Aliases for DAGLA Gene
External Ids for DAGLA Gene
Previous HGNC Symbols for DAGLA Gene
Previous GeneCards Identifiers for DAGLA Gene
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
GeneCards Summary for DAGLA Gene
DAGLA (Diacylglycerol Lipase Alpha) is a Protein Coding gene. Diseases associated with DAGLA include Spinocerebellar Ataxia 20 and Spasmodic Dysphonia. Among its related pathways are Cell-type Dependent Selectivity of CCK2R Signaling and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLB.
UniProtKB/Swiss-Prot Summary for DAGLA Gene
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.