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Aliases for CYSRT1 Gene

Aliases for CYSRT1 Gene

  • Cysteine Rich Tail 1 2 3 5
  • C9orf169 3 4
  • Similar To RIKEN CDNA 2310002J15 Gene 2
  • Chromosome 9 Open Reading Frame 169 2
  • Cysteine-Rich Tail Protein 1 3
  • UPF0574 Protein C9orf169 3

External Ids for CYSRT1 Gene

Previous HGNC Symbols for CYSRT1 Gene

  • C9orf169

Summaries for CYSRT1 Gene

GeneCards Summary for CYSRT1 Gene

CYSRT1 (Cysteine Rich Tail 1) is a Protein Coding gene.

Additional gene information for CYSRT1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSRT1 Gene

Genomics for CYSRT1 Gene

GeneHancer (GH) Regulatory Elements for CYSRT1 Gene

Promoters and enhancers for CYSRT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I137221 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.2 +2.5 2460 11.2 HDGF PKNOX1 CLOCK ZFP64 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B RNF224 SLC34A3 EHMT1 LOC651337 SDCCAG3 ANAPC2 RNF208 CYSRT1 NDOR1 MRPL41
GH09I137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.2 +13.7 13671 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 SDCCAG3 ANAPC2 NDOR1 DPH7 INPP5E LOC651337 MAN1B1 SNHG7
GH09I136323 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 -896.6 -896612 8.6 PKNOX1 ZNF133 SIN3A ZNF2 ETS1 GLIS2 ZNF548 FOS ATF7 SREBF1 GPSM1 DKFZP434A062 ANAPC2 INPP5E SNAPC4 SDCCAG3 SNHG7 QSOX2 MAN1B1 CYSRT1
GH09I137204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6 -18.9 -18923 3.3 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 ZNF143 SP3 NDOR1 TPRN TMEM203 PIR53478 EHMT1 SDCCAG3 CYSRT1 SLC34A3 RNF208
GH09I137216 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.7 -6.4 -6355 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 SLC30A9 POLR2B FOS NDOR1 RNF208 CYSRT1 NPDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYSRT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CYSRT1 Gene

Genomic Locations for CYSRT1 Gene
chr9:137,224,635-137,226,311
(GRCh38/hg38)
Size:
1,677 bases
Orientation:
Plus strand
chr9:140,119,087-140,120,763
(GRCh37/hg19)

Genomic View for CYSRT1 Gene

Genes around CYSRT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSRT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSRT1 Gene

Proteins for CYSRT1 Gene

  • Protein details for CYSRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MQ03-CRTP1_HUMAN
    Recommended name:
    Cysteine-rich tail protein 1
    Protein Accession:
    A8MQ03
    Secondary Accessions:
    • Q86UY7

    Protein attributes for CYSRT1 Gene

    Size:
    144 amino acids
    Molecular mass:
    15313 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYSRT1 Gene

Post-translational modifications for CYSRT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYSRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYSRT1 Gene

Domains & Families for CYSRT1 Gene

Gene Families for CYSRT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CYSRT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYSRT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MQ03

UniProtKB/Swiss-Prot:

CRTP1_HUMAN :
  • Belongs to the CYSRT1 family.
Family:
  • Belongs to the CYSRT1 family.
genes like me logo Genes that share domains with CYSRT1: view

Function for CYSRT1 Gene

Phenotypes From GWAS Catalog for CYSRT1 Gene

genes like me logo Genes that share phenotypes with CYSRT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYSRT1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYSRT1 Gene

Localization for CYSRT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYSRT1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (2)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYSRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CYSRT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CYSRT1 Gene

Pathways & Interactions for CYSRT1 Gene

SuperPathways for CYSRT1 Gene

No Data Available

Interacting Proteins for CYSRT1 Gene

Gene Ontology (GO) - Biological Process for CYSRT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CYSRT1 Gene

Drugs & Compounds for CYSRT1 Gene

No Compound Related Data Available

Transcripts for CYSRT1 Gene

mRNA/cDNA for CYSRT1 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYSRT1 Gene

No ASD Table

Relevant External Links for CYSRT1 Gene

GeneLoc Exon Structure for
CYSRT1
ECgene alternative splicing isoforms for
CYSRT1

Expression for CYSRT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYSRT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CYSRT1 Gene

This gene is overexpressed in Urine (41.1) and Cervix (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYSRT1 Gene



Protein tissue co-expression partners for CYSRT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYSRT1 Gene:

CYSRT1

Evidence on tissue expression from TISSUES for CYSRT1 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with CYSRT1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYSRT1 Gene

Orthologs for CYSRT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYSRT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf169 33
  • 99.09 (n)
C9orf169 34
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf169 33
  • 81.29 (n)
cow
(Bos Taurus)
Mammalia C11H9orf169 34 33
  • 80.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560880 33
  • 76.74 (n)
mouse
(Mus musculus)
Mammalia 2310002J15Rik 33 34
  • 76.26 (n)
Cysrt1 16
Species where no ortholog for CYSRT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYSRT1 Gene

ENSEMBL:
Gene Tree for CYSRT1 (if available)
TreeFam:
Gene Tree for CYSRT1 (if available)

Paralogs for CYSRT1 Gene

No data available for Paralogs for CYSRT1 Gene

Variants for CYSRT1 Gene

Sequence variations from dbSNP and Humsavar for CYSRT1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000364277 -- 137,224,936(+) T/A 5_prime_UTR_variant
rs1000707195 -- 137,223,492(+) C/G/T upstream_transcript_variant
rs1000770746 -- 137,223,767(+) G/A upstream_transcript_variant
rs1000987831 -- 137,223,515(+) C/G upstream_transcript_variant
rs1001645598 -- 137,226,022(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CYSRT1 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
dgv13011n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for CYSRT1 Gene

Gene Damage Index Score: 1.29; 25.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYSRT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYSRT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYSRT1 Gene

Disorders for CYSRT1 Gene

Additional Disease Information for CYSRT1

No disorders were found for CYSRT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYSRT1 Gene

Publications for CYSRT1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58
  3. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle JJ … Zoghbi HY (Human molecular genetics 2011) 3 58
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 58
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass AL … Elledge SJ (Science (New York, N.Y.) 2008) 3 58

Products for CYSRT1 Gene

Sources for CYSRT1 Gene

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