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Aliases for DAD1 Gene

Aliases for DAD1 Gene

  • Defender Against Cell Death 1 2 3 4 5
  • Oligosaccharyltransferase Subunit 2 (Non-Catalytic) 2 3
  • Oligosaccharyl Transferase Subunit DAD1 3 4
  • DAD-1 3 4
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit DAD1 3
  • Oligosaccharyltransferase 2 Homolog (S. Cerevisiae) 2
  • Oligosaccharyltransferase 2 Homolog 3
  • OST2 3

External Ids for DAD1 Gene

Previous GeneCards Identifiers for DAD1 Gene

  • GC14M020406
  • GC14M016821
  • GC14M021023
  • GC14M022103
  • GC14M023033
  • GC14M003152

Summaries for DAD1 Gene

Entrez Gene Summary for DAD1 Gene

  • DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAD1 Gene

DAD1 (Defender Against Cell Death 1) is a Protein Coding gene. Diseases associated with DAD1 include Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb. Among its related pathways are Protein processing in endoplasmic reticulum and N-Glycan biosynthesis. Gene Ontology (GO) annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity.

UniProtKB/Swiss-Prot for DAD1 Gene

  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis.

Gene Wiki entry for DAD1 Gene

Additional gene information for DAD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAD1 Gene

Genomics for DAD1 Gene

GeneHancer (GH) Regulatory Elements for DAD1 Gene

Promoters and enhancers for DAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022587 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665 +0.2 195 3.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B DAD1 ACIN1 PRMT5 OXA1L MMP14 HAUS4 ABHD4 C14orf93 OR6J1 SLC22A17
GH14J022504 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +51.1 51081 66.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 SSRP1 TRAJ7 TRAJ6 GC14P024317 GC14P024294 NGDN MMP14 ACIN1 PRMT5 ABHD4 DAD1
GH14J022844 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -260.0 -260012 9.9 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 PIR54043 NGDN LRP10 REM2 OXA1L PABPN1 RBM23 DAD1 PRMT5-AS1 THTPA
GH14J022596 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.6 -9.1 -9139 3 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 FOS SP3 ABHD4 ENSG00000275552 GC14P024328 NGDN PRMT5 SLC7A8 DAD1
GH14J022571 Enhancer 1 ENCODE dbSUPER 18.8 +16.6 16600 1.7 FOXA2 ARID4B DNMT3B RARA ETS1 ZNF614 FOS CREM HMG20B ELF1 DAD1 OR6J1 ABHD4 MMP14 OXA1L SLC7A7 MRPL52 PRMT5 C14orf93 LINC02332
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DAD1 gene promoter:
  • p53
  • deltaCREB
  • CREB
  • Sp1
  • TBP
  • Pax-2a
  • Pax-2
  • Pax-2b
  • POU3F2
  • GCNF-2

Genomic Locations for DAD1 Gene

Genomic Locations for DAD1 Gene
chr14:22,564,905-22,589,269
(GRCh38/hg38)
Size:
24,365 bases
Orientation:
Minus strand
chr14:23,033,805-23,058,175
(GRCh37/hg19)
Size:
24,371 bases
Orientation:
Minus strand

Genomic View for DAD1 Gene

Genes around DAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAD1 Gene

Proteins for DAD1 Gene

  • Protein details for DAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61803-DAD1_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
    Protein Accession:
    P61803
    Secondary Accessions:
    • D3DS25
    • O08552
    • O70364
    • P46966
    • P46968
    • Q6FGA3
    • Q96GB7

    Protein attributes for DAD1 Gene

    Size:
    113 amino acids
    Molecular mass:
    12497 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.

neXtProt entry for DAD1 Gene

Post-translational modifications for DAD1 Gene

  • Ubiquitination at Lys82
  • Modification sites at PhosphoSitePlus

Other Protein References for DAD1 Gene

No data available for DME Specific Peptides for DAD1 Gene

Domains & Families for DAD1 Gene

Gene Families for DAD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for DAD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61803

UniProtKB/Swiss-Prot:

DAD1_HUMAN :
  • Belongs to the DAD/OST2 family.
Family:
  • Belongs to the DAD/OST2 family.
genes like me logo Genes that share domains with DAD1: view

Function for DAD1 Gene

Molecular function for DAD1 Gene

UniProtKB/Swiss-Prot Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis.
GENATLAS Biochemistry:
defender against apoptosis

Phenotypes From GWAS Catalog for DAD1 Gene

Gene Ontology (GO) - Molecular Function for DAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 contributes_to oligosaccharyl transferase activity ISS,IBA --
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC,IEA 15835887
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DAD1: view
genes like me logo Genes that share phenotypes with DAD1: view

Animal Models for DAD1 Gene

MGI Knock Outs for DAD1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAD1 Gene

Localization for DAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAD1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAD1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IEA --
GO:0008250 oligosaccharyltransferase complex IEA,TAS 15835887
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAD1: view

Pathways & Interactions for DAD1 Gene

genes like me logo Genes that share pathways with DAD1: view

Pathways by source for DAD1 Gene

UniProtKB/Swiss-Prot P61803-DAD1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for DAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006486 protein glycosylation IEA,ISS --
GO:0006487 protein N-linked glycosylation IBA --
GO:0006915 apoptotic process IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with DAD1: view

No data available for SIGNOR curated interactions for DAD1 Gene

Drugs & Compounds for DAD1 Gene

(1) Drugs for DAD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved, Investigational Nutra 0

(1) Additional Compounds for DAD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
37247-98-6
genes like me logo Genes that share compounds with DAD1: view

Transcripts for DAD1 Gene

mRNA/cDNA for DAD1 Gene

Unigene Clusters for DAD1 Gene

Defender against cell death 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -

Relevant External Links for DAD1 Gene

GeneLoc Exon Structure for
DAD1
ECgene alternative splicing isoforms for
DAD1

Expression for DAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DAD1 Gene

This gene is overexpressed in Nasal epithelium (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAD1 Gene



Protein tissue co-expression partners for DAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAD1 Gene:

DAD1

SOURCE GeneReport for Unigene cluster for DAD1 Gene:

Hs.82890

Evidence on tissue expression from TISSUES for DAD1 Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Skin(4.4)
  • Kidney(2.4)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
  • Gall bladder(2.1)
  • Heart(2)
  • Intestine(2)
  • Liver(2)
  • Lung(2)
  • Lymph node(2)
  • Muscle(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with DAD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAD1 Gene

Orthologs for DAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAD1 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DAD1 34 33
  • 93.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DAD1 34 33
  • 92.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dad1 16 34 33
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Dad1 33
  • 90.27 (n)
oppossum
(Monodelphis domestica)
Mammalia DAD1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAD1 34 33
  • 74.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAD1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dad1 33
  • 75.52 (n)
Str.10052 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397721 33
zebrafish
(Danio rerio)
Actinopterygii dad1 34 33
  • 70.5 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13393 35
  • 71 (a)
l(2)k12914 34 33
  • 63.55 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008491 33
  • 63.06 (n)
worm
(Caenorhabditis elegans)
Secernentea dad-1 34 35 33
  • 61.65 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OST2 36 34
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATDAD1 33
  • 55.56 (n)
rice
(Oryza sativa)
Liliopsida Os04g0397000 33
  • 56.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5446 34
  • 63 (a)
OneToOne
Species where no ortholog for DAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAD1 Gene

ENSEMBL:
Gene Tree for DAD1 (if available)
TreeFam:
Gene Tree for DAD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAD1: view image

Paralogs for DAD1 Gene

Pseudogenes.org Pseudogenes for DAD1 Gene

genes like me logo Genes that share paralogs with DAD1: view

No data available for Paralogs for DAD1 Gene

Variants for DAD1 Gene

Sequence variations from dbSNP and Humsavar for DAD1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000099074 -- 22,565,540(-) T/C intron_variant
rs1000137365 -- 22,581,560(-) G/A intron_variant
rs1000204462 -- 22,588,770(-) G/C intron_variant
rs1000474025 -- 22,582,961(-) G/A intron_variant
rs1000522752 -- 22,582,723(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DAD1 Gene

Variant ID Type Subtype PubMed ID
esv2678511 CNV deletion 23128226
esv3633757 CNV loss 21293372
esv3892469 CNV gain+loss 25118596
nsv1047315 CNV gain 25217958
nsv519534 CNV loss 19592680
nsv563998 CNV gain 21841781
nsv832746 CNV gain 17160897
nsv832748 CNV gain 17160897

Variation tolerance for DAD1 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAD1 Gene

Disorders for DAD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1q21.1 deletion syndrome, 1.35-mb
  • chromosome 1q21.1 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DAD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DAD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAD1 Gene

Publications for DAD1 Gene

  1. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. (PMID: 8413235) Nakashima T … Nishimoto T (Molecular and cellular biology 1993) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  5. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. (PMID: 18383209) Kulke MH … Shivdasani RA (Genes, chromosomes & cancer 2008) 3 22 58

Products for DAD1 Gene

Sources for DAD1 Gene

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