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Aliases for DAW1 Gene

Aliases for DAW1 Gene

  • Dynein Assembly Factor With WD Repeats 1 2 3 5
  • Dynein Assembly Factor With WDR Repeat Domains 1 3 4
  • Outer Row Dynein Assembly Protein 16 Homolog 3 4
  • WD Repeat-Containing Protein 69 3 4
  • WD Repeat Domain 69 2 3
  • WDR69 3 4
  • Outer Row Dynein Assembly 16 Homolog (Chlamydomonas) 2
  • Testis Tissue Sperm-Binding Protein Li 93mP 3
  • Outer Row Dynein Assembly 16 Homolog 3
  • ODA16 3

External Ids for DAW1 Gene

Previous HGNC Symbols for DAW1 Gene

  • WDR69

Previous GeneCards Identifiers for DAW1 Gene

  • GC02P228736

Summaries for DAW1 Gene

GeneCards Summary for DAW1 Gene

DAW1 (Dynein Assembly Factor With WD Repeats 1) is a Protein Coding gene. An important paralog of this gene is WDR88.

UniProtKB/Swiss-Prot for DAW1 Gene

Additional gene information for DAW1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAW1 Gene

Genomics for DAW1 Gene

GeneHancer (GH) Regulatory Elements for DAW1 Gene

Promoters and enhancers for DAW1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J227870 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 612.5 +0.1 70 2.2 RFX1 POLR2A NRF1 CEBPB RFX3 JUN SP1 RCOR1 JUND ZKSCAN8 DAW1 TDGF1P2 GC02M227870 GC02M227871 ENSG00000272237
GH02J227847 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 22.6 -22.2 -22153 2.2 SP1 ZNF687 RELA CREM ZNF680 ZBED1 IKZF1 IKZF2 CBFB DPF2 DAW1 TDGF1P2 CCL20 GC02P227844 GC02M227848
GH02J227839 Enhancer 1 FANTOM5 Ensembl ENCODE 21.1 -31.3 -31253 1.6 ZNF687 IKZF1 IKZF2 CEBPA DPF2 EED ELF1 NR2F1 ATF7 RARA DAW1 CCL20 TDGF1P2 AGFG1 GC02P227841 GC02P227817
GH02J227862 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.6 -8.6 -8553 5 CTCF CEBPG ZNF687 ZNF24 MAFK PPARG MLLT1 ZNF644 RAD21 FOSL2 GC02M227862 DAW1 GC02M227848
GH02J227875 Enhancer 1 FANTOM5 Ensembl ENCODE 12.5 +5.9 5932 3.2 CEBPB JUN SP1 JUND EP300 TCF7L2 ATF2 HLF DAW1 CCL20 GC02M227871 ENSG00000272237
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAW1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DAW1 Gene

Genomic Locations for DAW1 Gene
53,294 bases
Plus strand
53,291 bases
Plus strand

Genomic View for DAW1 Gene

Genes around DAW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAW1 Gene

Proteins for DAW1 Gene

  • Protein details for DAW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynein assembly factor with WDR repeat domains 1
    Protein Accession:
    Secondary Accessions:
    • Q6ZRY1
    • Q8N776

    Protein attributes for DAW1 Gene

    415 amino acids
    Molecular mass:
    45777 Da
    Quaternary structure:
    • Interacts with IFT46.

    Three dimensional structures from OCA and Proteopedia for DAW1 Gene

    Alternative splice isoforms for DAW1 Gene


neXtProt entry for DAW1 Gene

Post-translational modifications for DAW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAW1 Gene

No data available for DME Specific Peptides for DAW1 Gene

Domains & Families for DAW1 Gene

Gene Families for DAW1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DAW1 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat domain 69, isoform CRA_c (C9JBF9_HUMAN)
  • WD repeat-containing protein 69 (WDR69_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR69 family.
  • Belongs to the WD repeat WDR69 family.
genes like me logo Genes that share domains with DAW1: view

Function for DAW1 Gene

Molecular function for DAW1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in axonemal outer row dynein assembly.

Phenotypes From GWAS Catalog for DAW1 Gene

genes like me logo Genes that share phenotypes with DAW1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DAW1 - Now 50% OFF >
  • * DAW1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DAW1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DAW1 Gene

Localization for DAW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAW1 Gene

Cell projection, cilium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAW1 gene
Compartment Confidence
cytoskeleton 1
peroxisome 1
nucleus 1
cytosol 1
mitochondrion 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with DAW1: view

Pathways & Interactions for DAW1 Gene

PathCards logo

SuperPathways for DAW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DAW1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DAW1 Gene

Drugs & Compounds for DAW1 Gene

No Compound Related Data Available

Transcripts for DAW1 Gene

mRNA/cDNA for DAW1 Gene

Unigene Clusters for DAW1 Gene

Dynein assembly factor with WDR repeat domains 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DAW1 - Now 50% OFF >
  • * DAW1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DAW1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DAW1 Gene

No ASD Table

Relevant External Links for DAW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAW1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAW1 Gene

This gene is overexpressed in Testis (x20.1), Brain - Nucleus accumbens (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for DAW1 Gene

This gene is overexpressed in Testis (37.5) and Heart (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAW1 Gene

Protein tissue co-expression partners for DAW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAW1 Gene:


SOURCE GeneReport for Unigene cluster for DAW1 Gene:

genes like me logo Genes that share expression patterns with DAW1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAW1 Gene

Orthologs for DAW1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DAW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR69 35 34
  • 99.36 (n)
(Bos Taurus)
Mammalia DAW1 35 34
  • 90.36 (n)
(Canis familiaris)
Mammalia DAW1 35 34
  • 89.88 (n)
(Mus musculus)
Mammalia Daw1 35
  • 89 (a)
(Monodelphis domestica)
Mammalia DAW1 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Daw1 34
  • 84.42 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
-- 35
  • 84 (a)
(Gallus gallus)
Aves WDR69 34
  • 76.89 (n)
DAW1 35
  • 75 (a)
(Anolis carolinensis)
Reptilia DAW1 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia daw1 34
  • 73.09 (n)
MGC76247 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12681 34
(Danio rerio)
Actinopterygii daw1 35 34
  • 67.82 (n)
Dr.15604 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2611 34
fruit fly
(Drosophila melanogaster)
Insecta CG7568 35 34
  • 51.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009574 34
  • 31.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA4 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9620 35
  • 67 (a)
Cin.4284 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4284 34
Species where no ortholog for DAW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAW1 Gene

Gene Tree for DAW1 (if available)
Gene Tree for DAW1 (if available)
Evolutionary constrained regions (ECRs) for DAW1: view image

Paralogs for DAW1 Gene

(27) SIMAP similar genes for DAW1 Gene using alignment to 5 proteins:

  • C9JP90_HUMAN
  • G5EA46_HUMAN
genes like me logo Genes that share paralogs with DAW1: view

Variants for DAW1 Gene

Sequence variations from dbSNP and Humsavar for DAW1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs113776284 A breast cancer sample 227,893,863(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000009704 -- 227,886,551(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000049489 -- 227,891,342(+) T/C intron_variant
rs1000161202 -- 227,897,832(+) A/G intron_variant
rs1000250164 -- 227,876,189(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DAW1 Gene

Variant ID Type Subtype PubMed ID
dgv2165n106 CNV duplication 24896259
nsv10221 CNV loss 18304495
nsv1076505 CNV duplication 25765185
nsv1149946 CNV duplication 26484159
nsv3192 CNV insertion 18451855
nsv518157 CNV loss 19592680
nsv834562 CNV gain 17160897

Variation tolerance for DAW1 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.14; 84.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAW1 Gene

Disorders for DAW1 Gene

Additional Disease Information for DAW1

No disorders were found for DAW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAW1 Gene

Publications for DAW1 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom EF … King SM (Cytoskeleton (Hoboken, N.J.) 2011) 2 3 58
  2. Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis. (PMID: 20568242) Gao C … Mitchell DR (Developmental dynamics : an official publication of the American Association of Anatomists 2010) 2 3 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DAW1 Gene

Sources for DAW1 Gene

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