Aliases for CYP3A5 Gene
External Ids for CYP3A5 Gene
Previous GeneCards Identifiers for CYP3A5 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for CYP3A5 Gene
CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Tacrolimus Dose Selection. Among its related pathways are Tamoxifen Pathway, Pharmacokinetics and Vinka Alkaloid Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP3A4.
UniProtKB/Swiss-Prot for CYP3A5 Gene
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.