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Aliases for DAGLB Gene

Aliases for DAGLB Gene

  • Diacylglycerol Lipase Beta 2 3 5
  • DGL-Beta 3 4
  • KCCR13L 3 4
  • Sn1-Specific Diacylglycerol Lipase Beta 3
  • Diacylglycerol Lipase, Beta 2
  • EC 3.1.1.- 4
  • DAGLBETA 3

External Ids for DAGLB Gene

Summaries for DAGLB Gene

GeneCards Summary for DAGLB Gene

DAGLB (Diacylglycerol Lipase Beta) is a Protein Coding gene. Diseases associated with DAGLB include Hallucinogen Dependence. Among its related pathways are N-cadherin signaling events and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot for DAGLB Gene

  • Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Additional gene information for DAGLB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAGLB Gene

Genomics for DAGLB Gene

GeneHancer (GH) Regulatory Elements for DAGLB Gene

Promoters and enhancers for DAGLB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I006446 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 604.3 +35.4 35406 4.4 CLOCK MLX ZFP64 FEZF1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZC3H11A DAGLB ZNF316 C7orf26 ZNF12 USP42 ANKRD61 ENSG00000198580 ENSG00000228010 KDELR2 PMS2
GH07I006481 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 534 4.4 SMAD1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 ZHX2 REST SMARCB1 KDELR2 DAGLB ZNF316 C7orf26 USP42 ANKRD61 ZNF12 RNF216 CCZ1B GRID2IP
GH07I006372 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.5 +108.2 108212 6.3 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A ZNF2 RAC1 DAGLB ZNF12 USP42 ZNF316 C7orf26 CYTH3 PMS2 ZDHHC4 CCZ1
GH07I006381 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 41.5 +98.8 98825 7.5 HDGF ATF1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 YY1 SLC30A9 DAGLB FAM220A RAC1 CCZ1 ZDHHC4 USP42 PIR50924
GH07I006433 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 45.4 +47.5 47472 6.2 ELF3 RB1 ARID4B IRF4 RAD21 EGR1 ZNF143 FOS ATF7 IKZF2 GC07M006436 PIR51766 DAGLB RAC1 ZNF815P ZDHHC4 GC07M006432 GC07M006445
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DAGLB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DAGLB gene promoter:

Genomic Locations for DAGLB Gene

Genomic Locations for DAGLB Gene
chr7:6,409,116-6,484,190
(GRCh38/hg38)
Size:
75,075 bases
Orientation:
Minus strand
chr7:6,448,747-6,523,821
(GRCh37/hg19)

Genomic View for DAGLB Gene

Genes around DAGLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLB Gene

Proteins for DAGLB Gene

  • Protein details for DAGLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCG7-DGLB_HUMAN
    Recommended name:
    Sn1-specific diacylglycerol lipase beta
    Protein Accession:
    Q8NCG7
    Secondary Accessions:
    • A4D2P3
    • B3KV90
    • B4DQU0
    • Q6PIX3
    • Q8N2N2
    • Q8N9S1
    • Q8TED3
    • Q8WXE6

    Protein attributes for DAGLB Gene

    Size:
    672 amino acids
    Molecular mass:
    73732 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAGLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAGLB Gene

Post-translational modifications for DAGLB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAGLB Gene

No data available for DME Specific Peptides for DAGLB Gene

Domains & Families for DAGLB Gene

Gene Families for DAGLB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DAGLB Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCG7

UniProtKB/Swiss-Prot:

DGLB_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLB: view

Function for DAGLB Gene

Molecular function for DAGLB Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=74.1 uM for diacylglycerol {ECO:0000269 PubMed:14610053}; Vmax=3.45 nmol/min/mg enzyme {ECO:0000269 PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Enzyme Numbers (IUBMB) for DAGLB Gene

Phenotypes From GWAS Catalog for DAGLB Gene

Gene Ontology (GO) - Molecular Function for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047372 acylglycerol lipase activity TAS --
genes like me logo Genes that share ontologies with DAGLB: view

Phenotypes for DAGLB Gene

genes like me logo Genes that share phenotypes with DAGLB: view

Animal Models for DAGLB Gene

MGI Knock Outs for DAGLB:

Animal Model Products

  • Taconic Biosciences Mouse Models for DAGLB

miRNA for DAGLB Gene

miRTarBase miRNAs that target DAGLB

Clone Products

  • Addgene plasmids for DAGLB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLB Gene

Localization for DAGLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLB Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAGLB gene
Compartment Confidence
plasma membrane 5
lysosome 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005765 lysosomal membrane HDA,IDA 17897319
GO:0005886 plasma membrane IDA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAGLB: view

Pathways & Interactions for DAGLB Gene

genes like me logo Genes that share pathways with DAGLB: view

Pathways by source for DAGLB Gene

Gene Ontology (GO) - Biological Process for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007405 neuroblast proliferation IEA --
GO:0016042 lipid catabolic process IEA --
GO:0019369 arachidonic acid metabolic process IDA 14610053
GO:0022008 neurogenesis IEA --
genes like me logo Genes that share ontologies with DAGLB: view

No data available for SIGNOR curated interactions for DAGLB Gene

Drugs & Compounds for DAGLB Gene

(4) Drugs for DAGLB Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 54
calcium Approved Nutra 0
RHC80267 Pharma Inhibition, Inhibitor 0
RHC 80267 Pharma diacylglycerol lipase inhibitor 0

(5) Additional Compounds for DAGLB Gene - From: IUPHAR and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tetrahydrolipstatin
Inhibition, Inhibitor
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(1) ApexBio Compounds for DAGLB Gene

Compound Action Cas Number
RHC 80267 diacylglycerol lipase inhibitor 83654-05-1
genes like me logo Genes that share compounds with DAGLB: view

Drug Products

Transcripts for DAGLB Gene

Unigene Clusters for DAGLB Gene

Diacylglycerol lipase, beta:
Representative Sequences:

Clone Products

  • Addgene plasmids for DAGLB

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - -
SP10:
SP11: -
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DAGLB Gene

GeneLoc Exon Structure for
DAGLB
ECgene alternative splicing isoforms for
DAGLB

Expression for DAGLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAGLB Gene

Protein differential expression in normal tissues from HIPED for DAGLB Gene

This gene is overexpressed in NK cells (35.8), Breast (11.3), Peripheral blood mononuclear cells (9.1), and Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DAGLB Gene



Protein tissue co-expression partners for DAGLB Gene

NURSA nuclear receptor signaling pathways regulating expression of DAGLB Gene:

DAGLB

SOURCE GeneReport for Unigene cluster for DAGLB Gene:

Hs.487498

Evidence on tissue expression from TISSUES for DAGLB Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DAGLB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAGLB Gene

Orthologs for DAGLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612262 33
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia DAGLB 33 34
  • 83.68 (n)
cow
(Bos Taurus)
Mammalia DAGLB 33 34
  • 81.27 (n)
mouse
(Mus musculus)
Mammalia Daglb 33 16 34
  • 79.79 (n)
rat
(Rattus norvegicus)
Mammalia Daglb 33
  • 79.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DAGLB 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAGLB 33 34
  • 64.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia daglb 33
  • 62.73 (n)
zebrafish
(Danio rerio)
Actinopterygii daglb 33 34
  • 60 (n)
DAGLB (1 of 2) 34
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012171 33
  • 44.09 (n)
worm
(Caenorhabditis elegans)
Secernentea F42G9.6 33 34
  • 44.22 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05790 33
  • 38.57 (n)
Species where no ortholog for DAGLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAGLB Gene

ENSEMBL:
Gene Tree for DAGLB (if available)
TreeFam:
Gene Tree for DAGLB (if available)

Paralogs for DAGLB Gene

Paralogs for DAGLB Gene

(1) SIMAP similar genes for DAGLB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DAGLB: view

Variants for DAGLB Gene

Sequence variations from dbSNP and Humsavar for DAGLB Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000053523 -- 6,424,560(-) T/G intron_variant
rs1000107901 -- 6,441,600(-) G/A intron_variant
rs1000108332 -- 6,425,755(-) C/G intron_variant
rs1000118450 -- 6,425,616(-) A/C intron_variant
rs1000171059 -- 6,422,365(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DAGLB Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2733926 CNV deletion 23290073
esv2733927 CNV deletion 23290073
esv3541121 CNV deletion 23714750
nsv1020236 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv605999 CNV loss 21841781
nsv606000 CNV loss 21841781
nsv7392 OTHER inversion 18451855

Variation tolerance for DAGLB Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAGLB Gene

Human Gene Mutation Database (HGMD)
DAGLB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAGLB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAGLB Gene

Disorders for DAGLB Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAGLB Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hallucinogen dependence
- elite association - COSMIC cancer census association via MalaCards
Search DAGLB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DAGLB

genes like me logo Genes that share disorders with DAGLB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAGLB Gene

Publications for DAGLB Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PMID: 14610053) Bisogno T … Doherty P (The Journal of cell biology 2003) 3 4 58

Products for DAGLB Gene

  • Addgene plasmids for DAGLB

Sources for DAGLB Gene