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The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
CYTH2 (Cytohesin 2) is a Protein Coding gene. Diseases associated with CYTH2 include Differentiating Neuroblastoma and Neuroblastoma. Among its related pathways are Intra-Golgi traffic and Pathogenic Escherichia coli infection. Gene Ontology (GO) annotations related to this gene include lipid binding and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is CYTH1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IEA,ISS | -- |
GO:0005515 | protein binding | IPI | 10198630 |
GO:0008289 | lipid binding | IEA | -- |
GO:0070679 | inositol 1,4,5 trisphosphate binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005737 | cytoplasm | IEA,IDA | 17398095 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS,IDA | 17398095 |
GO:0005912 | adherens junction | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Endocytosis | ||
3 | Pathogenic Escherichia coli infection | ||
4 | Phospholipase D signaling pathway | ||
5 | Salmonella infection (KEGG) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | TAS | 9417041 |
GO:0030036 | actin cytoskeleton organization | TAS | 9417041 |
GO:0032012 | regulation of ARF protein signal transduction | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
1D-myo-inositol 1,4,5-trisphosphate | Experimental | Pharma | Target | 0 | ||
Brefeldin A | Experimental | Pharma | Target | Disrupts protein translocation to Golgi | 0 | |
Formic acid | Experimental, Investigational | Pharma | Target | 0 | ||
inositol 1,3,4,5-tetrakisphosphate | Experimental | Pharma | Target | 0 | ||
S,S-(2-Hydroxyethyl)Thiocysteine | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||
SP8: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | CYTH2 30 |
|
||
-- 31 |
|
OneToMany | |||
Chimpanzee (Pan troglodytes) |
Mammalia | CYTH2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CYTH2 30 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Cyth2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cyth2 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cyth1 30 |
|
||
Str.2989 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.10498 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CYTH2 31 |
|
OneToMany | |
si:dkey-283b15.4 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7084 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | step 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | grp-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC7 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
CSA.8851 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2658088 | CNV | deletion | 23128226 |
esv3556506 | CNV | deletion | 23714750 |
nsv1114021 | CNV | deletion | 24896259 |
nsv518578 | CNV | loss | 19592680 |
nsv828572 | CNV | loss | 20364138 |
nsv9739 | CNV | gain+loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
differentiating neuroblastoma |
|
|
neuroblastoma |
|
|