Aliases for DACT3 Gene

Aliases for DACT3 Gene

  • Dishevelled Binding Antagonist Of Beta Catenin 3 2 3 5
  • Antagonist Of Beta-Catenin Dapper Homolog 3 3 4
  • Arginine-Rich Region 1 Protein 3 4
  • Dapper Homolog 3 3 4
  • DAPPER3 2 3
  • RRR1 3 4
  • Dapper, Antagonist Of Beta-Catenin, Homolog 3 (Xenopus Laevis) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 3 3
  • Dapper Antagonist Of Catenin 3 4
  • Arginine Rich Region 1 2
  • MGC15476 2
  • DACT3 5

External Ids for DACT3 Gene

Previous HGNC Symbols for DACT3 Gene

  • RRR1

Previous GeneCards Identifiers for DACT3 Gene

  • GC19M051844
  • GC19M047150
  • GC19M043576

Summaries for DACT3 Gene

GeneCards Summary for DACT3 Gene

DACT3 (Dishevelled Binding Antagonist Of Beta Catenin 3) is a Protein Coding gene. Diseases associated with DACT3 include Spastic Paraparesis and Placenta Praevia. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase A binding. An important paralog of this gene is DACT1.

UniProtKB/Swiss-Prot Summary for DACT3 Gene

  • May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DACT3 Gene

Genomics for DACT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DACT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DACT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DACT3

Top Transcription factor binding sites by QIAGEN in the DACT3 gene promoter:
  • AML1a
  • CP2
  • ER-alpha
  • Lmo2
  • p53
  • Pax-5
  • SEF-1 (1)
  • TBP
  • TFIID
  • ZIC2

Genomic Locations for DACT3 Gene

Genomic Locations for DACT3 Gene
chr19:46,647,551-46,661,182
(GRCh38/hg38)
Size:
13,632 bases
Orientation:
Minus strand
chr19:47,150,869-47,164,395
(GRCh37/hg19)
Size:
13,527 bases
Orientation:
Minus strand

Genomic View for DACT3 Gene

Genes around DACT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DACT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DACT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACT3 Gene

Proteins for DACT3 Gene

  • Protein details for DACT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B18-DACT3_HUMAN
    Recommended name:
    Dapper homolog 3
    Protein Accession:
    Q96B18

    Protein attributes for DACT3 Gene

    Size:
    629 amino acids
    Molecular mass:
    64949 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.
    SequenceCaution:
    • Sequence=AAH16161.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for DACT3 Gene

Post-translational modifications for DACT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT3 Gene

Antibody Products

  • Abcam antibodies for DACT3
  • Boster Bio Antibodies for DACT3
  • Santa Cruz Biotechnology (SCBT) Antibodies for DACT3

No data available for DME Specific Peptides for DACT3 Gene

Domains & Families for DACT3 Gene

Gene Families for DACT3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DACT3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT3 Gene

GenScript: Design optimal peptide antigens:
  • Arginine-rich region 1 protein (DACT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96B18

UniProtKB/Swiss-Prot:

DACT3_HUMAN :
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
  • Belongs to the dapper family.
Domain:
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT3: view

Function for DACT3 Gene

Molecular function for DACT3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

Phenotypes From GWAS Catalog for DACT3 Gene

Gene Ontology (GO) - Molecular Function for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA,ISS --
GO:0008013 beta-catenin binding IBA --
GO:0042802 identical protein binding IEA --
GO:0051018 protein kinase A binding IEA,ISS --
GO:0070097 delta-catenin binding IEA,ISS --
genes like me logo Genes that share ontologies with DACT3: view
genes like me logo Genes that share phenotypes with DACT3: view

Animal Models for DACT3 Gene

MGI Knock Outs for DACT3:
  • Dact3 Dact3<tm1.1Yegc>
  • Dact3 Dact3<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for DACT3 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DACT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DACT3 Gene

Localization for DACT3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DACT3 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
genes like me logo Genes that share ontologies with DACT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DACT3 Gene

Pathways & Interactions for DACT3 Gene

PathCards logo

SuperPathways for DACT3 Gene

No Data Available

SIGNOR curated interactions for DACT3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030111 regulation of Wnt signaling pathway IBA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 18538736
GO:0030308 negative regulation of cell growth IDA 18538736
genes like me logo Genes that share ontologies with DACT3: view

No data available for Pathways by source for DACT3 Gene

Drugs & Compounds for DACT3 Gene

No Compound Related Data Available

Transcripts for DACT3 Gene

mRNA/cDNA for DACT3 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DACT3

Alternative Splicing Database (ASD) splice patterns (SP) for DACT3 Gene

No ASD Table

Relevant External Links for DACT3 Gene

GeneLoc Exon Structure for
DACT3

Expression for DACT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DACT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DACT3 Gene

This gene is overexpressed in Artery - Tibial (x4.4) and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for DACT3 Gene

This gene is overexpressed in Adipocyte (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DACT3 Gene



Protein tissue co-expression partners for DACT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DACT3

SOURCE GeneReport for Unigene cluster for DACT3 Gene:

Hs.515490

Evidence on tissue expression from TISSUES for DACT3 Gene

  • Skin(4.3)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with DACT3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DACT3 Gene

Orthologs for DACT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DACT3 30 31
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DACT3 30 31
  • 92.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DACT3 30 31
  • 88.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dact3 30 17 31
  • 83.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dact3 30
  • 82.81 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DACT3 31
  • 46 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DACT3 31
  • 38 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii DACT3 (1 of 2) 31
  • 33 (a)
OneToMany
DACT3 (2 of 2) 31
  • 25 (a)
OneToMany
Species where no ortholog for DACT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DACT3 Gene

ENSEMBL:
Gene Tree for DACT3 (if available)
TreeFam:
Gene Tree for DACT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DACT3: view image

Paralogs for DACT3 Gene

Paralogs for DACT3 Gene

genes like me logo Genes that share paralogs with DACT3: view

Variants for DACT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DACT3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1004016023 Uncertain Significance: Intellectual disability; Progressive spastic paraparesis 46,649,621(-) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for DACT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DACT3 Gene

Variant ID Type Subtype PubMed ID
dgv1789n106 CNV deletion 24896259
nsv1072888 CNV deletion 25765185
nsv828570 CNV gain 20364138
nsv833849 CNV loss 17160897

Variation tolerance for DACT3 Gene

Gene Damage Index Score: 1.75; 33.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DACT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DACT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT3 Gene

Disorders for DACT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DACT3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DACT3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DACT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DACT3 Gene

Publications for DACT3 Gene

  1. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. (PMID: 16881060) Fisher DA … Cheyette BN (Developmental dynamics : an official publication of the American Association of Anatomists 2006) 2 3 4
  2. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. (PMID: 18538736) Jiang X … Yu Q (Cancer cell 2008) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3

Products for DACT3 Gene

  • Signalway Proteins for DACT3

Sources for DACT3 Gene