Aliases for DARS1 Gene
External Ids for DARS1 Gene
Previous HGNC Symbols for DARS1 Gene
This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for DARS1 Gene
DARS1 (Aspartyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with DARS1 include Hypomyelination With Brainstem And Spinal Cord Involvement And Leg Spasticity and Spasticity. Among its related pathways are Viral mRNA Translation and tRNA Aminoacylation. An important paralog of this gene is NARS1.
UniProtKB/Swiss-Prot Summary for DARS1 Gene
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.