Aliases for DALRD3 Gene
Aliases for DALRD3 Gene
External Ids for DALRD3 Gene
- HGNC: 25536
- Entrez Gene: 55152
- Ensembl: ENSG00000178149
- UniProtKB: Q5D0E6
Previous GeneCards Identifiers for DALRD3 Gene
- GC03M049029
- GC03M049055
- GC03M049059
- GC03M049062
- GC03M049063
- GC03M049064
- GC03M049065
- GC03M049066
- GC03M049068
- GC03M049073
- GC03M049076
Summaries for DALRD3 Gene
-
The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]
GeneCards Summary for DALRD3 Gene
DALRD3 (DALR Anticodon Binding Domain Containing 3) is a Protein Coding gene. Diseases associated with DALRD3 include Mitochondrial Complex I Deficiency. Gene Ontology (GO) annotations related to this gene include nucleotide binding and arginine-tRNA ligase activity.
Additional gene information for DALRD3 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DALRD3 Gene
Genomics for DALRD3 Gene
GeneHancer (GH) Regulatory Elements for DALRD3 Gene
Promoters and enhancers for DALRD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DALRD3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DALRD3 gene promoter:
Regulatory Element Products
Genomic Locations for DALRD3 Gene
Genomic Locations for DALRD3 Gene
- chr3:49,015,488-49,022,293
- (GRCh38/hg38)
- Size:
- 6,806 bases
- Orientation:
- Minus strand
- chr3:49,052,435-49,059,726
- (GRCh37/hg19)
Genomic View for DALRD3 Gene
Genes around DALRD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by Entrez Gene
- 3p21.31 by HGNC
- 3p21.31 by Ensembl
DALRD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DALRD3 Gene
Proteins for DALRD3 Gene
-
Protein details for DALRD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5D0E6-DALD3_HUMAN
- Recommended name:
- DALR anticodon-binding domain-containing protein 3
- Protein Accession:
- Q5D0E6
- Q7Z5S7
- Q86WY1
- Q8N105
- Q8NA89
- Q9NVU8
Protein attributes for DALRD3 Gene
- Size:
- 543 amino acids
- Molecular mass:
- 59363 Da
- Quaternary structure:
- No Data Available
Protein Expression for DALRD3 Gene
Post-translational modifications for DALRD3 Gene
Other Protein References for DALRD3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DALRD3
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-
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Protein Products
-
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- antibodies-online: Search results for 3 available DALRD3 Proteins ranked by validation data
- Compare Top DALRD3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for DALRD3
Assay Products
No data available for DME Specific Peptides for DALRD3 Gene
Domains & Families for DALRD3 Gene
Gene Families for DALRD3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DALRD3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DALRD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DALRD3 Gene
Function for DALRD3 Gene
Phenotypes From GWAS Catalog for DALRD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004812 | aminoacyl-tRNA ligase activity | IEA | -- |
| GO:0004814 | arginine-tRNA ligase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for DALRD3 Gene
- GenomeRNAi human phenotypes for DALRD3:
Animal Model Products
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-
CRISPR Products
-
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- Overview of 101 available DALRD3 gene related products
- Applied Biological Materials CRISPR for DALRD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DALRD3
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miRNA for DALRD3 Gene
- miRTarBase miRNAs that target DALRD3
miRNA Products
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DALRD3
- Applied Biological Materials Clones for DALRD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DALRD3
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DALRD3 Gene
Localization for DALRD3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Nuclear bodies (2)
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DALRD3 Gene
Pathways & Interactions for DALRD3 Gene
No Data Available
Interacting Proteins for DALRD3 Gene
Selected Interacting proteins:
Q5D0E6-DALD3_HUMAN
ENSP00000344989
for DALRD3 Gene via
IID
MINT
STRING
UniProtKB
GPS-Prot Interaction Network for DALRD3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006418 | tRNA aminoacylation for protein translation | IEA | -- |
| GO:0006420 | arginyl-tRNA aminoacylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for DALRD3 Gene
Transcripts for DALRD3 Gene
mRNA/cDNA for DALRD3 Gene
- (304) Selected AceView cDNA sequences:
- (10) Additional mRNA sequences :
- (9) REFSEQ mRNAs :
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000313778 1968 bps (uc003cvm.4)
- ENST00000341949 1739 bps (uc003cvk.4)
- ENST00000420952 881 bps (uc062jox.1)
- ENST00000438585 654 bps (uc062joq.1)
- ENST00000440857 2014 bps (uc010hko.4)
Unigene Clusters for DALRD3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DALRD3
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- genomics-online: gRNA clones - Search results for 101 available DALRD3 gene related products
- Overview of 101 available DALRD3 gene related products
- Applied Biological Materials CRISPR for DALRD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DALRD3
- GenScript: Design CRISPR guide RNA sequences for DALRD3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DALRD3
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- Overview of 101 available DALRD3 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DALRD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DALRD3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DALRD3
- Applied Biological Materials Clones for DALRD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 |
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| SP7: |
Expression for DALRD3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Plasma (64.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DALRD3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DALRD3 Gene:
DALRD3SOURCE GeneReport for Unigene cluster for DALRD3 Gene:
Hs.708076Evidence on tissue expression from TISSUES for DALRD3 Gene
- Nervous system(4.6)
- Blood(4)
Primer Products
-
OriGene qPCR primer pairs for DALRD3
-
OriGene qPCR primer pairs and template standards for DALRD3
- genomics-online: primer clones - Search results for 101 available DALRD3 gene related products
- Overview of 101 available DALRD3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DALRD3 Gene
Orthologs for DALRD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | DALRD3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DALRD3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dalrd3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dalrd3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DALRD3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DALRD3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DALRD3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DALRD3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | dalrd3 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG8097 34 |
|
OneToOne |
- Species where no ortholog for DALRD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DALRD3 Gene
- ENSEMBL:
- Gene Tree for DALRD3 (if available)
- TreeFam:
- Gene Tree for DALRD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DALRD3: view image
Paralogs for DALRD3 Gene
No data available for Paralogs for DALRD3 Gene
Variants for DALRD3 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1002214482 | uncertain-significance, Mitochondrial complex I deficiency | 49,021,896(-) | C/T | upstream_transcript_variant | |
| rs1049628962 | uncertain-significance, Mitochondrial complex I deficiency | 49,023,341(-) | G/C | upstream_transcript_variant | |
| rs121918134 | pathogenic, Mitochondrial complex I deficiency | 49,022,497(-) | G/A/C | upstream_transcript_variant | |
| rs121918135 | pathogenic, Mitochondrial complex I deficiency | 49,022,903(-) | G/C | upstream_transcript_variant | |
| rs121918136 | pathogenic, Mitochondrial complex I deficiency | 49,022,146(-) | T/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.73;
15.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DALRD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DALRD3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DALRD3 Gene
Disorders for DALRD3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mitochondrial complex i deficiency |
|
|
Search DALRD3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DALRD3
No data available for UniProtKB/Swiss-Prot and Genatlas for DALRD3 Gene
Publications for DALRD3 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for DALRD3 Gene
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- VectorBuilder custom plasmid, inducible vectors for DALRD3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 27 available DALRD3 Antibodies ranked by validation data
- Compare Top DALRD3 Antibodies
- antibodies-online: Search results for available DALRD3 related products ranked by validation data
- antibodies-online: Search results for 3 available DALRD3 Proteins ranked by validation data
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- Quality Products:
- GeneTex DALRD3 Antibody for DALRD3
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- genomics-online: cdna clones - Search results for 101 available DALRD3 gene related products
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Sources for DALRD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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