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This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
CYP4X1 (Cytochrome P450 Family 4 Subfamily X Member 1) is a Protein Coding gene. Diseases associated with CYP4X1 include Bietti Crystalline Corneoretinal Dystrophy and Akinetic Mutism. Among its related pathways are Cytochrome P450 - arranged by substrate type and acetone degradation I (to methylglyoxal). Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4Z1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J047024 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.2 | +62.6 | 62637 | 1.6 | PRDM10 ZNF629 ZNF692 ZNF174 PRDM1 ZIC2 POLR2A PATZ1 ZNF501 EZH2 | CYP4X1 NSUN4 TEX38 LRRC41 CYP4A22 CYP4Z1 piR-47211-015 MN309174-005 | |
GH01J047004 | Promoter | 0.4 | EPDnew | 600.3 | +42.8 | 42803 | 0.1 | SCRT2 | CYP4A44P lnc-CYP4A11-2 CYP4X1 piR-59297-022 CYP4Z1 | |
GH01J046815 | Promoter | 0.3 | EPDnew | 600.1 | -146.2 | -146198 | 0.1 | CYP4X1 CYP4B1 piR-39858-015 piR-40110-021 CYP4A11 | ||
GH01J046813 | Promoter | 0.3 | EPDnew | 600.1 | -147.5 | -147469 | 0.1 | CYP4X1 CYP4A11 piR-39858-015 piR-40110-021 CYP4B1 | ||
GH01J046798 | Promoter/Enhancer | 1.1 | EPDnew Ensembl dbSUPER | 4.8 | -160.7 | -160665 | 3.4 | ZNF512 ZKSCAN1 SMAD4 | CYP4B1 CYP4A22 CYP4A11 FAAH CYP4X1 piR-59769-007 piR-39858-015 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004497 | monooxygenase activity | IEA | -- |
GO:0005506 | iron ion binding | IEA | -- |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0031090 | organelle membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type | ||
2 | superpathway of tryptophan utilization | ||
3 | nicotine degradation IV | ||
4 | Serotonergic synapse | ||
5 | acetone degradation I (to methylglyoxal) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Caffeine | Approved | Pharma | Antagonist, Activator | 603 | ||
Citalopram | Approved | Pharma | 597 | |||
Codeine | Approved, Illicit | Pharma | Agonist, Full agonist | 94 | ||
Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1113 | ||
Estrone | Approved | Pharma | Agonist | Estrogenic hormone | 22 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
11,12,15-THETA |
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11,12-EpETrE |
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81276-02-0 |
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11,14,15-THETA |
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11H-14,15-EETA |
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219535-29-2 |
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12,13-EpOME |
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This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CYP4X1 31 |
|
OneToOne | |
LOC456833 30 |
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Dog (Canis familiaris) |
Mammalia | CYP4X1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cyp4x1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cyp4x1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | LOC100847677 30 |
|
||
CYP4X1 31 |
|
OneToOne | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CYP714A1 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os11g0119700 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv32e212 | CNV | gain | 25503493 |
esv2763300 | CNV | gain | 21179565 |
esv3585949 | CNV | loss | 21293372 |
esv3585950 | CNV | gain | 21293372 |
nsv1009338 | CNV | gain | 25217958 |
nsv1077760 | OTHER | inversion | 25765185 |
nsv461428 | CNV | gain | 19166990 |
nsv546166 | CNV | loss | 21841781 |
nsv546167 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bietti crystalline corneoretinal dystrophy |
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akinetic mutism |
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