This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can ... See more...

Aliases for CYP4F12 Gene

Aliases for CYP4F12 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 12 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 12 2 3
  • Cytochrome P450, Subfamily IVF, Polypeptide 12 2 3
  • Cytochrome P450 4F12 3 4
  • CYPIVF12 3 4
  • EC 1.14.14.1 4
  • F22329_1 3

External Ids for CYP4F12 Gene

Previous GeneCards Identifiers for CYP4F12 Gene

  • GC19M016362
  • GC19P016177
  • GC19P015483
  • GC19P015644
  • GC19P015783
  • GC19P015352

Summaries for CYP4F12 Gene

Entrez Gene Summary for CYP4F12 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP4F12 Gene

CYP4F12 (Cytochrome P450 Family 4 Subfamily F Member 12) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F11.

UniProtKB/Swiss-Prot Summary for CYP4F12 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate (PubMed:11162607). Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids (PubMed:16112640). Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate (PubMed:11162645). Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine (PubMed:11162645).

Gene Wiki entry for CYP4F12 Gene

Additional gene information for CYP4F12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP4F12 Gene

Genomics for CYP4F12 Gene

GeneHancer (GH) Regulatory Elements for CYP4F12 Gene

Promoters and enhancers for CYP4F12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4F12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP4F12 gene promoter:
  • Brachyury
  • c-Myc
  • HOXA5
  • HSF1 (long)
  • HSF1short
  • Max1
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1

Genomic Locations for CYP4F12 Gene

Genomic Locations for CYP4F12 Gene
chr19:15,672,757-15,698,819
(GRCh38/hg38)
Size:
26,063 bases
Orientation:
Plus strand
chr19:15,783,567-15,807,984
(GRCh37/hg19)
Size:
24,418 bases
Orientation:
Plus strand

Genomic View for CYP4F12 Gene

Genes around CYP4F12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F12 Gene

Proteins for CYP4F12 Gene

  • Protein details for CYP4F12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCS2-CP4FC_HUMAN
    Recommended name:
    Cytochrome P450 4F12
    Protein Accession:
    Q9HCS2
    Secondary Accessions:
    • E7ET51
    • O60389
    • Q5JPJ7
    • Q9HCS1

    Protein attributes for CYP4F12 Gene

    Size:
    524 amino acids
    Molecular mass:
    60309 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW84492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CYP4F12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F12 Gene

Post-translational modifications for CYP4F12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP4F12 Gene

Domains & Families for CYP4F12 Gene

Gene Families for CYP4F12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYP4F12 Gene

Suggested Antigen Peptide Sequences for CYP4F12 Gene

GenScript: Design optimal peptide antigens:
  • CYPIVF12 (CP4FC_HUMAN)
  • Cytochrome P450 4F12 (Q6QF45_HUMAN)
  • Cytochrome P450, family 4, subfamily F, polypeptide 12 (Q8IV39_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCS2

UniProtKB/Swiss-Prot:

CP4FC_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F12: view

Function for CYP4F12 Gene

Molecular function for CYP4F12 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate (PubMed:11162607). Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids (PubMed:16112640). Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate (PubMed:11162645). Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine (PubMed:11162645).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39811, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63590; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39812; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51108, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133938; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51109; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51104, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133937; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51105; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51100, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133936; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51101; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51096, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77224, ChEBI:CHEBI:133935; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51097; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133934; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51093; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133933; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51089; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51084, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133932; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51085; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51080, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:133931; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51081; Evidence=. ;.

Enzyme Numbers (IUBMB) for CYP4F12 Gene

Phenotypes From GWAS Catalog for CYP4F12 Gene

Gene Ontology (GO) - Molecular Function for CYP4F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity ISS --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP4F12: view
genes like me logo Genes that share phenotypes with CYP4F12: view

Animal Models for CYP4F12 Gene

MGI Knock Outs for CYP4F12:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4F12 Gene

Localization for CYP4F12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F12 Gene

Endoplasmic reticulum membrane. Microsome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4F12 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 4
extracellular 1
mitochondrion 1
cytosol 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CYP4F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4F12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4F12 Gene

Pathways & Interactions for CYP4F12 Gene

genes like me logo Genes that share pathways with CYP4F12: view

Pathways by source for CYP4F12 Gene

UniProtKB/Swiss-Prot Q9HCS2-CP4FC_HUMAN

  • Pathway: Lipid metabolism; arachidonate metabolism.

Gene Ontology (GO) - Biological Process for CYP4F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process ISS --
GO:0001676 long-chain fatty acid metabolic process ISS --
GO:0003091 renal water homeostasis ISS --
GO:0003095 pressure natriuresis ISS --
GO:0017144 drug metabolic process ISS --
genes like me logo Genes that share ontologies with CYP4F12: view

No data available for SIGNOR curated interactions for CYP4F12 Gene

Drugs & Compounds for CYP4F12 Gene

(8) Drugs for CYP4F12 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fingolimod Approved, Investigational Pharma Enzyme, substrate 0
Ketoconazole Approved, Investigational Pharma Pore Blocker, Enzyme, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 192
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYP4F12: view

Transcripts for CYP4F12 Gene

mRNA/cDNA for CYP4F12 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F12 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9: - -

Relevant External Links for CYP4F12 Gene

GeneLoc Exon Structure for
CYP4F12
ECgene alternative splicing isoforms for
CYP4F12

Expression for CYP4F12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP4F12 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4F12 Gene

This gene is overexpressed in Liver (x5.8), Small Intestine - Terminal Ileum (x5.6), Colon - Transverse (x5.1), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for CYP4F12 Gene

This gene is overexpressed in Stomach (35.3), Gallbladder (16.2), and Liver (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP4F12 Gene



Protein tissue co-expression partners for CYP4F12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP4F12 Gene:

CYP4F12

SOURCE GeneReport for Unigene cluster for CYP4F12 Gene:

Hs.131459

mRNA Expression by UniProt/SwissProt for CYP4F12 Gene:

Q9HCS2-CP4FC_HUMAN
Tissue specificity: Expressed in small intestine, liver, colon and heart.

Evidence on tissue expression from TISSUES for CYP4F12 Gene

  • Liver(4.6)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with CYP4F12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4F12 Gene

Orthologs for CYP4F12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4F12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468754 32
  • 98.16 (n)
CYP4F12 33
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4f1 32
  • 79.2 (n)
cow
(Bos Taurus)
Mammalia -- 33
  • 79 (a)
ManyToMany
-- 33
  • 77 (a)
ManyToMany
CYP4F2 33
  • 76 (a)
ManyToMany
-- 33
  • 76 (a)
ManyToMany
-- 33
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp4f14 17 33 32
  • 78.99 (n)
dog
(Canis familiaris)
Mammalia -- 33
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 62 (a)
ManyToMany
-- 33
  • 62 (a)
ManyToMany
-- 33
  • 61 (a)
ManyToMany
-- 33
  • 60 (a)
ManyToMany
-- 33
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 62 (a)
ManyToMany
-- 33
  • 59 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 33
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp4d14 34
  • 38 (a)
Cyp4d2 34
  • 37 (a)
Cyp4g15 34
  • 36 (a)
Cyp4c3 34
  • 36 (a)
Cyp4s3 34
  • 35 (a)
Cyp4ac3 34
  • 35 (a)
Cyp4d8 34
  • 34 (a)
Cyp4d1 34
  • 34 (a)
Cyp4p3 34
  • 33 (a)
Cyp4p1 34
  • 33 (a)
Cyp4d20 34
  • 33 (a)
Cyp4ae1 34
  • 32 (a)
Cyp4e3 34
  • 32 (a)
Cyp4d21 34
  • 32 (a)
Cyp4p2 34
  • 32 (a)
Cyp4e1 34
  • 31 (a)
Cyp312a1 34
  • 31 (a)
Cyp4ac1 34
  • 31 (a)
Cyp4e2 34
  • 31 (a)
Cyp311a1 34
  • 30 (a)
Cyp4ac2 34
  • 30 (a)
Cyp4ad1 34
  • 28 (a)
Cyp313a4 34
  • 27 (a)
Cyp4aa1 34
  • 26 (a)
Cyp4g1 34
  • 26 (a)
Cyp313b1 34
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea Y5H2B.5 34
  • 36 (a)
B0331.1 34
  • 34 (a)
Y17G9B.3 34
  • 34 (a)
F01D5.9 34
  • 34 (a)
F28G4.1 34
  • 33 (a)
Y80D3A.5 34
  • 33 (a)
Y38C9B.1 34
  • 32 (a)
C26F1.2 34
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BAS1 32
  • 44.65 (n)
rice
(Oryza sativa)
Liliopsida Os02g0204700 32
  • 46.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
ManyToMany
-- 33
  • 43 (a)
ManyToMany
-- 33
  • 41 (a)
ManyToMany
CSA.6060 33
  • 39 (a)
ManyToMany
-- 33
  • 39 (a)
ManyToMany
-- 33
  • 39 (a)
ManyToMany
CSA.3998 33
  • 39 (a)
ManyToMany
CSA.8060 33
  • 39 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 35 (a)
ManyToMany
-- 33
  • 33 (a)
ManyToMany
-- 33
  • 33 (a)
ManyToMany
Species where no ortholog for CYP4F12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F12 Gene

ENSEMBL:
Gene Tree for CYP4F12 (if available)
TreeFam:
Gene Tree for CYP4F12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4F12: view image

Paralogs for CYP4F12 Gene

(18) SIMAP similar genes for CYP4F12 Gene using alignment to 6 proteins:

  • CP4FC_HUMAN
  • E7ET51_HUMAN
  • F8VR75_HUMAN
  • F8VU50_HUMAN
  • F8VZP1_HUMAN
  • Q8IV39_HUMAN

Pseudogenes.org Pseudogenes for CYP4F12 Gene

genes like me logo Genes that share paralogs with CYP4F12: view

Variants for CYP4F12 Gene

Sequence variations from dbSNP and Humsavar for CYP4F12 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000017416 -- 15,689,651(+) T/C intron_variant
rs1000079460 -- 15,674,694(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000280461 -- 15,679,859(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000592893 -- 15,671,369(+) A/C upstream_transcript_variant
rs1000617577 -- 15,681,080(+) T/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP4F12 Gene

Variant ID Type Subtype PubMed ID
dgv137e55 CNV gain 17911159
dgv28n64 CNV gain 17921354
dgv3446n100 CNV gain 25217958
dgv3447n100 CNV gain 25217958
dgv3448n100 CNV gain 25217958
dgv3449n100 CNV gain 25217958
dgv3450n100 CNV gain 25217958
dgv3451n100 CNV gain 25217958
dgv3452n100 CNV gain 25217958
dgv3453n100 CNV gain 25217958
dgv397n27 CNV gain 19166990
dgv398n27 CNV gain 19166990
dgv506e201 CNV deletion 23290073
dgv507e201 CNV deletion 23290073
dgv508e201 CNV deletion 23290073
dgv627e199 CNV deletion 23128226
dgv6289n54 CNV gain 21841781
dgv6290n54 CNV gain 21841781
esv1029693 CNV insertion 17803354
esv1047697 CNV deletion 17803354
esv1095444 CNV deletion 17803354
esv1181428 CNV insertion 17803354
esv1195281 CNV deletion 17803354
esv1237749 CNV insertion 17803354
esv1436299 CNV deletion 17803354
esv1556855 CNV deletion 17803354
esv1718200 CNV insertion 17803354
esv2125708 CNV deletion 18987734
esv22534 CNV gain+loss 19812545
esv2421519 CNV duplication 20811451
esv2660305 CNV deletion 23128226
esv2661737 CNV deletion 23128226
esv2718235 CNV deletion 23290073
esv2718238 CNV deletion 23290073
esv2718240 CNV deletion 23290073
esv2718241 CNV deletion 23290073
esv2742342 CNV deletion 23290073
esv2758747 CNV gain+loss 17122850
esv2760506 CNV gain+loss 21179565
esv3260 OTHER inversion 18987735
esv3334671 CNV duplication 20981092
esv3556090 CNV deletion 23714750
esv3643776 CNV gain 21293372
esv6588 CNV loss 19470904
esv7528 CNV loss 19470904
nsv1064684 CNV gain 25217958
nsv1079032 OTHER inversion 25765185
nsv1113979 CNV deletion 24896259
nsv1123226 CNV deletion 24896259
nsv1133007 OTHER inversion 24896259
nsv1141884 OTHER inversion 24896259
nsv1142252 CNV tandem duplication 24896259
nsv1153107 OTHER inversion 26484159
nsv436858 CNV insertion 17901297
nsv442455 CNV gain 18776908
nsv442761 CNV gain 18776908
nsv458360 CNV gain 19166990
nsv470128 CNV gain 18288195
nsv516707 CNV gain 19592680
nsv526168 CNV gain 19592680
nsv578721 CNV gain 21841781
nsv578730 CNV gain 21841781
nsv953988 CNV deletion 24416366
nsv953989 CNV deletion 24416366
nsv954640 CNV deletion 24416366
nsv9671 CNV gain 18304495
nsv978781 CNV duplication 23825009

Variation tolerance for CYP4F12 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4F12 Gene

Human Gene Mutation Database (HGMD)
CYP4F12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4F12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F12 Gene

Disorders for CYP4F12 Gene

Additional Disease Information for CYP4F12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYP4F12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4F12 Gene

Publications for CYP4F12 Gene

  1. cDna cloning and expression of CYP4F12, a novel human cytochrome P450. (PMID: 11162607) Bylund J … Oliw EH (Biochemical and biophysical research communications 2001) 2 3 4 23 56
  2. cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. (PMID: 11162645) Hashizume T … Funae Y (Biochemical and biophysical research communications 2001) 3 4 23 56
  3. Expression and physiological function of CYP4F subfamily in human eosinophils. (PMID: 17980168) Kikuta Y … Ohkawa H (Biochimica et biophysica acta 2007) 3 23 56
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 56
  5. Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. (PMID: 16112640) Stark K … Oliw EH (Archives of biochemistry and biophysics 2005) 3 4 56

Products for CYP4F12 Gene

Sources for CYP4F12 Gene