Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DAND5 Gene

Aliases for DAND5 Gene

  • DAN Domain BMP Antagonist Family Member 5 2 3 5
  • Cysteine Knot Superfamily 1, BMP Antagonist 3 3 4
  • DAN Domain Family Member 5, BMP Antagonist 2 3
  • Cerberus-Like Protein 2 3 4
  • Gremlin-3 3 4
  • CKTSF1B3 3 4
  • Cerl-2 3 4
  • GREM3 3 4
  • CER2 3 4
  • SP1 3 4
  • DAN Domain Family, Member 5 3
  • DAN Domain Family Member 5 3
  • Cerberus-Like 2 3
  • Cerberus 2 3
  • CERL2 3
  • DANTE 3
  • CRL2 3
  • COCO 3

External Ids for DAND5 Gene

Previous GeneCards Identifiers for DAND5 Gene

  • GC19P012945
  • GC19P013081
  • GC19P012652

Summaries for DAND5 Gene

Entrez Gene Summary for DAND5 Gene

  • This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAND5 Gene

DAND5 (DAN Domain BMP Antagonist Family Member 5) is a Protein Coding gene. Diseases associated with DAND5 include Malignant Syringoma and Morpheaform Basal Cell Carcinoma. Among its related pathways are Signaling by NODAL and Developmental Biology. Gene Ontology (GO) annotations related to this gene include morphogen activity. An important paralog of this gene is CER1.

UniProtKB/Swiss-Prot for DAND5 Gene

  • Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).

Additional gene information for DAND5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAND5 Gene

Genomics for DAND5 Gene

GeneHancer (GH) Regulatory Elements for DAND5 Gene

Promoters and enhancers for DAND5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012964 Promoter/Enhancer 1.5 Ensembl ENCODE 560 +0.2 161 1.6 PKNOX1 ARNT ARID4B ZNF2 E2F8 ZNF143 DEK SP3 REST SMARCB1 DAND5 DCAF15 RNASEH2A ZNF44 ZNF136 CCDC130 ZNF844 ZNF564 ZNF433 WDR83OS
GH19I012969 Promoter 0.9 EPDnew 550.8 +4.2 4208 0.1 MEIS2 EGR1 NCOR1 GLIS1 CBFA2T3 RCOR1 PRDM10 ZIC2 EGR2 DAND5 NFIX
GH19I013011 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 +55.0 55036 17.2 HDGF FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF213 NFIX ZNF136 ZNF709 ZNF791 TRMT1 CCDC130 MRI1 ZNF44 ZNF564 ZNF625
GH19I013030 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13 +69.3 69267 8.2 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 KLF13 SP3 TRMT1 ZNF844 ZNF791 ZNF442 ZNF136 ZNF625 MRI1 RPS6P25 STX10 ZNF433
GH19I013042 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.9 +78.8 78814 3 CEBPG ZIC2 ZNF324 ZFHX2 POLR2A PATZ1 SCRT2 ATF7 ZNF600 EGR2 TRMT1 ZNF20 ZNF490 LYL1 NACC1 RNASEH2A NFIX DAND5 GADD45GIP1 DCAF15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DAND5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DAND5 gene promoter:

Genomic Locations for DAND5 Gene

Genomic Locations for DAND5 Gene
chr19:12,965,159-12,974,762
(GRCh38/hg38)
Size:
9,604 bases
Orientation:
Plus strand
chr19:13,075,973-13,085,567
(GRCh37/hg19)

Genomic View for DAND5 Gene

Genes around DAND5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAND5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAND5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAND5 Gene

Proteins for DAND5 Gene

  • Protein details for DAND5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N907-DAND5_HUMAN
    Recommended name:
    DAN domain family member 5
    Protein Accession:
    Q8N907

    Protein attributes for DAND5 Gene

    Size:
    189 amino acids
    Molecular mass:
    20180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAND5 Gene

Post-translational modifications for DAND5 Gene

  • Glycosylation at posLast=3838
  • Modification sites at PhosphoSitePlus

Other Protein References for DAND5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DAND5 Gene

Domains & Families for DAND5 Gene

Gene Families for DAND5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DAND5 Gene

Suggested Antigen Peptide Sequences for DAND5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N907

UniProtKB/Swiss-Prot:

DAND5_HUMAN :
  • Belongs to the DAN family.
Family:
  • Belongs to the DAN family.
genes like me logo Genes that share domains with DAND5: view

Function for DAND5 Gene

Molecular function for DAND5 Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).

Phenotypes From GWAS Catalog for DAND5 Gene

Gene Ontology (GO) - Molecular Function for DAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016015 morphogen activity IEA,ISS --
genes like me logo Genes that share ontologies with DAND5: view
genes like me logo Genes that share phenotypes with DAND5: view

Animal Models for DAND5 Gene

MGI Knock Outs for DAND5:

Animal Model Products

  • Taconic Biosciences Mouse Models for DAND5

Transcription Factor Targets for DAND5 Gene

Selected GeneGlobe predicted Target genes for DAND5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for DAND5 Gene

Localization for DAND5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAND5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAND5 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 15466485
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with DAND5: view

Pathways & Interactions for DAND5 Gene

genes like me logo Genes that share pathways with DAND5: view

Pathways by source for DAND5 Gene

Gene Ontology (GO) - Biological Process for DAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003140 determination of left/right asymmetry in lateral mesoderm ISS --
GO:0003281 ventricular septum development IEA,ISS --
GO:0003283 atrial septum development IEA,ISS --
GO:0007368 determination of left/right symmetry IEA --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with DAND5: view

No data available for SIGNOR curated interactions for DAND5 Gene

Drugs & Compounds for DAND5 Gene

(2) Drugs for DAND5 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target, cofactor 2430
genes like me logo Genes that share compounds with DAND5: view

Transcripts for DAND5 Gene

mRNA/cDNA for DAND5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DAND5 Gene

DAN domain family member 5, BMP antagonist:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAND5 Gene

No ASD Table

Relevant External Links for DAND5 Gene

GeneLoc Exon Structure for
DAND5
ECgene alternative splicing isoforms for
DAND5

Expression for DAND5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAND5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAND5 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.9) and Heart - Atrial Appendage (x13.2).

Protein differential expression in normal tissues from HIPED for DAND5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAND5 Gene



Protein tissue co-expression partners for DAND5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DAND5 Gene:

DAND5

SOURCE GeneReport for Unigene cluster for DAND5 Gene:

Hs.331981

Evidence on tissue expression from TISSUES for DAND5 Gene

  • Heart(4.4)
  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with DAND5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAND5 Gene

Orthologs for DAND5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAND5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAND5 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia DAND5 33 34
  • 77.43 (n)
rat
(Rattus norvegicus)
Mammalia Dand5 33
  • 72.89 (n)
mouse
(Mus musculus)
Mammalia Dand5 33 16 34
  • 72.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DAND5 34
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAND5 34
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dand5 34
  • 19 (a)
OneToMany
Species where no ortholog for DAND5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAND5 Gene

ENSEMBL:
Gene Tree for DAND5 (if available)
TreeFam:
Gene Tree for DAND5 (if available)

Paralogs for DAND5 Gene

Paralogs for DAND5 Gene

genes like me logo Genes that share paralogs with DAND5: view

Variants for DAND5 Gene

Sequence variations from dbSNP and Humsavar for DAND5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000082370 -- 12,972,676(+) G/T intron_variant
rs1000851120 -- 12,970,971(+) C/T intron_variant
rs1001918994 -- 12,973,988(+) G/A 3_prime_UTR_variant
rs1002371729 -- 12,970,658(+) TTTCCTTT/ intron_variant
rs1003076646 -- 12,971,871(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DAND5 Gene

Variant ID Type Subtype PubMed ID
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for DAND5 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAND5 Gene

Human Gene Mutation Database (HGMD)
DAND5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAND5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAND5 Gene

Disorders for DAND5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for DAND5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
malignant syringoma
  • microcystic adnexal carcinoma
morpheaform basal cell carcinoma
  • basal cell carcinoma, morphea
sweat gland cancer
  • malignant neoplasm of sweat gland
eccrine sweat gland neoplasm
  • eccrine skin neoplasm
norrie disease
  • nd
- elite association - COSMIC cancer census association via MalaCards
Search DAND5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DAND5

genes like me logo Genes that share disorders with DAND5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAND5 Gene

Publications for DAND5 Gene

  1. Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. (PMID: 15254711) Katoh M … Katoh M (Oncology reports 2004) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects. (PMID: 28738792) Cristo F … Belo JA (BMC medical genetics 2017) 3 58
  4. The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. (PMID: 26908452) Chi Y … Wu J (Oncotarget 2016) 3 58
  5. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 58

Products for DAND5 Gene

Sources for DAND5 Gene

Content
Loading form....