Aliases for DACH1 Gene
External Ids for DACH1 Gene
Previous HGNC Symbols for DACH1 Gene
Previous GeneCards Identifiers for DACH1 Gene
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for DACH1 Gene
DACH1 (Dachshund Family Transcription Factor 1) is a Protein Coding gene. Diseases associated with DACH1 include Colobomatous Microphthalmia and Deafness, Autosomal Dominant 10. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly. An important paralog of this gene is DACH2.
UniProtKB/Swiss-Prot Summary for DACH1 Gene
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).