Aliases for CYP4A22 Gene
External Ids for CYP4A22 Gene
Previous GeneCards Identifiers for CYP4A22 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
GeneCards Summary for CYP4A22 Gene
CYP4A22 (Cytochrome P450 Family 4 Subfamily A Member 22) is a Protein Coding gene. Diseases associated with CYP4A22 include Hypertension, Essential and Gliosarcoma. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4A11.
UniProtKB/Swiss-Prot Summary for CYP4A22 Gene
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.