The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardio... See more...

Aliases for CYSLTR2 Gene

Aliases for CYSLTR2 Gene

  • Cysteinyl Leukotriene Receptor 2 2 3 4 5
  • CYSLT2R 2 3 4
  • G-Protein Coupled Receptor GPCR21 3 4
  • G-Protein Coupled Receptor HG57 3 4
  • HGPCR21 3 4
  • CYSLT2 3 4
  • HPN321 3 4
  • Cysteinyl Leukotriene CysLT2 Receptor 3
  • PSEC0146 3
  • CysLT(2) 2
  • KPG_011 3
  • CYSLTR2 5
  • CysLTR2 4
  • GPCR21 3
  • HG57 3

External Ids for CYSLTR2 Gene

Previous GeneCards Identifiers for CYSLTR2 Gene

  • GC13P047280
  • GC13P043268
  • GC13P048217
  • GC13P047078
  • GC13P048178
  • GC13P049280
  • GC13P030074

Summaries for CYSLTR2 Gene

Entrez Gene Summary for CYSLTR2 Gene

  • The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYSLTR2 Gene

CYSLTR2 (Cysteinyl Leukotriene Receptor 2) is a Protein Coding gene. Diseases associated with CYSLTR2 include Melanoma, Uveal and Asthma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and cysteinyl leukotriene receptor activity. An important paralog of this gene is CYSLTR1.

UniProtKB/Swiss-Prot Summary for CYSLTR2 Gene

  • Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Tocris Summary for CYSLTR2 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for CYSLTR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYSLTR2 Gene

Genomics for CYSLTR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYSLTR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J048652 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 +0.5 517 2.7 RFX1 PRDM1 ZSCAN4 POLR2A BMI1 ZBTB48 SMARCA4 CYSLTR2 RB1-DT FNDC3A piR-33605-130
GH13J048600 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 -52.5 -52544 2.1 ATF7 PRDM10 ZNF629 PATZ1 ZNF501 ZNF600 ZNF341 ZNF561 SOX13 JUND CYSLTR2 FNDC3A RB1 piR-31199-086 piR-43325-025 RCBTB2
GH13J048729 Enhancer 1 FANTOM5 Ensembl ENCODE 11.9 +77.4 77436 2.6 CTCF KDM1A ZNF143 ZIC2 REST RAD21 TRIM22 KLF7 SMC3 YY1 lnc-CYSLTR2-2 FNDC3A CYSLTR2 RCBTB2 RB1 LPAR6 ITM2B piR-50437-146
GH13J048726 Enhancer 1 Ensembl ENCODE 11.9 +73.9 73923 3.1 PRDM10 ZNF629 ZNF600 ATF7 ZNF561 SCRT2 ZBTB44 ZNF639 ZEB1 TSHZ1 MED4 PPP1R26P1 CYSLTR2 SETDB2 FNDC3A lnc-CYSLTR2-2 piR-50437-146
GH13J048678 Enhancer 0.6 Ensembl ENCODE 12.8 +24.8 24807 3.4 USF1 SPI1 MAX CYSLTR2 piR-33605-130 piR-61101-158 FNDC3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYSLTR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYSLTR2

Top Transcription factor binding sites by QIAGEN in the CYSLTR2 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • POU2F1
  • POU2F1a
  • POU3F2

Genomic Locations for CYSLTR2 Gene

Genomic Locations for CYSLTR2 Gene
chr13:48,653,711-48,711,226
(GRCh38/hg38)
Size:
57,516 bases
Orientation:
Plus strand
chr13:49,280,951-49,283,498
(GRCh37/hg19)
Size:
2,548 bases
Orientation:
Plus strand

Genomic View for CYSLTR2 Gene

Genes around CYSLTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSLTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSLTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSLTR2 Gene

Proteins for CYSLTR2 Gene

  • Protein details for CYSLTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS75-CLTR2_HUMAN
    Recommended name:
    Cysteinyl leukotriene receptor 2
    Protein Accession:
    Q9NS75
    Secondary Accessions:
    • Q9HCQ2

    Protein attributes for CYSLTR2 Gene

    Size:
    346 amino acids
    Molecular mass:
    39635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYSLTR2 Gene

Post-translational modifications for CYSLTR2 Gene

  • Glycosylation at Asn20, Asn26, Asn30, and Asn181
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CYSLTR2
  • Boster Bio Antibodies for CYSLTR2

No data available for DME Specific Peptides for CYSLTR2 Gene

Domains & Families for CYSLTR2 Gene

Gene Families for CYSLTR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYSLTR2 Gene

InterPro:
Blocks:
  • Cysteinyl leukotriene receptor family signature
ProtoNet:

Suggested Antigen Peptide Sequences for CYSLTR2 Gene

GenScript: Design optimal peptide antigens:
  • Cysteinyl leukotriene receptor 2 splice variant VIII (A4ZKH2_HUMAN)
  • HPN321 (CLTR2_HUMAN)
  • cDNA FLJ78284, highly similar to Homo sapiens cysteinyl leukotriene receptor 2 (CYSLTR2), mRNA (Q5KU17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NS75

UniProtKB/Swiss-Prot:

CLTR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CYSLTR2: view

Function for CYSLTR2 Gene

Molecular function for CYSLTR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Phenotypes From GWAS Catalog for CYSLTR2 Gene

Gene Ontology (GO) - Molecular Function for CYSLTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001631 cysteinyl leukotriene receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004966 galanin receptor activity IBA --
GO:0004974 leukotriene receptor activity NAS 10913337
GO:0005515 protein binding IPI 21203429
genes like me logo Genes that share ontologies with CYSLTR2: view
genes like me logo Genes that share phenotypes with CYSLTR2: view

Human Phenotype Ontology for CYSLTR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYSLTR2 Gene

MGI Knock Outs for CYSLTR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYSLTR2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYSLTR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CYSLTR2 Gene

Localization for CYSLTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYSLTR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYSLTR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYSLTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYSLTR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYSLTR2 Gene

Pathways & Interactions for CYSLTR2 Gene

genes like me logo Genes that share pathways with CYSLTR2: view

Pathways by source for CYSLTR2 Gene

1 GeneGo (Thomson Reuters) pathway for CYSLTR2 Gene
  • Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

SIGNOR curated interactions for CYSLTR2 Gene

Activates:

Gene Ontology (GO) - Biological Process for CYSLTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10913337
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CYSLTR2: view

Drugs & Compounds for CYSLTR2 Gene

(40) Drugs for CYSLTR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nedocromil Approved, Investigational Pharma Target, antagonist 5
Zafirlukast Approved, Investigational Pharma Antagonist, antagonist 4
Leukotriene C4 Experimental, Investigational Pharma Target 0
Cinalukast Experimental Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
Pranlukast Investigational Pharma Antagonist, antagonist 4

(17) Additional Compounds for CYSLTR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CYSLTR2 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(2) ApexBio Compounds for CYSLTR2 Gene

Compound Action Cas Number
BAY-u 9773 Antagonist of CysLT1/CysLT2 receptors 154978-38-8
Pranlukast 103177-37-3
genes like me logo Genes that share compounds with CYSLTR2: view

Drug Products

Transcripts for CYSLTR2 Gene

mRNA/cDNA for CYSLTR2 Gene

8 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYSLTR2

Alternative Splicing Database (ASD) splice patterns (SP) for CYSLTR2 Gene

No ASD Table

Relevant External Links for CYSLTR2 Gene

GeneLoc Exon Structure for
CYSLTR2

Expression for CYSLTR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYSLTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYSLTR2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.5), Adrenal Gland (x6.3), and Heart - Left Ventricle (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYSLTR2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYSLTR2

SOURCE GeneReport for Unigene cluster for CYSLTR2 Gene:

Hs.253706

mRNA Expression by UniProt/SwissProt for CYSLTR2 Gene:

Q9NS75-CLTR2_HUMAN
Tissue specificity: Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Evidence on tissue expression from TISSUES for CYSLTR2 Gene

  • Heart(2.4)
  • Lung(2.4)
  • Muscle(2.4)
  • Intestine(2.3)
  • Blood(2.3)
  • Lymph node(2.3)
  • Kidney(2.1)
  • Nervous system(2.1)
  • Spleen(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with CYSLTR2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYSLTR2 Gene

Orthologs for CYSLTR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYSLTR2 30
  • 99.04 (n)
Dog
(Canis familiaris)
Mammalia CYSLTR2 30 31
  • 85.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CYSLTR2 30 31
  • 83.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cysltr2 30
  • 78.03 (n)
Mouse
(Mus musculus)
Mammalia Cysltr2 30 17 31
  • 77.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CYSLTR2 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CYSLTR2 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CYSLTR2 30 31
  • 62.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 22 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii LOC100002717 30
  • 49.88 (n)
CYSLTR2 31
  • 35 (a)
OneToOne
Species where no ortholog for CYSLTR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CYSLTR2 Gene

ENSEMBL:
Gene Tree for CYSLTR2 (if available)
TreeFam:
Gene Tree for CYSLTR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYSLTR2: view image

Paralogs for CYSLTR2 Gene

genes like me logo Genes that share paralogs with CYSLTR2: view

Variants for CYSLTR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYSLTR2 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
714627 Benign: not provided 48,707,087(+) G/A SYNONYMOUS_VARIANT
715815 Benign: not provided 48,707,627(+) C/T SYNONYMOUS_VARIANT
769848 Likely Benign: not provided 48,706,965(+) T/G MISSENSE_VARIANT
769849 Likely Benign: not provided 48,707,125(+) A/G MISSENSE_VARIANT
769850 Likely Benign: not provided 48,707,649(+) T/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CYSLTR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYSLTR2 Gene

Variant ID Type Subtype PubMed ID
nsv483118 CNV gain+loss 15286789
nsv832604 CNV loss 17160897
nsv832605 CNV gain 17160897

Variation tolerance for CYSLTR2 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYSLTR2 Gene

Human Gene Mutation Database (HGMD)
CYSLTR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYSLTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYSLTR2 Gene

Disorders for CYSLTR2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CYSLTR2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma, uveal
  • uveal melanoma
asthma
  • asthma, susceptibility to
adenoid hypertrophy
  • adenoidal hypertrophy
asthma, nasal polyps, and aspirin intolerance
  • asa triad
mckusick-kaufman syndrome
  • mkks
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYSLTR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYSLTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYSLTR2 Gene

Publications for CYSLTR2 Gene

  1. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. (PMID: 10913337) Takasaki J … Furuichi K (Biochemical and biophysical research communications 2000) 2 3 4 23
  2. Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. (PMID: 18366797) Al-Shemari H … Desrosiers M (BMC medical genetics 2008) 3 23 41
  3. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. (PMID: 17460547) Klotsman M … Anderson WH (Pharmacogenetics and genomics 2007) 3 23 41
  4. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. (PMID: 16771777) Zhang J … Noguchi E (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2006) 3 23 41
  5. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. (PMID: 15970796) Park JS … Shin HD (Pharmacogenetics and genomics 2005) 3 23 41

Products for CYSLTR2 Gene

  • Signalway ELISA kits for CYSLTR2

Sources for CYSLTR2 Gene