This gene produces a long non-coding RNA that functions as a negative regulator of cell differentiation. This transcript associates with enhancer of zeste homolog 2 to repress expression of the runt related transcription factor 2 gene. Increased expression of this transcript may be associated with cancer. Alternatively spliced transcript variants have been observed. [provided b... See more...

Aliases for DANCR Gene

Subcategory (RNA class) for DANCR Gene

lncRNA

Number of RNA Genes sources:

4 / 14

Aliases for DANCR Gene

  • Differentiation Antagonizing Non-Protein Coding RNA 2 3 4 5
  • KIAA0114 2 3 4
  • Small Nucleolar RNA Host Gene 13 (Non-Protein Coding) 2 3
  • Adipogenesis Up-Regulated Transcript 2 2 3
  • Anti-Differentiation Noncoding RNA 2 3
  • Anti-Differentiation NcRNA 2 3
  • SNHG13 3 4
  • DANCR 2 168
  • ANCR 3 4
  • Small Nucleolar RNA Host Gene Protein 13 4
  • Putative Uncharacterized Protein DANCR 4
  • Anti-Differentiation NcRNA Protein 4
  • NONHSAG037936 92
  • HSALNG0034419 167
  • LncRNA-ANCR 3
  • AGU2 3

External Ids for DANCR Gene

Previous HGNC Symbols for DANCR Gene

  • KIAA0114
  • SNHG13

Previous GeneCards Identifiers for DANCR Gene

  • GC04P053582
  • GC04P053584
  • GC04P053588

Summaries for DANCR Gene

Entrez Gene Summary for DANCR Gene

  • This gene produces a long non-coding RNA that functions as a negative regulator of cell differentiation. This transcript associates with enhancer of zeste homolog 2 to repress expression of the runt related transcription factor 2 gene. Increased expression of this transcript may be associated with cancer. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2016]

GeneCards Summary for DANCR Gene

DANCR (Differentiation Antagonizing Non-Protein Coding RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DANCR include Bone Disease and Osteoporosis.

Rfam classification for DANCR Gene

  • Small nucleolar RNA SNORA26

Additional gene information for DANCR Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for DANCR Gene

Genomics for DANCR Gene

GeneHancer (GH) Regulatory Elements for DANCR Gene

Promoters and enhancers for DANCR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DANCR on UCSC Golden Path with GeneCards custom track

Genomic Locations for DANCR Gene

Genomic Locations for DANCR Gene
chr4:52,712,258-52,720,697
(GRCh38/hg38)
Size:
8,440 bases
Orientation:
Plus strand
chr4:53,578,597-53,586,518
(GRCh37/hg19)
Size:
7,922 bases
Orientation:
Plus strand

Genomic View for DANCR Gene

Genes around DANCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DANCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DANCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DANCR Gene

Proteins for DANCR Gene

  • Protein details for DANCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C864-DANCR_HUMAN
    Recommended name:
    Putative uncharacterized protein DANCR
    Protein Accession:
    P0C864
    Secondary Accessions:
    • A0A024RD90

    Protein attributes for DANCR Gene

    Size:
    163 amino acids
    Molecular mass:
    16785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DANCR Gene

Post-translational modifications for DANCR Gene

No Post-translational modifications

No data available for DME Specific Peptides for DANCR Gene

Domains & Families for DANCR Gene

Protein Domains for DANCR Gene

ProtoNet:
genes like me logo Genes that share domains with DANCR: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DANCR Gene

Function for DANCR Gene

Phenotypes From GWAS Catalog for DANCR Gene

Phenotypes for DANCR Gene

genes like me logo Genes that share phenotypes with DANCR: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DANCR Gene

Localization for DANCR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DANCR gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DANCR Gene

Pathways & Interactions for DANCR Gene

PathCards logo

SuperPathways for DANCR Gene

No Data Available

Interacting Proteins for DANCR Gene

Selected Interacting proteins: P0C864-DANCR_HUMAN for DANCR Gene via IID

;

Gene Ontology (GO) - Biological Process for DANCR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DANCR Gene

Drugs & Compounds for DANCR Gene

No Compound Related Data Available

Transcripts for DANCR Gene

mRNA/cDNA for DANCR Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for DANCR Gene

No ASD Table

Relevant External Links for DANCR Gene

GeneLoc Exon Structure for
DANCR

Expression for DANCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DANCR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DANCR

SOURCE GeneReport for Unigene cluster for DANCR Gene:

Hs.744077

mRNA Expression by UniProt/SwissProt for DANCR Gene:

P0C864-DANCR_HUMAN
Tissue specificity: Expressed in keratinocytes.
genes like me logo Genes that share expression patterns with DANCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DANCR Gene

Orthologs for DANCR Gene

Evolution for DANCR Gene

ENSEMBL:
Gene Tree for DANCR (if available)
TreeFam:
Gene Tree for DANCR (if available)

No data available for Orthologs for DANCR Gene

Paralogs for DANCR Gene

No data available for Paralogs for DANCR Gene

Variants for DANCR Gene

Additional dbSNP identifiers (rs#s) for DANCR Gene

Structural Variations from Database of Genomic Variants (DGV) for DANCR Gene

Variant ID Type Subtype PubMed ID
nsv472482 CNV novel sequence insertion 20440878
nsv524494 CNV loss 19592680
nsv594201 CNV loss 21841781

Additional Variant Information for DANCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DANCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for DANCR Gene

Disorders for DANCR Gene

MalaCards: The human disease database

(12) MalaCards diseases for DANCR Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bone disease
  • skeletal disease
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
brain cancer
  • adult brain tumor
osteogenic sarcoma
  • osteosarcoma; osrc
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards
Search DANCR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DANCR

genes like me logo Genes that share disorders with DANCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DANCR Gene

Publications for DANCR Gene

  1. Suppression of progenitor differentiation requires the long noncoding RNA ANCR. (PMID: 22302877) Kretz M … Khavari PA (Genes & development 2012) 2 3 4 54
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T … Kotani H (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 54
  3. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PMID: 19531736) Kikuchi K … Aizawa Y (Nucleic acids research 2009) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. (PMID: 11752456) Xu XR … Han ZG (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 54

Products for DANCR Gene

Sources for DANCR Gene