This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 ... See more...

Aliases for CYP4F11 Gene

Aliases for CYP4F11 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 11 2 3 5
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 11 2 3
  • 3-Hydroxy Fatty Acids Omega-Hydroxylase CYP4F11 3 4
  • Cytochrome P450, Subfamily IVF, Polypeptide 11 2 3
  • Long-Chain Fatty Acid Omega-Monooxygenase 3 4
  • Phylloquinone Omega-Hydroxylase CYP4F11 3 4
  • Docosahexaenoic Acid Omega-Hydroxylase 3 4
  • Cytochrome P450 4F11 3 4
  • CYPIVF11 3 4
  • EC 1.14.14.79 4
  • EC 1.14.14.80 4
  • EC 1.14.14.78 4
  • EC 1.14.14.1 4

External Ids for CYP4F11 Gene

Previous GeneCards Identifiers for CYP4F11 Gene

  • GC19M016509
  • GC19M015726
  • GC19M015885
  • GC19M015884
  • GC19M016023
  • GC19M015594

Summaries for CYP4F11 Gene

Entrez Gene Summary for CYP4F11 Gene

  • This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4F11 Gene

CYP4F11 (Cytochrome P450 Family 4 Subfamily F Member 11) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F2.

UniProtKB/Swiss-Prot Summary for CYP4F11 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545).

Gene Wiki entry for CYP4F11 Gene

Additional gene information for CYP4F11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP4F11 Gene

Genomics for CYP4F11 Gene

GeneHancer (GH) Regulatory Elements for CYP4F11 Gene

Promoters and enhancers for CYP4F11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4F11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP4F11

Top Transcription factor binding sites by QIAGEN in the CYP4F11 gene promoter:
  • ARP-1
  • E47
  • GATA-1
  • Ik-3
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CYP4F11 Gene

Genomic Locations for CYP4F11 Gene
chr19:15,912,367-15,934,867
(GRCh38/hg38)
Size:
22,501 bases
Orientation:
Minus strand
chr19:16,023,177-16,045,677
(GRCh37/hg19)
Size:
22,501 bases
Orientation:
Minus strand

Genomic View for CYP4F11 Gene

Genes around CYP4F11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F11 Gene

Proteins for CYP4F11 Gene

  • Protein details for CYP4F11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBI6-CP4FB_HUMAN
    Recommended name:
    Cytochrome P450 4F11
    Protein Accession:
    Q9HBI6
    Secondary Accessions:
    • A0A024R7G0
    • A8K059
    • O75254
    • Q96AQ5

    Protein attributes for CYP4F11 Gene

    Size:
    524 amino acids
    Molecular mass:
    60146 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27731.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CYP4F11 Gene

Post-translational modifications for CYP4F11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F11 Gene

No data available for DME Specific Peptides for CYP4F11 Gene

Domains & Families for CYP4F11 Gene

Gene Families for CYP4F11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CYP4F11 Gene

Suggested Antigen Peptide Sequences for CYP4F11 Gene

GenScript: Design optimal peptide antigens:
  • CYPIVF11 (CP4FB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBI6

UniProtKB/Swiss-Prot:

CP4FB_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F11: view

Function for CYP4F11 Gene

Molecular function for CYP4F11 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269 PubMed:15364545, ECO:0000269 PubMed:18065749, ECO:0000269 PubMed:19932081, ECO:0000269 PubMed:24138531}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence={ECO:0000305 PubMed:15364545, ECO:0000305 PubMed:18065749, ECO:0000305 PubMed:24138531};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56748, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:140991, ChEBI:CHEBI:140992; EC=1.14.14.80; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56749; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38948; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40199, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:55329, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.80; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40200; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:41728, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30823, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78424; EC=1.14.14.80; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41729; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39755, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39756; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40155, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77015, ChEBI:CHEBI:77016; EC=1.14.14.79; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40156; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:48660, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:90716, ChEBI:CHEBI:90717; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48661; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39731, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63904, ChEBI:CHEBI:76613; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39732; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39735, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76614, ChEBI:CHEBI:76615; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39736; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:41516, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18067, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78276; EC=1.14.14.78; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41517; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:41520, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78277, ChEBI:CHEBI:78278; EC=1.14.14.78; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41521; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=47 uM for hexadecanoic acid {ECO:0000269 PubMed:19932081}; KM=85 uM for (9Z)-octadecenoic acid (oleate) {ECO:0000269 PubMed:19932081}; KM=80 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid {ECO:0000269 PubMed:19932081}; KM=48 uM for (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid {ECO:0000269 PubMed:19932081}; KM=74 uM for 3-hydroxyhexadecanoic acid {ECO:0000269 PubMed:19932081}; KM=105.8 uM for 3-hydroxyhexadecanoic acid {ECO:0000269 PubMed:18065749}; KM=53.5 uM for 3-hydroxyoctadecanoic acid {ECO:0000269 PubMed:18065749}; KM=2.4 uM for menaquinone-4 (MK-4) {ECO:0000269 PubMed:24138531}; KM=125 uM for erythromycin {ECO:0000269 PubMed:15364545}; Vmax=830 pmol/min/ng enzyme with erythromycin as substrate {ECO:0000269 PubMed:15364545}; Note=kcat is 0.088 min(-1) with menaquinone-4 (MK-4) as substrate (PubMed:24138531). kcat is 1.8 min(-1) with hexadecanoic acid as substrate. kcat is 1.0 min(-1) with (9Z)- octadecenoic acid as substrate. kcat is 0.54 min(-1) with (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) as substrate. kcat is 0.35 min(-1) with (4Z,7Z,10Z,13Z,16Z,19Z)- docosahexaenoic acid as substrate. kcat is 27.5 min(-1) with 3- hydroxyhexadecanoic acid as substrate (PubMed:19932081). {ECO:0000269 PubMed:19932081, ECO:0000269 PubMed:24138531};

Enzyme Numbers (IUBMB) for CYP4F11 Gene

Phenotypes From GWAS Catalog for CYP4F11 Gene

Gene Ontology (GO) - Molecular Function for CYP4F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005504 fatty acid binding IDA 18065749
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA 18065749
genes like me logo Genes that share ontologies with CYP4F11: view
genes like me logo Genes that share phenotypes with CYP4F11: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4F11 Gene

Localization for CYP4F11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F11 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4F11 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
cytoskeleton 1
nucleus 1
cytosol 1
golgi apparatus 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CYP4F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP4F11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4F11 Gene

Pathways & Interactions for CYP4F11 Gene

genes like me logo Genes that share pathways with CYP4F11: view

Pathways by source for CYP4F11 Gene

UniProtKB/Swiss-Prot Q9HBI6-CP4FB_HUMAN

  • Pathway: Lipid metabolism; arachidonate metabolism.
  • Pathway: Lipid metabolism; oxylipin biosynthesis.
  • Pathway: Cofactor degradation; phylloquinone degradation.
  • Pathway: Xenobiotic degradation.

Interacting Proteins for CYP4F11 Gene

;

Gene Ontology (GO) - Biological Process for CYP4F11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IDA 18065749
GO:0006954 inflammatory response TAS 10964514
GO:0007596 blood coagulation TAS 24138531
GO:0019369 arachidonic acid metabolic process IEA --
genes like me logo Genes that share ontologies with CYP4F11: view

No data available for SIGNOR curated interactions for CYP4F11 Gene

Drugs & Compounds for CYP4F11 Gene

(7) Drugs for CYP4F11 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Warfarin Approved Pharma 593
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
arachidonic acid Experimental Pharma Activator, Inhibitor, Agonist, Activation, Potentiation 39
NADP Experimental Pharma 0

(4) Additional Compounds for CYP4F11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • 20-Hydroxy arachidonic acid
  • 20-Hydroxyarachidonic acid
  • 20-Hydroxyicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
79551-86-3
20-Hydroxy-leukotriene B4
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate
  • 20-Hydroxy-LTB4
  • 20-OH-Leukotriene b4
  • 20-OH-LTB4
79516-82-8
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with CYP4F11: view

Transcripts for CYP4F11 Gene

mRNA/cDNA for CYP4F11 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F11 Gene

No ASD Table

Relevant External Links for CYP4F11 Gene

GeneLoc Exon Structure for
CYP4F11

Expression for CYP4F11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP4F11 Gene

mRNA differential expression in normal tissues according to GTEx for CYP4F11 Gene

This gene is overexpressed in Liver (x20.6).

Protein differential expression in normal tissues from HIPED for CYP4F11 Gene

This gene is overexpressed in Liver (33.6), Gallbladder (14.5), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP4F11 Gene



Protein tissue co-expression partners for CYP4F11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP4F11

SOURCE GeneReport for Unigene cluster for CYP4F11 Gene:

Hs.187393

mRNA Expression by UniProt/SwissProt for CYP4F11 Gene:

Q9HBI6-CP4FB_HUMAN
Tissue specificity: Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.

Evidence on tissue expression from TISSUES for CYP4F11 Gene

  • Liver(4.7)
  • Intestine(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CYP4F11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4F11 Gene

Orthologs for CYP4F11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4F11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4F11 31 30
  • 98.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 81 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
-- 31
  • 80 (a)
ManyToMany
CYP4F2 31
  • 79 (a)
ManyToMany
-- 31
  • 79 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp4f40 30
  • 79.99 (n)
mouse
(Mus musculus)
Mammalia Cyp4f40 17 30
  • 78.82 (n)
Cyp4f15 31
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 64 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 70 (a)
OneToMany
CYP4F22 30
  • 66.45 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 64 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 31
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp4d2 32
  • 38 (a)
Cyp4c3 32
  • 37 (a)
Cyp4d14 32
  • 37 (a)
Cyp4d8 32
  • 36 (a)
Cyp4p3 32
  • 35 (a)
Cyp4g15 32
  • 35 (a)
Cyp4ac3 32
  • 34 (a)
Cyp4d20 32
  • 34 (a)
Cyp4d1 32
  • 34 (a)
Cyp312a1 32
  • 34 (a)
Cyp4s3 32
  • 34 (a)
Cyp4ae1 32
  • 33 (a)
Cyp4p1 32
  • 33 (a)
Cyp4e2 32
  • 32 (a)
Cyp4ac1 32
  • 32 (a)
Cyp4e3 32
  • 32 (a)
Cyp4e1 32
  • 32 (a)
Cyp4p2 32
  • 32 (a)
Cyp311a1 32
  • 31 (a)
Cyp4d21 32
  • 31 (a)
Cyp4ac2 32
  • 31 (a)
Cyp4ad1 32
  • 31 (a)
Cyp4aa1 32
  • 29 (a)
Cyp313a4 32
  • 28 (a)
Cyp4g1 32
  • 27 (a)
Cyp313b1 32
  • 26 (a)
Cyp313a2 32
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea Y5H2B.5 32
  • 37 (a)
Y17G9B.3 32
  • 36 (a)
B0331.1 32
  • 35 (a)
F01D5.9 32
  • 34 (a)
F28G4.1 32
  • 34 (a)
C26F1.2 32
  • 33 (a)
Y38C9B.1 32
  • 32 (a)
Y80D3A.5 32
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
CSA.3998 31
  • 41 (a)
ManyToMany
CSA.8060 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
CSA.6060 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Species where no ortholog for CYP4F11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F11 Gene

ENSEMBL:
Gene Tree for CYP4F11 (if available)
TreeFam:
Gene Tree for CYP4F11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4F11: view image

Paralogs for CYP4F11 Gene

(17) SIMAP similar genes for CYP4F11 Gene using alignment to 3 proteins:

  • CP4FB_HUMAN
  • F8W978_HUMAN
  • V9GYP6_HUMAN

Pseudogenes.org Pseudogenes for CYP4F11 Gene

genes like me logo Genes that share paralogs with CYP4F11: view

Variants for CYP4F11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP4F11 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1060463 - p.Asp446Asn
rs57519667 - p.Arg146Cys
rs8104361 - p.Cys276Arg

Additional dbSNP identifiers (rs#s) for CYP4F11 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP4F11 Gene

Variant ID Type Subtype PubMed ID
dgv6291n54 CNV loss 21841781
esv1040025 CNV insertion 17803354
esv1311910 CNV deletion 17803354
esv21733 CNV gain+loss 19812545
esv2661548 CNV deletion 23128226
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv2718253 CNV deletion 23290073
esv3334671 CNV duplication 20981092
esv3643782 CNV loss 21293372
nsv1064684 CNV gain 25217958
nsv1151895 CNV duplication 26484159
nsv578731 CNV loss 21841781
nsv821195 CNV deletion 20802225
nsv833766 CNV loss 17160897
nsv960801 CNV duplication 23825009

Variation tolerance for CYP4F11 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4F11 Gene

Human Gene Mutation Database (HGMD)
CYP4F11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4F11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F11 Gene

Disorders for CYP4F11 Gene

Additional Disease Information for CYP4F11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYP4F11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP4F11 Gene

Publications for CYP4F11 Gene

  1. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. (PMID: 10964514) Cui X … Strobel HW (Genomics 2000) 2 3 4 23 54
  2. Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11. (PMID: 24138531) Edson KZ … Rettie AE (Biochemistry 2013) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 41 54
  5. Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. (PMID: 19932081) Tang Z … Guengerich FP (Archives of biochemistry and biophysics 2010) 4 23 54

Products for CYP4F11 Gene

Sources for CYP4F11 Gene