C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008] See more...

Aliases for CYTL1 Gene

Aliases for CYTL1 Gene

  • Cytokine Like 1 2 3 5
  • Cytokine-Like Protein 1 3 4
  • C4orf4 3 4
  • Cytokine-Like Protein C17 3
  • Cytokine-Like 1 2
  • Protein C17 4
  • C17 3

External Ids for CYTL1 Gene

Previous GeneCards Identifiers for CYTL1 Gene

  • GC04M005135

Summaries for CYTL1 Gene

Entrez Gene Summary for CYTL1 Gene

  • C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CYTL1 Gene

CYTL1 (Cytokine Like 1) is a Protein Coding gene. Diseases associated with CYTL1 include Corticosteroid Allergy and Acute Dacryocystitis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

Additional gene information for CYTL1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYTL1 Gene

Genomics for CYTL1 Gene

GeneHancer (GH) Regulatory Elements for CYTL1 Gene

Promoters and enhancers for CYTL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J005018 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 523.5 +0.4 396 1.6 CTCF MAX POLR2A EZH2 KDM1A CYTL1 HSALNG0032581 STK32B piR-38537-036
GH04J005040 Enhancer 0.7 ENCODE 30.6 -22.2 -22152 2 TOE1 BCL11A OVOL3 GATA3 TAL1 ZNF843 TCF12 POLR2A ZNF384 PRDM6 CYTL1 HSALNG0032584 lnc-STK32B-1
GH04J005050 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 8.9 -32.2 -32167 2.7 HNRNPK CTCF ZNF10 ZBTB10 ZBTB26 REST RAD21 SMC3 ZNF341 EZH2 STK32B lnc-CYTL1-2 CYTL1 piR-31508-040
GH04J005032 Enhancer 0.6 ENCODE 18.9 -14.4 -14423 2.5 REST ZNF592 FOS EGR1 GATA2 ZBTB33 JUN L3MBTL2 GATA1 POLR2A lnc-STK32B-1 CYTL1 HSALNG0032584
GH04J005044 Enhancer 0.5 ENCODE 13.3 -25.6 -25596 1.7 USF1 ZNF585B TRIM28 SPI1 FOS BHLHE40 ZFP36 L3MBTL2 MAX POLR2A HSALNG0032584 piR-48759-219 CYTL1 STK32B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYTL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYTL1

Top Transcription factor binding sites by QIAGEN in the CYTL1 gene promoter:
  • AREB6
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • IRF-1
  • NRSF form 1
  • NRSF form 2
  • p53
  • Sox9

Genomic Locations for CYTL1 Gene

Genomic Locations for CYTL1 Gene
chr4:5,014,586-5,019,470
(GRCh38/hg38)
Size:
4,885 bases
Orientation:
Minus strand
chr4:5,016,313-5,021,199
(GRCh37/hg19)
Size:
4,887 bases
Orientation:
Minus strand

Genomic View for CYTL1 Gene

Genes around CYTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTL1 Gene

Proteins for CYTL1 Gene

  • Protein details for CYTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR1-CYTL1_HUMAN
    Recommended name:
    Cytokine-like protein 1
    Protein Accession:
    Q9NRR1

    Protein attributes for CYTL1 Gene

    Size:
    136 amino acids
    Molecular mass:
    15577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYTL1 Gene

Post-translational modifications for CYTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTL1 Gene

No data available for DME Specific Peptides for CYTL1 Gene

Domains & Families for CYTL1 Gene

Gene Families for CYTL1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CYTL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYTL1 Gene

GenScript: Design optimal peptide antigens:
  • Protein C17 (CYTL1_HUMAN)
  • PNAS-31 (Q9BZT3_HUMAN)
genes like me logo Genes that share domains with CYTL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CYTL1 Gene

Function for CYTL1 Gene

Phenotypes From GWAS Catalog for CYTL1 Gene

Gene Ontology (GO) - Molecular Function for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10857752
genes like me logo Genes that share ontologies with CYTL1: view
genes like me logo Genes that share phenotypes with CYTL1: view

Animal Models for CYTL1 Gene

MGI Knock Outs for CYTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYTL1

CRISPR Products

miRNA for CYTL1 Gene

miRTarBase miRNAs that target CYTL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYTL1 Gene

Localization for CYTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYTL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 10857752
genes like me logo Genes that share ontologies with CYTL1: view

Pathways & Interactions for CYTL1 Gene

PathCards logo

SuperPathways for CYTL1 Gene

No Data Available

Interacting Proteins for CYTL1 Gene

;

Gene Ontology (GO) - Biological Process for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEA --
GO:0007165 signal transduction TAS 10857752
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0048839 inner ear development IEA --
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process IEA --
genes like me logo Genes that share ontologies with CYTL1: view

No data available for Pathways by source and SIGNOR curated interactions for CYTL1 Gene

Drugs & Compounds for CYTL1 Gene

No Compound Related Data Available

Transcripts for CYTL1 Gene

mRNA/cDNA for CYTL1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTL1

Alternative Splicing Database (ASD) splice patterns (SP) for CYTL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CYTL1 Gene

GeneLoc Exon Structure for
CYTL1

Expression for CYTL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTL1 Gene

This gene is overexpressed in Artery - Aorta (x22.6).

Protein differential expression in normal tissues from HIPED for CYTL1 Gene

This gene is overexpressed in Amniocyte (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYTL1 Gene



Protein tissue co-expression partners for CYTL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYTL1

SOURCE GeneReport for Unigene cluster for CYTL1 Gene:

Hs.13872

mRNA Expression by UniProt/SwissProt for CYTL1 Gene:

Q9NRR1-CYTL1_HUMAN
Tissue specificity: Specifically expressed in CD34+ hematopoietic cells.

Evidence on tissue expression from TISSUES for CYTL1 Gene

  • Blood(4.1)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with CYTL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYTL1 Gene

Orthologs for CYTL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTL1 31 30
  • 98.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CYTL1 31 30
  • 84.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CYTL1 31 30
  • 84.02 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cytl1 30
  • 77.1 (n)
mouse
(Mus musculus)
Mammalia Cytl1 17 31 30
  • 76.99 (n)
oppossum
(Monodelphis domestica)
Mammalia CYTL1 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYTL1 31
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYTL1 31 30
  • 68.89 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cytl1 30
  • 59.68 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01024686.1 31
  • 25 (a)
OneToOne
Species where no ortholog for CYTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYTL1 Gene

ENSEMBL:
Gene Tree for CYTL1 (if available)
TreeFam:
Gene Tree for CYTL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYTL1: view image

Paralogs for CYTL1 Gene

No data available for Paralogs for CYTL1 Gene

Variants for CYTL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYTL1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11722554 - p.Arg136Cys
rs35755546 - p.Ser51Leu

Additional dbSNP identifiers (rs#s) for CYTL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYTL1 Gene

Variant ID Type Subtype PubMed ID
dgv5094n100 CNV gain 25217958
esv34196 OTHER inversion 12058347
nsv593479 CNV gain 21841781
nsv593480 CNV loss 21841781
nsv997889 CNV gain 25217958

Variation tolerance for CYTL1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYTL1 Gene

Human Gene Mutation Database (HGMD)
CYTL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYTL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTL1 Gene

Disorders for CYTL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYTL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corticosteroid allergy
acute dacryocystitis
  • dacryocystitis - acute
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search CYTL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CYTL1

genes like me logo Genes that share disorders with CYTL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYTL1 Gene

Publications for CYTL1 Gene

  1. Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells. (PMID: 10857752) Liu X … Cheng L (Genomics 2000) 2 3 4 54
  2. Protein Cytl1: its role in chondrogenesis, cartilage homeostasis, and disease. (PMID: 31089746) Zhu S … Xu J (Cellular and molecular life sciences : CMLS 2019) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 54
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54

Products for CYTL1 Gene

Sources for CYTL1 Gene