This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010] See more...

Aliases for DAGLA Gene

Aliases for DAGLA Gene

  • Diacylglycerol Lipase Alpha 2 3 5
  • Neural Stem Cell-Derived Dendrite Regulator 2 3 4
  • NSDDR 2 3 4
  • Sn1-Specific Diacylglycerol Lipase Alpha 3 4
  • Diacylglycerol Lipase-Alpha 3 4
  • DAGL-Alpha 3 4
  • DAGLALPHA 2 3
  • DGL-Alpha 3 4
  • C11orf11 3 4
  • KIAA0659 2 4
  • Chromosome 11 Open Reading Frame 11 2
  • Diacylglycerol Lipase, Alpha 2
  • DAGL(ALPHA) 3
  • EC 3.1.1.- 4
  • DAGLA 5

External Ids for DAGLA Gene

Previous HGNC Symbols for DAGLA Gene

  • C11orf11

Previous GeneCards Identifiers for DAGLA Gene

  • GC11P061205
  • GC11P061447
  • GC11P057776

Summaries for DAGLA Gene

Entrez Gene Summary for DAGLA Gene

  • This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]

GeneCards Summary for DAGLA Gene

DAGLA (Diacylglycerol Lipase Alpha) is a Protein Coding gene. Diseases associated with DAGLA include Spinocerebellar Ataxia 20 and Spasmodic Dysphonia. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLB.

UniProtKB/Swiss-Prot Summary for DAGLA Gene

  • Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAGLA Gene

Genomics for DAGLA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DAGLA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J061679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.7 1748 4.4 ZNF207 ZNF600 SIX5 SSRP1 KLF9 MXD4 CTCF REST FOXA1 KLF11 DAGLA GANAB CPSF7 CSKMT TMEM138 RN7SL23P INTS5 MTA2 TUT1 EML3
GH11J061665 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 255.9 -12.8 -12848 3 ZMYM3 CHD4 KDM6A SMAD4 SAP130 DMAP1 CREM MYNN BCL6 KDM1A DAGLA MYRF-AS1 piR-49423-043 SYT7
GH11J061680 Enhancer 0.5 FANTOM5 ENCODE 271.2 -0.7 -728 0.2 FOSL2 DAGLA FTH1 CPSF7 SDHAF2 CYB561A3 HSALNG0084551 piR-49423-043 SYT7
GH11J061693 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.5 +17.7 17740 8.5 JUND ZIC2 CEBPB REST DEK ZNF341 CTCF MAX ZBTB7B ZNF217 MYRF MYRF-AS1 DAGLA SYT7 FTH1 CYB561A3 VWCE SDHAF2 DDB1 CPSF7
GH11J061625 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 17.3 -52.2 -52197 4.8 ZNF654 POLR2A REST CTCF SIN3A ZNF217 ELF1 CTBP1 ZNF623 SAP130 DAGLA SYT7 MYRF-AS1 MYRF LM611511-003 RPLP0P2 LOC101927495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAGLA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DAGLA

Top Transcription factor binding sites by QIAGEN in the DAGLA gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for DAGLA Gene

Latest Assembly
chr11:61,680,184-61,747,002
(GRCh38/hg38)
Size:
66,819 bases
Orientation:
Plus strand

Previous Assembly
chr11:61,447,863-61,514,473
(GRCh37/hg19 by Entrez Gene)
Size:
66,611 bases
Orientation:
Plus strand

chr11:61,447,905-61,514,473
(GRCh37/hg19 by Ensembl)
Size:
66,569 bases
Orientation:
Plus strand

Genomic View for DAGLA Gene

Genes around DAGLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLA Gene

Proteins for DAGLA Gene

  • Protein details for DAGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4D2-DGLA_HUMAN
    Recommended name:
    Diacylglycerol lipase-alpha
    Protein Accession:
    Q9Y4D2
    Secondary Accessions:
    • A0A024R517
    • A7E233
    • Q6WQJ0

    Protein attributes for DAGLA Gene

    Size:
    1042 amino acids
    Molecular mass:
    114952 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity (PubMed:23502535). Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization (By similarity).
    SequenceCaution:
    • Sequence=BAA31634.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DAGLA Gene

Post-translational modifications for DAGLA Gene

  • Phosphorylated at Ser-782 and Ser-808 by CAMK2A; phosphorylation by CAMK2A inhibits diacylglycerol lipase activity.
  • Glycosylation at Asn133
  • Modification sites at PhosphoSitePlus

Other Protein References for DAGLA Gene

Antibodies for research

  • Abcam antibodies for DAGLA
  • Boster Bio Antibodies for DAGLA
  • Santa Cruz Biotechnology (SCBT) Antibodies for DAGLA

No data available for DME Specific Peptides for DAGLA Gene

Domains & Families for DAGLA Gene

Gene Families for DAGLA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for DAGLA Gene

Suggested Antigen Peptide Sequences for DAGLA Gene

GenScript: Design optimal peptide antigens:
  • Neural stem cell-derived dendrite regulator (DGLA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4D2

UniProtKB/Swiss-Prot:

DGLA_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLA: view

Function for DAGLA Gene

Molecular function for DAGLA Gene

UniProtKB/Swiss-Prot Function:
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:52392, ChEBI:CHEBI:75728; Evidence={ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38515, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52392, ChEBI:CHEBI:75449; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+); Xref=Rhea:RHEA:38519, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75448, ChEBI:CHEBI:75456; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+); Xref=Rhea:RHEA:38523, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75450, ChEBI:CHEBI:75457; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+); Xref=Rhea:RHEA:38527, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75913, ChEBI:CHEBI:75914; Evidence={ECO:0000269|PubMed:14610053};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=154.7 uM for diacylglycerol {ECO:0000269|PubMed:14610053}; KM=158 uM for 1-steroyl-2-arachidonoylglycerol {ECO:0000269|PubMed:23502535}; Vmax=33.3 nmol/min/mg enzyme {ECO:0000269|PubMed:14610053}; Vmax=9.8 pmol/min/mg enzyme with 1-steroyl-2-arachidonoylglycerol as substrat {ECO:0000269|PubMed:23502535}; pH dependence: Optimum pH is 7.0. {ECO:0000269|PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 1,2,3-triazole urea covalent inhibitors KT172, DH376 and DO34 (PubMed:26668358). Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267 (PubMed:14610053). Diacylglycerol lipase activity is inhibited by the phosphorylation of Ser-782 and Ser-808 by CAMK2A (PubMed:23502535).

Enzyme Numbers (IUBMB) for DAGLA Gene

Phenotypes From GWAS Catalog for DAGLA Gene

Gene Ontology (GO) - Molecular Function for DAGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23502535
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DAGLA: view
genes like me logo Genes that share phenotypes with DAGLA: view

Animal Models for DAGLA Gene

MGI Knock Outs for DAGLA:
  • Dagla Dagla<tm1.1Kano>
  • Dagla Dagla<tm1a(EUCOMM)Wtsi>
  • Dagla Dagla<tm1Pado>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAGLA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLA Gene

Localization for DAGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLA Gene

Cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane. Multi-pass membrane protein. Early endosome membrane. Multi-pass membrane protein. Cell projection, dendritic spine membrane. Multi-pass membrane protein. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. {ECO:0000269 PubMed:27595600}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAGLA gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DAGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DAGLA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DAGLA Gene

Pathways & Interactions for DAGLA Gene

genes like me logo Genes that share pathways with DAGLA: view

Pathways by source for DAGLA Gene

1 GeneGo (Thomson Reuters) pathway for DAGLA Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
2 Cell Signaling Technology pathways for DAGLA Gene

Gene Ontology (GO) - Biological Process for DAGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007216 G protein-coupled glutamate receptor signaling pathway IEA,IBA 21873635
GO:0007405 neuroblast proliferation IEA --
GO:0016042 lipid catabolic process IEA --
GO:0019369 arachidonic acid metabolic process IEA,IDA 14610053
genes like me logo Genes that share ontologies with DAGLA: view

No data available for SIGNOR curated interactions for DAGLA Gene

Drugs & Compounds for DAGLA Gene

(5) Drugs for DAGLA Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 63
Cannabidivarin Investigational Pharma Target, inhibitor 0
RHC80267 Pharma Inhibitor, Inhibition 0
Rhc 80267 Pharma diacylglycerol lipase inhibitor 0
Calcium Nutra 6959

(6) Additional Compounds for DAGLA Gene - From: HMDB and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tetrahydrolipstatin
Inhibitor, Inhibition
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(1) ApexBio Compounds for DAGLA Gene

Compound Action Cas Number
RHC 80267 diacylglycerol lipase inhibitor 83654-05-1
genes like me logo Genes that share compounds with DAGLA: view

Drug products for research

Transcripts for DAGLA Gene

mRNA/cDNA for DAGLA Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DAGLA

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLA Gene

No ASD Table

Relevant External Links for DAGLA Gene

GeneLoc Exon Structure for
DAGLA

Expression for DAGLA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAGLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAGLA Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for DAGLA Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAGLA Gene



Protein tissue co-expression partners for DAGLA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DAGLA

SOURCE GeneReport for Unigene cluster for DAGLA Gene:

Hs.241564

mRNA Expression by UniProt/SwissProt for DAGLA Gene:

Q9Y4D2-DGLA_HUMAN
Tissue specificity: Highly expressed in brain and pancreas.

Evidence on tissue expression from TISSUES for DAGLA Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DAGLA: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DAGLA Gene

Orthologs for DAGLA Gene

This gene was present in the common ancestor of animals.

Orthologs for DAGLA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DAGLA 29 30
  • 98.95 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DAGLA 29 30
  • 91.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DAGLA 29 30
  • 91.71 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DAGLA 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Dagla 29 16 30
  • 89.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dagla 29
  • 89.35 (n)
Chicken
(Gallus gallus)
Aves DAGLA 29 30
  • 79.79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DAGLA 30
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dagla 29
  • 75.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii dagla 29 30
  • 67.26 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta inaE 30
  • 22 (a)
OneToOne
Species where no ortholog for DAGLA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DAGLA Gene

ENSEMBL:
Gene Tree for DAGLA (if available)
TreeFam:
Gene Tree for DAGLA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAGLA: view image
Alliance of Genome Resources:
Additional Orthologs for DAGLA

Paralogs for DAGLA Gene

Paralogs for DAGLA Gene

(1) SIMAP similar genes for DAGLA Gene using alignment to 2 proteins:

  • DGLA_HUMAN
  • F5GY58_HUMAN
genes like me logo Genes that share paralogs with DAGLA: view

Variants for DAGLA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DAGLA Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
932507 Likely Benign: not provided 61,741,185(+) G/C
NM_006133.3(DAGLA):c.2007G>C (p.Gly669=)
SYNONYMOUS
rs114103951 Benign: not provided 61,723,495(+) C/T
NM_006133.3(DAGLA):c.471C>T (p.Phe157=)
SYNONYMOUS
rs117050893 Benign: not provided 61,744,322(+) C/G
NM_006133.3(DAGLA):c.2962C>G (p.Leu988Val)
MISSENSE
rs199764983 Uncertain Significance: Attention deficit hyperactivity disorder 61,744,409(+) G/C
NM_006133.3(DAGLA):c.3049G>C (p.Asp1017His)
MISSENSE
rs35056845 Benign: not provided 61,743,564(+) G/Tp.Gly735Val
NM_006133.3(DAGLA):c.2204G>T (p.Gly735Val)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DAGLA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DAGLA Gene

Variant ID Type Subtype PubMed ID
esv1003572 CNV deletion 20482838
nsv528697 CNV loss 19592680
nsv832179 CNV loss 17160897
nsv952459 CNV deletion 24416366

Variation tolerance for DAGLA Gene

Residual Variation Intolerance Score: 2.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAGLA Gene

Human Gene Mutation Database (HGMD)
DAGLA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAGLA
Leiden Open Variation Database (LOVD)
DAGLA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAGLA Gene

Disorders for DAGLA Gene

MalaCards: The human disease database

(6) MalaCards diseases for DAGLA Gene - From: COP and GCD

Disorder Aliases PubMed IDs
spinocerebellar ataxia 20
  • sca20
spasmodic dysphonia
  • abductor spasmodic dysphonia
cannabis abuse
  • marijuana abuse
hallucinogen dependence
attention deficit-hyperactivity disorder
  • adhd
- elite association - COSMIC cancer census association via MalaCards
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UniProtKB/Swiss-Prot

DGLA_HUMAN
  • Spinocerebellar ataxia 20 (SCA20) [MIM:608687]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult-onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. {ECO:0000269 PubMed:18801880}. Note=The disease may be caused by variants affecting the gene represented in this entry. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA.

Additional Disease Information for DAGLA

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No data available for Genatlas for DAGLA Gene

Publications for DAGLA Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  2. Regulated endosomal trafficking of Diacylglycerol lipase alpha (DAGLα) generates distinct cellular pools; implications for endocannabinoid signaling. (PMID: 27595600) Zhou Y … Doherty P (Molecular and cellular neurosciences 2016) 3 4
  3. CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. (PMID: 23502535) Shonesy BC … Colbran RJ (Nature neuroscience 2013) 3 4
  4. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre RN … Steffen LM (PLoS genetics 2011) 3 40
  5. A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20. (PMID: 18801880) Knight MA … Singleton AB (Human molecular genetics 2008) 3 4

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