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The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity... See more...
Aliases for CYTH2 Gene
Aliases for CYTH2 Gene
- Cytohesin 2 2 3 5
- Cytohesin-2 2 3 4
- ARNO 2 3 4
- Pleckstrin Homology, Sec7 And Coiled/Coil Domains 2 (Cytohesin-2) 2 3
- PH, SEC7 And Coiled-Coil Domain-Containing Protein 2 3 4
- Pleckstrin Homology, Sec7 And Coiled-Coil Domains 2 2 3
- ARF Nucleotide-Binding Site Opener 3 4
- ARF Exchange Factor 3 4
- Sec7p-Like 2 3
External Ids for CYTH2 Gene
- HGNC: 9502
- Entrez Gene: 9266
- Ensembl: ENSG00000105443
- OMIM: 602488
- UniProtKB: Q99418
Previous HGNC Symbols for CYTH2 Gene
- PSCD2L
- PSCD2
Previous GeneCards Identifiers for CYTH2 Gene
- GC19P053667
- GC19P048972
- GC19P045352
Summaries for CYTH2 Gene
-
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for CYTH2 Gene
CYTH2 (Cytohesin 2) is a Protein Coding gene. Diseases associated with CYTH2 include Differentiating Neuroblastoma and Neuroblastoma. Among its related pathways are Intra-Golgi traffic and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include lipid binding and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is CYTH1.
UniProtKB/Swiss-Prot Summary for CYTH2 Gene
-
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity).
Additional gene information for CYTH2 Gene
- HGNC(9502)
- Entrez Gene(9266)
- Ensembl(ENSG00000105443)
- OMIM(602488)
- UniProtKB(Q99418)
- Open Targets Platform(ENSG00000105443)
- Search for CYTH2 at DataMed
- Search for CYTH2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYTH2 Gene
Genomics for CYTH2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CYTH2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYTH2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYTH2
- Top Transcription factor binding sites by QIAGEN in the CYTH2 gene promoter:
-
- AREB6
- Egr-2
- ITF-2
- NF-kappaB
- NF-kappaB1
- Pax-2
- Pax-2a
- PPAR-gamma1
- PPAR-gamma2
- Tal-1beta
Genomic Locations for CYTH2 Gene
Genomic Locations for CYTH2 Gene
- chr19:48,469,208-48,482,314
- (GRCh38/hg38)
- Size:
- 13,107 bases
- Orientation:
- Plus strand
- chr19:48,972,289-48,985,571
- (GRCh37/hg19)
- Size:
- 13,283 bases
- Orientation:
- Plus strand
Genomic View for CYTH2 Gene
Genes around CYTH2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
CYTH2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYTH2 Gene
Proteins for CYTH2 Gene
-
Protein details for CYTH2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99418-CYH2_HUMAN
- Recommended name:
- Cytohesin-2
- Protein Accession:
- Q99418
- A8K8P0
- Q8IXY9
- Q92958
Protein attributes for CYTH2 Gene
- Size:
- 400 amino acids
- Molecular mass:
- 46546 Da
- Quaternary structure:
-
- Heteromer. Composed of TAMALIN, CYTH2 and at least one GRM1 (By similarity). Interacts with ARRB1 (PubMed:17623778, PubMed:17398095). Interacts with ARL4D; the interaction is direct (PubMed:17398095). Directly interacts with CCDC120 through the coiled coil domain; this interaction stabilizes CCDC120, possibly by preventing its ubiquitination, and is required for neurite growth in neuroblastoma cells (PubMed:25326380). Interacts with ARF1 (PubMed:14654833). Interacts with FRMD4A (By similarity). Interacts (via N-terminal domain) with INAVA (via N-terminal domain) (PubMed:29420262).
Three dimensional structures from OCA and Proteopedia for CYTH2 Gene
Protein Expression for CYTH2 Gene
Post-translational modifications for CYTH2 Gene
Other Protein References for CYTH2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CYTH2
-
Abcam antibodies for CYTH2
- Invitrogen Antibodies for CYTH2 (AFLGC-CYTH2)
-
Biorbyt antibodies for CYTH2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYTH2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CYTH2
- Origene Custom Protein Services for CYTH2
- ProSpec Recombinant Proteins for CYTH2
-
Abcam proteins for CYTH2
Assay Products
- antibodies-online: Show 2 available Cytohesin 2 Elisa Kits ranked by validation data
- Compare Top Cytohesin 2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CYTH2 Gene
Domains & Families for CYTH2 Gene
Gene Families for CYTH2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CYTH2 Gene
- InterPro:
- Blocks:
-
- Pleckstrin-like
- SEC7-like domain
- ProtoNet:
Suggested Antigen Peptide Sequences for CYTH2 Gene
- GenScript: Design optimal peptide antigens:
-
- PH, SEC7 and coiled-coil domain-containing protein 2 (CYH2_HUMAN)
- Sec7p-like protein (Q15795_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99418UniProtKB/Swiss-Prot:
CYH2_HUMAN :- Binds via its PH domain to the inositol head group of phosphatidylinositol 1,4,5-trisphosphate. The PH domain is necessary and sufficient for plasma membrane relocalization.
- Domain:
-
- Binds via its PH domain to the inositol head group of phosphatidylinositol 1,4,5-trisphosphate. The PH domain is necessary and sufficient for plasma membrane relocalization.
- Autoinhibited by its C-terminal basic region.
- The coiled coil domain is involved in interaction with CCDC120.
Function for CYTH2 Gene
Molecular function for CYTH2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity).
Phenotypes From GWAS Catalog for CYTH2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IEA,ISS | -- |
| GO:0005515 | protein binding | IPI | 10198630 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0070679 | inositol 1,4,5 trisphosphate binding | ISS | -- |
Phenotypes for CYTH2 Gene
- MGI mutant phenotypes for CYTH2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CYTH2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYTH2 - Select products 50% OFF >
- * CYTH2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYTH2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYTH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYTH2
miRNA for CYTH2 Gene
- miRTarBase miRNAs that target CYTH2
-
- hsa-miR-26b-5p (MIRT030082)
- hsa-miR-191-5p (MIRT045806)
- hsa-miR-486-3p (MIRT712522)
- hsa-miR-6787-5p (MIRT712523)
- hsa-miR-663a (MIRT712524)
- hsa-miR-1908-5p (MIRT712525)
- hsa-miR-4660 (MIRT712526)
- hsa-miR-6775-5p (MIRT712527)
- hsa-miR-5090 (MIRT712528)
- hsa-miR-3937 (MIRT712529)
- hsa-miR-500b-3p (MIRT712530)
- hsa-miR-744-5p (MIRT712531)
- hsa-miR-6736-3p (MIRT715570)
- hsa-miR-1273f (MIRT736795)
- hsa-miR-25-3p (MIRT739354)
- hsa-miR-32-5p (MIRT741248)
- hsa-miR-363-3p (MIRT741799)
- hsa-miR-367-3p (MIRT742115)
- hsa-miR-3925-3p (MIRT742989)
- hsa-miR-4325 (MIRT744080)
- hsa-miR-508-5p (MIRT749613)
- hsa-miR-566 (MIRT751117)
- hsa-miR-652-3p (MIRT753410)
- hsa-miR-6789-3p (MIRT756006)
- hsa-miR-7703 (MIRT759710)
- hsa-miR-92a-3p (MIRT760618)
- hsa-miR-92b-3p (MIRT760646)
- hsa-miR-1273h-5p (MIRT762029)
- hsa-miR-149-3p (MIRT762778)
- hsa-miR-30b-3p (MIRT764567)
- hsa-miR-3192-5p (MIRT765417)
- hsa-miR-3689a-3p (MIRT766795)
- hsa-miR-3689b-3p (MIRT766883)
- hsa-miR-3689c (MIRT766971)
- hsa-miR-3689d (MIRT767057)
- hsa-miR-377-5p (MIRT767378)
- hsa-miR-455-3p (MIRT770296)
- hsa-miR-4728-5p (MIRT771693)
- hsa-miR-6086 (MIRT775509)
- hsa-miR-6134 (MIRT775930)
- hsa-miR-6516-5p (MIRT777093)
- hsa-miR-6779-5p (MIRT778872)
- hsa-miR-6780a-5p (MIRT778963)
- hsa-miR-6785-5p (MIRT779103)
- hsa-miR-6799-5p (MIRT779395)
- hsa-miR-6851-5p (MIRT780394)
- hsa-miR-6880-5p (MIRT780819)
- hsa-miR-6883-5p (MIRT780899)
- hsa-miR-7106-5p (MIRT781330)
- hsa-miR-7847-3p (MIRT782136)
- hsa-miR-7851-3p (MIRT782196)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYTH2
- Browse OriGene Inhibitory RNA Products For CYTH2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTH2
Clone Products
- Applied Biological Materials (abm): Clones for CYTH2 - Select products 50% OFF >
- * CYTH2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206279
- MG227046
- MR206279
- MR206279L3
- MR206279L4
- MR227046
- MR227046L3
- MR227046L4
- RC207179
- RC207179L3
- RC207179L4
- RC217980
- RC217980L1
- RC217980L2
- RC217980L3
- RC217980L4
- RG207179
- RG217980
- RR213576
- RR213576L3
- RR213576L4
- MR206279L3V
- MR206279L4V
- MR227046L3V
- MR227046L4V
- RC207179L3V
- RC207179L4V
- RC217980L1V
- RC217980L2V
- RC217980L3V
- RC217980L4V
- RR213576L3V
- RR213576L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYTH2
- Addgene plasmids for CYTH2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYTH2
Cell Line Products
-
Horizon Cell Lines for CYTH2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYTH2 Gene
Localization for CYTH2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYTH2 Gene
- Cell membrane. Peripheral membrane protein. Cytoplasm. Cell projection. Cell projection, growth cone. Cell junction, tight junction. Cell junction, adherens junction. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250 UniProtKB:P63034, ECO:0000269 PubMed:17398095}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endosome | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
- Plasma membrane (3)
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17398095 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS,IDA | 17398095 |
| GO:0005912 | adherens junction | IEA | -- |
Pathways & Interactions for CYTH2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Endocytosis | ||
| 3 | Pathogenic Escherichia coli infection | ||
| 4 | Phospholipase D signaling pathway | ||
| 5 | Salmonella infection (KEGG) | ||
Pathways by source for CYTH2 Gene
3 BioSystems pathways for CYTH2 Gene
4 Reactome pathways for CYTH2 Gene
5 KEGG pathways for CYTH2 Gene
Interacting Proteins for CYTH2 Gene
Selected Interacting proteins:
Q99418-CYH2_HUMAN
ENSP00000408236
for CYTH2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CYTH2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | TAS | 9417041 |
| GO:0030036 | actin cytoskeleton organization | TAS | 9417041 |
| GO:0032012 | regulation of ARF protein signal transduction | IEA | -- |
Drugs & Compounds for CYTH2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 1D-myo-inositol 1,4,5-trisphosphate | Experimental | Pharma | Target | 0 | ||
| Brefeldin A | Experimental | Pharma | Target | Disrupts protein translocation to Golgi | 0 | |
| Formic acid | Experimental, Investigational | Pharma | Target | 0 | ||
| inositol 1,3,4,5-tetrakisphosphate | Experimental | Pharma | Target | 0 | ||
| S,S-(2-Hydroxyethyl)Thiocysteine | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CYTH2 Gene
mRNA/cDNA for CYTH2 Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000452733 4443 nts (view in UCSC)
- ENST00000460595 1026 nts (view in UCSC)
- ENST00000391881 1546 nts (view in UCSC)
- ENST00000493260 4652 nts (view in UCSC)
- ENST00000462117 540 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYTH2 - Select products 50% OFF >
- * CYTH2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYTH2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYTH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYTH2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYTH2
- Browse OriGene Inhibitory RNA Products For CYTH2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTH2
Clone Products
- Applied Biological Materials (abm): Clones for CYTH2 - Select products 50% OFF >
- * CYTH2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206279
- MG227046
- MR206279
- MR206279L3
- MR206279L4
- MR227046
- MR227046L3
- MR227046L4
- RC207179
- RC207179L3
- RC207179L4
- RC217980
- RC217980L1
- RC217980L2
- RC217980L3
- RC217980L4
- RG207179
- RG217980
- RR213576
- RR213576L3
- RR213576L4
- MR206279L3V
- MR206279L4V
- MR227046L3V
- MR227046L4V
- RC207179L3V
- RC207179L4V
- RC217980L1V
- RC217980L2V
- RC217980L3V
- RC217980L4V
- RR213576L3V
- RR213576L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYTH2
- Addgene plasmids for CYTH2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYTH2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - |
Relevant External Links for CYTH2 Gene
- GeneLoc Exon Structure for
- CYTH2
Expression for CYTH2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Cervix (17.7), Serum (8.2), and Fetal heart (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYTH2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYTH2
SOURCE GeneReport for Unigene cluster for CYTH2 Gene:
Hs.144011mRNA Expression by UniProt/SwissProt for CYTH2 Gene:
Q99418-CYH2_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for CYTH2 Gene
- Nervous system(4.9)
- Lung(4.5)
- Kidney(2.7)
- Intestine(2.5)
- Muscle(2.4)
- Skin(2.3)
- Adrenal gland(2.2)
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs for CYTH2
-
OriGene qPCR primer pairs and template standards for CYTH2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYTH2 Gene
Orthologs for CYTH2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | CYTH2 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Chimpanzee (Pan troglodytes) |
Mammalia | CYTH2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CYTH2 30 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Cyth2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cyth2 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cyth1 30 |
|
||
| Str.2989 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10498 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CYTH2 31 |
|
OneToMany | |
| si:dkey-283b15.4 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7084 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | step 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | grp-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC7 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.8851 31 |
|
ManyToMany |
- Species where no ortholog for CYTH2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CYTH2 Gene
- ENSEMBL:
- Gene Tree for CYTH2 (if available)
- TreeFam:
- Gene Tree for CYTH2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYTH2: view image
Paralogs for CYTH2 Gene
Paralogs for CYTH2 Gene
(11) SIMAP similar genes for CYTH2 Gene using alignment to 5 proteins:
- CYH2_HUMAN
- F8W8E2_HUMAN
- G5E9B7_HUMAN
- J3KQA6_HUMAN
- M0R2J0_HUMAN
Variants for CYTH2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658088 | CNV | deletion | 23128226 |
| esv3556506 | CNV | deletion | 23714750 |
| nsv1114021 | CNV | deletion | 24896259 |
| nsv518578 | CNV | loss | 19592680 |
| nsv828572 | CNV | loss | 20364138 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
7.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYTH2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CYTH2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYTH2 Gene
Disorders for CYTH2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| differentiating neuroblastoma |
|
|
| neuroblastoma |
|
|
Search CYTH2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYTH2
No data available for UniProtKB/Swiss-Prot and Genatlas for CYTH2 Gene
Publications for CYTH2 Gene
- A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. (PMID: 8945478) Chardin P … Chabre M (Nature 1996) 2 3 4 23
- The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I … Munro S (Current biology : CB 2007) 3 4 23
- Structure of the Sec7 domain of the Arf exchange factor ARNO. (PMID: 9510256) Cherfils J … Chardin P (Nature 1998) 3 4 23
- C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. (PMID: 29420262) Mohanan V … Xavier RJ (Science (New York, N.Y.) 2018) 3 4
- GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. (PMID: 20016009) White DT … Santy LC (Molecular biology of the cell 2010) 3 23
ExternalLinks
Products for CYTH2 Gene
- Custom Antibody Services
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- OriGene qPCR primer pairs for CYTH2
- OriGene qPCR primer pairs and template standards for CYTH2
- OriGene CRISPR knockouts for CYTH2
- MG206279
- MG227046
- MR206279
- MR206279L3
- MR206279L4
- MR227046
- MR227046L3
- MR227046L4
- RC207179
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- RC217980L1V
- RC217980L2V
- RC217980L3V
- RC217980L4V
- RR213576L3V
- RR213576L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYTH2
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- Novus Biologicals proteins and lysates for CYTH2
- Browse Antibodies
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- Abcam proteins for CYTH2
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for CYTH2 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for CYTH2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CYTH2
- Addgene plasmids for CYTH2
- antibodies-online: Show 17 available Cytohesin 2 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Show 2 available Cytohesin 2 Elisa Kits ranked by validation data
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- antibodies-online: Show 10 available Cytohesin 2 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CYTH2
- Search Santa Cruz Biotechnology (SCBT) for CYTH2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYTH2
- Horizon Cell Lines for CYTH2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYTH2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYTH2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CYTH2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYTH2
- Biorbyt antibodies for CYTH2
Sources for CYTH2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
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- (98) ProteomicsDB
- (99) SCBT
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- (101) ClinicalTrials
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- (104) diseasecard
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- (115) NCBI Bookshelf
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- (122) ENCODE
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- (124) Horizon
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- (134) Gene ORGANizer
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- (140) HumanCyc
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- (143) Applied Biosystems
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- (152) DiseaseEnhancer
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
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- (163) LncBase
- (164) LncBook
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB