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Aliases for CYREN Gene

Aliases for CYREN Gene

  • Cell Cycle Regulator Of NHEJ 2 3 4
  • C7orf49 3 4 5
  • Modulator Of Retrovirus Infection Homolog 3 4
  • Chromosome 7 Open Reading Frame 49 2 5
  • MRI 3 4
  • Cell Cycle Regulator Of Non-Homologous End Joining 3
  • Modulator Of Retrovirus Infection 2
  • MRI-2 3

External Ids for CYREN Gene

Previous HGNC Symbols for CYREN Gene

  • C7orf49

Summaries for CYREN Gene

GeneCards Summary for CYREN Gene

CYREN (Cell Cycle Regulator Of NHEJ) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CYREN Gene

  • Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity).

  • Isoform 4: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974).

Additional gene information for CYREN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYREN Gene

Genomics for CYREN Gene

GeneHancer (GH) Regulatory Elements for CYREN Gene

Promoters and enhancers for CYREN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J135163 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 671.2 +2.3 2343 9.2 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 SSRP1 ZNF610 CYREN ENSG00000272941 PIR59130 NUP205 ENSG00000273219 ENSG00000231794 WDR91 TMEM140 AGBL3 CNOT4
GH07J135146 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.7 +21.3 21275 6.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT MLX ARID4B SIN3A YBX1 IRF4 TMEM140 NUP205 CYREN AGBL3 WDR91 CNOT4 GC07M135162 PIR50393
GH07J135158 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.5 +10.3 10334 4.6 HDGF PKNOX1 ARNT ARID4B YY1 ZNF766 CBX5 FOS REST ZNF592 TMEM140 PIR50393 GC07M135162 CYREN WDR91 CNOT4
GH07J134985 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.1 +183.9 183923 2.2 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 E2F8 AGBL3 NUP205 CYREN TMEM140 ENSG00000231794 PIR51313
GH07J134668 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +501.0 500954 3 JUN GATA3 CTBP1 POLR2A CBFA2T2 RCOR1 FOS RUNX3 CHD2 SMARCE1 TMEM140 CYREN WDR91 ENSG00000231794 BPGM ENSG00000224375
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYREN on UCSC Golden Path with GeneCards custom track

Genomic Locations for CYREN Gene

Genomic Locations for CYREN Gene
chr7:135,092,363-135,170,826
(GRCh38/hg38)
Size:
78,464 bases
Orientation:
Minus strand
chr7:134,777,115-134,855,547
(GRCh37/hg19)

Genomic View for CYREN Gene

Genes around CYREN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYREN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYREN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYREN Gene

Proteins for CYREN Gene

  • Protein details for CYREN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWK5-CYREN_HUMAN
    Recommended name:
    Cell cycle regulator of non-homologous end joining
    Protein Accession:
    Q9BWK5
    Secondary Accessions:
    • A0A024R780
    • A0A087WWQ8
    • Q6NWZ4
    • Q6ZNR5

    Protein attributes for CYREN Gene

    Size:
    157 amino acids
    Molecular mass:
    16829 Da
    Quaternary structure:
    • Isoform 1: Interacts (via KBM motif) with XRCC5/Ku80 and XRCC6/Ku70 heterodimer; interaction is restricted during the S and G2 phases (PubMed:24610814, PubMed:28959974). Isoform 4: Interacts (via KBM motif) with XRCC5/Ku80 and XRCC6/Ku70 heterodimer; interaction is restricted during the S and G2 phases (PubMed:24610814, PubMed:28959974). Isoform 3: Does not interact with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (PubMed:24610814).
    SequenceCaution:
    • Sequence=AAH00168.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CYREN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYREN Gene

Post-translational modifications for CYREN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYREN Gene

Domains & Families for CYREN Gene

Gene Families for CYREN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CYREN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYREN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWK5

UniProtKB/Swiss-Prot:

CYREN_HUMAN :
  • The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80 and XRCC6/Ku70.
Domain:
  • The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80 and XRCC6/Ku70.
genes like me logo Genes that share domains with CYREN: view

Function for CYREN Gene

Molecular function for CYREN Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 4: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974).

Phenotypes From GWAS Catalog for CYREN Gene

Gene Ontology (GO) - Molecular Function for CYREN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24610814
genes like me logo Genes that share ontologies with CYREN: view
genes like me logo Genes that share phenotypes with CYREN: view

Animal Models for CYREN Gene

MGI Knock Outs for CYREN:
  • Cyren Cyren<tm1.1(KOMP)Vlcg>

Animal Model Products

miRNA for CYREN Gene

miRTarBase miRNAs that target CYREN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYREN Gene

Localization for CYREN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYREN Gene

Isoform 1: Cytoplasm. Nucleus. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer. {ECO:0000269 PubMed:24610814}.
Isoform 3: Cytoplasm. Note=Some nuclear localization may be due to passive diffusion. {ECO:0000269 PubMed:24610814}.
Isoform 4: Cytoplasm. Nucleus. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer and increases upon etoposide treatment. {ECO:0000269 PubMed:24610814}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYREN gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYREN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24610814
GO:0005737 cytoplasm IDA,IEA 24610814
genes like me logo Genes that share ontologies with CYREN: view

Pathways & Interactions for CYREN Gene

SuperPathways for CYREN Gene

No Data Available

Interacting Proteins for CYREN Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376823%0d%0a9606.ENSP00000288985%0d%0a
Selected Interacting proteins: Q9BWK5-CYREN_HUMAN ENSP00000376823 for CYREN Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for CYREN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006303 double-strand break repair via nonhomologous end joining IDA 24610814
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining IDA 28959974
genes like me logo Genes that share ontologies with CYREN: view

No data available for Pathways by source and SIGNOR curated interactions for CYREN Gene

Drugs & Compounds for CYREN Gene

No Compound Related Data Available

Transcripts for CYREN Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYREN Gene

No ASD Table

Relevant External Links for CYREN Gene

GeneLoc Exon Structure for
CYREN
ECgene alternative splicing isoforms for
CYREN

Expression for CYREN Gene

NURSA nuclear receptor signaling pathways regulating expression of CYREN Gene:

CYREN

Evidence on tissue expression from TISSUES for CYREN Gene

  • Nervous system(2.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYREN Gene

Orthologs for CYREN Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYREN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf49 33
  • 99.36 (n)
C7orf49 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf49 33
  • 73.65 (n)
C7orf49 34
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C16H7orf49 33
  • 73.24 (n)
C7orf49 34
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500077 33
  • 72.4 (n)
mouse
(Mus musculus)
Mammalia 3110062M04Rik 34 33
  • 70.81 (n)
OneToOne
Cyren 16
oppossum
(Monodelphis domestica)
Mammalia C7orf49 34
  • 44 (a)
OneToOne
Species where no ortholog for CYREN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYREN Gene

ENSEMBL:
Gene Tree for CYREN (if available)
TreeFam:
Gene Tree for CYREN (if available)

Paralogs for CYREN Gene

No data available for Paralogs for CYREN Gene

Variants for CYREN Gene

Sequence variations from dbSNP and Humsavar for CYREN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs776124276 A colorectal cancer sample 135,166,840(-) G/A 3_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant
rs1000003403 -- 135,162,789(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000021723 -- 135,131,449(-) AAA/AA genic_downstream_transcript_variant, intron_variant
rs1000057053 -- 135,156,203(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000160436 -- 135,104,120(-) C/A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYREN Gene

Variant ID Type Subtype PubMed ID
nsv527014 CNV gain 19592680

Variation tolerance for CYREN Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYREN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYREN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYREN Gene

Disorders for CYREN Gene

Additional Disease Information for CYREN

No disorders were found for CYREN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYREN Gene

Publications for CYREN Gene

  1. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (PMID: 28959974) Arnoult N … Karlseder J (Nature 2017) 2 3 4 58
  2. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. (PMID: 24610814) Slavoff SA … Saghatelian A (The Journal of biological chemistry 2014) 2 3 4 58
  3. The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. (PMID: 27063109) Grundy GJ … Caldecott KW (Nature communications 2016) 2 3 58
  4. Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. (PMID: 17043244) Agarwal S … Somia NV (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58

Products for CYREN Gene

Sources for CYREN Gene

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