This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcrip... See more...

Aliases for CYP4A11 Gene

Aliases for CYP4A11 Gene

  • Cytochrome P450 Family 4 Subfamily A Member 11 2 3 5
  • CYP4AII 2 3 4
  • Cytochrome P450, Family 4, Subfamily A, Polypeptide 11 2 3
  • Cytochrome P450, Subfamily IVA, Polypeptide 11 2 3
  • Long-Chain Fatty Acid Omega-Monooxygenase 3 4
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Lauric Acid Omega-Hydroxylase 3 4
  • Fatty Acid Omega-Hydroxylase 3 4
  • Cytochrome P-450HK-Omega 3 4
  • Cytochrome P450HL-Omega 3 4
  • Cytochrome P450 4A11 3 4
  • 20-HETE Synthase 3 4
  • CYPIVA11 3 4
  • CYP4A2 3 4
  • Alkane-1 Monooxygenase 3
  • EC 1.14.14.80 4
  • P450HL-Omega 3
  • EC 1.14.14.1 4
  • CYP4A11 5
  • CP4Y 3

External Ids for CYP4A11 Gene

Previous HGNC Symbols for CYP4A11 Gene

  • CYP4A2

Previous GeneCards Identifiers for CYP4A11 Gene

  • GC01M047088
  • GC01M046351
  • GC01M046696
  • GC01M046764
  • GC01M047106
  • GC01M047167
  • GC01M047394
  • GC01M045510

Summaries for CYP4A11 Gene

Entrez Gene Summary for CYP4A11 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP4A11 Gene

CYP4A11 (Cytochrome P450 Family 4 Subfamily A Member 11) is a Protein Coding gene. Diseases associated with CYP4A11 include Hypertensive Nephropathy and Hypertension, Essential. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4A22.

UniProtKB/Swiss-Prot Summary for CYP4A11 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927).

Gene Wiki entry for CYP4A11 Gene

Additional gene information for CYP4A11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP4A11 Gene

Genomics for CYP4A11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP4A11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046939 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 616.1 +0.1 124 2.9 GATAD2A RXRB SP1 CEBPA FOXA2 YY1 ZBTB33 JUND FOXP1 RAD21 CYP4A11 CYP4B1 piR-47896-001
GH01J046798 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 5.7 +140.8 140785 3.4 ZNF512 ZKSCAN1 SMAD4 CYP4B1 CYP4A22 CYP4A11 FAAH CYP4X1 piR-59769-007 piR-39858-015
GH01J046804 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.7 +135.4 135443 4.4 CREB1 PRDM10 SP1 REST CEBPB PKNOX1 NR2F2 GATA3 MAX HLF CYP4B1 CYP4A11 CYP4X1 piR-39858-015 piR-59769-007
GH01J047577 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 4 -637.1 -637081 2.5 CREB1 KDM1A ZIC2 PATZ1 ZBTB20 SP2 NR2F2 WT1 ZFHX2 BCOR HSALNG0003419 CYP4A11 RF00998-005 FOXD2 TRABD2B
GH01J046954 Enhancer 0.2 ENCODE 15.4 -13.5 -13501 1.7 CYP4A11 CYP4B1 lnc-CYP4A11-1 CYP4X1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP4A11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP4A11

Top Transcription factor binding sites by QIAGEN in the CYP4A11 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • GR
  • GR-alpha
  • LCR-F1
  • MRF-2

Genomic Locations for CYP4A11 Gene

Genomic Locations for CYP4A11 Gene
chr1:46,929,177-46,941,484
(GRCh38/hg38)
Size:
12,308 bases
Orientation:
Minus strand
chr1:47,394,846-47,407,156
(GRCh37/hg19)
Size:
12,311 bases
Orientation:
Minus strand

Genomic View for CYP4A11 Gene

Genes around CYP4A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4A11 Gene

Proteins for CYP4A11 Gene

  • Protein details for CYP4A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02928-CP4AB_HUMAN
    Recommended name:
    Cytochrome P450 4A11
    Protein Accession:
    Q02928
    Secondary Accessions:
    • Q06766
    • Q16865
    • Q16866
    • Q5VSP8
    • Q86SU6
    • Q8IWY5

    Protein attributes for CYP4A11 Gene

    Size:
    519 amino acids
    Molecular mass:
    59348 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4A11 Gene

Post-translational modifications for CYP4A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP4A11 Gene

Domains & Families for CYP4A11 Gene

Gene Families for CYP4A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CYP4A11 Gene

InterPro:
Blocks:
  • Group II E-class P450 signature
ProtoNet:

Suggested Antigen Peptide Sequences for CYP4A11 Gene

GenScript: Design optimal peptide antigens:
  • Lauric acid omega-hydroxylase (CP4AB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02928

UniProtKB/Swiss-Prot:

CP4AB_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4A11: view

Function for CYP4A11 Gene

Molecular function for CYP4A11 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927, ECO:0000269|PubMed:8914854};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56748, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:140991, ChEBI:CHEBI:140992; EC=1.14.14.80; Evidence={ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38947, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:36204, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:8914854};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40203, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30807, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77033; Evidence={ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:1739747};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:40199, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:55329, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.80; Evidence={ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:1739747};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:41728, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30823, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78424; EC=1.14.14.80; Evidence={ECO:0000269|PubMed:10553002};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39755, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76624; Evidence={ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:15611369};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39055, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76298, ChEBI:CHEBI:76304; Evidence={ECO:0000269|PubMed:18182499};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39043, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76298, ChEBI:CHEBI:76299; Evidence={ECO:0000269|PubMed:18182499};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53556, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137459, ChEBI:CHEBI:137460; Evidence={ECO:0000269|PubMed:15145985};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39731, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63904, ChEBI:CHEBI:76613; Evidence={ECO:0000269|PubMed:18065749};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11 uM for dodecanoic acid {ECO:0000269|PubMed:15611369}; KM=37 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoic acid {ECO:0000269|PubMed:15611369}; Note=kcat is 42 min(-1) with dodecanoic acid as substrate. kcat is 50 min(-1) with tetradecanoic acid as substrate. kcat is 10 min(-1) with hexadecanoic acid as substrate. kcat is 0.4 min(-1) with (9Z)-octadecenoic acid as substrate. kcat is 0.4 min(-1) with (5Z,8Z,11Z,14Z)-eicosatetraenoic acid as substrate. {ECO:0000269|PubMed:10620324};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cytochrome b5.
GENATLAS Biochemistry:
cytochrome p450,subfamily IVA,polypeptide 11

Enzyme Numbers (IUBMB) for CYP4A11 Gene

Phenotypes From GWAS Catalog for CYP4A11 Gene

Gene Ontology (GO) - Molecular Function for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0008391 arachidonic acid monooxygenase activity IBA 21873635
GO:0008392 arachidonic acid epoxygenase activity IDA 9618440
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CYP4A11: view
genes like me logo Genes that share phenotypes with CYP4A11: view

Animal Models for CYP4A11 Gene

MGI Knock Outs for CYP4A11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4A11

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP4A11 Gene

Localization for CYP4A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4A11 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP4A11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
golgi apparatus 2
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10660572
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP4A11 Gene

Pathways & Interactions for CYP4A11 Gene

genes like me logo Genes that share pathways with CYP4A11: view

UniProtKB/Swiss-Prot Q02928-CP4AB_HUMAN

  • Pathway: Lipid metabolism; arachidonate metabolism.
  • Pathway: Lipid metabolism; oxylipin biosynthesis.

Gene Ontology (GO) - Biological Process for CYP4A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IDA 18433732
GO:0001822 kidney development IBA 21873635
GO:0003091 renal water homeostasis IEP 10660572
GO:0003095 pressure natriuresis IEP 10660572
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with CYP4A11: view

No data available for SIGNOR curated interactions for CYP4A11 Gene

Drugs & Compounds for CYP4A11 Gene

(30) Drugs for CYP4A11 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Enzyme, inducer Anti-inflammatory glucocorticoid 2886
Ethanol Approved Pharma Enzyme, inducer 3266
Cisplatin Approved Pharma Enzyme, inducer Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3412
Clofibrate Approved, Investigational Pharma Agonist, Enzyme, substrate, inducer 2
Pentamidine Approved, Investigational Pharma Enzyme, substrate 45

(9) Additional Compounds for CYP4A11 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • 20-Hydroxy arachidonic acid
  • 20-Hydroxyarachidonic acid
  • 20-Hydroxyicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
79551-86-3
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
18-Hydroxyretinoic acid
  • 18-Hydroxy-all-trans-retinoate
  • 18-Hydroxy-all-trans-retinoic acid
  • rac-18-Hydroxy-all-trans-retinoate
  • rac-18-Hydroxy-all-trans-retinoic acid
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
Hydroxylansoprazole
  • 5-Hydroxy lansoprazole
genes like me logo Genes that share compounds with CYP4A11: view

Transcripts for CYP4A11 Gene

mRNA/cDNA for CYP4A11 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP4A11

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4A11 Gene

No ASD Table

Relevant External Links for CYP4A11 Gene

GeneLoc Exon Structure for
CYP4A11

Expression for CYP4A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP4A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4A11 Gene

This gene is overexpressed in Liver (x35.1) and Kidney - Cortex (x17.2).

Protein differential expression in normal tissues from HIPED for CYP4A11 Gene

This gene is overexpressed in Gallbladder (41.9), Liver (14.7), Kidney (6.2), and Fetal Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP4A11 Gene



Protein tissue co-expression partners for CYP4A11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP4A11

SOURCE GeneReport for Unigene cluster for CYP4A11 Gene:

Hs.1645

mRNA Expression by UniProt/SwissProt for CYP4A11 Gene:

Q02928-CP4AB_HUMAN
Tissue specificity: Expressed in liver (PubMed:7679927). Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:7679927, PubMed:10660572).

Evidence on tissue expression from TISSUES for CYP4A11 Gene

  • Liver(4.8)
  • Kidney(4.8)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with CYP4A11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP4A11 Gene

Orthologs for CYP4A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4A11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC739864 30
  • 99.05 (n)
CYP4A11 31
  • 99 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cyp4a1 30
  • 79.4 (n)
Mouse
(Mus musculus)
Mammalia Cyp4a10 30 17 31
  • 79.27 (n)
ManyToMany
Cyp4a31 17
Cyp4a32 17
Dog
(Canis familiaris)
Mammalia CYP4A37 31
  • 79 (a)
ManyToMany
CYP4A38 31
  • 78 (a)
ManyToMany
CYP4A39 31
  • 78 (a)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 77 (a)
ManyToMany
-- 31
  • 77 (a)
ManyToMany
CYP4A22 31
  • 76 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 57 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia cypxl301-A-prov 30
Zebrafish
(Danio rerio)
Actinopterygii -- 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11716 30
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp4g15 32
  • 39 (a)
Cyp4s3 32
  • 37 (a)
Cyp4d2 32
  • 36 (a)
Cyp4d14 32
  • 34 (a)
Cyp4c3 32
  • 33 (a)
Cyp4d1 32
  • 33 (a)
Cyp4d20 32
  • 33 (a)
Cyp311a1 32
  • 32 (a)
Cyp4d8 32
  • 32 (a)
Cyp4e2 32
  • 32 (a)
Cyp4e3 32
  • 32 (a)
Cyp4ad1 32
  • 31 (a)
Cyp4d21 32
  • 31 (a)
Cyp4ac1 32
  • 30 (a)
Cyp4p3 32
  • 30 (a)
Cyp312a1 32
  • 29 (a)
Cyp4ac2 32
  • 29 (a)
Cyp4e1 32
  • 29 (a)
Cyp4p1 32
  • 29 (a)
Cyp4ae1 32
  • 28 (a)
Cyp4p2 32
  • 28 (a)
Cyp4g1 32
  • 27 (a)
Cyp313b1 32
  • 24 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y80D3A.5 32
  • 35 (a)
F01D5.9 32
  • 34 (a)
Y38C9B.1 32
  • 34 (a)
Y17G9B.3 32
  • 33 (a)
B0331.1 32
  • 31 (a)
F28G4.1 32
  • 30 (a)
Species where no ortholog for CYP4A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CYP4A11 Gene

ENSEMBL:
Gene Tree for CYP4A11 (if available)
TreeFam:
Gene Tree for CYP4A11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP4A11: view image

Paralogs for CYP4A11 Gene

(21) SIMAP similar genes for CYP4A11 Gene using alignment to 8 proteins:

  • CP4AB_HUMAN
  • E7EU77_HUMAN
  • E7EVL8_HUMAN
  • V9GY41_HUMAN
  • V9GYC6_HUMAN
  • V9GYK4_HUMAN
  • V9GYQ2_HUMAN
  • V9GZ77_HUMAN

Pseudogenes.org Pseudogenes for CYP4A11 Gene

genes like me logo Genes that share paralogs with CYP4A11: view

Variants for CYP4A11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4A11 Gene

CP4AB_HUMAN-Q02928
CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP4A11 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
727575 Benign: not provided 46,937,987(-) C/T INTRON_VARIANT
774797 Benign: not provided 46,930,214(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1126742 - p.Phe434Ser
rs12759923 - p.Asn226Ser
rs3899049 - p.Ser353Gly

Additional dbSNP identifiers (rs#s) for CYP4A11 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP4A11 Gene

Variant ID Type Subtype PubMed ID
esv2763300 CNV gain 21179565
esv3585938 CNV gain 21293372
esv3585943 CNV gain 21293372
esv3585944 CNV loss 21293372
esv3585945 CNV gain 21293372
nsv1009338 CNV gain 25217958
nsv1077760 OTHER inversion 25765185
nsv945928 CNV duplication 23825009
nsv950708 CNV deletion 24416366

Variation tolerance for CYP4A11 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP4A11 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP4A11
Human Gene Mutation Database (HGMD)
CYP4A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP4A11

Disorders for CYP4A11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYP4A11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertensive nephropathy
  • hnp1
hypertension, essential
  • eht
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP4A11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYP4A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4A11 Gene

Publications for CYP4A11 Gene

  1. Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. (PMID: 7679927) Palmer CN … Johnson EF (Biochimica et biophysica acta 1993) 2 3 4 23
  2. A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men. (PMID: 18300855) Fu Z … Ma Y (Journal of hypertension 2008) 3 23 41
  3. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. (PMID: 18391101) Ward NC … Croft KD (Hypertension (Dallas, Tex. : 1979) 2008) 3 23 41
  4. Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction. (PMID: 16957555) Mayer B … Schunkert H (Journal of hypertension 2006) 3 23 41
  5. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (PMID: 15611369) Gainer JV … Capdevila JH (Circulation 2005) 3 4 41

Products for CYP4A11 Gene

  • Signalway Proteins for CYP4A11

Sources for CYP4A11 Gene