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Aliases for DALRD3 Gene

Aliases for DALRD3 Gene

  • DALR Anticodon Binding Domain Containing 3 2 3 5
  • DALR Anticodon-Binding Domain-Containing Protein 3 3

External Ids for DALRD3 Gene

Previous GeneCards Identifiers for DALRD3 Gene

  • GC03M049029
  • GC03M049055
  • GC03M049059
  • GC03M049062
  • GC03M049063
  • GC03M049064
  • GC03M049065
  • GC03M049066
  • GC03M049068
  • GC03M049073
  • GC03M049076

Summaries for DALRD3 Gene

Entrez Gene Summary for DALRD3 Gene

  • The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]

GeneCards Summary for DALRD3 Gene

DALRD3 (DALR Anticodon Binding Domain Containing 3) is a Protein Coding gene. Diseases associated with DALRD3 include Mitochondrial Complex I Deficiency. Gene Ontology (GO) annotations related to this gene include nucleotide binding and arginine-tRNA ligase activity.

Additional gene information for DALRD3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DALRD3 Gene

Genomics for DALRD3 Gene

GeneHancer (GH) Regulatory Elements for DALRD3 Gene

Promoters and enhancers for DALRD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.5 +2.0 2032 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 MIR425 NDUFAF3 MIR191 GC03M049024 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.6 -323.8 -323757 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A USP4 AMT QRICH1 RBM6 RBM5 IP6K2 ATRIP USP19 WDR6 BSN-AS1
GH03J048085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +934.4 934392 5.3 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 MAP4 ATRIP DHX30 ZNF589 SETD2 ENSG00000235236 PTPN23 BOLA2P2 SCAP TMEM89
GH03J048896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 +124.0 124005 3.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC25A20 WDR6 QARS QRICH1 USP19 NME6 MRPS18AP1 ATRIP IP6K2 ZNF589
GH03J049164 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 -143.7 -143741 2.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 E2F8 CCDC71 PIR60212 WDR6 QRICH1 USP19 ZNF589 NME6 MRPS18AP1 QARS ATRIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DALRD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DALRD3 gene promoter:

Genomic Locations for DALRD3 Gene

Genomic Locations for DALRD3 Gene
chr3:49,015,488-49,022,293
(GRCh38/hg38)
Size:
6,806 bases
Orientation:
Minus strand
chr3:49,052,435-49,059,726
(GRCh37/hg19)

Genomic View for DALRD3 Gene

Genes around DALRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DALRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DALRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DALRD3 Gene

Proteins for DALRD3 Gene

  • Protein details for DALRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5D0E6-DALD3_HUMAN
    Recommended name:
    DALR anticodon-binding domain-containing protein 3
    Protein Accession:
    Q5D0E6
    Secondary Accessions:
    • Q7Z5S7
    • Q86WY1
    • Q8N105
    • Q8NA89
    • Q9NVU8

    Protein attributes for DALRD3 Gene

    Size:
    543 amino acids
    Molecular mass:
    59363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DALRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DALRD3 Gene

Post-translational modifications for DALRD3 Gene

  • Ubiquitination at Lys219
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DALRD3 Gene

Domains & Families for DALRD3 Gene

Gene Families for DALRD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DALRD3 Gene

Suggested Antigen Peptide Sequences for DALRD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DALRD3: view

No data available for UniProtKB/Swiss-Prot for DALRD3 Gene

Function for DALRD3 Gene

Phenotypes From GWAS Catalog for DALRD3 Gene

Gene Ontology (GO) - Molecular Function for DALRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004814 arginine-tRNA ligase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DALRD3: view
genes like me logo Genes that share phenotypes with DALRD3: view

Animal Model Products

miRNA for DALRD3 Gene

miRTarBase miRNAs that target DALRD3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DALRD3 Gene

Localization for DALRD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DALRD3 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DALRD3 Gene

Pathways & Interactions for DALRD3 Gene

SuperPathways for DALRD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DALRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation IEA --
GO:0006420 arginyl-tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with DALRD3: view

No data available for Pathways by source and SIGNOR curated interactions for DALRD3 Gene

Drugs & Compounds for DALRD3 Gene

No Compound Related Data Available

Transcripts for DALRD3 Gene

Unigene Clusters for DALRD3 Gene

DALR anticodon binding domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DALRD3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for DALRD3 Gene

GeneLoc Exon Structure for
DALRD3
ECgene alternative splicing isoforms for
DALRD3

Expression for DALRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DALRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DALRD3 Gene

This gene is overexpressed in Plasma (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DALRD3 Gene



Protein tissue co-expression partners for DALRD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DALRD3 Gene:

DALRD3

SOURCE GeneReport for Unigene cluster for DALRD3 Gene:

Hs.708076

Evidence on tissue expression from TISSUES for DALRD3 Gene

  • Nervous system(4.6)
  • Blood(4)
genes like me logo Genes that share expression patterns with DALRD3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DALRD3 Gene

Orthologs for DALRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DALRD3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DALRD3 34 33
  • 83.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DALRD3 34 33
  • 81.1 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dalrd3 16 34 33
  • 79.8 (n)
rat
(Rattus norvegicus)
Mammalia Dalrd3 33
  • 79.62 (n)
oppossum
(Monodelphis domestica)
Mammalia DALRD3 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DALRD3 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves DALRD3 34 33
  • 62.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DALRD3 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dalrd3 34 33
  • 53.35 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8097 34
  • 22 (a)
OneToOne
Species where no ortholog for DALRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DALRD3 Gene

ENSEMBL:
Gene Tree for DALRD3 (if available)
TreeFam:
Gene Tree for DALRD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DALRD3: view image

Paralogs for DALRD3 Gene

No data available for Paralogs for DALRD3 Gene

Variants for DALRD3 Gene

Sequence variations from dbSNP and Humsavar for DALRD3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1002214482 uncertain-significance, Mitochondrial complex I deficiency 49,021,896(-) C/T upstream_transcript_variant
rs1049628962 uncertain-significance, Mitochondrial complex I deficiency 49,023,341(-) G/C upstream_transcript_variant
rs121918134 pathogenic, Mitochondrial complex I deficiency 49,022,497(-) G/A/C upstream_transcript_variant
rs121918135 pathogenic, Mitochondrial complex I deficiency 49,022,903(-) G/C upstream_transcript_variant
rs121918136 pathogenic, Mitochondrial complex I deficiency 49,022,146(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DALRD3 Gene

Variant ID Type Subtype PubMed ID
nsv954488 CNV deletion 24416366

Variation tolerance for DALRD3 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DALRD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DALRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DALRD3 Gene

Disorders for DALRD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DALRD3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency
  • nadh:q(1) oxidoreductase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DALRD3

genes like me logo Genes that share disorders with DALRD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DALRD3 Gene

Publications for DALRD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for DALRD3 Gene

Sources for DALRD3 Gene

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