This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene... See more...

Aliases for CYP4F8 Gene

Aliases for CYP4F8 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 8 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 8 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 8 2 3
  • Cytochrome P450 4F8 3 4
  • CYPIVF8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • EC 1.14.14.1 4
  • CYP4F8 5
  • CPF8 3

External Ids for CYP4F8 Gene

Previous GeneCards Identifiers for CYP4F8 Gene

  • GC19P016105
  • GC19P016014
  • GC19P015481
  • GC19P015587
  • GC19P015726
  • GC19P015293
  • GC19P015616

Summaries for CYP4F8 Gene

Entrez Gene Summary for CYP4F8 Gene

  • This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F8 Gene

CYP4F8 (Cytochrome P450 Family 4 Subfamily F Member 8) is a Protein Coding gene. Diseases associated with CYP4F8 include Bietti Crystalline Corneoretinal Dystrophy. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F2.

UniProtKB/Swiss-Prot Summary for CYP4F8 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions (PubMed:10791960, PubMed:16112640, PubMed:15789615). Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) (PubMed:10791960). Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 (PubMed:10791960, PubMed:15789615). Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids (PubMed:16112640). Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4.

Gene Wiki entry for CYP4F8 Gene

Additional gene information for CYP4F8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP4F8 Gene

Genomics for CYP4F8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP4F8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015615 Promoter 0.3 EPDnew 600.7 0.0 -8 0.1 CYP4F8 ENSG00000266951 NONHSAG025004.2 ENSG00000268673 CYP4F22 lnc-OR7C2-1
GH19J015635 Enhancer 0.6 FANTOM5 12.9 +20.4 20393 0.2 REST SP1 FOXA2 YY1 JUND RAD21 TFAP4 HNF4A RXRA MAX CYP4F8 HSH2D RAB8A CYP4F3 BRD4 AKAP8 NONHSAG025004.2 lnc-OR7C2-1
GH19J015606 Enhancer 0.7 Ensembl 0.4 -8.2 -8206 1.6 JUND DPF2 HDAC1 SOX6 TCF12 CTBP1 HES1 HDAC2 TRIM24 NCOR1 lnc-PGLYRP2-1 piR-36531-010 piR-33422-204 piR-58297-235 CYP4F10P CLEC4O CYP4F3 CYP4F24P CYP4F8 piR-41525-324
GH19J015629 Enhancer 0.7 ENCODE 0.4 +14.3 14279 0.2 CTCF REST ZNF143 PHF21A RAD21 TRIM22 ZNF444 RCOR1 SMC3 PKNOX1 OR10H5 OR7C1 CYP4F3 CYP4F8 NONHSAG025004.2 lnc-OR7C2-1
GH19J015584 Enhancer 0.9 ENCODE 0.3 -30.4 -30392 0.1 GATAD2A CTCF ZNF692 JUND ZNF143 ZIC2 RBFOX2 REST RAD21 IRF2 CHERP AKAP8 C19orf44 CYP4F12 ZNF333 CYP4F11 OR10H5 BRD4 CYP4F3 piR-61580-312
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4F8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP4F8

Top Transcription factor binding sites by QIAGEN in the CYP4F8 gene promoter:
  • ATF6
  • Brachyury
  • c-Ets-1
  • C/EBPalpha
  • C/EBPbeta
  • CUTL1
  • Elk-1
  • NF-1
  • p300
  • Pax-5

Genomic Locations for CYP4F8 Gene

Genomic Locations for CYP4F8 Gene
chr19:15,615,207-15,630,639
(GRCh38/hg38)
Size:
15,433 bases
Orientation:
Plus strand
chr19:15,726,029-15,741,448
(GRCh37/hg19)
Size:
15,420 bases
Orientation:
Plus strand

Genomic View for CYP4F8 Gene

Genes around CYP4F8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F8 Gene

Proteins for CYP4F8 Gene

  • Protein details for CYP4F8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98187-CP4F8_HUMAN
    Recommended name:
    Cytochrome P450 4F8
    Protein Accession:
    P98187

    Protein attributes for CYP4F8 Gene

    Size:
    520 amino acids
    Molecular mass:
    59995 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP4F8 Gene

Post-translational modifications for CYP4F8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F8 Gene

No data available for DME Specific Peptides for CYP4F8 Gene

Domains & Families for CYP4F8 Gene

Gene Families for CYP4F8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYP4F8 Gene

Suggested Antigen Peptide Sequences for CYP4F8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55833, highly similar to Cytochrome P450 4F8 (EC 1.14.14.1) (B4DU85_HUMAN)
  • CYPIVF8 (CP4F8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P98187

UniProtKB/Swiss-Prot:

CP4F8_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F8: view

Function for CYP4F8 Gene

Molecular function for CYP4F8 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions (PubMed:10791960, PubMed:16112640, PubMed:15789615). Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) (PubMed:10791960). Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 (PubMed:10791960, PubMed:15789615). Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids (PubMed:16112640). Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:10791960, ECO:0000269|PubMed:15789615};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:48736, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:90790; Evidence={ECO:0000269|PubMed:10791960};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51112, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77226, ChEBI:CHEBI:133939; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:48796, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:90793, ChEBI:CHEBI:90801; Evidence={ECO:0000269|PubMed:10791960};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:48776, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57405, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:90797; Evidence={ECO:0000269|PubMed:10791960};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53932, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57403, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137987; Evidence={ECO:0000269|PubMed:15789615};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133934; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133933; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51084, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133932; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51080, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133931; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51108, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133938; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51104, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133937; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51100, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133936; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51096, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133935; Evidence={ECO:0000269|PubMed:16112640};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) {ECO:0000269|PubMed:10791960}; KM=40 uM for 6,9-alpha-methylene-PGI2 {ECO:0000269|PubMed:15789615}; Vmax=260 pmol/min/pmol enzyme with 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) {ECO:0000269|PubMed:10791960};
GENATLAS Biochemistry:
cytochrome p450,subfamily IV-F expressed in seminal vesicles,catalyzing in the synthesis of 19R-hydroxyprostaglandins by a NADPH-dependent omega2-hydroxylation

Enzyme Numbers (IUBMB) for CYP4F8 Gene

Phenotypes From GWAS Catalog for CYP4F8 Gene

Gene Ontology (GO) - Molecular Function for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0018685 alkane 1-monooxygenase activity TAS 10405341
genes like me logo Genes that share ontologies with CYP4F8: view
genes like me logo Genes that share phenotypes with CYP4F8: view

Animal Model Products

CRISPR Products

miRNA for CYP4F8 Gene

miRTarBase miRNAs that target CYP4F8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4F8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F8 Gene

Localization for CYP4F8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F8 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein. Microsome membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4F8 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4F8 Gene

Pathways & Interactions for CYP4F8 Gene

genes like me logo Genes that share pathways with CYP4F8: view

Pathways by source for CYP4F8 Gene

UniProtKB/Swiss-Prot P98187-CP4F8_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Gene Ontology (GO) - Biological Process for CYP4F8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006690 icosanoid metabolic process TAS --
GO:0006693 prostaglandin metabolic process TAS 10405341
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F8: view

No data available for SIGNOR curated interactions for CYP4F8 Gene

Drugs & Compounds for CYP4F8 Gene

(7) Drugs for CYP4F8 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
arachidonic acid Experimental Pharma Activator, Agonist, Inhibitor, Activation, Potentiation 40
NADP Experimental Pharma 0
NADPH Experimental Pharma 0

(6) Additional Compounds for CYP4F8 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • 20-Hydroxy arachidonic acid
  • 20-Hydroxyarachidonic acid
  • 20-Hydroxyicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
79551-86-3
20-Hydroxy-leukotriene B4
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate
  • 20-Hydroxy-LTB4
  • 20-OH-Leukotriene b4
  • 20-OH-LTB4
79516-82-8
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with CYP4F8: view

Transcripts for CYP4F8 Gene

mRNA/cDNA for CYP4F8 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4F8

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for CYP4F8 Gene

GeneLoc Exon Structure for
CYP4F8

Expression for CYP4F8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP4F8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x28.2), Prostate (x9.2), Skin - Sun Exposed (Lower leg) (x7.0), and Bladder (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP4F8

SOURCE GeneReport for Unigene cluster for CYP4F8 Gene:

Hs.268554

mRNA Expression by UniProt/SwissProt for CYP4F8 Gene:

P98187-CP4F8_HUMAN
Tissue specificity: Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions.
genes like me logo Genes that share expression patterns with CYP4F8: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4F8 Gene

Orthologs for CYP4F8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC748442 30
  • 99.17 (n)
Mouse
(Mus musculus)
Mammalia Cyp4f15 30 17
  • 78.52 (n)
Rat
(Rattus norvegicus)
Mammalia Cyp4f4 30
  • 78.46 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp4d2 32
  • 38 (a)
Cyp4c3 32
  • 37 (a)
Cyp4d8 32
  • 36 (a)
Cyp4d14 32
  • 35 (a)
Cyp4g15 32
  • 35 (a)
Cyp4ae1 32
  • 34 (a)
Cyp4d1 32
  • 34 (a)
Cyp4d20 32
  • 34 (a)
Cyp4s3 32
  • 34 (a)
Cyp4p1 32
  • 33 (a)
Cyp4ac3 32
  • 33 (a)
Cyp4ac1 32
  • 32 (a)
Cyp4ac2 32
  • 32 (a)
Cyp4d21 32
  • 32 (a)
Cyp4e2 32
  • 32 (a)
Cyp4e3 32
  • 32 (a)
Cyp4p2 32
  • 32 (a)
Cyp4p3 32
  • 32 (a)
Cyp4e1 32
  • 31 (a)
Cyp311a1 32
  • 30 (a)
Cyp312a1 32
  • 30 (a)
Cyp4aa1 32
  • 30 (a)
Cyp4ad1 32
  • 29 (a)
Cyp313a4 32
  • 29 (a)
Cyp4g1 32
  • 26 (a)
Cyp313b1 32
  • 25 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y17G9B.3 32
  • 36 (a)
B0331.1 32
  • 35 (a)
F01D5.9 32
  • 35 (a)
Y5H2B.5 32
  • 35 (a)
Y38C9B.1 32
  • 34 (a)
F28G4.1 32
  • 33 (a)
Y80D3A.5 32
  • 32 (a)
C26F1.2 32
  • 32 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYP72A15 30
  • 43.55 (n)
Species where no ortholog for CYP4F8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for CYP4F8 Gene

ENSEMBL:
Gene Tree for CYP4F8 (if available)
TreeFam:
Gene Tree for CYP4F8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4F8: view image

Paralogs for CYP4F8 Gene

(13) SIMAP similar genes for CYP4F8 Gene using alignment to 1 proteins:

  • CP4F8_HUMAN

Pseudogenes.org Pseudogenes for CYP4F8 Gene

genes like me logo Genes that share paralogs with CYP4F8: view

Variants for CYP4F8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP4F8 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2056822 - p.Pro447Gln
rs2072600 - p.Tyr125Phe

Additional dbSNP identifiers (rs#s) for CYP4F8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP4F8 Gene

Variant ID Type Subtype PubMed ID
dgv3443n100 CNV gain 25217958
dgv3444n100 CNV gain 25217958
dgv3445n100 CNV gain 25217958
dgv627e199 CNV deletion 23128226
esv1497518 CNV insertion 17803354
esv2718235 CNV deletion 23290073
nsv1064684 CNV gain 25217958
nsv1066963 CNV gain 25217958
nsv1066993 CNV gain 25217958
nsv1072865 CNV deletion 25765185
nsv1127656 CNV deletion 24896259
nsv1134756 CNV deletion 24896259

Additional Variant Information for CYP4F8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4F8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CYP4F8 Gene

Disorders for CYP4F8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CYP4F8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bietti crystalline corneoretinal dystrophy
  • bcd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP4F8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYP4F8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4F8 Gene

Publications for CYP4F8 Gene

  1. On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens. (PMID: 15789615) Stark K … Oliw EH (Prostaglandins & other lipid mediators 2005) 3 4 23
  2. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. (PMID: 12464258) Stark K … Oliw EH (Archives of biochemistry and biophysics 2003) 3 4 23
  3. Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. (PMID: 10791960) Bylund J … Oliw EH (The Journal of biological chemistry 2000) 3 4 23
  4. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. (PMID: 10405341) Bylund J … Oliw EH (Biochemical and biophysical research communications 1999) 2 3 4
  5. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S … Arnett DK (Pharmacogenetics and genomics 2012) 3 41

Products for CYP4F8 Gene

Sources for CYP4F8 Gene