This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susce... See more...

Aliases for DAOA Gene

Aliases for DAOA Gene

  • D-Amino Acid Oxidase Activator 2 3 4 5
  • Schizophrenia- And Bipolar Disorder-Associated Protein G72 3
  • G72 Transcript 2
  • Protein G72 4
  • LG72 3
  • SG72 3
  • G72 4

External Ids for DAOA Gene

Previous GeneCards Identifiers for DAOA Gene

  • GC13P103816
  • GC13P104916
  • GC13P106118
  • GC13P086708

Summaries for DAOA Gene

Entrez Gene Summary for DAOA Gene

  • This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

GeneCards Summary for DAOA Gene

DAOA (D-Amino Acid Oxidase Activator) is a Protein Coding gene. Diseases associated with DAOA include Schizophrenia and Bipolar Disorder. Gene Ontology (GO) annotations related to this gene include enzyme binding and enzyme activator activity.

UniProtKB/Swiss-Prot Summary for DAOA Gene

Additional gene information for DAOA Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAOA Gene

Genomics for DAOA Gene

GeneHancer (GH) Regulatory Elements for DAOA Gene

Promoters and enhancers for DAOA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J105464 Enhancer 0.4 Ensembl ENCODE 500.7 -0.8 -756 1.6 FOS DAOA ENSG00000275502 DAOA-AS1
GH13J105466 Enhancer 0.2 Ensembl 500.7 +0.6 634 0.6 DAOA DAOA-AS1
GH13J105436 Enhancer 0.6 Ensembl ENCODE 12 -29.0 -28966 1.8 MXI1 GATA2 JUN GATA1 POLR2A DAOA lnc-DAOA-8 ENSG00000275968
GH13J105138 Enhancer 1 FANTOM5 ENCODE 1.2 -325.9 -325887 2.2 CTCF MEF2C RCOR1 POLR2A BCL11A TCF12 CBFB SMC3 ARNT CHD1 DAOA lnc-DAOA-9 HSALNG0099104
GH13J105534 Enhancer 0.2 FANTOM5 5 +68.6 68622 0.3 DAOA HSALNG0099123 lnc-EFNB2-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAOA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAOA

Top Transcription factor binding sites by QIAGEN in the DAOA gene promoter:
  • CUTL1
  • GATA-1
  • GATA-2
  • GATA-3
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MyoD
  • Pbx1a
  • S8

Genomic Locations for DAOA Gene

Genomic Locations for DAOA Gene
chr13:105,465,867-105,491,034
(GRCh38/hg38)
Size:
25,168 bases
Orientation:
Plus strand
chr13:106,118,216-106,143,383
(GRCh37/hg19)
Size:
25,168 bases
Orientation:
Plus strand

Genomic View for DAOA Gene

Genes around DAOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAOA Gene

Proteins for DAOA Gene

  • Protein details for DAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59103-DAOA_HUMAN
    Recommended name:
    D-amino acid oxidase activator
    Protein Accession:
    P59103
    Secondary Accessions:
    • A6NKG7
    • Q0VAE6
    • Q5VX59
    • Q86Y17
    • Q8IWM4

    Protein attributes for DAOA Gene

    Size:
    153 amino acids
    Molecular mass:
    18108 Da
    Quaternary structure:
    • Associates with D-amino acid oxidase (DAAO).
    Miscellaneous:
    • [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for DAOA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAOA Gene

Post-translational modifications for DAOA Gene

No Post-translational modifications

No data available for DME Specific Peptides for DAOA Gene

Domains & Families for DAOA Gene

Gene Families for DAOA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for DAOA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DAOA Gene

GenScript: Design optimal peptide antigens:
  • Schizophrenia-and bipolar disorder-associated protein G72 isoform D (A2T115_HUMAN)
  • Protein G72 (DAOA_HUMAN)
  • Putative schizophrenia protein variant 4 (Q86Y17_HUMAN)
  • Putative schizophrenia protein variant 3 (Q8IWM2_HUMAN)
  • Putative schizophrenia protein variant 2 (Q8IWM3_HUMAN)
genes like me logo Genes that share domains with DAOA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DAOA Gene

Function for DAOA Gene

Molecular function for DAOA Gene

UniProtKB/Swiss-Prot Function:
Seems to activate D-amino acid oxidase.

Phenotypes From GWAS Catalog for DAOA Gene

Gene Ontology (GO) - Molecular Function for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IDA 12364586
GO:0019899 enzyme binding IPI 12364586
genes like me logo Genes that share ontologies with DAOA: view
genes like me logo Genes that share phenotypes with DAOA: view

Human Phenotype Ontology for DAOA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAOA

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DAOA Gene

Localization for DAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAOA Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAOA gene
Compartment Confidence
mitochondrion 5
golgi apparatus 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 21679769
GO:0005794 Golgi apparatus IEA,IDA 12364586
GO:0048471 perinuclear region of cytoplasm IDA 21679769
genes like me logo Genes that share ontologies with DAOA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DAOA Gene

Pathways & Interactions for DAOA Gene

PathCards logo

SuperPathways for DAOA Gene

No Data Available

Interacting Proteins for DAOA Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000483757 P59103-DAOA_HUMAN for DAOA Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043085 positive regulation of catalytic activity IDA 12364586
GO:1900758 negative regulation of D-amino-acid oxidase activity IDA 21679769
genes like me logo Genes that share ontologies with DAOA: view

No data available for Pathways by source and SIGNOR curated interactions for DAOA Gene

Drugs & Compounds for DAOA Gene

(5) Drugs for DAOA Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma 427

(1) Additional Compounds for DAOA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAOA: view

Transcripts for DAOA Gene

mRNA/cDNA for DAOA Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAOA

Alternative Splicing Database (ASD) splice patterns (SP) for DAOA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3:
SP4: - - -

Relevant External Links for DAOA Gene

GeneLoc Exon Structure for
DAOA

Expression for DAOA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAOA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAOA

SOURCE GeneReport for Unigene cluster for DAOA Gene:

Hs.381382

mRNA Expression by UniProt/SwissProt for DAOA Gene:

P59103-DAOA_HUMAN
Tissue specificity: Expressed in amygdala, caudate nucleus, spinal cord and testis.

Evidence on tissue expression from TISSUES for DAOA Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with DAOA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAOA Gene

Orthologs for DAOA Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DAOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAOA 31 30
  • 92.86 (n)
OneToOne
Species where no ortholog for DAOA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAOA Gene

ENSEMBL:
Gene Tree for DAOA (if available)
TreeFam:
Gene Tree for DAOA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAOA: view image

Paralogs for DAOA Gene

(1) SIMAP similar genes for DAOA Gene using alignment to 5 proteins:

  • DAOA_HUMAN
  • A2T115_HUMAN
  • M0R0L0_HUMAN
  • M0R2M6_HUMAN
  • M0R2W9_HUMAN
genes like me logo Genes that share paralogs with DAOA: view

No data available for Paralogs for DAOA Gene

Variants for DAOA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAOA Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
736608 Likely Benign: not provided 105,472,627(+) A/C MISSENSE_VARIANT,SYNONYMOUS_VARIANT
768627 Benign: not provided 105,472,644(+) A/T MISSENSE_VARIANT,SYNONYMOUS_VARIANT
768628 Benign: not provided 105,472,693(+) T/C INTRON_VARIANT
768629 Benign: not provided 105,490,025(+) C/G MISSENSE_VARIANT
rs2391191 Not Provided: not provided. - 105,467,097(+) G/Ap.Arg30Lys MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for DAOA Gene

Structural Variations from Database of Genomic Variants (DGV) for DAOA Gene

Variant ID Type Subtype PubMed ID
esv275034 CNV gain+loss 21479260
nsv1048036 CNV gain 25217958
nsv519018 CNV loss 19592680
nsv562996 CNV gain 21841781

Variation tolerance for DAOA Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAOA Gene

Human Gene Mutation Database (HGMD)
DAOA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAOA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAOA Gene

Disorders for DAOA Gene

MalaCards: The human disease database

(10) MalaCards diseases for DAOA Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
bipolar disorder
  • major affective disorder 1
psychotic disorder
  • mental or behavioural disorder
schizophrenia 7
  • sczd7
schizoaffective disorder
  • schizo-affective psychosis
- elite association - COSMIC cancer census association via MalaCards
Search DAOA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DAOA_HUMAN
  • Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:12364586}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for DAOA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DAOA: view

No data available for Genatlas for DAOA Gene

Publications for DAOA Gene

  1. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PMID: 12364586) Chumakov I … Realson J (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 23 54
  2. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PMID: 19439994) Jönsson EG … Terenius L (Neuropsychobiology 2009) 3 23 41 54
  3. Genetic variation in the G720/G30 gene locus (DAOA) influences the occurrence of psychotic symptoms in patients with Alzheimer's disease. (PMID: 20009237) Di Maria E … Gennarelli M (Journal of Alzheimer's disease : JAD 2009) 3 23 41 54
  4. Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder. (PMID: 19689504) Zuliani R … McIntosh AM (Bipolar disorders 2009) 3 23 41 54
  5. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. (PMID: 19237267) Ohi K … Takeda M (Schizophrenia research 2009) 3 23 41 54

Products for DAOA Gene

Sources for DAOA Gene