This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochro... See more...

Aliases for CYP3A5 Gene

Aliases for CYP3A5 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 5 2 3 5
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 2 3
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 2 3
  • Cytochrome P450-PCN3 3 4
  • Cytochrome P450 3A5 3 4
  • CYPIIIA5 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 HLp2 3
  • EC 1.14.14.1 54
  • EC 1.14.14.- 4
  • P450PCN3 3
  • CP35 3
  • PCN3 3

External Ids for CYP3A5 Gene

Previous GeneCards Identifiers for CYP3A5 Gene

  • GC07M097780
  • GC07M098843
  • GC07M098857
  • GC07M098891
  • GC07M099083
  • GC07M099246
  • GC07M093882

Summaries for CYP3A5 Gene

Entrez Gene Summary for CYP3A5 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CYP3A5 Gene

CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Tacrolimus Dose Selection. Among its related pathways are Imipramine/Desipramine Pathway, Pharmacokinetics and Carvedilol Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP3A4.

UniProtKB/Swiss-Prot Summary for CYP3A5 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228).

Gene Wiki entry for CYP3A5 Gene

PharmGKB "VIP" Summary for CYP3A5 Gene

Additional gene information for CYP3A5 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP3A5 Gene

Genomics for CYP3A5 Gene

GeneHancer (GH) Regulatory Elements for CYP3A5 Gene

Promoters and enhancers for CYP3A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP3A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP3A5 gene promoter:
  • ATF-2
  • C/EBPbeta
  • Ik-1
  • Ik-2
  • Ik-3
  • POU2F1
  • POU2F1a
  • POU3F1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CYP3A5 Gene

Genomic Locations for CYP3A5 Gene
chr7:99,648,189-99,680,026
(GRCh38/hg38)
Size:
31,838 bases
Orientation:
Minus strand
chr7:99,245,813-99,277,621
(GRCh37/hg19)
Size:
31,809 bases
Orientation:
Minus strand

Genomic View for CYP3A5 Gene

Genes around CYP3A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A5 Gene

Proteins for CYP3A5 Gene

  • Protein details for CYP3A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20815-CP3A5_HUMAN
    Recommended name:
    Cytochrome P450 3A5
    Protein Accession:
    P20815
    Secondary Accessions:
    • A4D289
    • B7Z5I7
    • Q53WY8
    • Q75MV0
    • Q9HB56

    Protein attributes for CYP3A5 Gene

    Size:
    502 amino acids
    Molecular mass:
    57109 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Three dimensional structures from OCA and Proteopedia for CYP3A5 Gene

    Alternative splice isoforms for CYP3A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A5 Gene

Selected DME Specific Peptides for CYP3A5 Gene

P20815:
  • LFPFLTP
  • LAVETWLLLAV
  • VLVKECYSVFTN
  • LVLLYLYGT
  • PGPTPLP
  • PCKETQIPLK
  • EEWKRIR
  • SVFTNRR
  • PNKAPPTYD
  • LLSPTFT
  • LSPTFTSG
  • PTFTSGK
  • DFLQLMIDSQ
  • EAEKGKP
  • SHKALSD

Post-translational modifications for CYP3A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A5 Gene

Domains & Families for CYP3A5 Gene

Gene Families for CYP3A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CYP3A5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56681, highly similar to Cytochrome P450 3A5 (EC 1.14.14.1) (B7Z5I7_HUMAN)
  • Cytochrome P450-PCN3 (CP3A5_HUMAN)
  • Truncated cytochrome P450, family 3, subfamily A, polypeptide 5 (Q14V85_HUMAN)
  • Cytochrome P450 (Q7Z446_HUMAN)
  • Cytochrome P450 (Q7Z447_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20815

UniProtKB/Swiss-Prot:

CP3A5_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A5: view

Function for CYP3A5 Gene

Molecular function for CYP3A5 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47213; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47281; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47209; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47293; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46296, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:34477, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46297; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16422, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87571; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47257; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47252, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17026, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62117; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47253; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42093; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51985; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=52.47 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269 PubMed:12865317}; KM=46.03 uM for 17beta-estradiol (4-hydroxylation) {ECO:0000269 PubMed:12865317}; KM=15.04 uM for estrone (2-hydroxylation) {ECO:0000269 PubMed:12865317}; KM=27.75 uM for estrone (4-hydroxylation) {ECO:0000269 PubMed:12865317}; KM=44 uM for all-trans-retinoate (4-hydroxylation) {ECO:0000269 PubMed:11093772}; Vmax=627.4 pmol/min/nmol enzyme toward 17beta-estradiol (2- hydroxylation) {ECO:0000269 PubMed:12865317}; Vmax=297.8 pmol/min/nmol enzyme toward 17beta-estradiol (4- hydroxylation) {ECO:0000269 PubMed:12865317}; Vmax=102.6 pmol/min/nmol enzyme toward estrone (2-hydroxylation) {ECO:0000269 PubMed:12865317}; Vmax=156.3 pmol/min/nmol enzyme toward estrone (4-hydroxylation) {ECO:0000269 PubMed:12865317}; Vmax=1124 pmol/min/nmol enzyme toward all-trans-retinoate (4- hydroxylation) {ECO:0000269 PubMed:11093772};
UniProtKB/Swiss-Prot Induction:
By glucocorticoids, such as dexamethesone.
GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 5 (niphedipine oxidase);see CYP3A@,expressed in the prostate and involved in the matabolism of sex hormones

Enzyme Numbers (IUBMB) for CYP3A5 Gene

Phenotypes From GWAS Catalog for CYP3A5 Gene

Gene Ontology (GO) - Molecular Function for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS,TAS --
GO:0005506 iron ion binding IEA --
GO:0008395 steroid hydroxylase activity IBA 21873635
GO:0008401 retinoic acid 4-hydroxylase activity IDA 11093772
GO:0016491 oxidoreductase activity IDA 15039299
genes like me logo Genes that share ontologies with CYP3A5: view
genes like me logo Genes that share phenotypes with CYP3A5: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP3A5 Gene

Localization for CYP3A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A5 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A5 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP3A5: view

Pathways & Interactions for CYP3A5 Gene

genes like me logo Genes that share pathways with CYP3A5: view

UniProtKB/Swiss-Prot P20815-CP3A5_HUMAN

  • Pathway: Steroid hormone biosynthesis.
  • Pathway: Cofactor metabolism; retinol metabolism.

Gene Ontology (GO) - Biological Process for CYP3A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 14559847
GO:0008210 estrogen metabolic process IDA 12865317
GO:0009822 alkaloid catabolic process IDA 15039299
genes like me logo Genes that share ontologies with CYP3A5: view

No data available for SIGNOR curated interactions for CYP3A5 Gene

Drugs & Compounds for CYP3A5 Gene

(401) Drugs for CYP3A5 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Midazolam Approved, Illicit Pharma Enzyme, substrate 959
Tacrolimus Approved, Investigational Pharma Enzyme, substrate 1265
Cilostazol Approved, Investigational Pharma Enzyme, substrate PDE3 inhibitor 120
Oxycodone Approved, Illicit, Investigational Pharma Enzyme, substrate 496
Carbamazepine Approved, Investigational Pharma Enzyme, substrate, inducer Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 103

(47) Additional Compounds for CYP3A5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2

(3) ApexBio Compounds for CYP3A5 Gene

Compound Action Cas Number
Clarithromycin 81103-11-9
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
Dafadine-A DAF-9 cytochrome P450 inhibitor 1065506-69-5
genes like me logo Genes that share compounds with CYP3A5: view

Transcripts for CYP3A5 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A5 Gene

No ASD Table

Relevant External Links for CYP3A5 Gene

GeneLoc Exon Structure for
CYP3A5
ECgene alternative splicing isoforms for
CYP3A5

Expression for CYP3A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP3A5 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A5 Gene

This gene is overexpressed in Liver (x19.3) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for CYP3A5 Gene

This gene is overexpressed in Gallbladder (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP3A5 Gene



Protein tissue co-expression partners for CYP3A5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP3A5 Gene:

CYP3A5

SOURCE GeneReport for Unigene cluster for CYP3A5 Gene:

Hs.571258

Evidence on tissue expression from TISSUES for CYP3A5 Gene

  • Liver(4.9)
  • Intestine(4.6)
  • Kidney(3.1)
  • Blood(2.5)
  • Skin(2.2)
  • Lung(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with CYP3A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A5 Gene

Orthologs for CYP3A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP3A5 33 32
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CYP3A12 33
  • 79 (a)
ManyToMany
CYP3A26 33
  • 77 (a)
ManyToMany
-- 33
  • 76 (a)
ManyToMany
-- 33
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 33 32
  • 78.24 (n)
ManyToMany
Cyp3a13 33
  • 74 (a)
ManyToMany
Cyp3a41b 33
  • 72 (a)
ManyToMany
Cyp3a41a 33
  • 72 (a)
ManyToMany
Cyp3a25 33
  • 71 (a)
ManyToMany
Cyp3a44 17 33
  • 70 (a)
Cyp3a16 33
  • 70 (a)
ManyToMany
Cyp3a59 33
  • 69 (a)
ManyToMany
Cyp3a57 33
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp3a23/3a1 32
  • 77.62 (n)
cow
(Bos Taurus)
Mammalia CYP3A5 33 33
  • 76 (a)
ManyToMany
-- 33
  • 74 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 65 (a)
ManyToMany
-- 33
  • 65 (a)
ManyToMany
-- 33
  • 65 (a)
ManyToMany
-- 33
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 56 (a)
ManyToMany
-- 33
  • 55 (a)
ManyToMany
-- 33
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A37 33
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 58 (a)
ManyToMany
-- 33
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19450 32
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 33
  • 51 (a)
ManyToMany
cyp3c4 33
  • 49 (a)
ManyToMany
cyp3c1l2 33
  • 49 (a)
ManyToMany
cyp3c1 33
  • 48 (a)
ManyToMany
si:dkey-21n8.3 33
  • 48 (a)
ManyToMany
Dr.25208 32
fruit fly
(Drosophila melanogaster)
Insecta Cyp9c1 34 32
  • 46.49 (n)
Cyp6a23 34
  • 34 (a)
Cyp6a17 34
  • 34 (a)
Cyp6v1 34
  • 33 (a)
Cyp9f2 34
  • 32 (a)
Cyp6a2 34
  • 32 (a)
Cyp6a13 34
  • 32 (a)
Cyp6g1 34
  • 32 (a)
Cyp6a14 34
  • 32 (a)
Cyp6a19 34
  • 32 (a)
Cyp6a9 34
  • 32 (a)
Cyp6a20 34
  • 31 (a)
Cyp6d4 34
  • 31 (a)
Cyp9b2 34
  • 31 (a)
Cyp6a18 34
  • 31 (a)
Cyp6a22 34
  • 31 (a)
Cyp9h1 34
  • 30 (a)
Cyp6d5 34
  • 30 (a)
Cyp6a21 34
  • 30 (a)
Cyp6a8 34
  • 30 (a)
Cyp6g2 34
  • 29 (a)
Cyp9b1 34
  • 29 (a)
Cyp6w1 34
  • 29 (a)
Cyp6t3 34
  • 28 (a)
Cyp28d2 34
  • 28 (a)
Cyp28d1 34
  • 28 (a)
Cyp6d2 34
  • 28 (a)
Cyp313a1 34
  • 27 (a)
Cyp317a1 34
  • 27 (a)
Cyp313a2 34
  • 26 (a)
Cyp28c1 34
  • 26 (a)
Cyp309a2 34
  • 26 (a)
Cyp6u1 34
  • 26 (a)
Cyp28a5 34
  • 25 (a)
Cyp309a1 34
  • 25 (a)
Cyp6t1 34
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F14F7.2 34
  • 32 (a)
T10B9.1 34
  • 32 (a)
T10B9.2 34
  • 31 (a)
F14F7.3 34
  • 31 (a)
T10B9.8 34
  • 30 (a)
C36A4.1 34
  • 29 (a)
C36A4.2 34
  • 29 (a)
T10B9.5 34
  • 29 (a)
T10B9.7 34
  • 29 (a)
C36A4.6 34
  • 28 (a)
F42A6.4 34
  • 28 (a)
T10B9.3 34
  • 28 (a)
ZK1320.4 34
  • 27 (a)
K06G5.2 34
  • 26 (a)
ccp-44 34
  • 25 (a)
Species where no ortholog for CYP3A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A5 Gene

ENSEMBL:
Gene Tree for CYP3A5 (if available)
TreeFam:
Gene Tree for CYP3A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP3A5: view image

Paralogs for CYP3A5 Gene

Paralogs for CYP3A5 Gene

(25) SIMAP similar genes for CYP3A5 Gene using alignment to 9 proteins:

  • CP3A5_HUMAN
  • F5H4S0_HUMAN
  • L8EC58_HUMAN
  • Q14V85_HUMAN
  • Q7Z446_HUMAN
  • Q7Z447_HUMAN
  • Q96RK6_HUMAN
  • Q96RK7_HUMAN
  • Q96RK8_HUMAN
genes like me logo Genes that share paralogs with CYP3A5: view

Variants for CYP3A5 Gene

Sequence variations from dbSNP and Humsavar for CYP3A5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs4646450 association, appendicular lean mass relative to body height 99,668,695(-) G/A 3_prime_UTR_variant, intron_variant
rs765108001 not-provided, Essential hypertension 99,652,641(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs776746 drug-response, sirolimus response - Dosage, cyclosporine response - Dosage, Metabolism/PK, tacrolimus response (donor genotype) - Dosage, Metabolism/PK, tacrolimus response - Efficacy, tacrolimus response (recipient genotype) - Dosage, Metabolism/PK, sirolimus response - Metabolism/PK 99,672,916(-) T/C intron_variant, splice_acceptor_variant
rs1000111953 -- 99,680,238(-) C/T upstream_transcript_variant
rs1000188828 -- 99,654,881(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A5 Gene

Variant ID Type Subtype PubMed ID
esv2619613 CNV insertion 19546169
nsv5865 CNV insertion 18451855
nsv970911 CNV duplication 23825009

Variation tolerance for CYP3A5 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP3A5 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP3A5
Human Gene Mutation Database (HGMD)
CYP3A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A5 Gene

Disorders for CYP3A5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CYP3A5 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypertension, essential
  • eht
tacrolimus dose selection
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
engraftment syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP3A5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP3A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP3A5 Gene

Publications for CYP3A5 Gene

  1. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. (PMID: 17554244) Kharasch ED … Ensign D (Clinical pharmacology and therapeutics 2007) 3 23 26 43 56
  2. Genetic polymorphism of cytochrome P450 3A5 in Chinese. (PMID: 11502729) Chou FC … Huang JD (Drug metabolism and disposition: the biological fate of chemicals 2001) 3 4 23 43 56
  3. Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. (PMID: 20357698) Mukonzo JK … Aklillu E (Therapeutic drug monitoring 2010) 3 23 43 56
  4. CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men. (PMID: 19812606) Zhang L … Muramatsu M (Journal of human hypertension 2010) 3 23 43 56
  5. Genetic polymorphisms in CYP3A5 and MDR1 genes and their correlations with plasma levels of tacrolimus and cyclosporine in renal transplant recipients. (PMID: 19376366) Mendes J … Pais L (Transplantation proceedings 2009) 3 23 43 56

Products for CYP3A5 Gene