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The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]
DALRD3 (DALR Anticodon Binding Domain Containing 3) is a Protein Coding gene. Diseases associated with DALRD3 include Epileptic Encephalopathy, Early Infantile, 86 and Mitochondrial Complex I Deficiency, Nuclear Type 1. Gene Ontology (GO) annotations related to this gene include nucleotide binding and arginine-tRNA ligase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004812 | aminoacyl-tRNA ligase activity | IEA | -- |
GO:0004814 | arginine-tRNA ligase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006418 | tRNA aminoacylation for protein translation | IEA | -- |
GO:0006420 | arginyl-tRNA aminoacylation | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | DALRD3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DALRD3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dalrd3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dalrd3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DALRD3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DALRD3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DALRD3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DALRD3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dalrd3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8097 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3087866 | - | p.Gln299Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
epileptic encephalopathy, early infantile, 86 |
|
|
mitochondrial complex i deficiency, nuclear type 1 |
|
|