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Aliases for CYTIP Gene

Aliases for CYTIP Gene

  • Cytohesin 1 Interacting Protein 2 3 5
  • Cytohesin Binder And Regulator 2 3 4
  • Pleckstrin Homology Sec7 And Coiled-Coil Domains-Binding Protein 3 4
  • Cytohesin-Associated Scaffolding Protein 3 4
  • Cytohesin Binding Protein HE 2 3
  • Cbp HE 3 4
  • PSCDBP 3 4
  • CASP 3 4
  • CYBR 3 4
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains, Binding Protein 2
  • Cytohesin-Interacting Protein 3
  • Cytohesin-Binding Protein HE 4
  • CYTHIP 3
  • B3-1 3
  • HE 3

External Ids for CYTIP Gene

Previous HGNC Symbols for CYTIP Gene

  • PSCDBP

Previous GeneCards Identifiers for CYTIP Gene

  • GC02M157982
  • GC02M158271
  • GC02M150156

Summaries for CYTIP Gene

Entrez Gene Summary for CYTIP Gene

  • The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]

GeneCards Summary for CYTIP Gene

CYTIP (Cytohesin 1 Interacting Protein) is a Protein Coding gene. Among its related pathways are Amplification and Expansion of Oncogenic Pathways as Metastatic Traits. An important paralog of this gene is GRASP.

UniProtKB/Swiss-Prot for CYTIP Gene

  • By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

Gene Wiki entry for CYTIP Gene

Additional gene information for CYTIP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTIP Gene

Genomics for CYTIP Gene

GeneHancer (GH) Regulatory Elements for CYTIP Gene

Promoters and enhancers for CYTIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I157431 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.7 +50.2 50237 15 HDGF PKNOX1 SMAD1 RB1 YBX1 BATF KLF5 IRF4 ZNF207 ATF7 CYTIP GC02M157436 LOC105373711
GH02I157485 Enhancer 0.9 ENCODE dbSUPER 550.8 +1.4 1399 3.9 FOXA2 MAX FEZF1 RAD21 YY1 ZKSCAN1 ZFHX2 EGR2 EZH2 RXRA CYTIP ERMN LOC105373712 GC02M157436
GH02I157410 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.9 +72.3 72286 11.7 PKNOX1 ATF1 SMAD1 BMI1 BATF YY1 ZNF207 ETV6 ATF7 BCLAF1 CYTIP ACVR1 FAM133DP ERMN GPD2 LOC105373711 GC02M157436
GH02I157452 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26.2 +35.4 35440 2 ATF1 SMAD1 BMI1 NFXL1 RAD21 ZBTB40 CBX5 ZNF143 ATF7 BCLAF1 CYTIP GC02M157436
GH02I157467 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +19.6 19598 4.2 PKNOX1 SMAD1 RB1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF207 ATF7 CYTIP GC02M157436 LOC105373712
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYTIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYTIP gene promoter:

Genomic Locations for CYTIP Gene

Genomic Locations for CYTIP Gene
chr2:157,414,619-157,488,961
(GRCh38/hg38)
Size:
74,343 bases
Orientation:
Minus strand
chr2:158,271,131-158,345,473
(GRCh37/hg19)

Genomic View for CYTIP Gene

Genes around CYTIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTIP Gene

Proteins for CYTIP Gene

  • Protein details for CYTIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60759-CYTIP_HUMAN
    Recommended name:
    Cytohesin-interacting protein
    Protein Accession:
    O60759
    Secondary Accessions:
    • B4DWH9
    • Q15630
    • Q8NE32

    Protein attributes for CYTIP Gene

    Size:
    359 amino acids
    Molecular mass:
    40010 Da
    Quaternary structure:
    • Interacts with CYTH1 and SNX27.
    SequenceCaution:
    • Sequence=AAA16575.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CYTIP Gene

    Alternative splice isoforms for CYTIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYTIP Gene

Post-translational modifications for CYTIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYTIP Gene

No data available for DME Specific Peptides for CYTIP Gene

Domains & Families for CYTIP Gene

Gene Families for CYTIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CYTIP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYTIP: view

No data available for UniProtKB/Swiss-Prot for CYTIP Gene

Function for CYTIP Gene

Molecular function for CYTIP Gene

UniProtKB/Swiss-Prot Function:
By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
UniProtKB/Swiss-Prot Induction:
By TNF and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for CYTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11867758
genes like me logo Genes that share ontologies with CYTIP: view
genes like me logo Genes that share phenotypes with CYTIP: view

Animal Models for CYTIP Gene

MGI Knock Outs for CYTIP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYTIP Gene

Localization for CYTIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTIP Gene

Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYTIP gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12606567
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CYTIP: view

Pathways & Interactions for CYTIP Gene

genes like me logo Genes that share pathways with CYTIP: view

Pathways by source for CYTIP Gene

Gene Ontology (GO) - Biological Process for CYTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030155 regulation of cell adhesion IDA 12606567
genes like me logo Genes that share ontologies with CYTIP: view

No data available for SIGNOR curated interactions for CYTIP Gene

Drugs & Compounds for CYTIP Gene

No Compound Related Data Available

Transcripts for CYTIP Gene

Unigene Clusters for CYTIP Gene

Cytohesin 1 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYTIP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for CYTIP Gene

GeneLoc Exon Structure for
CYTIP
ECgene alternative splicing isoforms for
CYTIP

Expression for CYTIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYTIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTIP Gene

This gene is overexpressed in Whole Blood (x30.2).

Protein differential expression in normal tissues from HIPED for CYTIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.1) and CD8 Tcells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYTIP Gene



Protein tissue co-expression partners for CYTIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYTIP Gene:

CYTIP

SOURCE GeneReport for Unigene cluster for CYTIP Gene:

Hs.270

mRNA Expression by UniProt/SwissProt for CYTIP Gene:

O60759-CYTIP_HUMAN
Tissue specificity: Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow.

Evidence on tissue expression from TISSUES for CYTIP Gene

  • Blood(4.5)
  • Intestine(2.5)
  • Lymph node(2.3)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with CYTIP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYTIP Gene

Orthologs for CYTIP Gene

This gene was present in the common ancestor of animals.

Orthologs for CYTIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTIP 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia CYTIP 33 34
  • 87.23 (n)
cow
(Bos Taurus)
Mammalia CYTIP 33 34
  • 86.55 (n)
mouse
(Mus musculus)
Mammalia Cytip 33 16 34
  • 82.77 (n)
rat
(Rattus norvegicus)
Mammalia Cytip 33
  • 82.68 (n)
oppossum
(Monodelphis domestica)
Mammalia CYTIP 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYTIP 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYTIP 33 34
  • 65 (n)
lizard
(Anolis carolinensis)
Reptilia CYTIP 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cytip 33
  • 60.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537036 33
  • 53.5 (n)
CABZ01075242.1 34
  • 39 (a)
ManyToMany
si:dkey-276j7.2 34
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6619 34
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gras-1 34
  • 17 (a)
OneToMany
Species where no ortholog for CYTIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYTIP Gene

ENSEMBL:
Gene Tree for CYTIP (if available)
TreeFam:
Gene Tree for CYTIP (if available)

Paralogs for CYTIP Gene

Paralogs for CYTIP Gene

(2) SIMAP similar genes for CYTIP Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CYTIP: view

Variants for CYTIP Gene

Sequence variations from dbSNP and Humsavar for CYTIP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000165741 -- 157,413,329(-) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000233226 -- 157,414,590(-) A/ACA 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000238425 -- 157,443,719(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000464971 -- 157,420,854(-) G/A/C intron_variant
rs1000603832 -- 157,413,381(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYTIP Gene

Variant ID Type Subtype PubMed ID
esv3893503 CNV gain 25118596
nsv1011505 CNV gain 25217958
nsv1160876 CNV duplication 26073780
nsv834432 CNV gain 17160897
nsv955270 CNV duplication 24416366

Variation tolerance for CYTIP Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYTIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYTIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTIP Gene

Disorders for CYTIP Gene

Additional Disease Information for CYTIP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYTIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTIP Gene

Publications for CYTIP Gene

  1. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. (PMID: 11867758) Tang P … Gadina M (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 22 58
  2. Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. (PMID: 17577583) MacNeil AJ … Pohajdak B (Biochemical and biophysical research communications 2007) 3 4 22 58
  3. Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping. (PMID: 10343115) Kim HS (Cytogenetics and cell genetics 1999) 2 3 22 58
  4. Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. (PMID: 21562043) Theodoridis AA … Steinkasserer A (Blood 2011) 2 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CYTIP Gene

Sources for CYTIP Gene

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