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Aliases for CYP4F3 Gene

Aliases for CYP4F3 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 3 2 3 5
  • Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega Hydroxylase) 2 3
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 2 3
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Leukotriene-B(4) Omega-Hydroxylase 2 3 4
  • Leukotriene-B(4) 20-Monooxygenase 2 3 4
  • Cytochrome P450-LTB-Omega 3 4
  • Cytochrome P450 4F3 3 4
  • 20-HETE Synthase 3 4
  • CYPIVF3 3 4
  • LTB4H 3 4
  • Docosahexaenoic Acid Omega-Hydroxylase CYP4F3 3
  • Leukotriene B4 Omega Hydroxylase 3
  • Leukotriene-B4 20-Monooxygenase 3
  • Cytochrome P-450 3
  • EC 1.14.13.199 4
  • EC 1.14.13.30 4
  • EC 1.14.13.- 4
  • CYP4F 3
  • CPF3 3

External Ids for CYP4F3 Gene

Previous HGNC Symbols for CYP4F3 Gene

  • LTB4H

Previous GeneCards Identifiers for CYP4F3 Gene

  • GC19P016130
  • GC19P016013
  • GC19P015482
  • GC19P015612
  • GC19P015751
  • GC19P015320
  • GC19P015615

Summaries for CYP4F3 Gene

Entrez Gene Summary for CYP4F3 Gene

  • This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP4F3 Gene

CYP4F3 (Cytochrome P450 Family 4 Subfamily F Member 3) is a Protein Coding gene. Diseases associated with CYP4F3 include Inflammatory Bowel Disease 6 and Hypoactive Sexual Desire Disorder. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F2.

UniProtKB/Swiss-Prot for CYP4F3 Gene

  • Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.

  • Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Tocris Summary for CYP4F3 Gene

  • Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-beta hydroxylase (E.C. 1.14.15.4), and LTB4 omega-hydroxylase (E.C. 1.14.13.30).

Gene Wiki entry for CYP4F3 Gene

Additional gene information for CYP4F3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F3 Gene

Genomics for CYP4F3 Gene

GeneHancer (GH) Regulatory Elements for CYP4F3 Gene

Promoters and enhancers for CYP4F3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015639 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 663.1 +0.2 245 3.3 FOXA2 ARID4B SIN3A ZNF48 YY1 ZFP91 NFKBIZ RXRA MIER2 REST CYP4F3 BRD4 CYP4F12 AKAP8 HSH2D CYP4F10P RAB8A OR10H5 TPM4 ZNF333
GH19J015584 Enhancer 1.1 Ensembl ENCODE 5 -56.2 -56161 0.7 ARID4B DMAP1 ZNF2 ZBTB7B ZNF48 ARID2 ZNF143 SP3 SP5 YY2 CHERP AKAP8 C19orf44 CYP4F12 ZNF333 CYP4F11 OR10H5 BRD4 CYP4F10P CYP4F24P
GH19J015611 Promoter 0.5 Ensembl 8.6 -29.1 -29096 0.4 ENSG00000267135 GC19P015613 RPL23AP2 CYP4F3 GC19P015593
GH19J015587 Enhancer 0.8 Ensembl ENCODE 5.3 -53.0 -52996 1 CTCF GATA3 POLR2A HLF MAX REST MYC SPI1 CYP4F12 CYP4F11 OR10H5 CYP4F24P CYP4F3 GC19P015580 GC19P015593
GH19J015499 Enhancer 0.9 FANTOM5 ENCODE 3.1 -141.7 -141659 0.3 PKNOX1 SP3 SP2 REST ZIC2 SP1 ZFHX2 GLIS1 CREB1 PRDM10 PGLYRP2 CYP4F22 CYP4F2 CYP4F3 CYP4F11 OR10H4 OR1I1 GC19M015202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4F3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP4F3 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • deltaCREB
  • CREB
  • Brachyury
  • Elk-1
  • AP-1
  • c-Fos
  • c-Jun
  • FosB

Genomic Locations for CYP4F3 Gene

Genomic Locations for CYP4F3 Gene
chr19:15,640,897-15,662,825
(GRCh38/hg38)
Size:
21,929 bases
Orientation:
Plus strand
chr19:15,751,707-15,773,635
(GRCh37/hg19)
Size:
21,929 bases
Orientation:
Plus strand

Genomic View for CYP4F3 Gene

Genes around CYP4F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F3 Gene

Proteins for CYP4F3 Gene

  • Protein details for CYP4F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08477-CP4F3_HUMAN
    Recommended name:
    Docosahexaenoic acid omega-hydroxylase CYP4F3
    Protein Accession:
    Q08477
    Secondary Accessions:
    • B7Z8Z3
    • O60634
    • Q5U740

    Protein attributes for CYP4F3 Gene

    Size:
    520 amino acids
    Molecular mass:
    59847 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F3 Gene

Post-translational modifications for CYP4F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP4F3 Gene

Domains & Families for CYP4F3 Gene

Gene Families for CYP4F3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CYP4F3 Gene

Suggested Antigen Peptide Sequences for CYP4F3 Gene

Graphical View of Domain Structure for InterPro Entry

Q08477

UniProtKB/Swiss-Prot:

CP4F3_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F3: view

Function for CYP4F3 Gene

Molecular function for CYP4F3 Gene

UniProtKB/Swiss-Prot Function:
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
UniProtKB/Swiss-Prot Function:
Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).
UniProtKB/Swiss-Prot CatalyticActivity:
Docosahexaenoate + NADPH + O(2) = 22-hydroxydocosahexaenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by carbon monoxide (CO).
GENATLAS Biochemistry:
cytochrome p450,subfamily IVF,polypeptide 3,59.8kDa,expressed in granulocytes,catalyzing the inactivation of leukotrienne beta 4 with two forms resulting from tissue specific splicing and alternative promoters

Enzyme Numbers (IUBMB) for CYP4F3 Gene

Gene Ontology (GO) - Molecular Function for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 8486631
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0019825 oxygen binding TAS --
genes like me logo Genes that share ontologies with CYP4F3: view
genes like me logo Genes that share phenotypes with CYP4F3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4F3

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F3 Gene

Localization for CYP4F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F3 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4F3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
peroxisome 2
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4F3 Gene

Pathways & Interactions for CYP4F3 Gene

genes like me logo Genes that share pathways with CYP4F3: view

Pathways by source for CYP4F3 Gene

UniProtKB/Swiss-Prot Q08477-CP4F3_HUMAN

  • Pathway: Lipid metabolism; leukotriene B4 degradation.

Gene Ontology (GO) - Biological Process for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006690 icosanoid metabolic process TAS --
GO:0006691 leukotriene metabolic process TAS --
GO:0036101 leukotriene B4 catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

No data available for SIGNOR curated interactions for CYP4F3 Gene

Drugs & Compounds for CYP4F3 Gene

(11) Drugs for CYP4F3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon monoxide Approved, Investigational Pharma 132
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
Metyrapone Approved, Investigational Pharma 11-beta hydroxylase inhibitor 13
arachidonic acid Experimental Nutra Activator, Inhibitor, Agonist, Activation, Potentiation 33

(8) Additional Compounds for CYP4F3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12(S)-Leukotriene B4
  • 12-Epi-LTB4
  • 12S-LTB4
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoate
  • 2-Epi-LTB4
83709-73-3
12-Keto-tetrahydro-leukotriene B4
  • 12-keto-10,11,14,15-tetrahydro-LTB4
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoate
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoic acid
18-Hydroxyarachidonic acid
  • (18R)-HETE
  • (5Z,8Z,11Z,14Z,18R)-18-Hydroxyicosatetraenoic acid
  • 18(R)-Hydroxyeicosatetraenoic acid
  • Hydroxyarachidonic acid
  • 18-Hydroxyarachidonate
124411-81-0
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • 20-Hydroxy arachidonic acid
  • 20-Hydroxyarachidonic acid
  • 20-Hydroxyicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
79551-86-3
20-Hydroxy-leukotriene B4
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate
  • 20-Hydroxy-LTB4
  • 20-OH-Leukotriene b4
  • 20-OH-LTB4
79516-82-8

(4) Tocris Compounds for CYP4F3 Gene

Compound Action Cas Number
17-ODYA LTB omega-hydroxylase inhibitor 34450-18-5
DMOG Prolyl hydroxylase inhibitor 89464-63-1
Metyrapone 11-beta hydroxylase inhibitor 54-36-4
p-Chlorophenylalanine Tryptophan hydroxylase inhibitor 7424-00-2
genes like me logo Genes that share compounds with CYP4F3: view

Transcripts for CYP4F3 Gene

Unigene Clusters for CYP4F3 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4F3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for CYP4F3 Gene

GeneLoc Exon Structure for
CYP4F3
ECgene alternative splicing isoforms for
CYP4F3

Expression for CYP4F3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F3 Gene

This gene is overexpressed in Liver (x26.2), Whole Blood (x10.9), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for CYP4F3 Gene

This gene is overexpressed in Liver (32.9) and Gallbladder (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP4F3 Gene



Protein tissue co-expression partners for CYP4F3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP4F3 Gene:

CYP4F3

SOURCE GeneReport for Unigene cluster for CYP4F3 Gene:

Hs.106242

mRNA Expression by UniProt/SwissProt for CYP4F3 Gene:

Q08477-CP4F3_HUMAN
Tissue specificity: Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.

Evidence on tissue expression from TISSUES for CYP4F3 Gene

  • Blood(4.5)
  • Liver(3.8)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with CYP4F3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4F3 Gene

Orthologs for CYP4F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4F3 34
  • 99 (a)
OneToOne
LOC748117 33
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia CYP4F3 34
  • 86 (a)
OneToOne
LOC484867 33
  • 81.33 (n)
cow
(Bos Taurus)
Mammalia LOC534967 33
  • 82.02 (n)
CYP4F3 34
  • 78 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4f18 34
  • 80 (a)
OneToOne
Cyp4f13 16 33
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Cyp4f6 33
  • 78.72 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
-- 34
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 34
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp4d2 35
  • 38 (a)
Cyp4d14 35
  • 37 (a)
Cyp4s3 35
  • 37 (a)
Cyp4c3 35
  • 36 (a)
Cyp4d8 35
  • 36 (a)
Cyp4d1 35
  • 36 (a)
Cyp4g15 35
  • 35 (a)
Cyp4p3 35
  • 35 (a)
Cyp4p1 35
  • 35 (a)
Cyp4d20 35
  • 34 (a)
Cyp4e2 35
  • 33 (a)
Cyp4ac3 35
  • 33 (a)
Cyp4ac1 35
  • 33 (a)
Cyp4ae1 35
  • 33 (a)
Cyp312a1 35
  • 33 (a)
Cyp4e3 35
  • 33 (a)
Cyp4p2 35
  • 33 (a)
Cyp4d21 35
  • 32 (a)
Cyp4ac2 35
  • 32 (a)
Cyp4e1 35
  • 32 (a)
Cyp311a1 35
  • 31 (a)
Cyp4ad1 35
  • 30 (a)
Cyp4aa1 35
  • 30 (a)
Cyp313a3 35
  • 27 (a)
Cyp4g1 35
  • 26 (a)
Cyp313b1 35
  • 26 (a)
Cyp313a4 35
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea Y17G9B.3 35
  • 36 (a)
F01D5.9 35
  • 36 (a)
Y5H2B.5 35
  • 36 (a)
B0331.1 35
  • 35 (a)
Y80D3A.5 35
  • 34 (a)
Y38C9B.1 35
  • 34 (a)
F28G4.1 35
  • 33 (a)
C26F1.2 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
CSA.8060 34
  • 41 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
CSA.3998 34
  • 40 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
CSA.6060 34
  • 37 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
Species where no ortholog for CYP4F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F3 Gene

ENSEMBL:
Gene Tree for CYP4F3 (if available)
TreeFam:
Gene Tree for CYP4F3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4F3: view image

Paralogs for CYP4F3 Gene

Variants for CYP4F3 Gene

Sequence variations from dbSNP and Humsavar for CYP4F3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs483352698 uncertain-significance, not provided 15,650,089(+) G/A coding_sequence_variant, missense_variant
rs1000128213 -- 15,650,587(+) T/A intron_variant
rs1000149432 -- 15,643,889(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000241751 -- 15,645,724(+) C/T 5_prime_UTR_variant, coding_sequence_variant, intron_variant, synonymous_variant
rs1000384642 -- 15,640,216(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4F3 Gene

Variant ID Type Subtype PubMed ID
dgv3443n100 CNV gain 25217958
dgv3445n100 CNV gain 25217958
dgv627e199 CNV deletion 23128226
esv1597130 CNV insertion 17803354
esv2269626 CNV deletion 18987734
esv22910 CNV loss 19812545
esv2477444 CNV deletion 19546169
esv2674388 CNV deletion 23128226
esv2718235 CNV deletion 23290073
esv2718237 CNV deletion 23290073
esv3556089 CNV deletion 23714750
esv3643775 CNV loss 21293372
nsv1064684 CNV gain 25217958
nsv1066963 CNV gain 25217958
nsv1071160 CNV deletion 25765185
nsv1131406 CNV deletion 24896259
nsv470128 CNV gain 18288195
nsv578718 CNV gain 21841781
nsv954612 CNV deletion 24416366
nsv963014 CNV duplication 23825009
nsv9670 CNV loss 18304495

Variation tolerance for CYP4F3 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4F3 Gene

Human Gene Mutation Database (HGMD)
CYP4F3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F3 Gene

Disorders for CYP4F3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP4F3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 6
  • ibd6
hypoactive sexual desire disorder
  • lack or loss of sexual desire
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP4F3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP4F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4F3 Gene

Publications for CYP4F3 Gene

  1. Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. (PMID: 9539102) Kikuta Y … Kusunose M (DNA and cell biology 1998) 2 3 4 22 58
  2. Alternative splicing determines the function of CYP4F3 by switching substrate specificity. (PMID: 11461919) Christmas P … Soberman RJ (The Journal of biological chemistry 2001) 3 4 22 58
  3. Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. (PMID: 10409674) Christmas P … Soberman RJ (The Journal of biological chemistry 1999) 3 4 22 58
  4. A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase. (PMID: 8486631) Kikuta Y … Kusunose M (The Journal of biological chemistry 1993) 2 3 4 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for CYP4F3 Gene

Sources for CYP4F3 Gene

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