Aliases for DAAM2 Gene

Aliases for DAAM2 Gene

  • Dishevelled Associated Activator Of Morphogenesis 2 2 3 5
  • Disheveled-Associated Activator Of Morphogenesis 2 3 4
  • DJ90A20A.1 3
  • KIAA0381 4

External Ids for DAAM2 Gene

Previous GeneCards Identifiers for DAAM2 Gene

  • GC06P039837
  • GC06P039807
  • GC06P039868
  • GC06P039535

Summaries for DAAM2 Gene

GeneCards Summary for DAAM2 Gene

DAAM2 (Dishevelled Associated Activator Of Morphogenesis 2) is a Protein Coding gene. Diseases associated with DAAM2 include Cerebral Amyloid Angiopathy, Itm2b-Related, 2 and Guillain-Barre Syndrome. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and WNT Signaling. Gene Ontology (GO) annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot Summary for DAAM2 Gene

  • Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.

Additional gene information for DAAM2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DAAM2 Gene

Genomics for DAAM2 Gene

GeneHancer (GH) Regulatory Elements for DAAM2 Gene

Promoters and enhancers for DAAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039791 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 755.5 +0.8 812 3.4 RAD21 PRDM1 CREB1 PKNOX1 ZIC2 ZBTB8A PRDM10 ZNF629 ZNF561 ZBTB48 DAAM2 KIF6 ENSG00000281969
GH06J039846 Promoter/Enhancer 1 EPDnew Ensembl ENCODE dbSUPER 750.2 +55.8 55769 2.3 DAAM2 MOCS1 ENSG00000281969 lnc-MOCS1-6
GH06J039790 Enhancer 0.2 dbSUPER 750.6 -1.5 -1453 0.7 DAAM2 KIF6 piR-60731-014
GH06J039879 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +92.3 92265 10.3 RBPJ TCF7L2 NR2F1 NR2F6 MIXL1 ELF3 AHR SP1 TFE3 PPARG DAAM2 MOCS1 DAAM2-AS1 lnc-MOCS1-6
GH06J039820 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +30.7 30702 4.4 SP1 ZIC2 RXRA SCRT2 ZXDB OSR2 NR2F2 ZFHX2 FEZF1 REST DAAM2 ENSG00000281969 lnc-MOCS1-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DAAM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DAAM2 gene promoter:
  • AML1a
  • AREB6
  • GR
  • GR-alpha
  • GR-beta
  • Pax-2
  • Pax-2a
  • ZIC2

Genomic Locations for DAAM2 Gene

Genomic Locations for DAAM2 Gene
chr6:39,792,298-39,904,877
(GRCh38/hg38)
Size:
112,580 bases
Orientation:
Plus strand
chr6:39,760,142-39,872,653
(GRCh37/hg19)
Size:
112,512 bases
Orientation:
Plus strand

Genomic View for DAAM2 Gene

Genes around DAAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAAM2 Gene

Proteins for DAAM2 Gene

  • Protein details for DAAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T65-DAAM2_HUMAN
    Recommended name:
    Disheveled-associated activator of morphogenesis 2
    Protein Accession:
    Q86T65
    Secondary Accessions:
    • G5EA45
    • Q5T4T8
    • Q5T4U0
    • Q9NQI5
    • Q9Y4G0

    Protein attributes for DAAM2 Gene

    Size:
    1068 amino acids
    Molecular mass:
    123499 Da
    Quaternary structure:
    • Interacts with DVL3.
    SequenceCaution:
    • Sequence=BAA20835.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAAM2 Gene

Post-translational modifications for DAAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DAAM2 Gene

Domains & Families for DAAM2 Gene

Gene Families for DAAM2 Gene

Suggested Antigen Peptide Sequences for DAAM2 Gene

GenScript: Design optimal peptide antigens:
  • Disheveled-associated activator of morphogenesis 2 (DAAM2_HUMAN)
  • DAAM2 protein (Q6DCB0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86T65

UniProtKB/Swiss-Prot:

DAAM2_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with DAAM2: view

Function for DAAM2 Gene

Molecular function for DAAM2 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.

Phenotypes From GWAS Catalog for DAAM2 Gene

Gene Ontology (GO) - Molecular Function for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DAAM2: view
genes like me logo Genes that share phenotypes with DAAM2: view

Animal Models for DAAM2 Gene

MGI Knock Outs for DAAM2:
  • Daam2 Daam2<tm1Tpy>
  • Daam2 Daam2<tm1b(KOMP)Wtsi>
  • Daam2 Daam2<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAAM2 Gene

Localization for DAAM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAAM2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 18570454
genes like me logo Genes that share ontologies with DAAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DAAM2 Gene

Pathways & Interactions for DAAM2 Gene

PathCards logo

SuperPathways for DAAM2 Gene

genes like me logo Genes that share pathways with DAAM2: view

Pathways by source for DAAM2 Gene

1 KEGG pathway for DAAM2 Gene
1 Qiagen pathway for DAAM2 Gene
  • WNT Signaling

Gene Ontology (GO) - Biological Process for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007368 determination of left/right symmetry IEA --
GO:0016043 cellular component organization IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0021516 dorsal spinal cord development ISS --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with DAAM2: view

No data available for SIGNOR curated interactions for DAAM2 Gene

Drugs & Compounds for DAAM2 Gene

No Compound Related Data Available

Transcripts for DAAM2 Gene

mRNA/cDNA for DAAM2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAAM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DAAM2 Gene

GeneLoc Exon Structure for
DAAM2
ECgene alternative splicing isoforms for
DAAM2

Expression for DAAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAAM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for DAAM2 Gene

This gene is overexpressed in Spinal cord (29.8) and Frontal cortex (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAAM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DAAM2 Gene:

DAAM2

SOURCE GeneReport for Unigene cluster for DAAM2 Gene:

Hs.357128

mRNA Expression by UniProt/SwissProt for DAAM2 Gene:

Q86T65-DAAM2_HUMAN
Tissue specificity: Expressed in most tissues examined.

Evidence on tissue expression from TISSUES for DAAM2 Gene

  • Nervous system(4.9)
  • Liver(4.1)
  • Blood(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with DAAM2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAAM2 Gene

Orthologs for DAAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAAM2 33 32
  • 98.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DAAM2 33 32
  • 91.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DAAM2 33 32
  • 91.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Daam2 32
  • 87.34 (n)
oppossum
(Monodelphis domestica)
Mammalia DAAM2 33
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daam2 17 33 32
  • 86.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DAAM2 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAAM2 33 32
  • 75.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAAM2 33
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii daam2 33
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:114D9.2 34
  • 44 (a)
DAAM 33
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56E10.2 34
  • 33 (a)
daam-1 33
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 50 (a)
OneToMany
Species where no ortholog for DAAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DAAM2 Gene

ENSEMBL:
Gene Tree for DAAM2 (if available)
TreeFam:
Gene Tree for DAAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DAAM2: view image

Paralogs for DAAM2 Gene

(5) SIMAP similar genes for DAAM2 Gene using alignment to 3 proteins:

  • DAAM2_HUMAN
  • F2Z2Q2_HUMAN
  • Q6DCB0_HUMAN
genes like me logo Genes that share paralogs with DAAM2: view

Variants for DAAM2 Gene

Sequence variations from dbSNP and Humsavar for DAAM2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs112059918 likely-benign, uncertain-significance, Combined molybdoflavoprotein enzyme deficiency 39,904,690(+) CTATCTATCT/CTATCT/CTATCTATCTATCT 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs112997952 benign, Combined molybdoflavoprotein enzyme deficiency 39,904,579(+) AAATAAA/AAATAAATAAA/AAATAAATAAATAAA 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs115706925 likely-benign, Combined molybdoflavoprotein enzyme deficiency 39,905,355(+) G/A downstream_transcript_variant
rs144859841 likely-benign, Combined molybdoflavoprotein enzyme deficiency 39,904,968(+) TTT/TTTT downstream_transcript_variant
rs151159237 uncertain-significance, Combined molybdoflavoprotein enzyme deficiency 39,904,933(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DAAM2 Gene

Variant ID Type Subtype PubMed ID
esv2731956 CNV deletion 23290073
esv3351675 CNV duplication 20981092
esv3389616 CNV duplication 20981092
esv3446870 CNV duplication 20981092
nsv1074924 CNV deletion 25765185
nsv1142460 CNV tandem duplication 24896259
nsv462921 CNV loss 19166990
nsv509130 CNV insertion 20534489
nsv512877 CNV insertion 21212237
nsv602965 CNV loss 21841781

Variation tolerance for DAAM2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DAAM2 Gene

Human Gene Mutation Database (HGMD)
DAAM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAAM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAAM2 Gene

Disorders for DAAM2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DAAM2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cerebral amyloid angiopathy, itm2b-related, 2
  • dementia, familial danish; fdd
guillain-barre syndrome
  • gbs
epithelial basement membrane dystrophy
  • corneal dystrophy, epithelial basement membrane
autoimmune disease of peripheral nervous system
- elite association - COSMIC cancer census association via MalaCards
Search DAAM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DAAM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DAAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAAM2 Gene

Publications for DAAM2 Gene

  1. Identification and characterization of human DAAM2 gene in silico. (PMID: 12632087) Katoh M … Katoh M (International journal of oncology 2003) 2 3 23 56
  2. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E … Tobin MD (Nature genetics 2010) 3 43 56
  3. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H … Dahiya R (Cancer 2009) 3 43 56
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  5. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PMID: 11779461) Habas R … He X (Cell 2001) 2 3 56

Products for DAAM2 Gene

Sources for DAAM2 Gene