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Aliases for CYR61 Gene

Aliases for CYR61 Gene

  • Cysteine Rich Angiogenic Inducer 61 2 3 5
  • Insulin-Like Growth Factor-Binding Protein 10 3 4
  • IGF-Binding Protein 10 3 4
  • CCN Family Member 1 3 4
  • IGFBP-10 3 4
  • IGFBP10 3 4
  • IBP-10 3 4
  • CCN1 3 4
  • GIG1 3 4
  • Cysteine-Rich Heparin-Binding Protein 61 3
  • Cysteine-Rich, Anigogenic Inducer, 61 3
  • Cysteine-Rich, Angiogenic Inducer, 61 2
  • Cysteine-Rich Angiogenic Inducer 61 4
  • Protein CYR61 3
  • Protein GIG1 4

External Ids for CYR61 Gene

Previous HGNC Symbols for CYR61 Gene

  • IGFBP10

Previous GeneCards Identifiers for CYR61 Gene

  • GC01P086445
  • GC01P085188
  • GC01P085334
  • GC01P085469
  • GC01P085758
  • GC01P086046
  • GC01P084157

Summaries for CYR61 Gene

Entrez Gene Summary for CYR61 Gene

  • The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

GeneCards Summary for CYR61 Gene

CYR61 (Cysteine Rich Angiogenic Inducer 61) is a Protein Coding gene. Diseases associated with CYR61 include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Epispadias. Among its related pathways are RhoA signaling pathway and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and extracellular matrix binding. An important paralog of this gene is CTGF.

UniProtKB/Swiss-Prot for CYR61 Gene

  • Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene Wiki entry for CYR61 Gene

Additional gene information for CYR61 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYR61 Gene

Genomics for CYR61 Gene

GeneHancer (GH) Regulatory Elements for CYR61 Gene

Promoters and enhancers for CYR61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J085575 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +0.0 40 11.4 FEZF1 DMAP1 YY1 ZNF143 ZNF548 MCM3 SP3 ZFP41 MEF2D ZNF610 DDAH1 CYR61 ODF2L ZNHIT6 ENSG00000232622 LOC100420166 C1orf52 BCL10 GC01P085583 ENSG00000272691
GH01J085604 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +28.8 28792 10 PKNOX1 FOXA2 ARID4B SIN3A ETS1 YY1 GLIS2 ZNF143 FOS RXRA CYR61 ZNHIT6 DDAH1 ODF2L ENSG00000230285 GC01P085628
GH01J085459 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 -117.8 -117831 7.1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF143 DDAH1 ODF2L CYR61 ENSG00000273264 GC01M085455
GH01J085520 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -56.7 -56660 7.6 HDGF PKNOX1 ZNF133 NEUROD1 FEZF1 ZNF2 BRCA1 ZNF121 FOS ATF7 ZNHIT6 CYR61 DDAH1 C1orf52 ENSG00000282057 ENSG00000273264
GH01J085706 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +127.4 127446 2.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNHIT6 ODF2L CYR61 DDAH1 PIR53460
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYR61 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYR61 gene promoter:
  • SRF (504 AA)
  • SRF
  • CREB
  • deltaCREB
  • E2F
  • E2F-1

Genomic Locations for CYR61 Gene

Genomic Locations for CYR61 Gene
chr1:85,580,761-85,583,967
(GRCh38/hg38)
Size:
3,207 bases
Orientation:
Plus strand
chr1:86,046,444-86,049,650
(GRCh37/hg19)
Size:
3,207 bases
Orientation:
Plus strand

Genomic View for CYR61 Gene

Genes around CYR61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYR61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYR61 Gene

Proteins for CYR61 Gene

  • Protein details for CYR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00622-CYR61_HUMAN
    Recommended name:
    Protein CYR61
    Protein Accession:
    O00622
    Secondary Accessions:
    • O14934
    • O43775
    • Q9BZL7

    Protein attributes for CYR61 Gene

    Size:
    381 amino acids
    Molecular mass:
    42027 Da
    Quaternary structure:
    • Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

    Three dimensional structures from OCA and Proteopedia for CYR61 Gene

neXtProt entry for CYR61 Gene

Post-translational modifications for CYR61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYR61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYR61 Gene

Domains & Families for CYR61 Gene

Gene Families for CYR61 Gene

Graphical View of Domain Structure for InterPro Entry

O00622

UniProtKB/Swiss-Prot:

CYR61_HUMAN :
  • Belongs to the CCN family.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CYR61: view

Function for CYR61 Gene

Molecular function for CYR61 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
GENATLAS Biochemistry:
cysteine-rich angiogenic 61,related protein 4,immediate early gene,low affinity,expressed in embryonic tissues and in tumor cell lines derived from the nervous system,putatively involved in the control of cell proliferation,promoting angiogenesis and chondrogenesis during mouse development (see TSG1E)

Phenotypes From GWAS Catalog for CYR61 Gene

Gene Ontology (GO) - Molecular Function for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA,IBA --
GO:0005515 protein binding IEA --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA --
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with CYR61: view
genes like me logo Genes that share phenotypes with CYR61: view

Animal Models for CYR61 Gene

MGI Knock Outs for CYR61:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYR61 Gene

Localization for CYR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYR61 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYR61 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 extracellular matrix HDA 23658023
genes like me logo Genes that share ontologies with CYR61: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYR61 Gene

Pathways & Interactions for CYR61 Gene

genes like me logo Genes that share pathways with CYR61: view

Pathways by source for CYR61 Gene

Gene Ontology (GO) - Biological Process for CYR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20675382
GO:0002041 intussusceptive angiogenesis IEA --
GO:0003181 atrioventricular valve morphogenesis IEA --
genes like me logo Genes that share ontologies with CYR61: view

No data available for SIGNOR curated interactions for CYR61 Gene

Drugs & Compounds for CYR61 Gene

(9) Drugs for CYR61 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for CYR61 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYR61: view

Transcripts for CYR61 Gene

mRNA/cDNA for CYR61 Gene

(1) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(608) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYR61 Gene

Cysteine-rich, angiogenic inducer, 61:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYR61 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for CYR61 Gene

GeneLoc Exon Structure for
CYR61
ECgene alternative splicing isoforms for
CYR61

Expression for CYR61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYR61 Gene

mRNA differential expression in normal tissues according to GTEx for CYR61 Gene

This gene is overexpressed in Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for CYR61 Gene

This gene is overexpressed in Ovary (34.0), Breast (12.6), Amniocyte (10.7), and Bone marrow mesenchymal stem cell (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYR61 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYR61 Gene:

CYR61

SOURCE GeneReport for Unigene cluster for CYR61 Gene:

Hs.8867

Evidence on tissue expression from TISSUES for CYR61 Gene

  • Lung(4.7)
  • Skin(4.7)
  • Nervous system(4.4)
  • Liver(3.5)
  • Kidney(3.3)
  • Bone(3.2)
  • Heart(3.2)
  • Muscle(3)
  • Intestine(2.5)
  • Lymph node(2.5)
  • Gall bladder(2.4)
  • Pancreas(2.4)
  • Spleen(2.3)
  • Stomach(2.3)
  • Thyroid gland(2.2)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with CYR61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYR61 Gene

Orthologs for CYR61 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYR61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYR61 34 33
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CYR61 34 33
  • 92.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CYR61 34 33
  • 90.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cyr61 16 34 33
  • 88.95 (n)
rat
(Rattus norvegicus)
Mammalia Cyr61 33
  • 88.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYR61 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYR61 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYR61 34 33
  • 78.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYR61 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyr61 33
  • 71.56 (n)
Str.9694 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64237 33
zebrafish
(Danio rerio)
Actinopterygii zgc:85866 33
  • 68.4 (n)
cyr61 34
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ccn 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
-- 34
  • 37 (a)
OneToMany
Species where no ortholog for CYR61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYR61 Gene

ENSEMBL:
Gene Tree for CYR61 (if available)
TreeFam:
Gene Tree for CYR61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYR61: view image

Paralogs for CYR61 Gene

Paralogs for CYR61 Gene

(5) SIMAP similar genes for CYR61 Gene using alignment to 3 proteins:

  • CYR61_HUMAN
  • Q6FI18_HUMAN
  • Q9UID7_HUMAN
genes like me logo Genes that share paralogs with CYR61: view

Variants for CYR61 Gene

Sequence variations from dbSNP and Humsavar for CYR61 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000706725 -- 85,579,245(+) G/C upstream_transcript_variant
rs1000846287 -- 85,580,855(+) C/G 5_prime_UTR_variant
rs1001078275 -- 85,579,665(+) G/A/T upstream_transcript_variant
rs1002071007 -- 85,580,184(+) G/C upstream_transcript_variant
rs1002730214 -- 85,582,258(+) A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CYR61 Gene

Variant ID Type Subtype PubMed ID
nsv950203 CNV deletion 24416366

Variation tolerance for CYR61 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYR61 Gene

Human Gene Mutation Database (HGMD)
CYR61
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYR61

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYR61 Gene

Disorders for CYR61 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CYR61 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthropathy, progressive pseudorheumatoid, of childhood
  • ppac
epispadias
wilms tumor 5
  • nephroblastoma
rhabdomyosarcoma
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CYR61 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CYR61

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYR61: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYR61 Gene

Publications for CYR61 Gene

  1. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p. (PMID: 9135077) Jay P … Berta P (Oncogene 1997) 2 3 4 22 58
  2. CYR61 polymorphisms are associated with plasma HDL-cholesterol levels in obese individuals. (PMID: 17718860) Bouchard L … Vohl MC (Clinical genetics 2007) 3 22 44 58
  3. Organization and expression of the Cyr61 gene in normal human fibroblasts. (PMID: 11810026) Leng E … Sadowski I (Journal of biomedical science 2002) 3 4 22 58
  4. CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. (PMID: 11287419) Grzeszkiewicz TM … Lau LF (The Journal of biological chemistry 2001) 3 4 22 58
  5. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. (PMID: 11584015) Chen CC … Lau LF (The Journal of biological chemistry 2001) 3 4 22 58

Products for CYR61 Gene

  • Boster Bio Antibodies for CYR61
  • Boster Bio ELISA Kits for CYR61

Sources for CYR61 Gene

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