CYP4X1 Gene (Protein Coding)

Cytochrome P450 Family 4 Subfamily X Member 1

GC01P046961
GIFtS:
37
This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests... See more...

Aliases for CYP4X1 Gene

Aliases for CYP4X1 Gene

  • Cytochrome P450 Family 4 Subfamily X Member 1 2 3 5
  • Cytochrome P450, Family 4, Subfamily X, Polypeptide 1 2 3
  • Cytochrome P450 4X1 3 4
  • CYPIVX1 3 4
  • EC 1.14.14.- 4
  • MGC40051 2
  • CYP4X1 5

External Ids for CYP4X1 Gene

Previous GeneCards Identifiers for CYP4X1 Gene

  • GC00U991261
  • GC01U900708
  • GC01P046859
  • GC01P047201
  • GC01P047261
  • GC01P047489
  • GC01P045605
  • GC01P047023

Summaries for CYP4X1 Gene

Entrez Gene Summary for CYP4X1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for CYP4X1 Gene

CYP4X1 (Cytochrome P450 Family 4 Subfamily X Member 1) is a Protein Coding gene. Diseases associated with CYP4X1 include Bietti Crystalline Corneoretinal Dystrophy and Akinetic Mutism. Among its related pathways are Cytochrome P450 - arranged by substrate type and acetone degradation I (to methylglyoxal). Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4Z1.

UniProtKB/Swiss-Prot Summary for CYP4X1 Gene

  • A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

Gene Wiki entry for CYP4X1 Gene

Additional gene information for CYP4X1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP4X1 Gene

Genomics for CYP4X1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CYP4X1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J047024 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.2 +62.6 62637 1.6 PRDM10 ZNF629 ZNF692 ZNF174 PRDM1 ZIC2 POLR2A PATZ1 ZNF501 EZH2 CYP4X1 NSUN4 TEX38 LRRC41 CYP4A22 CYP4Z1 piR-47211-015 MN309174-005
GH01J047004 Promoter 0.4 EPDnew 600.3 +42.8 42803 0.1 SCRT2 CYP4A44P lnc-CYP4A11-2 CYP4X1 piR-59297-022 CYP4Z1
GH01J046815 Promoter 0.3 EPDnew 600.1 -146.2 -146198 0.1 CYP4X1 CYP4B1 piR-39858-015 piR-40110-021 CYP4A11
GH01J046813 Promoter 0.3 EPDnew 600.1 -147.5 -147469 0.1 CYP4X1 CYP4A11 piR-39858-015 piR-40110-021 CYP4B1
GH01J046798 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 4.8 -160.7 -160665 3.4 ZNF512 ZKSCAN1 SMAD4 CYP4B1 CYP4A22 CYP4A11 FAAH CYP4X1 piR-59769-007 piR-39858-015
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4X1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP4X1

Top Transcription factor binding sites by QIAGEN in the CYP4X1 gene promoter:
  • AREB6
  • FOXL1
  • HEN1
  • MRF-2
  • NCX
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1

Genomic Locations for CYP4X1 Gene

Genomic Locations for CYP4X1 Gene
chr1:46,961,364-47,055,432
(GRCh38/hg38)
Size:
94,069 bases
Orientation:
Plus strand
chr1:47,427,036-47,516,423
(GRCh37/hg19)
Size:
89,388 bases
Orientation:
Plus strand

Genomic View for CYP4X1 Gene

Genes around CYP4X1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4X1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4X1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP4X1 Gene

Proteins for CYP4X1 Gene

Products:

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  • Protein details for CYP4X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N118-CP4X1_HUMAN
    Recommended name:
    Cytochrome P450 4X1
    Protein Accession:
    Q8N118
    Secondary Accessions:
    • G3V1U1
    • Q5VVE5
    • Q6ZN67
    • Q8NAZ3

    Protein attributes for CYP4X1 Gene

    Size:
    509 amino acids
    Molecular mass:
    58875 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4X1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4X1 Gene

Protein Expression for CYP4X1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CYP4X1 Gene

  • Ubiquitination at Lys75 and Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP4X1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP4X1 Gene

Domains & Families for CYP4X1 Gene

Gene Families for CYP4X1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CYP4X1 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
ProtoNet:

Suggested Antigen Peptide Sequences for CYP4X1 Gene

GenScript: Design optimal peptide antigens:
  • CYPIVX1 (CP4X1_HUMAN)
  • Cytochrome P450, family 4, subfamily X, polypeptide 1, isoform CRA_b (Q5VVE5_HUMAN)
  • cDNA FLJ34487 fis, clone HLUNG2004273, weakly similar to CYTOCHROME P450 4A4 (EC 1.14.14.1) (Q8NAZ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N118

UniProtKB/Swiss-Prot:

CP4X1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4X1: view

Function for CYP4X1 Gene

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Molecular function for CYP4X1 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53148, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136991; Evidence={ECO:0000269|PubMed:18549450};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=65 uM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (14,15 epoxidation) {ECO:0000269|PubMed:18549450};

Enzyme Numbers (IUBMB) for CYP4X1 Gene

Gene Ontology (GO) - Molecular Function for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP4X1: view
genes like me logo Genes that share phenotypes with CYP4X1: view

Animal Models for CYP4X1 Gene

MGI Knock Outs for CYP4X1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP4X1

CRISPR Products

miRNA for CYP4X1 Gene

miRTarBase miRNAs that target CYP4X1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4X1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP4X1 Gene

Localization for CYP4X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4X1 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein. Microsome membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4X1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4X1 Gene

Pathways & Interactions for CYP4X1 Gene

genes like me logo Genes that share pathways with CYP4X1: view

Pathways by source for CYP4X1 Gene

1 KEGG pathway for CYP4X1 Gene

Interacting Proteins for CYP4X1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000360968 Q8N118-CP4X1_HUMAN for CYP4X1 Gene via STRING IID

GPS-Prot Interaction Network for CYP4X1

Gene Ontology (GO) - Biological Process for CYP4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4X1: view

No data available for SIGNOR curated interactions for CYP4X1 Gene

Drugs & Compounds for CYP4X1 Gene

Products:

  1. Drug

(21) Drugs for CYP4X1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Pharma Antagonist, Activator 603
Citalopram Approved Pharma 597
Codeine Approved, Illicit Pharma Agonist, Full agonist 94
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1113
Estrone Approved Pharma Agonist Estrogenic hormone 22

(20) Additional Compounds for CYP4X1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
 81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
 219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP4X1: view

Transcripts for CYP4X1 Gene

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  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for CYP4X1 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4X1

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4X1 Gene

No ASD Table

Relevant External Links for CYP4X1 Gene

GeneLoc Exon Structure for
CYP4X1

Expression for CYP4X1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP4X1 Gene

mRNA expression in normal human tissues for CYP4X1 Gene
mRNA expression by BioGPS for CYP4X1 GenemRNA expression by GTEx for CYP4X1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CYP4X1 Gene

This gene is overexpressed in Breast (38.5), Heart (9.0), and Fetal Brain (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP4X1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP4X1

SOURCE GeneReport for Unigene cluster for CYP4X1 Gene:

Hs.439760

mRNA Expression by UniProt/SwissProt for CYP4X1 Gene:

Q8N118-CP4X1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney and skin and, at lower levels, in skeletal muscle and liver (PubMed:16478468, PubMed:18549450). In the brain, high levels are detected in amygdala and lower levels in globus pallidus and cerebellum (PubMed:18549450). In the heart, very high levels in aorta, but very low levels in other heart regions (PubMed:16478468, PubMed:18549450). Also expressed in breast, prostate and colon (PubMed:18549450).

Evidence on tissue expression from TISSUES for CYP4X1 Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with CYP4X1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4X1 Gene

Orthologs for CYP4X1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4X1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CYP4X1 31
  • 100 (a)
 OneToOne
LOC456833 30
  • 99.61 (n)
Dog
(Canis familiaris)
 Mammalia CYP4X1 30 31
  • 84.32 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cyp4x1 30 17 31
  • 81.07 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cyp4x1 30
  • 80.47 (n)
Cow
(Bos Taurus)
 Mammalia LOC100847677 30
  • 79.37 (n)
CYP4X1 31
  • 66 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 54 (a)
 ManyToMany
-- 31
  • 43 (a)
 ManyToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 45 (a)
 ManyToMany
-- 31
  • 43 (a)
 ManyToMany
-- 31
  • 39 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 50 (a)
 ManyToMany
-- 31
  • 49 (a)
 ManyToMany
-- 31
  • 47 (a)
 ManyToMany
-- 31
  • 47 (a)
 ManyToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons CYP714A1 30
  • 43.66 (n)
Rice
(Oryza sativa)
 Liliopsida Os11g0119700 30
  • 42.98 (n)
Species where no ortholog for CYP4X1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CYP4X1 Gene

ENSEMBL:
Gene Tree for CYP4X1 (if available)
TreeFam:
Gene Tree for CYP4X1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4X1: view image

Paralogs for CYP4X1 Gene

Paralogs for CYP4X1 Gene

(13) SIMAP similar genes for CYP4X1 Gene using alignment to 1 proteins:

  • CP4X1_HUMAN
genes like me logo Genes that share paralogs with CYP4X1: view

Variants for CYP4X1 Gene

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Additional dbSNP identifiers (rs#s) for CYP4X1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP4X1 Gene

Variant ID Type Subtype PubMed ID
dgv32e212 CNV gain 25503493
esv2763300 CNV gain 21179565
esv3585949 CNV loss 21293372
esv3585950 CNV gain 21293372
nsv1009338 CNV gain 25217958
nsv1077760 OTHER inversion 25765185
nsv461428 CNV gain 19166990
nsv546166 CNV loss 21841781
nsv546167 CNV gain 21841781

Variation tolerance for CYP4X1 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4X1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4X1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP4X1 Gene

Disorders for CYP4X1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP4X1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bietti crystalline corneoretinal dystrophy
  • bcd
akinetic mutism
  • coma vigilans
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP4X1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYP4X1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4X1 Gene

Publications for CYP4X1 Gene

  1. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. (PMID: 18549450) Stark K … Guengerich FP (The FEBS journal 2008) 3 4
  2. Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PMID: 15797250) Savas U … Johnson EF (Archives of biochemistry and biophysics 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

ExternalLinks

View latest publications for CYP4X1 gene in Mastermind

Products for CYP4X1 Gene

  • Signalway Proteins for CYP4X1

Sources for CYP4X1 Gene