This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encodi... See more...

Aliases for CYP4A22 Gene

Aliases for CYP4A22 Gene

  • Cytochrome P450 Family 4 Subfamily A Member 22 2 3 5
  • Cytochrome P450, Family 4, Subfamily A, Polypeptide 22 2 3
  • Long-Chain Fatty Acid Omega-Monooxygenase 3 4
  • Lauric Acid Omega-Hydroxylase 3 4
  • Fatty Acid Omega-Hydroxylase 3 4
  • Cytochrome P450 4A22 3 4
  • CYPIVA22 3 4
  • Cytochrome P450 4A22K 3
  • EC 1.14.14.80 4
  • CYP4A22 5

External Ids for CYP4A22 Gene

Previous GeneCards Identifiers for CYP4A22 Gene

  • GC00U916975
  • GC01P047314
  • GC01P047376
  • GC01P047603
  • GC01P045719

Summaries for CYP4A22 Gene

Entrez Gene Summary for CYP4A22 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for CYP4A22 Gene

CYP4A22 (Cytochrome P450 Family 4 Subfamily A Member 22) is a Protein Coding gene. Diseases associated with CYP4A22 include Gliosarcoma and Hypertension, Essential. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4A11.

UniProtKB/Swiss-Prot Summary for CYP4A22 Gene

  • Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.

Gene Wiki entry for CYP4A22 Gene

Additional gene information for CYP4A22 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP4A22 Gene

Genomics for CYP4A22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP4A22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J047137 Promoter 0.6 EPDnew 600.7 +0.0 15 0.1 SP1 HNF4A RXRA CYP4A22 piR-47896-002 CYP4A22-AS1 PDZK1IP1
GH01J047024 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 -113.4 -113424 1.6 PRDM10 ZNF629 ZNF692 ZNF174 PRDM1 ZIC2 POLR2A PATZ1 ZNF501 EZH2 CYP4X1 NSUN4 TEX38 LRRC41 CYP4A22 CYP4Z1 piR-47211-015 MN309174-005
GH01J047178 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.6 +43.4 43437 4.5 BRCA1 ARHGAP35 CREB1 GATAD2A CTCF PRDM10 ZNF629 REST ZNF512 LEF1 CYP4A22-AS1 lnc-PDZK1IP1-6 LRRC41 PDZK1IP1 EFCAB14-AS1 TAL1 STIL ENSG00000226252 MOB3C CYP4B1
GH01J047175 Enhancer 1 Ensembl ENCODE 10.4 +37.9 37851 1.1 CTCF IKZF1 ZNF692 PRDM1 MTA2 ZNF143 PKNOX1 ZNF24 PATZ1 REST LOC105378701 CYP4A22 CYP4A22-AS1 piR-40110-025 lnc-PDZK1IP1-6 PDZK1IP1
GH01J046798 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 9.4 -336.7 -336726 3.4 ZNF512 ZKSCAN1 SMAD4 CYP4B1 CYP4A22 CYP4A11 FAAH CYP4X1 piR-59769-007 piR-39858-015
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4A22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP4A22

Top Transcription factor binding sites by QIAGEN in the CYP4A22 gene promoter:
  • AML1a
  • ATF6
  • GR
  • GR-alpha
  • HTF
  • LCR-F1
  • MRF-2
  • SEF-1 (1)

Genomic Locations for CYP4A22 Gene

Genomic Locations for CYP4A22 Gene
chr1:47,137,425-47,149,738
(GRCh38/hg38)
Size:
12,314 bases
Orientation:
Plus strand
chr1:47,603,107-47,615,413
(GRCh37/hg19)
Size:
12,307 bases
Orientation:
Plus strand

Genomic View for CYP4A22 Gene

Genes around CYP4A22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4A22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4A22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4A22 Gene

Proteins for CYP4A22 Gene

  • Protein details for CYP4A22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCH4-CP4AM_HUMAN
    Recommended name:
    Cytochrome P450 4A22
    Protein Accession:
    Q5TCH4
    Secondary Accessions:
    • Q5TCH3
    • Q6JXK7
    • Q6JXK8
    • Q9NRM4

    Protein attributes for CYP4A22 Gene

    Size:
    519 amino acids
    Molecular mass:
    59246 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4A22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4A22 Gene

Post-translational modifications for CYP4A22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP4A22 Gene

Domains & Families for CYP4A22 Gene

Gene Families for CYP4A22 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CYP4A22 Gene

Suggested Antigen Peptide Sequences for CYP4A22 Gene

GenScript: Design optimal peptide antigens:
  • CYP4A22 protein (A5PKT5_HUMAN)
  • CYP4A22 protein (A5PL05_HUMAN)
  • Lauric acid omega-hydroxylase (CP4AM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5TCH4

UniProtKB/Swiss-Prot:

CP4AM_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4A22: view

Function for CYP4A22 Gene

Molecular function for CYP4A22 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56748, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:140991, ChEBI:CHEBI:140992; EC=1.14.14.80; Evidence={ECO:0000269|PubMed:10860550};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=56.7 uM for laurate {ECO:0000269|PubMed:10860550}; Note=Vmax:15.2 umol/min/umol enzyme.;

Enzyme Numbers (IUBMB) for CYP4A22 Gene

Phenotypes From GWAS Catalog for CYP4A22 Gene

Gene Ontology (GO) - Molecular Function for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0008391 arachidonic acid monooxygenase activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP4A22: view
genes like me logo Genes that share phenotypes with CYP4A22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4A22

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP4A22 Gene

Localization for CYP4A22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4A22 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4A22 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
mitochondrion 2
peroxisome 2
nucleus 2
golgi apparatus 2
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16806293
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4A22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4A22 Gene

Pathways & Interactions for CYP4A22 Gene

genes like me logo Genes that share pathways with CYP4A22: view

Gene Ontology (GO) - Biological Process for CYP4A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IBA 21873635
GO:0002933 lipid hydroxylation IDA 10860550
GO:0019369 arachidonic acid metabolic process IBA 21873635
GO:0043651 linoleic acid metabolic process IBA 21873635
GO:0046456 icosanoid biosynthetic process IBA 21873635
genes like me logo Genes that share ontologies with CYP4A22: view

No data available for SIGNOR curated interactions for CYP4A22 Gene

Drugs & Compounds for CYP4A22 Gene

(11) Drugs for CYP4A22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycolic acid Approved, Investigational Pharma 31
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
NADH Approved Nutra 0
Tretinoin Approved, Investigational Nutra Agonist, Full agonist, Antagonist 273

(5) Additional Compounds for CYP4A22 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
18-Hydroxyretinoic acid
  • 18-Hydroxy-all-trans-retinoate
  • 18-Hydroxy-all-trans-retinoic acid
  • rac-18-Hydroxy-all-trans-retinoate
  • rac-18-Hydroxy-all-trans-retinoic acid
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • 20-Hydroxy arachidonic acid
  • 20-Hydroxyarachidonic acid
  • 20-Hydroxyicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
79551-86-3
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
Octane
  • CH3-[CH2]6-CH3
  • N-Octane
  • N-Oktan
  • Oktan
111-65-9
genes like me logo Genes that share compounds with CYP4A22: view

Transcripts for CYP4A22 Gene

mRNA/cDNA for CYP4A22 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4A22

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4A22 Gene

No ASD Table

Relevant External Links for CYP4A22 Gene

GeneLoc Exon Structure for
CYP4A22

Expression for CYP4A22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP4A22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lung (Respiratory System)
  • Kidney (Urinary System)
  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for CYP4A22 Gene

This gene is overexpressed in Liver (x43.8) and Kidney - Cortex (x7.1).

Protein differential expression in normal tissues from HIPED for CYP4A22 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP4A22 Gene



Protein tissue co-expression partners for CYP4A22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP4A22

Evidence on tissue expression from TISSUES for CYP4A22 Gene

  • Liver(4.7)
  • Kidney(4.6)
genes like me logo Genes that share expression patterns with CYP4A22: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4A22 Gene

Orthologs for CYP4A22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP4A22 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC456835 30
  • 99.23 (n)
CYP4A22 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CYP4A38 30 31
  • 82.65 (n)
ManyToMany
CYP4A37 31
  • 77 (a)
ManyToMany
CYP4A39 31
  • 76 (a)
ManyToMany
-- 31
  • 73 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia CYP4A22 30 31
  • 80.79 (n)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Cyp4a8 30
  • 79.82 (n)
Mouse
(Mus musculus)
Mammalia Cyp4a12b 30 17
  • 79.62 (n)
Cyp4a12a 17 31
  • 75 (a)
ManyToMany
Cyp4a32 31
  • 74 (a)
ManyToMany
Cyp4a31 31
  • 73 (a)
ManyToMany
Cyp4a14 31
  • 70 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 55 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CYP4B1 30
  • 61.93 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYP715A1 30
  • 44.14 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0824100 30
  • 43.96 (n)
Species where no ortholog for CYP4A22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CYP4A22 Gene

ENSEMBL:
Gene Tree for CYP4A22 (if available)
TreeFam:
Gene Tree for CYP4A22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4A22: view image

Paralogs for CYP4A22 Gene

(14) SIMAP similar genes for CYP4A22 Gene using alignment to 4 proteins:

  • CP4AM_HUMAN
  • A5PKT5_HUMAN
  • A5PL05_HUMAN
  • Q5TCH5_HUMAN
genes like me logo Genes that share paralogs with CYP4A22: view

Variants for CYP4A22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP4A22 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs10789501 - p.Cys231Arg
rs12564525 - p.Arg126Trp
rs2056899 - p.Asn152Tyr
rs2056900 - p.Gly130Ser
rs2405599 - p.Leu428Pro

Additional dbSNP identifiers (rs#s) for CYP4A22 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP4A22 Gene

Variant ID Type Subtype PubMed ID
esv2763300 CNV gain 21179565
nsv1077760 OTHER inversion 25765185
nsv945929 CNV duplication 23825009

Variation tolerance for CYP4A22 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.98; 99.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4A22 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP4A22
Human Gene Mutation Database (HGMD)
CYP4A22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4A22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4A22 Gene

Disorders for CYP4A22 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP4A22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CYP4A22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4A22 Gene

Publications for CYP4A22 Gene

  1. Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site. (PMID: 20079672) Gajendrarao P … Lee KW (Journal of molecular graphics & modelling 2010) 3 23
  2. Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population. (PMID: 16806293) Hiratsuka M … Mizugaki M (Mutation research 2006) 3 4
  3. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PMID: 15611369) Gainer JV … Capdevila JH (Circulation 2005) 3 4
  4. Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. (PMID: 10860550) Kawashima H … Kishimoto T (Archives of biochemistry and biophysics 2000) 3 4
  5. Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22. (PMID: 31199497) Durairaj P … Bureik M (FEBS letters 2019) 3

Products for CYP4A22 Gene

Sources for CYP4A22 Gene