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Aliases for DAPL1 Gene

Aliases for DAPL1 Gene

  • Death Associated Protein Like 1 2 3 5
  • Early Epithelial Differentiation-Associated Protein 4
  • Death Associated Protein-Like 1 2
  • EEDA 4

External Ids for DAPL1 Gene

Previous GeneCards Identifiers for DAPL1 Gene

  • GC00U911651
  • GC02U900711
  • GC02P159361
  • GC02P159651
  • GC02P151540

Summaries for DAPL1 Gene

GeneCards Summary for DAPL1 Gene

DAPL1 (Death Associated Protein Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for DAPL1 Gene

  • May play a role in the early stages of epithelial differentiation or in apoptosis.

Additional gene information for DAPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPL1 Gene

Genomics for DAPL1 Gene

GeneHancer (GH) Regulatory Elements for DAPL1 Gene

Promoters and enhancers for DAPL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I158795 Promoter/Enhancer 1 EPDnew Ensembl 559.9 +0.2 184 0.6 USF1 POLR2A SCRT2 ZNF223 TCF7L2 DAPL1 OR7E28P OR7E89P
GH02I158983 Enhancer 0.7 dbSUPER 5.1 +189.3 189349 1.8 CEBPG ZFHX2 ZNF366 ZNF143 ATF7 ZNF600 EGR2 HLF CEBPB TSHZ1 RNU2-21P TANC1 DAPL1 OR7E28P OR7E90P GC02P158993
GH02I158772 Enhancer 0.2 ENCODE 12.1 -22.6 -22640 1.2 DAPL1 OR7E28P GC02M158745
GH02I158744 Enhancer 0.2 ENCODE 7.7 -50.3 -50319 0.2 DAPL1 GC02M158745 PKP4-AS1 ENSG00000228586
GH02I158868 Enhancer 0.3 ENCODE 4.5 +73.3 73347 0.9 TEAD3 OR7E28P DAPL1 OR7E90P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DAPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DAPL1 gene promoter:

Genomic Locations for DAPL1 Gene

Genomic Locations for DAPL1 Gene
67,465 bases
Plus strand

Genomic View for DAPL1 Gene

Genes around DAPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPL1 Gene

Proteins for DAPL1 Gene

  • Protein details for DAPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death-associated protein-like 1
    Protein Accession:
    Secondary Accessions:
    • A0PJW9
    • B9EIK6

    Protein attributes for DAPL1 Gene

    107 amino acids
    Molecular mass:
    11880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAPL1 Gene

Post-translational modifications for DAPL1 Gene

No Post-translational modifications

Other Protein References for DAPL1 Gene

No data available for DME Specific Peptides for DAPL1 Gene

Domains & Families for DAPL1 Gene

Gene Families for DAPL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DAPL1 Gene


Suggested Antigen Peptide Sequences for DAPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAPL1: view

No data available for UniProtKB/Swiss-Prot for DAPL1 Gene

Function for DAPL1 Gene

Molecular function for DAPL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the early stages of epithelial differentiation or in apoptosis.

Phenotypes From GWAS Catalog for DAPL1 Gene

Gene Ontology (GO) - Molecular Function for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004984 olfactory receptor activity IEA --
GO:0070513 death domain binding IBA --
genes like me logo Genes that share ontologies with DAPL1: view
genes like me logo Genes that share phenotypes with DAPL1: view

Animal Model Products

miRNA for DAPL1 Gene

miRTarBase miRNAs that target DAPL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAPL1 Gene

Localization for DAPL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAPL1 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAPL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DAPL1 Gene

Pathways & Interactions for DAPL1 Gene

SuperPathways for DAPL1 Gene

No Data Available

Interacting Proteins for DAPL1 Gene

Gene Ontology (GO) - Biological Process for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0010507 negative regulation of autophagy IBA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DAPL1: view

No data available for Pathways by source and SIGNOR curated interactions for DAPL1 Gene

Drugs & Compounds for DAPL1 Gene

No Compound Related Data Available

Transcripts for DAPL1 Gene

Unigene Clusters for DAPL1 Gene

Death associated protein-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAPL1 Gene

No ASD Table

Relevant External Links for DAPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.2), Skin - Not Sun Exposed (Suprapubic) (x11.3), Esophagus - Mucosa (x10.4), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for DAPL1 Gene

This gene is overexpressed in Serum (40.6) and Lung (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAPL1 Gene

Protein tissue co-expression partners for DAPL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DAPL1 Gene:


SOURCE GeneReport for Unigene cluster for DAPL1 Gene:


mRNA Expression by UniProt/SwissProt for DAPL1 Gene:

Tissue specificity: Expressed in hair follicle (at protein level).

Evidence on tissue expression from TISSUES for DAPL1 Gene

  • Eye(4.2)
  • Nervous system(4.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with DAPL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DAPL1 Gene

Orthologs for DAPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DAPL1 33 34
  • 98.75 (n)
(Bos Taurus)
Mammalia DAPL1 33 34
  • 90.34 (n)
(Canis familiaris)
Mammalia DAPL1 33 34
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Dapl1 33
  • 83.49 (n)
(Mus musculus)
Mammalia Dapl1 33 16 34
  • 82.87 (n)
(Ornithorhynchus anatinus)
Mammalia DAPL1 34
  • 66 (a)
(Monodelphis domestica)
Mammalia DAPL1 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dapl1 33
  • 64.49 (n)
Str.17117 33
Species where no ortholog for DAPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAPL1 Gene

Gene Tree for DAPL1 (if available)
Gene Tree for DAPL1 (if available)

Paralogs for DAPL1 Gene

No data available for Paralogs for DAPL1 Gene

Variants for DAPL1 Gene

Sequence variations from dbSNP and Humsavar for DAPL1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000037431 -- 158,807,805(+) C/A intron_variant
rs1000208151 -- 158,799,056(+) T/G intron_variant
rs1000245212 -- 158,815,943(+) C/A 3_prime_UTR_variant
rs1000284617 -- 158,805,019(+) A/G intron_variant
rs1000326223 -- 158,810,505(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DAPL1 Gene

Variant ID Type Subtype PubMed ID
nsv834434 CNV gain 17160897
nsv583457 CNV loss 21841781
nsv583451 CNV loss 21841781
nsv583450 CNV loss 21841781
nsv583449 CNV gain 21841781
nsv213414 CNV deletion 16902084
nsv1127774 CNV deletion 24896259
nsv1001024 CNV gain 25217958
esv3593087 CNV loss 21293372
esv3593085 CNV gain 21293372
esv3593084 CNV gain 21293372
esv3593083 CNV loss 21293372
esv3584119 CNV loss 25503493
esv3560422 CNV deletion 23714750
esv2721022 CNV deletion 23290073
esv2676504 CNV deletion 23128226
esv23088 CNV loss 19812545
dgv7135n54 CNV loss 21841781
dgv7134n54 CNV loss 21841781
dgv7133n54 CNV loss 21841781
dgv478n27 CNV gain 19166990

Variation tolerance for DAPL1 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAPL1 Gene

Disorders for DAPL1 Gene

Additional Disease Information for DAPL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DAPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAPL1 Gene

Publications for DAPL1 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  2. DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium. (PMID: 28334846) Ma X … Hou L (Human molecular genetics 2017) 3 58
  3. A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD). (PMID: 25680934) Grassmann F … Weber BH (Neuromolecular medicine 2015) 3 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. EEDA: a protein associated with an early stage of stratified epithelial differentiation. (PMID: 15920738) Sun L … Lavker RM (Journal of cellular physiology 2006) 4 58

Products for DAPL1 Gene

Sources for DAPL1 Gene

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