DARS1 Gene (Protein Coding)

Aspartyl-TRNA Synthetase 1

GC02M135905
GIFtS:
37
This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript va... See more...

Aliases for DARS1 Gene

Aliases for DARS1 Gene

  • Aspartyl-TRNA Synthetase 1 2 3 5
  • Cell Proliferation-Inducing Gene 40 Protein 3 4
  • Aspartate TRNA Ligase 1, Cytoplasmic 2 3
  • Aspartate--TRNA Ligase, Cytoplasmic 3 4
  • Aspartyl-TRNA Synthetase 2 4
  • EC 6.1.1.12 4 51
  • AspRS 3 4
  • DARS 3 4
  • Aspartyl-TRNA Synthetase, Cytoplasmic 3
  • Testicular Tissue Protein Li 192 3
  • DARS1 5
  • HBSL 3

External Ids for DARS1 Gene

Previous HGNC Symbols for DARS1 Gene

  • DARS

Summaries for DARS1 Gene

Entrez Gene Summary for DARS1 Gene

  • This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DARS1 Gene

DARS1 (Aspartyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with DARS1 include Hypomyelination With Brainstem And Spinal Cord Involvement And Leg Spasticity and Spasticity. Among its related pathways are Viral mRNA Translation and tRNA Aminoacylation. An important paralog of this gene is NARS1.

UniProtKB/Swiss-Prot Summary for DARS1 Gene

  • Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Gene Wiki entry for DARS1 Gene

Additional gene information for DARS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DARS1 Gene

Genomics for DARS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DARS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J135983 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 267 +1.1 1135 3.7 ZSCAN16 CHD2 TBP ZBTB10 SP1 MXD4 NR2C1 MNT IKZF1 BRCA1 DARS1 DARS1-AS1 lnc-MCM6-2 UBXN4 MCM6 CXCR4
GH02J135874 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.6 +110.4 110399 3 TBP SP1 MNT SMAD5 IRF2 HES1 MBD2 ZNF217 POLR2A ZEB1 MCM6 CXCR4 DARS1 UBXN4 piR-34822-184 LCT
GH02J135741 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 8.4 +242.5 242498 5.2 CHD2 TBP MXD4 CEBPA SIX5 SMAD5 ETS1 IRF2 MBD2 ZNF217 UBXN4 LOC107985946 NONHSAG029369.2 CCNT2 R3HDM1 DARS1 MCM6 MAP3K19 NONHSAG029370.2 LCT
GH02J135960 Enhancer 1.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.5 +23.1 23099 6.4 JUND MAFK FOXA1 PKNOX1 DPF2 GATA2 ZNF217 MEIS2 IKZF1 ATF7 DARS1 MCM6 lnc-MCM6-2 lnc-MCM6-1
GH02J135997 Enhancer 1 Ensembl ENCODE dbSUPER 14.7 -13.6 -13601 6.6 CTCF TRIM22 MAFF EBF1 YY1 ZNF316 RAD21 PKNOX1 IKZF1 MAFK DARS1 CXCR4 DARS1-AS1 HSALNG0019086
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DARS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DARS1

Genomic Locations for DARS1 Gene

Latest Assembly
chr2:135,905,881-135,986,100
(GRCh38/hg38)
Size:
80,220 bases
Orientation:
Minus strand

Previous Assembly
chr2:136,663,451-136,743,254
(GRCh37/hg19 by Entrez Gene)
Size:
79,804 bases
Orientation:
Minus strand

chr2:136,664,247-136,743,670
(GRCh37/hg19 by Ensembl)
Size:
79,424 bases
Orientation:
Minus strand

Genomic View for DARS1 Gene

Genes around DARS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DARS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DARS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DARS1 Gene

Proteins for DARS1 Gene

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  • Protein details for DARS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14868-SYDC_HUMAN
    Recommended name:
    Aspartate--tRNA ligase, cytoplasmic
    Protein Accession:
    P14868
    Secondary Accessions:
    • A8K3J2
    • D3DP77
    • Q2TNI3
    • Q32Q69
    • Q53HV4
    • Q53YC5
    • Q68CR9
    • Q9BW52

    Protein attributes for DARS1 Gene

    Size:
    501 amino acids
    Molecular mass:
    57136 Da
    Quaternary structure:
    • Homodimer (PubMed:23609930). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464).

    Three dimensional structures from OCA and Proteopedia for DARS1 Gene

    Alternative splice isoforms for DARS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DARS1 Gene

Selected DME Specific Peptides for DARS1 Gene

P14868:
  • PPHAGGGIGLERV
  • PKIISAASE
  • DLSTPNEKLLG
  • IGPVFRAE
  • QSPQLYK
  • CFLVLRQ
  • FPRDPKRL
  • DAAEDYAKERYG
  • FMRGEEI
  • DTRLDNR

Post-translational modifications for DARS1 Gene

  • Ubiquitination at Lys103 and Lys330
  • Modification sites at PhosphoSitePlus

Other Protein References for DARS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DARS1 Gene

Gene Families for DARS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for DARS1 Gene

InterPro:
Blocks:
  • Aspartyl-tRNA synthetase signature
  • tRNA synthetase, class II (D, K and N)
  • OB-fold nucleic acid binding domain
ProtoNet:

Suggested Antigen Peptide Sequences for DARS1 Gene

GenScript: Design optimal peptide antigens:
  • Aspartyl-tRNA synthetase, isoform CRA_b (D3DP78_HUMAN)
  • Cell proliferation-inducing gene 40 protein (SYDC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14868

UniProtKB/Swiss-Prot:

SYDC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
genes like me logo Genes that share domains with DARS1: view

Function for DARS1 Gene

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  6. Cell Lines for research

Molecular function for DARS1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp); Xref=Rhea:RHEA:19649, Rhea:RHEA-COMP:9660, Rhea:RHEA-COMP:9678, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78516, ChEBI:CHEBI:456215; EC=6.1.1.12; Evidence={ECO:0000250|UniProtKB:P15178};.

Enzyme Numbers (IUBMB) for DARS1 Gene

Phenotypes From GWAS Catalog for DARS1 Gene

Gene Ontology (GO) - Molecular Function for DARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0004046 aminoacylase activity TAS 8449960
GO:0004812 aminoacyl-tRNA ligase activity IEA --
genes like me logo Genes that share ontologies with DARS1: view
genes like me logo Genes that share phenotypes with DARS1: view

Human Phenotype Ontology for DARS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for DARS1 Gene

miRTarBase miRNAs that target DARS1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DARS1

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DARS1 Gene

Localization for DARS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DARS1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DARS1 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 8449960
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex IBA,IDA 19131329
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with DARS1: view

Pathways & Interactions for DARS1 Gene

genes like me logo Genes that share pathways with DARS1: view

Pathways by source for DARS1 Gene

1 BioSystems pathway for DARS1 Gene
1 KEGG pathway for DARS1 Gene

Gene Ontology (GO) - Biological Process for DARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,TAS 8449960
GO:0006418 tRNA aminoacylation for protein translation IEA,TAS --
GO:0006422 aspartyl-tRNA aminoacylation IEA,IBA 21873635
GO:0065003 protein-containing complex assembly TAS 8449960
genes like me logo Genes that share ontologies with DARS1: view

No data available for SIGNOR curated interactions for DARS1 Gene

Drugs & Compounds for DARS1 Gene

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  1. Drug products for research

(8) Drugs for DARS1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspartic acid Approved Nutra Target 193
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
Ureidosuccinic acid Experimental Pharma 0
ATP Investigational Nutra 0

(7) Additional Compounds for DARS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
 14000-31-8
genes like me logo Genes that share compounds with DARS1: view

Transcripts for DARS1 Gene

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mRNA/cDNA for DARS1 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DARS1

Alternative Splicing Database (ASD) splice patterns (SP) for DARS1 Gene

No ASD Table

Relevant External Links for DARS1 Gene

GeneLoc Exon Structure for
DARS1

Expression for DARS1 Gene

Products:

  1. Primer products for research

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DARS1

SOURCE GeneReport for Unigene cluster for DARS1 Gene:

Hs.503787

mRNA Expression by UniProt/SwissProt for DARS1 Gene:

P14868-SYDC_HUMAN
Tissue specificity: Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon.

Evidence on tissue expression from TISSUES for DARS1 Gene

  • Liver(4.6)
  • Nervous system(4.5)
  • Heart(4.5)
  • Blood(4.4)
  • Eye(4.3)
  • Kidney(2.5)
  • Skin(2.5)
  • Muscle(2.4)
  • Spleen(2.3)
  • Thyroid gland(2.1)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DARS1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • eye
  • head
Thorax:
  • chest wall
Abdomen:
  • abdominal wall
Limb:
  • foot
  • lower limb
General:
  • spinal cord

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DARS1 Gene

Orthologs for DARS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DARS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DARS 30 31
  • 99.73 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia DARS 31
  • 95 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DARS 30 31
  • 93.88 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DARS 30 31
  • 93.21 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Dars 30 17 31
  • 91.75 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Dars 30
  • 90.95 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia DARS 31
  • 82 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DARS 30 31
  • 82.17 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia DARS 31
  • 85 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dars 30
  • 77.71 (n)
MGC76305 30
African clawed frog
(Xenopus laevis)
 Amphibia dars-prov 30
Zebrafish
(Danio rerio)
 Actinopterygii dars 30 31
  • 76.6 (n)
 OneToOne
wufc17a11 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Aats-asp 30 31
  • 62.92 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005576 30
  • 60.13 (n)
Worm
(Caenorhabditis elegans)
 Secernentea dars-1 30 31
  • 62.57 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D03839g 30
  • 58.18 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes DPS1 30 31 33
  • 57.74 (n)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADL039C 30
  • 55.47 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT4G31180 30
  • 55.85 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.10065 30
Soybean
(Glycine max)
 eudicotyledons Gma.1067 30
Rice
(Oryza sativa)
 Liliopsida Os02g0686400 30
  • 55.71 (n)
Os.12716 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.2597 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.14416 30
Corn
(Zea mays)
 Liliopsida Zm.3547 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9554 31
  • 76 (a)
 OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes drs1 30
  • 56.19 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU07082 30
  • 50.07 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.6166 30
Species where no ortholog for DARS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DARS1 Gene

ENSEMBL:
Gene Tree for DARS1 (if available)
TreeFam:
Gene Tree for DARS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DARS1: view image

Paralogs for DARS1 Gene

Paralogs for DARS1 Gene

genes like me logo Genes that share paralogs with DARS1: view

Variants for DARS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DARS1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
982592 Uncertain Significance: Hypomyelination with brainstem and spinal cord involvement and leg spasticity 135,920,567(-) T/G
NM_001349.4(DARS1):c.845A>C (p.His282Pro) 		MISSENSE
rs1057521361 Likely Benign: not specified 135,961,518(-) C/A
NM_001349.4(DARS1):c.218-20G>T 		INTRON
rs1060499772 Likely Pathogenic: Abnormality of brain morphology 135,943,412(-) C/G
NM_001349.4(DARS1):c.389G>C (p.Cys130Ser) 		MISSENSE
rs112205661 Likely Benign: not specified 135,920,590(-) C/T
NM_001349.4(DARS1):c.822G>A (p.Ala274=) 		SYNONYMOUS
rs115253602 Benign: not specified 135,911,121(-) G/A
NM_001349.4(DARS1):c.1414+18C>T 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DARS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for DARS1 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DARS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DARS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DARS1 Gene

Disorders for DARS1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DARS1 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search DARS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYDC_HUMAN
  • Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL) [MIM:615281]: An autosomal recessive leukoencephalopathy characterized by onset in the first year of life of severe spasticity, mainly affecting the lower limbs and resulting in an inability to achieve independent ambulation. Affected individuals show delayed motor development and nystagmus; some may have mild mental retardation. Brain MRI shows hypomyelination and white matter lesions in the cerebrum, brainstem, cerebellum, and spinal cord. {ECO:0000269 PubMed:23643384}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for DARS1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DARS1: view

No data available for Genatlas for DARS1 Gene

Publications for DARS1 Gene

  1. Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. (PMID: 23643384) Taft RJ … Wolf NI (American journal of human genetics 2013) 3 4 74
  2. Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro. (PMID: 18029264) Guzzo CM … Yang DC (Biochemical and biophysical research communications 2008) 3 4 23
  3. cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase. (PMID: 2674137) Jacobo-Molina A … Yang DC (The Journal of biological chemistry 1989) 2 3 4
  4. Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. (PMID: 23609930) Kim KR … Han BW (Proteins 2013) 3 4
  5. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. (PMID: 19131329) Kaminska M … Mirande M (The Journal of biological chemistry 2009) 3 4

ExternalLinks

View latest publications for DARS1 gene in Mastermind

Products for DARS1 Gene

Sources for DARS1 Gene