Aliases for DAO Gene
External Ids for DAO Gene
Previous GeneCards Identifiers for DAO Gene
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
GeneCards Summary for DAO Gene
DAO (D-Amino Acid Oxidase) is a Protein Coding gene. Diseases associated with DAO include Amyotrophic Lateral Sclerosis 1 and Bipolar Disorder. Among its related pathways are Arginine and proline metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein dimerization activity. An important paralog of this gene is DDO.
UniProtKB/Swiss-Prot Summary for DAO Gene
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.