This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] See more...

Aliases for DAP Gene

Aliases for DAP Gene

  • Death Associated Protein 2 3 5
  • Death-Associated Protein 1 3 4
  • DAP-1 3 4
  • DAP1 4
  • DAP 5

External Ids for DAP Gene

Previous GeneCards Identifiers for DAP Gene

  • GC05M010790
  • GC05M010732

Summaries for DAP Gene

Entrez Gene Summary for DAP Gene

  • This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for DAP Gene

DAP (Death Associated Protein) is a Protein Coding gene. Diseases associated with DAP include Refractory Hairy Cell Leukemia and Refractory Hematologic Cancer. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include death domain binding.

UniProtKB/Swiss-Prot Summary for DAP Gene

  • Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.

Gene Wiki entry for DAP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAP Gene

Genomics for DAP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J010759 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 260.7 +0.0 44 4.4 SP1 NCOR1 MYC ZNF600 IKZF1 JUND ZNF592 KLF9 CEBPA NFIC DAP lnc-ANKRD33B-15 lnc-CTNND2-10 MARCHF6 DAP-DT CMBL ROPN1L ANKRD33B
GH05J010732 Enhancer 1.3 Ensembl ENCODE dbSUPER 26 +26.9 26931 5.4 MYC NCOR1 IKZF1 ZNF592 NFIC YY1 CTCF TRIM22 HES1 MBD2 DAP lnc-ANKRD33B-9 piR-55110-073 lnc-CTNND2-10 ANKRD33B
GH05J010723 Enhancer 1.1 ENCODE dbSUPER 24.2 +35.6 35584 4.5 NCOR1 MYC IKZF1 JUND ZNF592 NFIC BCL11A CEBPB REST DEK DAP piR-55110-073 lnc-ANKRD33B-9 lnc-CTNND2-10 ANKRD33B
GH05J010699 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.8 +57.5 57507 9.1 SP1 ZNF654 IKZF1 NCOR1 JUND ZNF592 NFIC CTCF CEBPB BHLHE40 DAP lnc-ANKRD33B-6 lnc-ANKRD33B-7 lnc-CTNND2-6 lnc-CTNND2-10 ANKRD33B
GH05J010729 Enhancer 0.7 Ensembl dbSUPER 23.2 +30.9 30934 1.8 RBM22 POLR2A SPI1 MYC MAX REST GLIS1 DAP lnc-ANKRD33B-9 piR-55110-073 lnc-CTNND2-10 ANKRD33B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAP

Top Transcription factor binding sites by QIAGEN in the DAP gene promoter:
  • ITF-2
  • LCR-F1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • p53
  • Sox9
  • Tal-1beta

Genomic Locations for DAP Gene

Latest Assembly
chr5:10,679,230-10,761,234
(GRCh38/hg38)
Size:
82,005 bases
Orientation:
Minus strand

Previous Assembly
chr5:10,679,342-10,761,346
(GRCh37/hg19 by Entrez Gene)
Size:
82,005 bases
Orientation:
Minus strand

chr5:10,679,342-10,761,384
(GRCh37/hg19 by Ensembl)
Size:
82,043 bases
Orientation:
Minus strand

Genomic View for DAP Gene

Genes around DAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAP Gene

Proteins for DAP Gene

  • Protein details for DAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51397-DAP1_HUMAN
    Recommended name:
    Death-associated protein 1
    Protein Accession:
    P51397
    Secondary Accessions:
    • Q6FGC3
    • Q9BUC9

    Protein attributes for DAP Gene

    Size:
    102 amino acids
    Molecular mass:
    11165 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAP Gene

Post-translational modifications for DAP Gene

  • Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAP Gene

No data available for DME Specific Peptides for DAP Gene

Domains & Families for DAP Gene

Gene Families for DAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DAP Gene

InterPro:

Suggested Antigen Peptide Sequences for DAP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55133, weakly similar to Death-associated protein 1 (B4DQ75_HUMAN)
  • Death-associated protein 1 (DAP1_HUMAN)
  • Death-associated protein, isoform CRA_b (Q7KZT7_HUMAN)
genes like me logo Genes that share domains with DAP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DAP Gene

Function for DAP Gene

Molecular function for DAP Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
GENATLAS Biochemistry:
positive mediator of apoptosis,15kDa,triggered by interferon gamma,death associated protein 1

Phenotypes From GWAS Catalog for DAP Gene

Gene Ontology (GO) - Molecular Function for DAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070513 death domain binding IPI 1087798
genes like me logo Genes that share ontologies with DAP: view
genes like me logo Genes that share phenotypes with DAP: view

Animal Models for DAP Gene

MGI Knock Outs for DAP:
  • Dap Dap<tm1a(KOMP)Mbp>

miRNA for DAP Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAP Gene

Localization for DAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAP gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DAP Gene

Pathways & Interactions for DAP Gene

PathCards logo

SuperPathways for DAP Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 Akt Signaling
.60
.60
4 PAK Pathway
.56
.56
5 Apoptosis and Autophagy
genes like me logo Genes that share pathways with DAP: view

Pathways by source for DAP Gene

15 Qiagen pathways for DAP Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling
1 Cell Signaling Technology pathway for DAP Gene

Interacting Proteins for DAP Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000230895 P51397-DAP1_HUMAN for DAP Gene via STRING IID

SIGNOR curated interactions for DAP Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IGI 7828849
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 1087798
GO:0010507 negative regulation of autophagy IMP 20537536
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 1087798
genes like me logo Genes that share ontologies with DAP: view

Drugs & Compounds for DAP Gene

(2) Drugs for DAP Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifampridine Approved, Investigational Pharma 22
Potassium Channel Blockers Pharma 189
genes like me logo Genes that share compounds with DAP: view

Transcripts for DAP Gene

mRNA/cDNA for DAP Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAP

Alternative Splicing Database (ASD) splice patterns (SP) for DAP Gene

No ASD Table

Relevant External Links for DAP Gene

GeneLoc Exon Structure for
DAP

Expression for DAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DAP Gene

This gene is overexpressed in Skin (16.0), Stomach (14.6), and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAP

SOURCE GeneReport for Unigene cluster for DAP Gene:

Hs.75189

Evidence on tissue expression from TISSUES for DAP Gene

  • Nervous system(4.5)
  • Skin(4)
  • Lung(3.4)
  • Kidney(3.2)
  • Intestine(2.6)
  • Pancreas(2.5)
  • Eye(2.4)
  • Liver(2.4)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Muscle(2.1)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with DAP: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAP Gene

Orthologs for DAP Gene

This gene was present in the common ancestor of animals.

Orthologs for DAP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DAP 29
  • 99.02 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DAP 30
  • 89 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DAP 29
  • 88.56 (n)
Cow
(Bos Taurus)
Mammalia DAP 29 30
  • 88.56 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dap 29 16 30
  • 86.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dap 29
  • 85.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia DAP 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DAP 29 30
  • 79.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DAP 30
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dap 29
  • 72.55 (n)
Str.15389 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.13581 29
Zebrafish
(Danio rerio)
Actinopterygii dap 29 30
  • 63.4 (n)
OneToOne
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG12384 30
  • 44 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.826 30
  • 44 (a)
OneToOne
Species where no ortholog for DAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DAP Gene

ENSEMBL:
Gene Tree for DAP (if available)
TreeFam:
Gene Tree for DAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAP: view image
Alliance of Genome Resources:
Additional Orthologs for DAP

Paralogs for DAP Gene

(1) SIMAP similar genes for DAP Gene using alignment to 3 proteins:

  • DAP1_HUMAN
  • B4DQ75_HUMAN
  • Q7KZT7_HUMAN
genes like me logo Genes that share paralogs with DAP: view

No data available for Paralogs for DAP Gene

Variants for DAP Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DAP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DAP Gene

Variant ID Type Subtype PubMed ID
dgv3037n106 CNV deletion 24896259
dgv9582n54 CNV gain+loss 21841781
esv22939 CNV loss 19812545
esv2312126 CNV deletion 18987734
esv23832 CNV gain 19812545
esv24449 CNV loss 19812545
esv2464339 CNV deletion 19546169
esv2664774 CNV deletion 23128226
esv2729746 CNV deletion 23290073
esv2729747 CNV deletion 23290073
esv3565522 CNV deletion 23714750
esv3604006 CNV loss 21293372
nsv1073859 CNV deletion 25765185
nsv1119029 CNV deletion 24896259
nsv1137521 CNV deletion 24896259
nsv473156 CNV novel sequence insertion 20440878
nsv518038 CNV gain 19592680
nsv521304 CNV loss 19592680
nsv597139 CNV gain 21841781
nsv597142 CNV gain 21841781
nsv597143 CNV loss 21841781
nsv819968 CNV loss 19587683

Variation tolerance for DAP Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAP
Leiden Open Variation Database (LOVD)
DAP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAP Gene

Disorders for DAP Gene

MalaCards: The human disease database

(2) MalaCards diseases for DAP Gene - From: COP

Disorder Aliases PubMed IDs
refractory hairy cell leukemia
refractory hematologic cancer
  • refractory hematologic malignancy
- elite association - COSMIC cancer census association via MalaCards
Search DAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DAP

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAP Gene

Publications for DAP Gene

  1. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. (PMID: 7828849) Deiss LP … Kimchi A (Genes & development 1995) 2 3 4 22
  2. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 40
  3. DAP1, a novel substrate of mTOR, negatively regulates autophagy. (PMID: 20537536) Koren I … Kimchi A (Current biology : CB 2010) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PMID: 16602700) Zougman A … Wiśniewski JR (Journal of proteome research 2006) 3 4

Products for DAP Gene

Sources for DAP Gene