Aliases for DAP3 Gene
External Ids for DAP3 Gene
Previous GeneCards Identifiers for DAP3 Gene
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
GeneCards Summary for DAP3 Gene
DAP3 (Death Associated Protein 3) is a Protein Coding gene. Diseases associated with DAP3 include Grange Syndrome. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.
UniProtKB/Swiss-Prot Summary for DAP3 Gene
Involved in mediating interferon-gamma-induced cell death.