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Aliases for CYTL1 Gene

Aliases for CYTL1 Gene

  • Cytokine Like 1 2 3 5
  • C4orf4 3 4
  • Cytokine-Like Protein C17 3
  • Cytokine-Like Protein 1 3
  • Cytokine-Like 1 2
  • Protein C17 4
  • C17 3

External Ids for CYTL1 Gene

Previous GeneCards Identifiers for CYTL1 Gene

  • GC04M005135

Summaries for CYTL1 Gene

Entrez Gene Summary for CYTL1 Gene

  • C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CYTL1 Gene

CYTL1 (Cytokine Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

Additional gene information for CYTL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTL1 Gene

Genomics for CYTL1 Gene

GeneHancer (GH) Regulatory Elements for CYTL1 Gene

Promoters and enhancers for CYTL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J005018 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 673.6 +0.3 324 1.3 CTCF POLR2A MAX CYTL1 STK32B GC04M005011
GH04J005040 Enhancer 0.7 ENCODE 30.6 -22.2 -22150 2 TAL1 TCF12 ZNF766 GATA3 CBFA2T2 SOX6 OVOL3 CBFA2T3 DPF2 ZEB2 CYTL1 STK32B
GH04J005032 Enhancer 0.8 Ensembl ENCODE 18.9 -14.4 -14421 2.5 ZNF639 L3MBTL2 JUN ZNF592 EGR1 ZNF24 ZBTB33 MGA CYTL1 STK32B
GH04J005044 Enhancer 0.8 Ensembl ENCODE 13.3 -25.6 -25594 1.7 USF1 L3MBTL2 BHLHE40 MAX ZNF585B ZFP36 SPI1 TRIM28 CYTL1 TMEM128 STK32B
GH04J005036 Enhancer 1.4 FANTOM5 Ensembl ENCODE 5.4 -18.6 -18586 4 PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF766 GATA2 FOS ATF7 SP3 CYTL1 STK32B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYTL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYTL1 gene promoter:
  • AREB6
  • Sox9
  • p53
  • NRSF form 2
  • NRSF form 1
  • HNF-4alpha1
  • IRF-1
  • GR-beta
  • GR-alpha
  • GR

Genomic Locations for CYTL1 Gene

Genomic Locations for CYTL1 Gene
4,887 bases
Minus strand
4,887 bases
Minus strand

Genomic View for CYTL1 Gene

Genes around CYTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTL1 Gene

Proteins for CYTL1 Gene

  • Protein details for CYTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytokine-like protein 1
    Protein Accession:

    Protein attributes for CYTL1 Gene

    136 amino acids
    Molecular mass:
    15577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYTL1 Gene

Post-translational modifications for CYTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTL1 Gene

No data available for DME Specific Peptides for CYTL1 Gene

Domains & Families for CYTL1 Gene

Gene Families for CYTL1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CYTL1 Gene


Suggested Antigen Peptide Sequences for CYTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYTL1: view

No data available for UniProtKB/Swiss-Prot for CYTL1 Gene

Function for CYTL1 Gene

Phenotypes From GWAS Catalog for CYTL1 Gene

Gene Ontology (GO) - Molecular Function for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10857752
genes like me logo Genes that share ontologies with CYTL1: view
genes like me logo Genes that share phenotypes with CYTL1: view

Animal Models for CYTL1 Gene

MGI Knock Outs for CYTL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYTL1

CRISPR Products

miRNA for CYTL1 Gene

miRTarBase miRNAs that target CYTL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTL1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYTL1 Gene

Localization for CYTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYTL1 gene
Compartment Confidence
extracellular 5
mitochondrion 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 10857752
genes like me logo Genes that share ontologies with CYTL1: view

Pathways & Interactions for CYTL1 Gene

SuperPathways for CYTL1 Gene

No Data Available

Interacting Proteins for CYTL1 Gene

Gene Ontology (GO) - Biological Process for CYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEA --
GO:0007165 signal transduction TAS 10857752
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0048839 inner ear development IEA --
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process IEA --
genes like me logo Genes that share ontologies with CYTL1: view

No data available for Pathways by source and SIGNOR curated interactions for CYTL1 Gene

Drugs & Compounds for CYTL1 Gene

No Compound Related Data Available

Transcripts for CYTL1 Gene

mRNA/cDNA for CYTL1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYTL1 Gene

Cytokine-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYTL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for CYTL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYTL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTL1 Gene

This gene is overexpressed in Artery - Aorta (x22.6).

Protein differential expression in normal tissues from HIPED for CYTL1 Gene

This gene is overexpressed in Amniocyte (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYTL1 Gene

Protein tissue co-expression partners for CYTL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYTL1 Gene:


SOURCE GeneReport for Unigene cluster for CYTL1 Gene:


mRNA Expression by UniProt/SwissProt for CYTL1 Gene:

Tissue specificity: Specifically expressed in CD34+ hematopoietic cells.

Evidence on tissue expression from TISSUES for CYTL1 Gene

  • Blood(4.1)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with CYTL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYTL1 Gene

Orthologs for CYTL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYTL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYTL1 34 33
  • 98.53 (n)
(Canis familiaris)
Mammalia CYTL1 34 33
  • 84.97 (n)
(Bos Taurus)
Mammalia CYTL1 34 33
  • 84.02 (n)
(Rattus norvegicus)
Mammalia Cytl1 33
  • 77.1 (n)
(Mus musculus)
Mammalia Cytl1 16 34 33
  • 76.99 (n)
(Monodelphis domestica)
Mammalia CYTL1 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CYTL1 34
  • 56 (a)
(Gallus gallus)
Aves CYTL1 34 33
  • 68.89 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cytl1 33
  • 59.68 (n)
(Danio rerio)
Actinopterygii CABZ01024686.1 34
  • 25 (a)
Species where no ortholog for CYTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYTL1 Gene

Gene Tree for CYTL1 (if available)
Gene Tree for CYTL1 (if available)
Evolutionary constrained regions (ECRs) for CYTL1: view image

Paralogs for CYTL1 Gene

No data available for Paralogs for CYTL1 Gene

Variants for CYTL1 Gene

Sequence variations from dbSNP and Humsavar for CYTL1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10002918 -- 5,017,880(-) G/A intron_variant
rs10006676 -- 5,019,359(-) G/T coding_sequence_variant, synonymous_variant
rs1000954058 -- 5,017,211(-) C/G intron_variant
rs1001954729 -- 5,015,329(-) C/T intron_variant
rs1002403088 -- 5,020,572(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYTL1 Gene

Variant ID Type Subtype PubMed ID
dgv5094n100 CNV gain 25217958
esv34196 OTHER inversion 12058347
nsv593479 CNV gain 21841781
nsv593480 CNV loss 21841781
nsv997889 CNV gain 25217958

Variation tolerance for CYTL1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYTL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTL1 Gene

Disorders for CYTL1 Gene

Additional Disease Information for CYTL1

No disorders were found for CYTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTL1 Gene

Publications for CYTL1 Gene

  1. Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells. (PMID: 10857752) Liu X … Cheng L (Genomics 2000) 2 3 4 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Biochemical and biophysical characterization of cytokine-like protein 1 (CYTL1). (PMID: 28478073) Tomczak A … Murphy PM (Cytokine 2017) 3 58

Products for CYTL1 Gene

Sources for CYTL1 Gene

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