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Aliases for CYSLTR1 Gene

Aliases for CYSLTR1 Gene

  • Cysteinyl Leukotriene Receptor 1 2 3 3 5
  • Cysteinyl Leukotriene D4 Receptor 3 4
  • G-Protein Coupled Receptor HG55 3 4
  • LTD4 Receptor 3 4
  • HMTMF81 3 4
  • CYSLT1 3 4
  • CYSLT1R 3
  • CysLTR1 4
  • CYSLTR 3

External Ids for CYSLTR1 Gene

Previous GeneCards Identifiers for CYSLTR1 Gene

  • GC0XM073074
  • GC0XM074489
  • GC0XM075569
  • GC0XM076284
  • GC0XM077334
  • GC0XM077526
  • GC0XM071107

Summaries for CYSLTR1 Gene

Entrez Gene Summary for CYSLTR1 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CYSLTR1 Gene

CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include Asthma and Adenoid Hypertrophy. Among its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is CYSLTR2.

UniProtKB/Swiss-Prot for CYSLTR1 Gene

  • Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Tocris Summary for CYSLTR1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for CYSLTR1 Gene

Additional gene information for CYSLTR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYSLTR1 Gene

Genomics for CYSLTR1 Gene

GeneHancer (GH) Regulatory Elements for CYSLTR1 Gene

Promoters and enhancers for CYSLTR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ078325 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 662.8 -0.7 -739 5.8 SRF NR2F1 JUNB EBF1 MEF2B BATF IKZF1 RUNX3 CYSLTR1 TAF9B FGF16 HMGN1P34
GH0XJ078657 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 650.1 -331.6 -331550 2.7 IKZF1 RUNX3 MAFK RTL3 CYSLTR1 TAF9B UBE2V1P7
GH0XJ078102 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.9 +222.6 222637 4.6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GC0XP078104 GC0XP078105 PGK1 TAF9B CYSLTR1 FGF16 GC0XM078132 GC0XM078131 GC0XM078130
GH0XJ078652 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 3.6 -325.6 -325608 2.4 FOXA2 BATF RARA YY1 ATF7 FOS IKZF2 RUNX3 MIXL1 RXRA LPAR4 TAF9B CYSLTR1 RTL3 UBE2V1P7
GH0XJ078516 Enhancer 0.7 ENCODE 5.2 -189.7 -189744 1.5 BATF IRF4 NFATC1 EED ETV6 IKZF2 RUNX3 CREM SRF ZBED1 CYSLTR1 HMGN1P34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYSLTR1 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXF2

Genomic Locations for CYSLTR1 Gene

Genomic Locations for CYSLTR1 Gene
chrX:78,271,464-78,327,691
(GRCh38/hg38)
Size:
56,228 bases
Orientation:
Minus strand
chrX:77,526,961-77,583,087
(GRCh37/hg19)
Size:
56,127 bases
Orientation:
Minus strand

Genomic View for CYSLTR1 Gene

Genes around CYSLTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYSLTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYSLTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYSLTR1 Gene

Proteins for CYSLTR1 Gene

  • Protein details for CYSLTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y271-CLTR1_HUMAN
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Protein Accession:
    Q9Y271
    Secondary Accessions:
    • B2R954
    • D3DTE4
    • Q5JS94
    • Q8IV19

    Protein attributes for CYSLTR1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38541 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.

neXtProt entry for CYSLTR1 Gene

Post-translational modifications for CYSLTR1 Gene

  • Glycosylation at posLast=262262, posLast=180180, Asn169, and posLast=66
  • Modification sites at PhosphoSitePlus

Other Protein References for CYSLTR1 Gene

No data available for DME Specific Peptides for CYSLTR1 Gene

Domains & Families for CYSLTR1 Gene

Gene Families for CYSLTR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for CYSLTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y271

UniProtKB/Swiss-Prot:

CLTR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CYSLTR1: view

Function for CYSLTR1 Gene

Molecular function for CYSLTR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Phenotypes From GWAS Catalog for CYSLTR1 Gene

Gene Ontology (GO) - Molecular Function for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001631 cysteinyl leukotriene receptor activity IBA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004966 galanin receptor activity IBA --
GO:0004974 leukotriene receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with CYSLTR1: view
genes like me logo Genes that share phenotypes with CYSLTR1: view

Animal Models for CYSLTR1 Gene

MGI Knock Outs for CYSLTR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYSLTR1

miRNA for CYSLTR1 Gene

miRTarBase miRNAs that target CYSLTR1

Clone Products

  • R&D Systems cDNA Clones for CYSLTR1 (Cysteinyl Leukotriene R1/CysLTR1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYSLTR1 Gene

Localization for CYSLTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYSLTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYSLTR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA --
GO:0016020 membrane TAS 10391245
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYSLTR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYSLTR1 Gene

Pathways & Interactions for CYSLTR1 Gene

genes like me logo Genes that share pathways with CYSLTR1: view

Gene Ontology (GO) - Biological Process for CYSLTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0003013 circulatory system process IBA --
GO:0006816 calcium ion transport IEA --
GO:0006935 chemotaxis IEA --
GO:0006952 defense response TAS 10391245
genes like me logo Genes that share ontologies with CYSLTR1: view

No data available for SIGNOR curated interactions for CYSLTR1 Gene

Drugs & Compounds for CYSLTR1 Gene

(44) Drugs for CYSLTR1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved, Investigational Pharma Antagonist, antagonist, Target 3
Zafirlukast Approved, Investigational Pharma Antagonist, antagonist, Target 3
Montelukast Approved Pharma Antagonist, antagonist, Target 280
Cinalukast Approved Pharma antagonist, Target Potent, selective CysLT1 (LTD4) antagonist; orally active 0
Nedocromil Approved, Investigational Pharma Target, suppressor 5

(14) Additional Compounds for CYSLTR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CYSLTR1 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2

(6) ApexBio Compounds for CYSLTR1 Gene

Compound Action Cas Number
BAY-u 9773 Antagonist of CysLT1/CysLT2 receptors 154978-38-8
MK 571 leukotriene D4 receptor antagonist, orally active 115104-28-4
MK-571 sodium salt hydrate 115103-85-0
Montelukast Sodium Leukotriene receptor antagonist 151767-02-1
Pranlukast 103177-37-3
Zafirlukast 107753-78-6
genes like me logo Genes that share compounds with CYSLTR1: view

Drug Products

Transcripts for CYSLTR1 Gene

mRNA/cDNA for CYSLTR1 Gene

Unigene Clusters for CYSLTR1 Gene

Cysteinyl leukotriene receptor 1:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for CYSLTR1 (Cysteinyl Leukotriene R1/CysLTR1)

Alternative Splicing Database (ASD) splice patterns (SP) for CYSLTR1 Gene

No ASD Table

Relevant External Links for CYSLTR1 Gene

GeneLoc Exon Structure for
CYSLTR1
ECgene alternative splicing isoforms for
CYSLTR1

Expression for CYSLTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYSLTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYSLTR1 Gene

This gene is overexpressed in Esophagus - Muscularis (x9.3), Esophagus - Gastroesophageal Junction (x7.9), and Whole Blood (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of CYSLTR1 Gene:

CYSLTR1

SOURCE GeneReport for Unigene cluster for CYSLTR1 Gene:

Hs.733809

mRNA Expression by UniProt/SwissProt for CYSLTR1 Gene:

Q9Y271-CLTR1_HUMAN
Tissue specificity: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

Evidence on tissue expression from TISSUES for CYSLTR1 Gene

  • Blood(4.4)
  • Spleen(4.3)
  • Pancreas(4)
  • Lung(2.7)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with CYSLTR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYSLTR1 Gene

Orthologs for CYSLTR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYSLTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYSLTR1 34 33
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CYSLTR1 34 33
  • 92.26 (n)
OneToMany
-- 34
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYSLTR1 34 33
  • 91.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cysltr1 16 34 33
  • 87.56 (n)
rat
(Rattus norvegicus)
Mammalia Cysltr1 33
  • 86.83 (n)
oppossum
(Monodelphis domestica)
Mammalia CYSLTR1 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYSLTR1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYSLTR1 34 33
  • 66.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYSLTR1 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cysltr1 33
  • 65.72 (n)
zebrafish
(Danio rerio)
Actinopterygii cysltr1 34 33
  • 62.24 (n)
OneToOne
Dr.26064 33
Species where no ortholog for CYSLTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYSLTR1 Gene

ENSEMBL:
Gene Tree for CYSLTR1 (if available)
TreeFam:
Gene Tree for CYSLTR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYSLTR1: view image

Paralogs for CYSLTR1 Gene

genes like me logo Genes that share paralogs with CYSLTR1: view

Variants for CYSLTR1 Gene

Sequence variations from dbSNP and Humsavar for CYSLTR1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs193920986 uncertain-significance, Malignant tumor of prostate 78,273,679(-) TT/T coding_sequence_variant, frameshift
rs1000021866 -- 78,312,845(-) A/G intron_variant
rs1000033134 -- 78,312,534(-) T/C intron_variant
rs1000148060 -- 78,315,044(-) G/A intron_variant
rs1000164127 -- 78,303,619(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYSLTR1 Gene

Variant ID Type Subtype PubMed ID
esv3574111 CNV loss 25503493

Variation tolerance for CYSLTR1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYSLTR1 Gene

Human Gene Mutation Database (HGMD)
CYSLTR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYSLTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYSLTR1 Gene

Disorders for CYSLTR1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CYSLTR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
adenoid hypertrophy
  • adenoidal hypertrophy
rhinitis
  • runny nose
sinusitis
bronchial disease
  • bronchospasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYSLTR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYSLTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYSLTR1 Gene

Publications for CYSLTR1 Gene

  1. Characterization of the human cysteinyl leukotriene CysLT1 receptor. (PMID: 10391245) Lynch KR … Evans JF (Nature 1999) 2 3 4 22 58
  2. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. (PMID: 10462554) Sarau HM … Hay DW (Molecular pharmacology 1999) 2 3 4 22 58
  3. Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity. (PMID: 19450127) York TP … van den Oord EJ (Pharmacogenomics 2009) 3 22 44 58
  4. 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira KG … Weiss ST (Pharmacogenetics and genomics 2009) 3 22 44 58
  5. Variable expression of cysteinyl leukotriene type I receptor splice variants in asthmatic females with different promoter haplotypes. (PMID: 20003473) Sokolowska M … Pawliczak R (BMC immunology 2009) 3 22 44 58

Products for CYSLTR1 Gene

Sources for CYSLTR1 Gene

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