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Aliases for CYTH4 Gene

Aliases for CYTH4 Gene

  • Cytohesin 4 2 3 5
  • PH, SEC7 And Coiled-Coil Domain-Containing Protein 4 3 4
  • Pleckstrin Homology, Sec7 And Coiled/Coil Domains 4 2 3
  • PSCD4 3 4
  • CYT4 3 4
  • Pleckstrin Homology, Sec7 And Coiled-Coil Domains 4 2
  • Cytohesin-4 3
  • DJ63G5.1 3

External Ids for CYTH4 Gene

Previous HGNC Symbols for CYTH4 Gene

  • PSCD4

Previous GeneCards Identifiers for CYTH4 Gene

  • GC22P036008
  • GC22P037681
  • GC22P020643

Summaries for CYTH4 Gene

Entrez Gene Summary for CYTH4 Gene

  • This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for CYTH4 Gene

CYTH4 (Cytohesin 4) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Endocytosis. Gene Ontology (GO) annotations related to this gene include lipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot for CYTH4 Gene

  • Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Gene Wiki entry for CYTH4 Gene

Additional gene information for CYTH4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYTH4 Gene

Genomics for CYTH4 Gene

GeneHancer (GH) Regulatory Elements for CYTH4 Gene

Promoters and enhancers for CYTH4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I037281 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 573.4 +1.8 1758 4.3 HDGF IRF4 ZNF143 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 ELF1 ZNF217 CYTH4 CSF2RB GGA1 NCF4 RAC2 LGALS2 SH3BP1 RPS15AP38 MFNG NOL12
GH22I037227 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -45.3 -45320 18.7 HDGF PKNOX1 SMAD1 ARNT POLR2B E2F8 ZNF207 ZNF143 FOS REST RAC2 CYTH4 GGA1 CSF2RB SSTR3 C1QTNF6 NCF4 SH3BP1 ENSG00000226233 MFNG
GH22I036911 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.4 -368.5 -368521 3.5 HDGF ZSCAN4 MAX ZMYM3 POLR2A ZNF143 ETV6 ATF7 IKZF2 SMARCA5 CSF2RB NCF4 CYTH4 NCF4-AS1 RAC2 LOC105373022
GH22I037182 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -95.2 -95165 8.6 PKNOX1 CLOCK NEUROD1 SIN3A GLIS2 ZNF143 FOS SP3 RXRA NFYC C1QTNF6 EIF3D ENSG00000235237 TMPRSS6 ENSG00000231467 CYTH4 APOL4 CARD10 ENSG00000226233 ENSG00000229971
GH22I037191 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 10.3 -85.5 -85549 9.5 HDGF PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 C1QTNF6 IL2RB ENSG00000235237 TMPRSS6 ENSG00000231467 PICK1 CYTH4 SSTR3 GC22M037168
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYTH4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYTH4 gene promoter:

Genomic Locations for CYTH4 Gene

Genomic Locations for CYTH4 Gene
chr22:37,282,027-37,315,348
(GRCh38/hg38)
Size:
33,322 bases
Orientation:
Plus strand
chr22:37,678,068-37,711,389
(GRCh37/hg19)

Genomic View for CYTH4 Gene

Genes around CYTH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYTH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYTH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYTH4 Gene

Proteins for CYTH4 Gene

  • Protein details for CYTH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIA0-CYH4_HUMAN
    Recommended name:
    Cytohesin-4
    Protein Accession:
    Q9UIA0
    Secondary Accessions:
    • Q5R3F9
    • Q9UGT6

    Protein attributes for CYTH4 Gene

    Size:
    394 amino acids
    Molecular mass:
    45672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYTH4 Gene

Post-translational modifications for CYTH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYTH4 Gene

Domains & Families for CYTH4 Gene

Gene Families for CYTH4 Gene

Protein Domains for CYTH4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIA0

UniProtKB/Swiss-Prot:

CYH4_HUMAN :
  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
Domain:
  • Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
  • Autoinhibited by its C-terminal basic region.
genes like me logo Genes that share domains with CYTH4: view

Function for CYTH4 Gene

Molecular function for CYTH4 Gene

UniProtKB/Swiss-Prot Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.

Phenotypes From GWAS Catalog for CYTH4 Gene

Gene Ontology (GO) - Molecular Function for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005086 ARF guanyl-nucleotide exchange factor activity IEA,IDA 10652308
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with CYTH4: view
genes like me logo Genes that share phenotypes with CYTH4: view

Animal Model Products

miRNA for CYTH4 Gene

miRTarBase miRNAs that target CYTH4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYTH4 Gene

Localization for CYTH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYTH4 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYTH4 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA,IEA 17398095
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CYTH4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYTH4 Gene

Pathways & Interactions for CYTH4 Gene

genes like me logo Genes that share pathways with CYTH4: view

Pathways by source for CYTH4 Gene

Gene Ontology (GO) - Biological Process for CYTH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032012 regulation of ARF protein signal transduction IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with CYTH4: view

No data available for SIGNOR curated interactions for CYTH4 Gene

Drugs & Compounds for CYTH4 Gene

(1) Drugs for CYTH4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CYTH4: view

Transcripts for CYTH4 Gene

Unigene Clusters for CYTH4 Gene

Cytohesin 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYTH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: -
SP7: -
SP8:
SP9: -

ExUns: 15a · 15b ^ 16a · 16b · 16c
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CYTH4 Gene

GeneLoc Exon Structure for
CYTH4
ECgene alternative splicing isoforms for
CYTH4

Expression for CYTH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYTH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYTH4 Gene

This gene is overexpressed in Whole Blood (x32.9) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for CYTH4 Gene

This gene is overexpressed in CD8 Tcells (17.3), Pancreas (9.9), Blymphocyte (9.2), Peripheral blood mononuclear cells (7.9), Monocytes (6.7), Spleen (6.3), and NK cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYTH4 Gene



Protein tissue co-expression partners for CYTH4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYTH4 Gene:

CYTH4

SOURCE GeneReport for Unigene cluster for CYTH4 Gene:

Hs.170944

mRNA Expression by UniProt/SwissProt for CYTH4 Gene:

Q9UIA0-CYH4_HUMAN
Tissue specificity: Expressed predominantly in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CYTH4 Gene

  • Blood(4.5)
  • Nervous system(4.4)
  • Liver(4.1)
  • Adrenal gland(2.6)
genes like me logo Genes that share expression patterns with CYTH4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYTH4 Gene

Orthologs for CYTH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYTH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTH4 33 34
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia CYTH4 33 34
  • 89.59 (n)
dog
(Canis familiaris)
Mammalia CYTH4 33 34
  • 89.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyth4 33
  • 86.82 (n)
mouse
(Mus musculus)
Mammalia Cyth4 33 16 34
  • 86.68 (n)
oppossum
(Monodelphis domestica)
Mammalia CYTH4 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYTH4 33 34
  • 74.05 (n)
lizard
(Anolis carolinensis)
Reptilia CYTH4 34
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyth4b 33 34
  • 69.78 (n)
cyth4a 34
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta step 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grp-1 34
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC7 34
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8851 34
  • 58 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
Species where no ortholog for CYTH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYTH4 Gene

ENSEMBL:
Gene Tree for CYTH4 (if available)
TreeFam:
Gene Tree for CYTH4 (if available)

Paralogs for CYTH4 Gene

genes like me logo Genes that share paralogs with CYTH4: view

Variants for CYTH4 Gene

Sequence variations from dbSNP and Humsavar for CYTH4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000099098 -- 37,280,948(+) A/G upstream_transcript_variant
rs1000163646 -- 37,311,794(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000265954 -- 37,306,969(+) G/A intron_variant
rs1000313886 -- 37,295,196(+) C/A intron_variant
rs1000326184 -- 37,281,001(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYTH4 Gene

Variant ID Type Subtype PubMed ID
esv3412646 CNV insertion 20981092
nsv1118077 CNV deletion 24896259
nsv471196 CNV loss 18288195
nsv817992 CNV gain 17921354
nsv829203 CNV loss 20364138
nsv834188 CNV loss 17160897
nsv834189 CNV gain+loss 17160897
nsv834190 CNV loss 17160897

Variation tolerance for CYTH4 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 54.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYTH4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYTH4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYTH4 Gene

Disorders for CYTH4 Gene

Additional Disease Information for CYTH4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYTH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYTH4 Gene

Publications for CYTH4 Gene

  1. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I … Munro S (Current biology : CB 2007) 3 4 22 58
  2. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. (PMID: 10652308) Ogasawara M … Vaughan M (The Journal of biological chemistry 2000) 3 4 22 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58

Products for CYTH4 Gene

Sources for CYTH4 Gene

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