12P049918
  • GC12P051634
  • GC12P048665

Summaries for DAZAP2 Gene

Entrez Gene Summary for DAZAP2 Gene

  • This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for DAZAP2 Gene

DAZAP2 (DAZ Associated Protein 2) is a Protein Coding gene. Diseases associated with DAZAP2 include Thyroid Hormone Resistance, Selective Pituitary and Azoospermia. Among its related pathways are Diurnally Regulated Genes with Circadian Orthologs. Gene Ontology (GO) annotations related to this gene include WW domain binding.

Gene Wiki entry for DAZAP2 Gene

Additional gene information for DAZAP2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAZAP2 Gene

Genomics for DAZAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DAZAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAZAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAZAP2

Top Transcription factor binding sites by QIAGEN in the DAZAP2 gene promoter:
  • AML1a
  • c-Myb
  • FOXJ2
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • p53
  • Pax-6
  • Sp1

Genomic Locations for DAZAP2 Gene

Genomic Locations for DAZAP2 Gene
chr12:51,238,724-51,271,362
(GRCh38/hg38)
Size:
32,639 bases
Orientation:
Plus strand
chr12:51,632,076-51,665,146
(GRCh37/hg19)
Size:
33,071 bases
Orientation:
Plus strand

Genomic View for DAZAP2 Gene

Genes around DAZAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAZAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAZAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZAP2 Gene

Proteins for DAZAP2 Gene

  • Protein details for DAZAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15038-DAZP2_HUMAN
    Recommended name:
    DAZ-associated protein 2
    Protein Accession:
    Q15038
    Secondary Accessions:
    • A8K254
    • B4DDT5
    • B4E1G3
    • C9JA96
    • C9JP84
    • E9PB45
    • F8VU62

    Protein attributes for DAZAP2 Gene

    Size:
    168 amino acids
    Molecular mass:
    17319 Da
    Quaternary structure:
    • Interacts with SOX6 (By similarity). Interacts with DAZ and DAZL. Interacts with IL17RB. May interact with FAM168B. Interacts with INCA1 (PubMed:21750715).
    SequenceCaution:
    • Sequence=BAA06545.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for DAZAP2 Gene

neXtProt entry for DAZAP2 Gene

Post-translational modifications for DAZAP2 Gene

  • Ubiquitinated by SMURF2, leading to proteasomal degradation.
  • Ubiquitination at Lys153
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DAZAP2
  • Boster Bio Antibodies for DAZAP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for DAZAP2

No data available for DME Specific Peptides for DAZAP2 Gene

Domains & Families for DAZAP2 Gene

Gene Families for DAZAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DAZAP2 Gene

InterPro:
Blocks:
  • Binding-protein-dependent transport systems inner membrane component
ProtoNet:

Suggested Antigen Peptide Sequences for DAZAP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59575, highly similar to DAZ-associated protein 2 (B4DDT5_HUMAN)
  • Deleted in azoospermia-associated protein 2 (DAZP2_HUMAN)
genes like me logo Genes that share domains with DAZAP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DAZAP2 Gene

Function for DAZAP2 Gene

Phenotypes From GWAS Catalog for DAZAP2 Gene

Gene Ontology (GO) - Molecular Function for DAZAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10857750
GO:0030971 receptor tyrosine kinase binding IEA --
GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0043539 protein serine/threonine kinase activator activity IEA --
genes like me logo Genes that share ontologies with DAZAP2: view
genes like me logo Genes that share phenotypes with DAZAP2: view

Animal Model Products

CRISPR Products

miRNA for DAZAP2 Gene

miRTarBase miRNAs that target DAZAP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAZAP2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAZAP2 Gene

Localization for DAZAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZAP2 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAZAP2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
golgi apparatus 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAZAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA --
GO:0032991 protein-containing complex IDA 10857750
genes like me logo Genes that share ontologies with DAZAP2: view

Pathways & Interactions for DAZAP2 Gene

PathCards logo

SuperPathways for DAZAP2 Gene

genes like me logo Genes that share pathways with DAZAP2: view

Pathways by source for DAZAP2 Gene

1 BioSystems pathway for DAZAP2 Gene

Gene Ontology (GO) - Biological Process for DAZAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071902 positive regulation of protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with DAZAP2: view

No data available for SIGNOR curated interactions for DAZAP2 Gene

Drugs & Compounds for DAZAP2 Gene

No Compound Related Data Available

Transcripts for DAZAP2 Gene

mRNA/cDNA for DAZAP2 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAZAP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for DAZAP2 Gene

GeneLoc Exon Structure for
DAZAP2

Expression for DAZAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAZAP2 Gene

mRNA differential expression in normal tissues according to GTEx for DAZAP2 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for DAZAP2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAZAP2 Gene



Protein tissue co-expression partners for DAZAP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAZAP2

SOURCE GeneReport for Unigene cluster for DAZAP2 Gene:

Hs.369761

mRNA Expression by UniProt/SwissProt for DAZAP2 Gene:

Q15038-DAZP2_HUMAN
Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma.

Evidence on tissue expression from TISSUES for DAZAP2 Gene

  • Nervous system(5)
  • Blood(4.9)
  • Lung(4.9)
  • Bone marrow(4.6)
  • Intestine(4.3)
  • Kidney(4.1)
  • Spleen(3.7)
  • Pancreas(3.1)
  • Skin(3.1)
  • Eye(2.9)
  • Heart(2.8)
  • Liver(2.8)
  • Lymph node(2.7)
  • Stomach(2.7)
  • Muscle(2.7)
  • Thyroid gland(2.6)
  • Gall bladder(2.3)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with DAZAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAZAP2 Gene

Orthologs for DAZAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAZAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DAZAP2 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DAZAP2 30 31
  • 95.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DAZAP2 30 31
  • 95.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dazap2 30 17 31
  • 93.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DAZAP2 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dazap2 30
  • 70.88 (n)
MGC76067 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29509 30
Zebrafish
(Danio rerio)
Actinopterygii dazap2 30 31
  • 67.27 (n)
OneToOne
wufi04d04 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.345 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1706 31
  • 18 (a)
OneToOne
Species where no ortholog for DAZAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DAZAP2 Gene

ENSEMBL:
Gene Tree for DAZAP2 (if available)
TreeFam:
Gene Tree for DAZAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAZAP2: view image

Paralogs for DAZAP2 Gene

Pseudogenes.org Pseudogenes for DAZAP2 Gene

genes like me logo Genes that share paralogs with DAZAP2: view

No data available for Paralogs for DAZAP2 Gene

Variants for DAZAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAZAP2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs57917280 - p.Ser102Ala

Additional dbSNP identifiers (rs#s) for DAZAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DAZAP2 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV loss 18971310
esv3892200 CNV loss 25118596
nsv704 CNV insertion 18451855

Variation tolerance for DAZAP2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAZAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAZAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAZAP2 Gene

Disorders for DAZAP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DAZAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thyroid hormone resistance, selective pituitary
  • prth
azoospermia
  • spermatogenic failure
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DAZAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAZAP2 Gene

Publications for DAZAP2 Gene

  1. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. (PMID: 10857750) Tsui S … Yen PH (Genomics 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4
  3. Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. (PMID: 22070932) Popova A … Gratchev A (Immunobiology 2012) 3 4
  4. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. (PMID: 21750715) Zhang F … Müller-Tidow C (PloS one 2011) 3 4
  5. Molecular features and expression of DAZAP2 in human multiple myeloma. (PMID: 17935665) Shi YW … Hu WX (Chinese medical journal 2007) 3 4

Products for DAZAP2 Gene

  • Signalway ELISA kits for DAZAP2

Sources for DAZAP2 Gene