This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochro... See more...

Aliases for CYP3A5 Gene

Aliases for CYP3A5 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 5 2 3 5
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 2 3
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 2 3
  • Cytochrome P450-PCN3 3 4
  • Cytochrome P450 3A5 3 4
  • EC 1.14.14.1 4 50
  • CYPIIIA5 3 4
  • P450PCN3 2 3
  • CP35 2 3
  • PCN3 2 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 HLp2 3
  • CYP3A5 5

External Ids for CYP3A5 Gene

Previous GeneCards Identifiers for CYP3A5 Gene

  • GC07M097780
  • GC07M098843
  • GC07M098857
  • GC07M098891
  • GC07M099083
  • GC07M099246
  • GC07M093882

Summaries for CYP3A5 Gene

Entrez Gene Summary for CYP3A5 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP3A5 Gene

CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Multiple Chemical Sensitivity. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP3A4.

UniProtKB/Swiss-Prot Summary for CYP3A5 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228).

Gene Wiki entry for CYP3A5 Gene

PharmGKB "VIP" Summary for CYP3A5 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP3A5 Gene

Genomics for CYP3A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP3A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP3A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP3A5

Top Transcription factor binding sites by QIAGEN in the CYP3A5 gene promoter:
  • ATF-2
  • C/EBPbeta
  • Ik-1
  • Ik-2
  • Ik-3
  • POU2F1
  • POU2F1a
  • POU3F1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CYP3A5 Gene

Latest Assembly
chr7:99,648,194-99,679,998
(GRCh38/hg38)
Size:
31,805 bases
Orientation:
Minus strand

Previous Assembly
chr7:99,245,817-99,277,619
(GRCh37/hg19 by Entrez Gene)
Size:
31,803 bases
Orientation:
Minus strand

chr7:99,245,817-99,277,621
(GRCh37/hg19 by Ensembl)
Size:
31,805 bases
Orientation:
Minus strand

Genomic View for CYP3A5 Gene

Genes around CYP3A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A5 Gene

Proteins for CYP3A5 Gene

  • Protein details for CYP3A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20815-CP3A5_HUMAN
    Recommended name:
    Cytochrome P450 3A5
    Protein Accession:
    P20815
    Secondary Accessions:
    • A4D289
    • B7Z5I7
    • Q53WY8
    • Q75MV0
    • Q9HB56

    Protein attributes for CYP3A5 Gene

    Size:
    502 amino acids
    Molecular mass:
    57109 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Three dimensional structures from OCA and Proteopedia for CYP3A5 Gene

    Alternative splice isoforms for CYP3A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A5 Gene

Selected DME Specific Peptides for CYP3A5 Gene

P20815:
  • LFPFLTP
  • LAVETWLLLAV
  • VLVKECYSVFTN
  • LVLLYLYGT
  • PGPTPLP
  • PCKETQIPLK
  • EEWKRIR
  • SVFTNRR
  • PNKAPPTYD
  • LLSPTFT
  • LSPTFTSG
  • PTFTSGK
  • DFLQLMIDSQ
  • EAEKGKP
  • SHKALSD

Post-translational modifications for CYP3A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CYP3A5 Gene

Gene Families for CYP3A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYP3A5 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
  • Group II E-class P450 signature
  • CYP3A P450 family signature

Suggested Antigen Peptide Sequences for CYP3A5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56681, highly similar to Cytochrome P450 3A5 (EC 1.14.14.1) (B7Z5I7_HUMAN)
  • Cytochrome P450-PCN3 (CP3A5_HUMAN)
  • Truncated cytochrome P450, family 3, subfamily A, polypeptide 5 (Q14V85_HUMAN)
  • Cytochrome P450 (Q7Z446_HUMAN)
  • Cytochrome P450 (Q7Z447_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20815

UniProtKB/Swiss-Prot:

CP3A5_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A5: view

Function for CYP3A5 Gene

Molecular function for CYP3A5 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:2732228};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46296, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:34477, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:2732228};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16422, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87571; Evidence={ECO:0000269|PubMed:2732228};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47252, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17026, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62117; Evidence={ECO:0000269|PubMed:2732228};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence={ECO:0000269|PubMed:11093772};.
UniProtKB/Swiss-Prot Induction:
By glucocorticoids, such as dexamethesone.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=52.47 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:12865317}; KM=46.03 uM for 17beta-estradiol (4-hydroxylation) {ECO:0000269|PubMed:12865317}; KM=15.04 uM for estrone (2-hydroxylation) {ECO:0000269|PubMed:12865317}; KM=27.75 uM for estrone (4-hydroxylation) {ECO:0000269|PubMed:12865317}; KM=44 uM for all-trans-retinoate (4-hydroxylation) {ECO:0000269|PubMed:11093772}; Vmax=627.4 pmol/min/nmol enzyme toward 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:12865317}; Vmax=297.8 pmol/min/nmol enzyme toward 17beta-estradiol (4-hydroxylation) {ECO:0000269|PubMed:12865317}; Vmax=102.6 pmol/min/nmol enzyme toward estrone (2-hydroxylation) {ECO:0000269|PubMed:12865317}; Vmax=156.3 pmol/min/nmol enzyme toward estrone (4-hydroxylation) {ECO:0000269|PubMed:12865317}; Vmax=1124 pmol/min/nmol enzyme toward all-trans-retinoate (4-hydroxylation) {ECO:0000269|PubMed:11093772};
GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved in the matabolism of sex hormones

Enzyme Numbers (IUBMB) for CYP3A5 Gene

Phenotypes From GWAS Catalog for CYP3A5 Gene

Gene Ontology (GO) - Molecular Function for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS,ISS --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 32814053
GO:0008395 steroid hydroxylase activity IBA 21873635
GO:0008401 retinoic acid 4-hydroxylase activity IDA 11093772
genes like me logo Genes that share ontologies with CYP3A5: view
genes like me logo Genes that share phenotypes with CYP3A5: view

Human Phenotype Ontology for CYP3A5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYP3A5 Gene

MGI Knock Outs for CYP3A5:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP3A5

No data available for Transcription Factor Targets and HOMER Transcription for CYP3A5 Gene

Localization for CYP3A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A5 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A5 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP3A5: view

Pathways & Interactions for CYP3A5 Gene

PathCards logo

SuperPathways for CYP3A5 Gene

SuperPathway Contained pathways
1 Drug metabolism - cytochrome P450
.31
2 Cytochrome P450 - arranged by substrate type
.01
3 Imipramine/Desipramine Pathway, Pharmacokinetics
4 Erlotinib Pathway, Pharmacokinetics
5 Phenytoin Pathway, Pharmacokinetics
genes like me logo Genes that share pathways with CYP3A5: view

UniProtKB/Swiss-Prot P20815-CP3A5_HUMAN

  • Pathway: Steroid hormone biosynthesis.
  • Pathway: Cofactor metabolism; retinol metabolism.

Gene Ontology (GO) - Biological Process for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IBA,IDA 14559847
GO:0008210 estrogen metabolic process IDA 12865317
genes like me logo Genes that share ontologies with CYP3A5: view

No data available for SIGNOR curated interactions for CYP3A5 Gene

Drugs & Compounds for CYP3A5 Gene

(427) Drugs for CYP3A5 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Midazolam Approved, Illicit Pharma Enzyme, substrate 1146
Tacrolimus Approved, Investigational Pharma Enzyme, substrate 1328
Oxycodone Approved, Illicit, Investigational Pharma Enzyme, substrate 535
Cilostazol Approved, Investigational Pharma Enzyme, substrate PDE3 inhibitor 132
Carbamazepine Approved, Investigational Pharma Enzyme, substrate, inducer Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 109

(45) Additional Compounds for CYP3A5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (11S,12R)-EpETrE
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-icosatrienoic acid
  • 11(S),12(R)-EET
  • 11(S),12(R)-EpETrE
123931-40-8
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosatrienoic acid
  • 11,14,15-Trihydroxy-(5Z,8Z,12E)-eicosatrienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoic acid
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid

(2) ApexBio Compounds for CYP3A5 Gene

Compound Action Cas Number
Clarithromycin 81103-11-9
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
genes like me logo Genes that share compounds with CYP3A5: view

Drug products for research

Transcripts for CYP3A5 Gene

mRNA/cDNA for CYP3A5 Gene

4 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP3A5

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A5 Gene

No ASD Table

Relevant External Links for CYP3A5 Gene

GeneLoc Exon Structure for
CYP3A5

Expression for CYP3A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP3A5 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A5 Gene

This gene is overexpressed in Liver (x19.3) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for CYP3A5 Gene

This gene is overexpressed in Gallbladder (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP3A5 Gene



Protein tissue co-expression partners for CYP3A5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP3A5

SOURCE GeneReport for Unigene cluster for CYP3A5 Gene:

Hs.571258

Evidence on tissue expression from TISSUES for CYP3A5 Gene

  • Liver(4.9)
  • Intestine(4.7)
  • Kidney(3.1)
  • Stomach(2.9)
  • Skin(2.7)
  • Blood(2.5)
  • Gall bladder(2.4)
  • Nervous system(2.2)
  • Adrenal gland(2.1)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with CYP3A5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A5 Gene

Orthologs for CYP3A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYP3A5 29 30
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CYP3A12 30
  • 79 (a)
ManyToMany
CYP3A26 30
  • 77 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
-- 30
  • 74 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Cyp3a11 29 16 30
  • 78.24 (n)
ManyToMany
Cyp3a13 30
  • 74 (a)
ManyToMany
Cyp3a41a 16 30
  • 72 (a)
ManyToMany
Cyp3a41b 16 30
  • 72 (a)
ManyToMany
Cyp3a25 30
  • 71 (a)
ManyToMany
Cyp3a16 16 30
  • 70 (a)
ManyToMany
Cyp3a44 16 30
  • 70 (a)
ManyToMany
Cyp3a59 30
  • 69 (a)
ManyToMany
Cyp3a57 30
  • 68 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Cyp3a23/3a1 29
  • 77.62 (n)
Cow
(Bos Taurus)
Mammalia CYP3A5 30 30
  • 76 (a)
ManyToMany
-- 30
  • 74 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 56 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
-- 30
  • 53 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CYP3A37 30
  • 58 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 58 (a)
ManyToMany
-- 30
  • 52 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.19450 29
Zebrafish
(Danio rerio)
Actinopterygii cyp3a65 30
  • 51 (a)
ManyToMany
cyp3c4 30
  • 49 (a)
ManyToMany
cyp3c1l2 30
  • 49 (a)
ManyToMany
cyp3c1 30
  • 48 (a)
ManyToMany
si:dkey-21n8.3 30
  • 48 (a)
ManyToMany
Dr.25208 29
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp9c1 29 31
  • 46.49 (n)
Cyp6a17 31
  • 34 (a)
Cyp6a23 31
  • 34 (a)
Cyp6v1 31
  • 33 (a)
Cyp6a13 31
  • 32 (a)
Cyp6a14 31
  • 32 (a)
Cyp6a19 31
  • 32 (a)
Cyp6a2 31
  • 32 (a)
Cyp6a9 31
  • 32 (a)
Cyp6g1 31
  • 32 (a)
Cyp9f2 31
  • 32 (a)
Cyp6a18 31
  • 31 (a)
Cyp6a20 31
  • 31 (a)
Cyp6a22 31
  • 31 (a)
Cyp6d4 31
  • 31 (a)
Cyp9b2 31
  • 31 (a)
Cyp6a21 31
  • 30 (a)
Cyp6a8 31
  • 30 (a)
Cyp6d5 31
  • 30 (a)
Cyp9h1 31
  • 30 (a)
Cyp6g2 31
  • 29 (a)
Cyp6w1 31
  • 29 (a)
Cyp9b1 31
  • 29 (a)
Cyp28d1 31
  • 28 (a)
Cyp28d2 31
  • 28 (a)
Cyp6d2 31
  • 28 (a)
Cyp6t3 31
  • 28 (a)
Cyp313a1 31
  • 27 (a)
Cyp317a1 31
  • 27 (a)
Cyp28c1 31
  • 26 (a)
Cyp309a2 31
  • 26 (a)
Cyp313a2 31
  • 26 (a)
Cyp6u1 31
  • 26 (a)
Cyp28a5 31
  • 25 (a)
Cyp309a1 31
  • 25 (a)
Cyp6t1 31
  • 24 (a)
Worm
(Caenorhabditis elegans)
Secernentea F14F7.2 31
  • 32 (a)
T10B9.1 31
  • 32 (a)
F14F7.3 31
  • 31 (a)
T10B9.2 31
  • 31 (a)
T10B9.8 31
  • 30 (a)
C36A4.1 31
  • 29 (a)
C36A4.2 31
  • 29 (a)
T10B9.5 31
  • 29 (a)
T10B9.7 31
  • 29 (a)
C36A4.6 31
  • 28 (a)
F42A6.4 31
  • 28 (a)
T10B9.3 31
  • 28 (a)
ZK1320.4 31
  • 27 (a)
K06G5.2 31
  • 26 (a)
ccp-44 31
  • 25 (a)
Species where no ortholog for CYP3A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CYP3A5 Gene

ENSEMBL:
Gene Tree for CYP3A5 (if available)
TreeFam:
Gene Tree for CYP3A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP3A5: view image
Alliance of Genome Resources:
Additional Orthologs for CYP3A5

Paralogs for CYP3A5 Gene

Paralogs for CYP3A5 Gene

(25) SIMAP similar genes for CYP3A5 Gene using alignment to 9 proteins:

  • CP3A5_HUMAN
  • F5H4S0_HUMAN
  • L8EC58_HUMAN
  • Q14V85_HUMAN
  • Q7Z446_HUMAN
  • Q7Z447_HUMAN
  • Q96RK6_HUMAN
  • Q96RK7_HUMAN
  • Q96RK8_HUMAN
genes like me logo Genes that share paralogs with CYP3A5: view

Variants for CYP3A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP3A5 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1584406744 Likely Benign: not provided 99,652,600(-) G/A
NM_000777.5(CYP3A5):c.1206C>T (p.His402=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON
rs28365069 Benign: not provided 99,648,403(-) A/G
NM_000777.5(CYP3A5):c.1414-3T>C
INTRON
rs4646450 Association: appendicular lean mass relative to body height 99,668,695(-) G/A
NM_000777.5(CYP3A5):c.319-1630C>T
THREE_PRIME_UTR_VARIANT,INTRON
rs765108001 Not Provided: Essential hypertension 99,652,641(-) G/A
NM_000777.5(CYP3A5):c.1165C>T (p.Pro389Ser)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs776746 Drug Response: sirolimus response - Metabolism/PK; tacrolimus response (donor genotype) - Dosage, Metabolism/PK; tacrolimus response (recipient genotype) - Dosage, Metabolism/PK; cyclosporine response - Dosage, Metabolism/PK; sirolimus response - Dosage; tacrolimus response - Efficacy; not provided 99,672,916(-) T/.
NM_000777.5(CYP3A5):c.219-237=
SPLICE_ACCEPTOR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CYP3A5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CYP3A5 Gene

Variant ID Type Subtype PubMed ID
esv2619613 CNV insertion 19546169
nsv5865 CNV insertion 18451855
nsv970911 CNV duplication 23825009

Variation tolerance for CYP3A5 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP3A5 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP3A5
Human Gene Mutation Database (HGMD)
CYP3A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A5
Leiden Open Variation Database (LOVD)
CYP3A5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A5 Gene

Disorders for CYP3A5 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CYP3A5 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
hypertension, essential
  • eht
multiple chemical sensitivity
  • 20th century disease
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
proctitis
  • ulcerative proctitis
coumarin resistance
  • coumarin, poor metabolism of
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP3A5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CYP3A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP3A5 Gene

Publications for CYP3A5 Gene

  1. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PMID: 17554244) Kharasch ED … Ensign D (Clinical pharmacology and therapeutics 2007) 3 22 25 40
  2. Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PMID: 11502729) Chou FC … Huang JD (Drug metabolism and disposition: the biological fate of chemicals 2001) 3 4 22 40
  3. The genetic determinants of the CYP3A5 polymorphism. (PMID: 11740341) Hustert E … Wojnowski L (Pharmacogenetics 2001) 3 22 40 72
  4. Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. (PMID: 20357698) Mukonzo JK … Aklillu E (Therapeutic drug monitoring 2010) 3 22 40
  5. Explaining variability in ciclosporin exposure in adult kidney transplant recipients. (PMID: 20354687) Press RR … Guchelaar HJ (European journal of clinical pharmacology 2010) 3 22 40

Products for CYP3A5 Gene