The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counter... See more...

Aliases for CLPS Gene

Aliases for CLPS Gene

  • Colipase 2 3 4 5
  • Colipase, Pancreatic 2 3
  • Pancreatic Colipase Preproprotein 3
  • Pancreatic Colipase 2

External Ids for CLPS Gene

Previous GeneCards Identifiers for CLPS Gene

  • GC06M035764
  • GC06M035809
  • GC06M035870
  • GC06M035480
  • GC06M035765
  • GC06M035867
  • GC06M035927
  • GC06M036109
  • GC06M038963
  • GC06M039654
  • GC06M039960
  • GC06M036305
  • GC06M036672
  • GC06M037025
  • GC06M037375
  • GC06M037731
  • GC06M038077
  • GC06M038467
  • GC06M038812

Summaries for CLPS Gene

Entrez Gene Summary for CLPS Gene

  • The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CLPS Gene

CLPS (Colipase) is a Protein Coding gene. Diseases associated with CLPS include Johanson-Blizzard Syndrome and Obsessive-Compulsive Personality Disorder. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include enzyme activator activity. An important paralog of this gene is CLPSL1.

UniProtKB/Swiss-Prot Summary for CLPS Gene

  • Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
  • Enterostatin has a biological activity as a satiety signal.

Gene Wiki entry for CLPS Gene

Additional gene information for CLPS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CLPS Gene

Genomics for CLPS Gene

GeneHancer (GH) Regulatory Elements for CLPS Gene

Promoters and enhancers for CLPS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J035797 Promoter 0.7 EPDnew 500.7 +0.0 1 0.1 POLR2A ZFHX2 BHLHE40 TCF12 TAF15 EGR2 CBFA2T2 ZNF311 NRF1 CBFA2T3 CLPS LHFPL5 lnc-SRPK1-1 TAF11
GH06J035798 Enhancer 0.2 Ensembl 500.7 -1.5 -1457 1.2 CLPS LHFPL5 lnc-SRPK1-1 piR-41405-044 RPL10A ENSG00000246982
GH06J035776 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 12.2 +20.6 20643 1 USF1 ZIC2 ZBTB10 ZNF423 ZBTB26 KLF4 ZBTB7A EZH2 HDAC2 POLR2A CLPSL2 piR-50437-563 CLPS ENSG00000232909 ARMC12 FKBP5
GH06J036289 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 9.6 -494.0 -494008 3 EP300 ZNF623 TARDBP RFX1 CTBP1 ZNF341 ESRRA NFRKB NEUROD1 ZNF282 PNPLA1 BNIP5 CLPS BRPF3 MAPK13 lnc-C6orf222-2 piR-50437-565
GH06J035738 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 10.6 +57.4 57404 2.9 NCOR1 TEAD4 KDM6A TEAD1 ZNF341 FOXA2 TBP SAP130 NANOG MBD1 piR-56580-039 ENSG00000212579 CLPS MAPK13 TEAD3 SLC26A8 ENSG00000228559 ARMC12 piR-57461-205
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLPS on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CLPS

Top Transcription factor binding sites by QIAGEN in the CLPS gene promoter:
  • GATA-1
  • Ik-2
  • MRF-2
  • NF-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • RP58
  • TGIF

Genomic Locations for CLPS Gene

Genomic Locations for CLPS Gene
chr6:35,794,982-35,797,344
(GRCh38/hg38)
Size:
2,363 bases
Orientation:
Minus strand
chr6:35,762,759-35,765,102
(GRCh37/hg19)
Size:
2,344 bases
Orientation:
Minus strand

Genomic View for CLPS Gene

Genes around CLPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLPS Gene

Proteins for CLPS Gene

  • Protein details for CLPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04118-COL_HUMAN
    Recommended name:
    Colipase
    Protein Accession:
    P04118
    Secondary Accessions:
    • Q5T9G7
    • Q5U809

    Protein attributes for CLPS Gene

    Size:
    112 amino acids
    Molecular mass:
    11954 Da
    Quaternary structure:
    • Forms a 1:1 stoichiometric complex with pancreatic lipase.

neXtProt entry for CLPS Gene

Post-translational modifications for CLPS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLPS Gene

Protein Products

  • Signalway Proteins for CLPS
  • Abcam proteins for CLPS

No data available for DME Specific Peptides for CLPS Gene

Domains & Families for CLPS Gene

Gene Families for CLPS Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CLPS Gene

Blocks:
  • Colipase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CLPS Gene

GenScript: Design optimal peptide antigens:
  • Colipase (COL_HUMAN)
  • Colipase (Q5U808_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04118

UniProtKB/Swiss-Prot:

COL_HUMAN :
  • Belongs to the colipase family.
Family:
  • Belongs to the colipase family.
genes like me logo Genes that share domains with CLPS: view

Function for CLPS Gene

Molecular function for CLPS Gene

UniProtKB/Swiss-Prot Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
UniProtKB/Swiss-Prot Function:
Enterostatin has a biological activity as a satiety signal.
GENATLAS Biochemistry:
colipase,pancreatic

Phenotypes From GWAS Catalog for CLPS Gene

Gene Ontology (GO) - Molecular Function for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with CLPS: view
genes like me logo Genes that share phenotypes with CLPS: view

Animal Models for CLPS Gene

MGI Knock Outs for CLPS:
  • Clps Clps<tm1b(EUCOMM)Wtsi>
  • Clps Clps<tm1Lowe>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLPS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CLPS Gene

Localization for CLPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLPS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLPS gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with CLPS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLPS Gene

Pathways & Interactions for CLPS Gene

genes like me logo Genes that share pathways with CLPS: view

Gene Ontology (GO) - Biological Process for CLPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process NAS 2045105
GO:0007586 digestion IEA --
GO:0009617 response to bacterium IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with CLPS: view

No data available for SIGNOR curated interactions for CLPS Gene

Drugs & Compounds for CLPS Gene

(9) Drugs for CLPS Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(Hydroxyethyloxy)Tri(Ethyloxy)Octane Experimental Pharma Target 0
B-nonylglucoside Experimental Pharma Target 0
METHOXYUNDECYLPHOSPHINIC ACID Experimental Pharma Target 0

(12) Additional Compounds for CLPS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLPS: view

Transcripts for CLPS Gene

mRNA/cDNA for CLPS Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLPS

Alternative Splicing Database (ASD) splice patterns (SP) for CLPS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for CLPS Gene

GeneLoc Exon Structure for
CLPS

Expression for CLPS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CLPS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLPS Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CLPS Gene

This gene is overexpressed in Pancreatic juice (56.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLPS Gene



Protein tissue co-expression partners for CLPS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CLPS

SOURCE GeneReport for Unigene cluster for CLPS Gene:

Hs.1340

mRNA Expression by UniProt/SwissProt for CLPS Gene:

P04118-COL_HUMAN
Tissue specificity: Expressed by the pancreas.

Evidence on tissue expression from TISSUES for CLPS Gene

  • Pancreas(4.9)
  • Intestine(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with CLPS: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CLPS Gene

Orthologs for CLPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLPS 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CLPS 31 30
  • 85.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CLPS 31 30
  • 81.85 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Clps 17 31 30
  • 81.25 (n)
rat
(Rattus norvegicus)
Mammalia Clps 30
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia CLPS 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CLPS 31 30
  • 70.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLPS 31
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clps 30
  • 56.92 (n)
Species where no ortholog for CLPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLPS Gene

ENSEMBL:
Gene Tree for CLPS (if available)
TreeFam:
Gene Tree for CLPS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLPS: view image

Paralogs for CLPS Gene

Paralogs for CLPS Gene

(1) SIMAP similar genes for CLPS Gene using alignment to 2 proteins:

  • COL_HUMAN
  • Q5U808_HUMAN
genes like me logo Genes that share paralogs with CLPS: view

Variants for CLPS Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLPS Gene

COL_HUMAN-P04118
Variant Cys-109 is statistically significantly associated with an increased risk of type 2 diabetes.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CLPS Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
780119 Benign: not provided 35,795,788(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs2766595 Benign: not specified 35,796,793(-) G/A INTRON_VARIANT
rs2766597 - p.Leu8Pro
rs41270082 - p.Arg109Cys

Additional dbSNP identifiers (rs#s) for CLPS Gene

Structural Variations from Database of Genomic Variants (DGV) for CLPS Gene

Variant ID Type Subtype PubMed ID
dgv1043n67 CNV gain 20364138
dgv10630n54 CNV gain 21841781
dgv10631n54 CNV loss 21841781
dgv10632n54 CNV loss 21841781
dgv1177e214 CNV gain 21293372
dgv156e180 CNV gain 20482838
dgv3300n106 CNV duplication 24896259
dgv3489e59 CNV duplication 20981092
dgv3490e59 CNV tandem duplication 20981092
dgv3491e59 CNV duplication 20981092
esv25108 CNV gain 19812545
esv2759420 CNV gain 17122850
esv2860458 CNV duplication 24192839
esv33535 CNV gain 17666407
esv3608689 CNV gain 21293372
esv3890842 CNV gain 25118596
esv990474 CNV insertion 20482838
nsv1077999 CNV duplication 25765185
nsv1143148 CNV tandem duplication 24896259
nsv1149062 CNV duplication 26484159
nsv428143 CNV gain 18775914
nsv511122 OTHER complex 20534489
nsv513737 CNV insertion 21212237
nsv5259 CNV insertion 18451855
nsv602938 CNV gain+loss 21841781
nsv602939 CNV gain 21841781
nsv602940 CNV gain 21841781
nsv602944 CNV loss 21841781
nsv602945 CNV loss 21841781
nsv7891 CNV gain 18304495
nsv819076 CNV gain 19587683
nsv821646 CNV loss 15273396
nsv970364 CNV duplication 23825009

Variation tolerance for CLPS Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLPS Gene

Human Gene Mutation Database (HGMD)
CLPS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLPS

SNP Genotyping and Copy Number Assay Products

Disorders for CLPS Gene

MalaCards: The human disease database

(12) MalaCards diseases for CLPS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
johanson-blizzard syndrome
  • jbs
obsessive-compulsive personality disorder
  • anankastic personality disorder
dicrocoeliasis
  • disease due to dicrocoeliidae
avoidant personality disorder
  • anxious personality disorder
schizoid personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search CLPS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CLPS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLPS Gene

Publications for CLPS Gene

  1. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. (PMID: 16189801) Lindner I … Schrezenmeir J (Molecular nutrition & food research 2005) 3 4 23 41 54
  2. Procolipase gene: no association with early-onset obesity or fat intake. (PMID: 20054203) Wermter AK … Hebebrand J (Obesity facts 2009) 3 23 41 54
  3. Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians. (PMID: 18726866) Weyrich P … Häring HU (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2009) 3 23 41 54
  4. The human colipase gene: isolation, chromosomal location, and tissue-specific expression. (PMID: 1643046) Sims HF … Lowe ME (Biochemistry 1992) 3 4 23 54
  5. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. (PMID: 2045105) Davis RC … Lusis AJ (Genomics 1991) 2 3 23 54

Products for CLPS Gene

Sources for CLPS Gene