Aliases for DAGLB Gene

Aliases for DAGLB Gene

  • Diacylglycerol Lipase Beta 2 3 5
  • KCCR13L 2 3 4
  • Sn1-Specific Diacylglycerol Lipase Beta 3 4
  • PUFA-Specific Triacylglycerol Lipase 3 4
  • Diacylglycerol Lipase-Beta 3 4
  • DAGL-Beta 3 4
  • DAGLBETA 2 3
  • DGL-Beta 3 4
  • Diacylglycerol Lipase, Beta 2
  • EC 3.1.1.- 4
  • EC 3.1.1.3 4
  • DAGLB 5

External Ids for DAGLB Gene

Summaries for DAGLB Gene

GeneCards Summary for DAGLB Gene

DAGLB (Diacylglycerol Lipase Beta) is a Protein Coding gene. Diseases associated with DAGLB include Hallucinogen Dependence. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot Summary for DAGLB Gene

  • Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAGLB Gene

Genomics for DAGLB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DAGLB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAGLB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAGLB

Top Transcription factor binding sites by QIAGEN in the DAGLB gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • En-1
  • Hand1

Genomic Locations for DAGLB Gene

Latest Assembly
chr7:6,409,126-6,484,190
(GRCh38/hg38)
Size:
75,065 bases
Orientation:
Minus strand

Previous Assembly
chr7:6,448,760-6,487,585
(GRCh37/hg19 by Entrez Gene)
Size:
38,826 bases
Orientation:
Minus strand

chr7:6,448,757-6,523,821
(GRCh37/hg19 by Ensembl)
Size:
75,065 bases
Orientation:
Minus strand

Genomic View for DAGLB Gene

Genes around DAGLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLB Gene

Proteins for DAGLB Gene

  • Protein details for DAGLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCG7-DGLB_HUMAN
    Recommended name:
    Diacylglycerol lipase-beta
    Protein Accession:
    Q8NCG7
    Secondary Accessions:
    • A4D2P3
    • B3KV90
    • B4DQU0
    • Q6PIX3
    • Q8N2N2
    • Q8N9S1
    • Q8TED3
    • Q8WXE6

    Protein attributes for DAGLB Gene

    Size:
    672 amino acids
    Molecular mass:
    73732 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAGLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAGLB Gene

Post-translational modifications for DAGLB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAGLB Gene

Antibodies for research

  • Abcam antibodies for DAGLB
  • Santa Cruz Biotechnology (SCBT) Antibodies for DAGLB

No data available for DME Specific Peptides for DAGLB Gene

Domains & Families for DAGLB Gene

Gene Families for DAGLB Gene

Protein Domains for DAGLB Gene

Suggested Antigen Peptide Sequences for DAGLB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53161, highly similar to Homo sapiens diacylglycerol lipase beta (B4DQU0_HUMAN)
  • cDNA FLJ52774, highly similar to Homo sapiens diacylglycerol lipase beta (B4DVJ1_HUMAN)
  • KCCR13L (DGLB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCG7

UniProtKB/Swiss-Prot:

DGLB_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLB: view

Function for DAGLB Gene

Molecular function for DAGLB Gene

UniProtKB/Swiss-Prot Function:
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:52392, ChEBI:CHEBI:75728; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38515, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52392, ChEBI:CHEBI:75449; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+); Xref=Rhea:RHEA:38519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75448, ChEBI:CHEBI:75456; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+); Xref=Rhea:RHEA:38523, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75450, ChEBI:CHEBI:75457; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+); Xref=Rhea:RHEA:38527, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75913, ChEBI:CHEBI:75914; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000250|UniProtKB:Q91WC9};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+); Xref=Rhea:RHEA:63432, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:147308, ChEBI:CHEBI:147309; Evidence={ECO:0000250|UniProtKB:Q91WC9};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + a di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+); Xref=Rhea:RHEA:63436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77016, ChEBI:CHEBI:147310, ChEBI:CHEBI:147311; Evidence={ECO:0000250|UniProtKB:Q91WC9};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=74.1 uM for diacylglycerol {ECO:0000269|PubMed:14610053}; Vmax=3.45 nmol/min/mg enzyme {ECO:0000269|PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269|PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the 1,2,3-triazole urea covalent inhibitors KT109 and KT172 (By similarity). Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not by PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.

Enzyme Numbers (IUBMB) for DAGLB Gene

Phenotypes From GWAS Catalog for DAGLB Gene

Gene Ontology (GO) - Molecular Function for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity ISS 31991095
GO:0005515 protein binding IPI 32296183
GO:0016298 lipase activity IDA 14610053
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DAGLB: view
genes like me logo Genes that share phenotypes with DAGLB: view

Animal Models for DAGLB Gene

MGI Knock Outs for DAGLB:

Animal Models for research

  • Taconic Biosciences Mouse Models for DAGLB

miRNA for DAGLB Gene

miRTarBase miRNAs that target DAGLB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAGLB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLB Gene

Localization for DAGLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLB Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAGLB gene
Compartment Confidence
plasma membrane 5
nucleus 4
lysosome 4
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane IDA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAGLB: view

Pathways & Interactions for DAGLB Gene

genes like me logo Genes that share pathways with DAGLB: view

Pathways by source for DAGLB Gene

1 GeneGo (Thomson Reuters) pathway for DAGLB Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
2 Cell Signaling Technology pathways for DAGLB Gene

Gene Ontology (GO) - Biological Process for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS --
GO:0006629 lipid metabolic process IEA --
GO:0006690 icosanoid metabolic process IEA --
GO:0007216 G protein-coupled glutamate receptor signaling pathway IBA 21873635
GO:0007405 neuroblast proliferation IEA --
genes like me logo Genes that share ontologies with DAGLB: view

No data available for SIGNOR curated interactions for DAGLB Gene

Drugs & Compounds for DAGLB Gene

(4) Drugs for DAGLB Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 63
RHC80267 Pharma Inhibitor, Inhibition 0
Rhc 80267 Pharma diacylglycerol lipase inhibitor 0
Calcium Nutra 6959

(6) Additional Compounds for DAGLB Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tetrahydrolipstatin
Inhibitor, Inhibition
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(1) ApexBio Compounds for DAGLB Gene

Compound Action Cas Number
RHC 80267 diacylglycerol lipase inhibitor 83654-05-1
genes like me logo Genes that share compounds with DAGLB: view

Drug products for research

Transcripts for DAGLB Gene

mRNA/cDNA for DAGLB Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAGLB

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - -
SP10:
SP11: -
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DAGLB Gene

GeneLoc Exon Structure for
DAGLB

Expression for DAGLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAGLB Gene

Protein differential expression in normal tissues from HIPED for DAGLB Gene

This gene is overexpressed in NK cells (35.8), Breast (11.3), Peripheral blood mononuclear cells (9.1), and Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAGLB Gene



Protein tissue co-expression partners for DAGLB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAGLB

SOURCE GeneReport for Unigene cluster for DAGLB Gene:

Hs.487498

Evidence on tissue expression from TISSUES for DAGLB Gene

  • Nervous system(4.6)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with DAGLB: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAGLB Gene

Orthologs for DAGLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100612262 29
  • 99.57 (n)
Dog
(Canis familiaris)
Mammalia DAGLB 29 30
  • 83.68 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DAGLB 29 30
  • 81.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Daglb 29 16 30
  • 79.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Daglb 29
  • 79.06 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 79 (a)
OneToMany
-- 30
  • 62 (a)
OneToMany
-- 30
  • 24 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia DAGLB 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DAGLB 29 30
  • 64.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 64 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia daglb 29
  • 62.73 (n)
Zebrafish
(Danio rerio)
Actinopterygii daglb 29 30
  • 60 (n)
OneToMany
DAGLB (1 of 2) 30
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012171 29
  • 44.09 (n)
Worm
(Caenorhabditis elegans)
Secernentea F42G9.6 29 30
  • 44.22 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G05790 29
  • 38.57 (n)
Species where no ortholog for DAGLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DAGLB Gene

ENSEMBL:
Gene Tree for DAGLB (if available)
TreeFam:
Gene Tree for DAGLB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAGLB: view image
Alliance of Genome Resources:
Additional Orthologs for DAGLB

Paralogs for DAGLB Gene

Paralogs for DAGLB Gene

(1) SIMAP similar genes for DAGLB Gene using alignment to 6 proteins:

  • DGLB_HUMAN
  • B4DVJ1_HUMAN
  • C9JA85_HUMAN
  • E7ET49_HUMAN
  • E7EVQ4_HUMAN
  • F8WBN0_HUMAN
genes like me logo Genes that share paralogs with DAGLB: view

Variants for DAGLB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAGLB Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs112772921 Likely Benign: not provided 6,430,575(-) G/A
NM_139179.4(DAGLB):c.834C>T (p.Cys278=)
SYNONYMOUS_VARIANT,INTRON
rs116243689 Benign: not provided 6,409,881(-) C/T
NM_139179.4(DAGLB):c.1975G>A (p.Val659Ile)
MISSENSE
rs116541573 Benign: not provided 6,416,703(-) G/A
NM_139179.4(DAGLB):c.1351C>T (p.Leu451=)
SYNONYMOUS
rs139753251 Benign: not provided 6,410,163(-) A/G
NM_139179.4(DAGLB):c.1787T>C (p.Ile596Thr)
MISSENSE
rs141846216 Benign: not provided 6,409,960(-) A/G
NM_139179.4(DAGLB):c.1896T>C (p.Gly632=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DAGLB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DAGLB Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2733926 CNV deletion 23290073
esv2733927 CNV deletion 23290073
esv3541121 CNV deletion 23714750
nsv1020236 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv605999 CNV loss 21841781
nsv606000 CNV loss 21841781
nsv7392 OTHER inversion 18451855

Variation tolerance for DAGLB Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAGLB Gene

Human Gene Mutation Database (HGMD)
DAGLB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAGLB
Leiden Open Variation Database (LOVD)
DAGLB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAGLB Gene

Disorders for DAGLB Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAGLB Gene - From: COP

Disorder Aliases PubMed IDs
hallucinogen dependence
- elite association - COSMIC cancer census association via MalaCards
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Additional Disease Information for DAGLB

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No data available for UniProtKB/Swiss-Prot and Genatlas for DAGLB Gene

Publications for DAGLB Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
  5. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PMID: 14610053) Bisogno T … Doherty P (The Journal of cell biology 2003) 3 4

Products for DAGLB Gene