Aliases for DAGLB Gene

Aliases for DAGLB Gene

  • Diacylglycerol Lipase Beta 2 3 5
  • Sn1-Specific Diacylglycerol Lipase Beta 3 4
  • DGL-Beta 3 4
  • KCCR13L 3 4
  • Diacylglycerol Lipase, Beta 2
  • EC 3.1.1.- 4
  • DAGLBETA 3

External Ids for DAGLB Gene

Summaries for DAGLB Gene

GeneCards Summary for DAGLB Gene

DAGLB (Diacylglycerol Lipase Beta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot Summary for DAGLB Gene

  • Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Additional gene information for DAGLB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAGLB Gene

Genomics for DAGLB Gene

GeneHancer (GH) Regulatory Elements for DAGLB Gene

Promoters and enhancers for DAGLB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAGLB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAGLB

Top Transcription factor binding sites by QIAGEN in the DAGLB gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • En-1
  • Hand1

Genomic Locations for DAGLB Gene

Genomic Locations for DAGLB Gene
chr7:6,409,116-6,484,190
(GRCh38/hg38)
Size:
75,075 bases
Orientation:
Minus strand
chr7:6,448,747-6,523,821
(GRCh37/hg19)
Size:
75,075 bases
Orientation:
Minus strand

Genomic View for DAGLB Gene

Genes around DAGLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLB Gene

Proteins for DAGLB Gene

  • Protein details for DAGLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCG7-DGLB_HUMAN
    Recommended name:
    Sn1-specific diacylglycerol lipase beta
    Protein Accession:
    Q8NCG7
    Secondary Accessions:
    • A4D2P3
    • B3KV90
    • B4DQU0
    • Q6PIX3
    • Q8N2N2
    • Q8N9S1
    • Q8TED3
    • Q8WXE6

    Protein attributes for DAGLB Gene

    Size:
    672 amino acids
    Molecular mass:
    73732 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAGLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAGLB Gene

Post-translational modifications for DAGLB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAGLB Gene

No data available for DME Specific Peptides for DAGLB Gene

Domains & Families for DAGLB Gene

Gene Families for DAGLB Gene

Protein Domains for DAGLB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DAGLB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53161, highly similar to Homo sapiens diacylglycerol lipase beta (B4DQU0_HUMAN)
  • cDNA FLJ52774, highly similar to Homo sapiens diacylglycerol lipase beta (B4DVJ1_HUMAN)
  • KCCR13L (DGLB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCG7

UniProtKB/Swiss-Prot:

DGLB_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLB: view

Function for DAGLB Gene

Molecular function for DAGLB Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=74.1 uM for diacylglycerol {ECO:0000269 PubMed:14610053}; Vmax=3.45 nmol/min/mg enzyme {ECO:0000269 PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:14610053};

Enzyme Numbers (IUBMB) for DAGLB Gene

Phenotypes From GWAS Catalog for DAGLB Gene

Gene Ontology (GO) - Molecular Function for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DAGLB: view
genes like me logo Genes that share phenotypes with DAGLB: view

Animal Models for DAGLB Gene

MGI Knock Outs for DAGLB:

Animal Model Products

  • Taconic Biosciences Mouse Models for DAGLB

CRISPR Products

miRNA for DAGLB Gene

miRTarBase miRNAs that target DAGLB

Clone Products

  • Addgene plasmids for DAGLB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLB Gene

Localization for DAGLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLB Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAGLB gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAGLB: view

Pathways & Interactions for DAGLB Gene

genes like me logo Genes that share pathways with DAGLB: view

Pathways by source for DAGLB Gene

1 GeneGo (Thomson Reuters) pathway for DAGLB Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
2 Cell Signaling Technology pathways for DAGLB Gene

Gene Ontology (GO) - Biological Process for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007216 G protein-coupled glutamate receptor signaling pathway IBA 21873635
GO:0007405 neuroblast proliferation IEA --
GO:0016042 lipid catabolic process IEA --
GO:0019369 arachidonic acid metabolic process IDA 14610053
genes like me logo Genes that share ontologies with DAGLB: view

No data available for SIGNOR curated interactions for DAGLB Gene

Drugs & Compounds for DAGLB Gene

(4) Drugs for DAGLB Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 60
Calcium Approved Nutra 7884
RHC80267 Pharma Inhibition, Inhibitor 0
Rhc 80267 Pharma diacylglycerol lipase inhibitor 0

(5) Additional Compounds for DAGLB Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tetrahydrolipstatin
Inhibition, Inhibitor
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(1) ApexBio Compounds for DAGLB Gene

Compound Action Cas Number
RHC 80267 diacylglycerol lipase inhibitor 83654-05-1
genes like me logo Genes that share compounds with DAGLB: view

Drug Products

Transcripts for DAGLB Gene

mRNA/cDNA for DAGLB Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for DAGLB

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - -
SP10:
SP11: -
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DAGLB Gene

GeneLoc Exon Structure for
DAGLB

Expression for DAGLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAGLB Gene

Protein differential expression in normal tissues from HIPED for DAGLB Gene

This gene is overexpressed in NK cells (35.8), Breast (11.3), Peripheral blood mononuclear cells (9.1), and Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAGLB Gene



Protein tissue co-expression partners for DAGLB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAGLB

SOURCE GeneReport for Unigene cluster for DAGLB Gene:

Hs.487498

Evidence on tissue expression from TISSUES for DAGLB Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DAGLB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAGLB Gene

Orthologs for DAGLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612262 30
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia DAGLB 31 30
  • 83.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DAGLB 31 30
  • 81.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Daglb 17 31 30
  • 79.79 (n)
rat
(Rattus norvegicus)
Mammalia Daglb 30
  • 79.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 62 (a)
OneToMany
-- 31
  • 24 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DAGLB 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAGLB 31 30
  • 64.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 64 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia daglb 30
  • 62.73 (n)
zebrafish
(Danio rerio)
Actinopterygii daglb 31 30
  • 60 (n)
OneToMany
DAGLB (1 of 2) 31
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012171 30
  • 44.09 (n)
worm
(Caenorhabditis elegans)
Secernentea F42G9.6 31 30
  • 44.22 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05790 30
  • 38.57 (n)
Species where no ortholog for DAGLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAGLB Gene

ENSEMBL:
Gene Tree for DAGLB (if available)
TreeFam:
Gene Tree for DAGLB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAGLB: view image

Paralogs for DAGLB Gene

Paralogs for DAGLB Gene

(1) SIMAP similar genes for DAGLB Gene using alignment to 6 proteins:

  • DGLB_HUMAN
  • B4DVJ1_HUMAN
  • C9JA85_HUMAN
  • E7ET49_HUMAN
  • E7EVQ4_HUMAN
  • F8WBN0_HUMAN
genes like me logo Genes that share paralogs with DAGLB: view

Variants for DAGLB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAGLB Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
714345 Benign: not provided 6,409,881(-) C/T MISSENSE_VARIANT
720368 Benign: not provided 6,410,389(-) G/A INTRON_VARIANT
720369 Benign: not provided 6,432,927(-) C/T MISSENSE_VARIANT,SYNONYMOUS_VARIANT
723916 Likely Benign: not provided 6,410,363(-) G/A SYNONYMOUS_VARIANT
740250 Likely Benign: not provided 6,430,575(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for DAGLB Gene

Structural Variations from Database of Genomic Variants (DGV) for DAGLB Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2733926 CNV deletion 23290073
esv2733927 CNV deletion 23290073
esv3541121 CNV deletion 23714750
nsv1020236 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv605999 CNV loss 21841781
nsv606000 CNV loss 21841781
nsv7392 OTHER inversion 18451855

Variation tolerance for DAGLB Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAGLB Gene

Human Gene Mutation Database (HGMD)
DAGLB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAGLB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAGLB Gene

Disorders for DAGLB Gene

Additional Disease Information for DAGLB

No disorders were found for DAGLB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAGLB Gene

Publications for DAGLB Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  5. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PMID: 14610053) Bisogno T … Doherty P (The Journal of cell biology 2003) 3 4 54

Products for DAGLB Gene