Aliases for CYSLTR2 Gene
External Ids for CYSLTR2 Gene
Previous GeneCards Identifiers for CYSLTR2 Gene
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYSLTR2 Gene
CYSLTR2 (Cysteinyl Leukotriene Receptor 2) is a Protein Coding gene. Diseases associated with CYSLTR2 include Melanoma, Uveal and Asthma. Among its related pathways are Signaling by GPCR and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and cysteinyl leukotriene receptor activity. An important paralog of this gene is CYSLTR1.
UniProtKB/Swiss-Prot Summary for CYSLTR2 Gene
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.