Aliases for DAPP1 Gene

Aliases for DAPP1 Gene

  • Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1 2 3 5
  • BAM32 2 3 4
  • Dual Adapter For Phosphotyrosine And 3-Phosphotyrosine And 3-Phosphoinositide 3 4
  • B Lymphocyte Adapter Protein Bam32 3 4
  • B-Cell Adapter Molecule Of 32 KDa 3 4
  • HDAPP1 3 4
  • DAPP1 5

External Ids for DAPP1 Gene

Previous GeneCards Identifiers for DAPP1 Gene

  • GC04P100985
  • GC04P101130
  • GC04P101196
  • GC04P101095
  • GC04P100737
  • GC04P096476

Summaries for DAPP1 Gene

GeneCards Summary for DAPP1 Gene

DAPP1 (Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1) is a Protein Coding gene. Among its related pathways are B cell receptor signaling pathway (KEGG) and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include phospholipid binding and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is SLA.

UniProtKB/Swiss-Prot Summary for DAPP1 Gene

  • May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Gene Wiki entry for DAPP1 Gene

Additional gene information for DAPP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAPP1 Gene

Genomics for DAPP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DAPP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J099814 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 614.2 +0.1 123 4.1 SP1 POLR2A BACH1 ZNF143 RELA RXRB SMAD5 IKZF2 RCOR1 TRIM22 DAPP1 TRMT10A MTTP DNAJB14 H2AZ1 H2AZ1-DT LAMTOR3 ENSG00000279913 ENSG00000248676
GH04J099810 Promoter/Enhancer 0.5 EPDnew FANTOM5 608.8 -6.3 -6272 0.3 DAPP1 TRMT10A MTTP DNAJB14 H2AZ1 H2AZ1-DT piR-38051-200 ENSG00000248676 C4orf54
GH04J099845 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 22.9 +29.4 29373 5.6 SP1 ZNF512 POLR2A BACH1 ZNF143 RELA TCF12 IKZF2 RCOR1 TRIM22 ENSG00000248676 RF00017-4374 DAPP1 TRMT10A MTTP LAMTOR3 DNAJB14 ENSG00000279913
GH04J099841 Enhancer 0.6 FANTOM5 dbSUPER 32.5 +24.6 24605 0.3 RUNX3 MEF2D DAPP1 TRMT10A MTTP LAMTOR3 ENSG00000279913 ENSG00000248676
GH04J099819 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +4.6 4604 3.2 STAT3 IKZF2 EED CBX3 RELB RUNX3 BCLAF1 TRIM28 TRIM24 NBN DNAJB14 TRMT10A DAPP1 H2AZ1 MTTP H2AZ1-DT LAMTOR3 DDIT4L ENSG00000279913 ENSG00000248676
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAPP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAPP1

Top Transcription factor binding sites by QIAGEN in the DAPP1 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for DAPP1 Gene

Genomic Locations for DAPP1 Gene
chr4:99,816,827-99,872,290
(GRCh38/hg38)
Size:
55,464 bases
Orientation:
Plus strand
chr4:100,737,981-100,791,347
(GRCh37/hg19)
Size:
53,367 bases
Orientation:
Plus strand

Genomic View for DAPP1 Gene

Genes around DAPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPP1 Gene

Proteins for DAPP1 Gene

  • Protein details for DAPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN19-DAPP1_HUMAN
    Recommended name:
    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
    Protein Accession:
    Q9UN19
    Secondary Accessions:
    • Q8TCK5
    • Q9UHF2

    Protein attributes for DAPP1 Gene

    Size:
    280 amino acids
    Molecular mass:
    32194 Da
    Quaternary structure:
    • Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.

    Three dimensional structures from OCA and Proteopedia for DAPP1 Gene

    Alternative splice isoforms for DAPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAPP1 Gene

Post-translational modifications for DAPP1 Gene

Other Protein References for DAPP1 Gene

No data available for DME Specific Peptides for DAPP1 Gene

Domains & Families for DAPP1 Gene

Gene Families for DAPP1 Gene

Protein Domains for DAPP1 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Pleckstrin-like
ProtoNet:

Suggested Antigen Peptide Sequences for DAPP1 Gene

GenScript: Design optimal peptide antigens:
  • B-cell adapter molecule of 32 kDa (DAPP1_HUMAN)
genes like me logo Genes that share domains with DAPP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DAPP1 Gene

Function for DAPP1 Gene

Molecular function for DAPP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
UniProtKB/Swiss-Prot Induction:
Upon B-cell activation.

Phenotypes From GWAS Catalog for DAPP1 Gene

Gene Ontology (GO) - Molecular Function for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
GO:0005543 phospholipid binding NAS 10432293
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11001876
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 11001876
genes like me logo Genes that share ontologies with DAPP1: view
genes like me logo Genes that share phenotypes with DAPP1: view

Animal Models for DAPP1 Gene

MGI Knock Outs for DAPP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAPP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DAPP1 Gene

Localization for DAPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAPP1 Gene

Cytoplasm. Membrane. Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAPP1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DAPP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DAPP1 Gene

Pathways & Interactions for DAPP1 Gene

genes like me logo Genes that share pathways with DAPP1: view

Pathways by source for DAPP1 Gene

1 KEGG pathway for DAPP1 Gene
1 Qiagen pathway for DAPP1 Gene
  • PI3K Signaling in B-Lymphocyte
1 Cell Signaling Technology pathway for DAPP1 Gene

SIGNOR curated interactions for DAPP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation NAS 10432293
GO:0007165 signal transduction TAS 10432293
genes like me logo Genes that share ontologies with DAPP1: view

Drugs & Compounds for DAPP1 Gene

(1) Drugs for DAPP1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0

(1) Additional Compounds for DAPP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAPP1: view

Transcripts for DAPP1 Gene

mRNA/cDNA for DAPP1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAPP1

Alternative Splicing Database (ASD) splice patterns (SP) for DAPP1 Gene

No ASD Table

Relevant External Links for DAPP1 Gene

GeneLoc Exon Structure for
DAPP1

Expression for DAPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.1) and Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for DAPP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.1) and Platelet (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAPP1 Gene



Protein tissue co-expression partners for DAPP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAPP1

SOURCE GeneReport for Unigene cluster for DAPP1 Gene:

Hs.436271

mRNA Expression by UniProt/SwissProt for DAPP1 Gene:

Q9UN19-DAPP1_HUMAN
Tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.

Evidence on tissue expression from TISSUES for DAPP1 Gene

  • Lymph node(4.5)
  • Blood(4.5)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with DAPP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DAPP1 Gene

Orthologs for DAPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DAPP1 30 31
  • 99.88 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DAPP1 30 31
  • 92.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DAPP1 30 31
  • 91.19 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dapp1 30 17 31
  • 87.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dapp1 30
  • 85.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia DAPP1 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DAPP1 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DAPP1 30 31
  • 75.58 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DAPP1 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dapp1 30
  • 73.87 (n)
Zebrafish
(Danio rerio)
Actinopterygii dapp1 30 31
  • 66.26 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8525 31
  • 50 (a)
OneToOne
Species where no ortholog for DAPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DAPP1 Gene

ENSEMBL:
Gene Tree for DAPP1 (if available)
TreeFam:
Gene Tree for DAPP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAPP1: view image

Paralogs for DAPP1 Gene

Paralogs for DAPP1 Gene

(2) SIMAP similar genes for DAPP1 Gene using alignment to 2 proteins:

  • DAPP1_HUMAN
  • J3KNB3_HUMAN
genes like me logo Genes that share paralogs with DAPP1: view

Variants for DAPP1 Gene

Additional dbSNP identifiers (rs#s) for DAPP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DAPP1 Gene

Variant ID Type Subtype PubMed ID
dgv2865n106 CNV tandem duplication 24896259
esv3306095 CNV mobile element insertion 20981092
esv3357480 CNV insertion 20981092
nsv1136895 CNV deletion 24896259
nsv520074 CNV loss 19592680

Variation tolerance for DAPP1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAPP1 Gene

Human Gene Mutation Database (HGMD)
DAPP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAPP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAPP1 Gene

Disorders for DAPP1 Gene

No disorders were found for DAPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAPP1 Gene

Publications for DAPP1 Gene

  1. A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. (PMID: 10770799) Marshall AJ … Clark EA (The Journal of experimental medicine 2000) 3 4 23
  2. DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. (PMID: 10432293) Dowler S … Alessi DR (The Biochemical journal 1999) 2 3 4
  3. Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. (PMID: 17823121) Manna D … Cho W (The Journal of biological chemistry 2007) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. (PMID: 15247305) Allam A … Marshall AJ (The Journal of biological chemistry 2004) 3 23

Products for DAPP1 Gene

  • Signalway ELISA kits for DAPP1

Sources for DAPP1 Gene