Aliases for DAD1 Gene
- Defender Against Cell Death 1 2 3 4 5
- Oligosaccharyltransferase Subunit 2 (Non-Catalytic) 2 3
- Oligosaccharyl Transferase Subunit DAD1 3 4
- DAD-1 3 4
- Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit DAD1 3
- Oligosaccharyltransferase 2 Homolog (S. Cerevisiae) 2
- Oligosaccharyltransferase 2 Homolog 3
- OST2 3
External Ids for DAD1 Gene
Previous GeneCards Identifiers for DAD1 Gene
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
GeneCards Summary for DAD1 Gene
DAD1 (Defender Against Cell Death 1) is a Protein Coding gene. Diseases associated with DAD1 include Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb. Among its related pathways are Protein processing in endoplasmic reticulum and N-Glycan biosynthesis. Gene Ontology (GO) annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity.
UniProtKB/Swiss-Prot for DAD1 Gene
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis.