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CYP3A4 Gene(Protein Coding)

Cytochrome P450 Family 3 Subfamily A Member 4

GCID:
GC07M099759
GIFtS:
56
Genes Participants
UDN Logo

Aliases for CYP3A4 Gene

Aliases for CYP3A4 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 4 2 3 5
  • EC 1.14.14.- 4 4 4 4
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4 2 3
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 2 3
  • Taurochenodeoxycholate 6-Alpha-Hydroxylase 3 4
  • 1,8-Cineole 2-Exo-Monooxygenase 3 4
  • Cholesterol 25-Hydroxylase 3 4
  • Albendazole Monooxygenase 3 4
  • Albendazole Sulfoxidase 3 4
  • Quinine 3-Monooxygenase 3 4
  • Cytochrome P450 NF-25 3 4
  • Cytochrome P450-PCN1 3 4
  • Cytochrome P450 3A3 3 4
  • Cytochrome P450 HLp 3 4
  • Nifedipine Oxidase 3 4
  • CYPIIIA3 3 4
  • CYPIIIA4 3 4
  • CYP3A3 3 4
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3 3
  • Glucocorticoid-Inducible P450 3
  • P450-III, Steroid Inducible 3
  • Cytochrome P450 3A4 3
  • EC 1.14.14.56 4
  • EC 1.14.14.55 4
  • P450PCN1 3
  • P450C3 3
  • CYP3A 3
  • NF-25 3
  • CP33 3
  • CP34 3
  • HLP 3

External Ids for CYP3A4 Gene

Previous HGNC Symbols for CYP3A4 Gene

  • CYP3A3

Previous GeneCards Identifiers for CYP3A4 Gene

  • GC07M097889
  • GC07M098952
  • GC07M098967
  • GC07M098968
  • GC07M098892
  • GC07M098999
  • GC07M099192
  • GC07M099355
  • GC07M093991

Summaries for CYP3A4 Gene

Entrez Gene Summary for CYP3A4 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

GeneCards Summary for CYP3A4 Gene

CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with CYP3A4 include Acetaminophen Metabolism and Tacrolimus Dose Selection. Among its related pathways are Drug metabolism - cytochrome P450 and Phenytoin Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP3A7.

UniProtKB/Swiss-Prot for CYP3A4 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).

Tocris Summary for CYP3A4 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP3A4 Gene

PharmGKB "VIP" Summary for CYP3A4 Gene

Additional gene information for CYP3A4 Gene

No data available for CIViC summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A4 Gene

Genomics for CYP3A4 Gene

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GeneHancer (GH) Regulatory Elements for CYP3A4 Gene

Promoters and enhancers for CYP3A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J099783 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 -0.2 -178 2 SP1 TAF1 RXRA REST CYP3A4 ATP5MF PVRIG CYP3A137P
GH07J099797 Promoter 0.5 EPDnew 650.4 -13.0 -12959 0.1 CYP3A4 CYP3A137P
GH07J099692 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +90.0 90016 2.7 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 PTCD1 ZSCAN25 PPP1R35 MEPCE PDAP1 TRRAP ZNF3 TRIM4 ZNF789 C7orf43
GH07J099791 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 0.4 -8.3 -8251 2.9 FOXA2 MAX CEBPG RAD21 RARA ZNF7 YY1 IRF9 EGR1 HNF4G SAP25 CYP3A43 CYP3A5 CYP3A4 CYP3A137P
GH07J099794 Enhancer 1.1 ENCODE dbSUPER 0.4 -10.9 -10946 1.4 FOXA2 ARID4B DMAP1 ZNF48 YY1 ATF7 NFKBIZ RXRA MXD4 NFIL3 GIGYF1 CYP3A43 CYP3A4 CYP3A137P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP3A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP3A4 gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP-TF
  • COUP
  • GR-alpha
  • GR
  • STAT3
  • NF-kappaB1
  • GATA-6

Genomic Locations for CYP3A4 Gene

Genomic Locations for CYP3A4 Gene
chr7:99,756,960-99,784,265
(GRCh38/hg38)
Size:
27,306 bases
Orientation:
Minus strand
chr7:99,354,583-99,381,888
(GRCh37/hg19)
Size:
27,306 bases
Orientation:
Minus strand

Genomic View for CYP3A4 Gene

Genes around CYP3A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP3A4 Gene

Proteins for CYP3A4 Gene

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  • Protein details for CYP3A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08684-CP3A4_HUMAN
    Recommended name:
    Cytochrome P450 3A4
    Protein Accession:
    P08684
    Secondary Accessions:
    • P05184
    • Q16757
    • Q9UK50

    Protein attributes for CYP3A4 Gene

    Size:
    503 amino acids
    Molecular mass:
    57343 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Three dimensional structures from OCA and Proteopedia for CYP3A4 Gene

neXtProt entry for CYP3A4 Gene

Protein Expression for CYP3A4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CYP3A4 Gene

  • Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP3A4 Gene

Domains & Families for CYP3A4 Gene

Gene Families for CYP3A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYP3A4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP3A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08684

UniProtKB/Swiss-Prot:

CP3A4_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A4: view

Function for CYP3A4 Gene

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Molecular function for CYP3A4 Gene

UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
UniProtKB/Swiss-Prot CatalyticActivity:
Quinine + [reduced NADPH--hemoprotein reductase] + O(2) = 3-hydroxyquinine + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Taurochenodeoxycholate + [reduced NADPH--hemoprotein reductase] + O(2) = taurohyocholate + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Lithocholate + [reduced NADPH--hemoprotein reductase] + O(2) = hyodeoxycholate + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Albendazole + [reduced NADPH--hemoprotein reductase] + O(2) = albendazole S-oxide + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Fenbendazole + [reduced NADPH--hemoprotein reductase] + O(2) = fenbendazole S-oxide + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
1,8-cineole + [reduced NADPH--hemoprotein reductase] + O(2) = 2-exo-hydroxy-1,8-cineole + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = 25-hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Induction:
By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 4 (niphedipine oxidase);highly expressed in the liver,see CYP3A@,with a significant association of the wild type enzyme with epipodophyllotoxin-induced leukemogenesis

Enzyme Numbers (IUBMB) for CYP3A4 Gene

Phenotypes From GWAS Catalog for CYP3A4 Gene

Gene Ontology (GO) - Molecular Function for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA,ISS --
GO:0005496 steroid binding IDA 15256616
GO:0005506 iron ion binding IDA,IEA 15256616
GO:0008395 steroid hydroxylase activity IMP 18356043
GO:0016491 oxidoreductase activity IDA,IEA 15039299
genes like me logo Genes that share ontologies with CYP3A4: view
genes like me logo Genes that share phenotypes with CYP3A4: view

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miRNA for CYP3A4 Gene

miRTarBase miRNAs that target CYP3A4

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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP3A4 Gene

Localization for CYP3A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A4 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP3A4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18446064
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP3A4: view

Pathways & Interactions for CYP3A4 Gene

SuperPathways for CYP3A4 Gene

PathCards logo More details on SuperPathways for CYP3A4
SuperPathway Contained pathways
1 Drug metabolism - cytochrome P450
Drug metabolism - cytochrome P450
.71
Metabolism of xenobiotics by cytochrome P450
.71
Chemical carcinogenesis
.70
Drug metabolism - other enzymes
.38
Retinol metabolism
.33
Retinol metabolism
.32
Benzodiazepine Pathway, Pharmacokinetics
.01
Celecoxib Pathway, Pharmacokinetics
.01
Haloperidol Pathway, Pharmacokinetics
.01
Ifosfamide Pathway, Pharmacokinetics
.01
Oxycodone Pathway, Pharmacokinetics
.01
Voriconazole Pathway, Pharmacokinetics
.01
Benzo[a]pyrene metabolism
.01
Aflatoxin B1 metabolism
.01
2 Paroxetine Pathway, Pharmacokinetics
Imipramine/Desipramine Pathway, Pharmacokinetics
.57
Paroxetine Pathway, Pharmacokinetics
.57
Verapamil Pathway, Pharmacokinetics
.56
Amitriptyline and Nortriptyline Pathway, Pharmacokinetics
.50
Olanzapine Pathway, Pharmacokinetics
.50
Venlafaxine Pathway, Pharmacokinetics
.50
Clopidogrel Pathway, Pharmacokinetics
.42
Clozapine Pathway, Pharmacokinetics
.40
Citalopram Pathway, Pharmacokinetics
.01
Clomipramine Pathway, Pharmacokinetics
.01
Proton Pump Inhibitor Pathway, Pharmacokinetics
.01
Lidocaine metabolism
.01
3 Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type
.64
Oxidation by Cytochrome P450
.64
Phase 1 - Functionalization of compounds
.63
Biological oxidations
.49
Xenobiotics
.39
Metapathway biotransformation
.36
Clobazam Pathway, Pharmacokinetics
.01
Estradiol metabolism
.01
Vitamin D2 (ergocalciferol) metabolism
.01
Benzo(a)pyrene metabolism
.01
Fatty Acid Omega Oxidation
.01
4 Gefitinib Pathway, Pharmacokinetics
Gefitinib Pathway, Pharmacokinetics
.58
Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
.58
Warfarin Pathway, Pharmacokinetics
.45
Nevirapine Pathway, Pharmacokinetics
.40
Pazopanib Pathway, Pharmacokinetics
.36
Doxepin Pathway, Pharmacokinetics
.01
Fluoxetine Pathway, Pharmacokinetics
.01
5 Statin Pathway - Generalized, Pharmacokinetics
Ibuprofen Pathway, Pharmacokinetics
.42
Statin Pathway - Generalized, Pharmacokinetics
.42
Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
.01
Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
.01
Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
.01
Fluvastatin Pathway, Pharmacokinetics
.01
genes like me logo Genes that share pathways with CYP3A4: view

Gene Ontology (GO) - Biological Process for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006629 lipid metabolic process TAS 2492107
GO:0006706 steroid catabolic process IMP 18356043
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 3259858
genes like me logo Genes that share ontologies with CYP3A4: view

No data available for SIGNOR curated interactions for CYP3A4 Gene

Drugs & Compounds for CYP3A4 Gene

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(972) Drugs for CYP3A4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ketoconazole Approved, Investigational Pharma Pore Blocker, Enzyme, substrate, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 179
Carbamazepine Approved, Investigational Pharma Enzyme, substrate, inducer Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 134
Clarithromycin Approved Pharma Enzyme, substrate, inhibitor, inducer 312
Clopidogrel Approved Pharma Enzyme, substrate P2Y12 receptor antagonist 814
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 53

(108) Additional Compounds for CYP3A4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Hydroxyquinine
  • 3-Hydroxyquinidine
  • 6'-Methoxycinchonan-3,9-diol
  • 3-Hydroxyquinidine, (3alpha,9S)-isomer
  • 3-Hydroxyquinidine, (8alpha,9R)-isomer
 53467-23-5
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
Paraxanthine
  • 3,7-dihydro-1,7-Dimethyl-1H-purine-2,6-dione
  • P-Xanthine
  • 1,7-Dimethyl-xanthine
  • 1,7-Dimethylxanthine
 611-59-6
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
 81276-02-0

(5) Tocris Compounds for CYP3A4 Gene

Compound Action Cas Number
Anastrozole Potent aromatase (CYP19) inhibitor 120511-73-1
Exemestane Steroidal aromatase (CYP19) inhibitor 107868-30-4
Ketoconazole Cytochrome P450c17 inhibitor 65277-42-1
TMS Cytochrome P450 1B1 inhibitor 24144-92-1
YM 511 Potent aromatase (CYP19) inhibitor 148869-05-0
genes like me logo Genes that share compounds with CYP3A4: view

Transcripts for CYP3A4 Gene

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mRNA/cDNA for CYP3A4 Gene

(4) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(189) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP3A4 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 4:
Representative Sequences:

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Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A4 Gene

No ASD Table

Relevant External Links for CYP3A4 Gene

GeneLoc Exon Structure for
CYP3A4
ECgene alternative splicing isoforms for
CYP3A4

Expression for CYP3A4 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP3A4 Gene

mRNA expression in normal human tissues for CYP3A4 Gene
mRNA expression by BioGPS for CYP3A4 GenemRNA expression by GTEx for CYP3A4 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A4 Gene

This gene is overexpressed in Liver (x43.8) and Small Intestine - Terminal Ileum (x6.9).

Protein differential expression in normal tissues from HIPED for CYP3A4 Gene

This gene is overexpressed in Gallbladder (35.3), Liver (24.7), and Fetal Liver (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP3A4 Gene



Protein tissue co-expression partners for CYP3A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP3A4 Gene:

CYP3A4

SOURCE GeneReport for Unigene cluster for CYP3A4 Gene:

Hs.728751

mRNA Expression by UniProt/SwissProt for CYP3A4 Gene:

P08684-CP3A4_HUMAN
Tissue specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).

Evidence on tissue expression from TISSUES for CYP3A4 Gene

  • Liver(5)
  • Blood(3.2)
  • Intestine(3.1)
  • Urine(2.6)
  • Kidney(2.5)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with CYP3A4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP3A4 Gene

Orthologs for CYP3A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CYP3A4 34 33
  • 99.4 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CYP3A4 33
  • 84.56 (n)
CYP3A12 34
  • 81 (a)
 ManyToMany
CYP3A26 34
  • 78 (a)
 ManyToMany
-- 34
  • 77 (a)
 ManyToMany
-- 34
  • 76 (a)
 ManyToMany
cow
(Bos Taurus)
 Mammalia CYP3A5 34 34 33
  • 82.64 (n)
 ManyToMany
-- 34
  • 77 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Cyp3a2 33
  • 77.2 (n)
mouse
(Mus musculus)
 Mammalia Cyp3a13 34
  • 75 (a)
 ManyToMany
Cyp3a11 34
  • 73 (a)
 ManyToMany
Cyp3a25 34
  • 71 (a)
 ManyToMany
Cyp3a41a 34
  • 71 (a)
 ManyToMany
Cyp3a41b 34
  • 71 (a)
 ManyToMany
Cyp3a16 34
  • 70 (a)
 ManyToMany
Cyp3a44 34
  • 69 (a)
 ManyToMany
Cyp3a59 34
  • 69 (a)
 ManyToMany
Cyp3a57 34
  • 68 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 67 (a)
 ManyToMany
-- 34
  • 66 (a)
 ManyToMany
-- 34
  • 65 (a)
 ManyToMany
-- 34
  • 57 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 56 (a)
 ManyToMany
-- 34
  • 55 (a)
 ManyToMany
-- 34
  • 53 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves CYP3A4 33
  • 63.04 (n)
CYP3A37 34
  • 58 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 60 (a)
 ManyToMany
-- 34
  • 52 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100487054 33
  • 60.78 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC68821 33
zebrafish
(Danio rerio)
 Actinopterygii cyp3a65 34
  • 54 (a)
 ManyToMany
cyp3c1l2 34
  • 51 (a)
 ManyToMany
si:dkey-21n8.3 34
  • 49 (a)
 ManyToMany
cyp3c1 34
  • 48 (a)
 ManyToMany
cyp3c4 34
  • 48 (a)
 ManyToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6641 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP012293 33
  • 48.95 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Cyp9f2 35 33
  • 47.35 (n)
Cyp6a23 35
  • 35 (a)
Cyp6a17 35
  • 34 (a)
Cyp6d4 35
  • 33 (a)
Cyp6g1 35
  • 33 (a)
Cyp6a14 35
  • 33 (a)
Cyp6a13 35
  • 32 (a)
Cyp9b2 35
  • 32 (a)
Cyp6v1 35
  • 32 (a)
Cyp6a22 35
  • 32 (a)
Cyp6a2 35
  • 32 (a)
Cyp9c1 35
  • 31 (a)
Cyp6a9 35
  • 31 (a)
Cyp6a20 35
  • 31 (a)
Cyp6a19 35
  • 31 (a)
Cyp6d5 35
  • 31 (a)
Cyp6a18 35
  • 31 (a)
Cyp9h1 35
  • 30 (a)
Cyp28d2 35
  • 30 (a)
Cyp6a21 35
  • 30 (a)
Cyp6g2 35
  • 30 (a)
Cyp6w1 35
  • 30 (a)
Cyp6a8 35
  • 30 (a)
Cyp6d2 35
  • 29 (a)
Cyp6t3 35
  • 27 (a)
Cyp313a1 35
  • 27 (a)
Cyp28d1 35
  • 27 (a)
Cyp9b1 35
  • 27 (a)
Cyp6t1 35
  • 26 (a)
Cyp6u1 35
  • 26 (a)
Cyp309a2 35
  • 25 (a)
Cyp28c1 35
  • 25 (a)
Cyp313a2 35
  • 25 (a)
Cyp28a5 35
  • 24 (a)
Cyp317a1 35
  • 24 (a)
Cyp309a1 35
  • 24 (a)
worm
(Caenorhabditis elegans)
 Secernentea cyp-25A1 33
  • 46.71 (n)
F14F7.3 35
  • 32 (a)
C36A4.1 35
  • 31 (a)
F14F7.2 35
  • 31 (a)
C36A4.2 35
  • 30 (a)
T10B9.2 35
  • 30 (a)
T10B9.1 35
  • 30 (a)
T10B9.7 35
  • 30 (a)
T10B9.5 35
  • 30 (a)
T10B9.8 35
  • 29 (a)
T10B9.3 35
  • 29 (a)
F42A6.4 35
  • 28 (a)
C36A4.6 35
  • 28 (a)
ZK1320.4 35
  • 26 (a)
K06G5.2 35
  • 25 (a)
Species where no ortholog for CYP3A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A4 Gene

ENSEMBL:
Gene Tree for CYP3A4 (if available)
TreeFam:
Gene Tree for CYP3A4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP3A4: view image

Paralogs for CYP3A4 Gene

Paralogs for CYP3A4 Gene

(14) SIMAP similar genes for CYP3A4 Gene using alignment to 5 proteins:

  • CP3A4_HUMAN
  • C9JBD2_HUMAN
  • E7EVM8_HUMAN
  • Q6GRK0_HUMAN
  • Q7Z448_HUMAN

Pseudogenes.org Pseudogenes for CYP3A4 Gene

genes like me logo Genes that share paralogs with CYP3A4: view

Variants for CYP3A4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CYP3A4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs2740574 benign, drug-response, CYP3A4 PROMOTER POLYMORPHISM, Cyp3a4-v, tacrolimus response - Dosage 99,784,473(-) C/T upstream_transcript_variant
rs765598920 uncertain-significance, not specified 99,758,182(-) G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000025030 -- 99,766,738(-) T/G intron_variant
rs1000383193 -- 99,780,605(-) C/A intron_variant
rs1000775179 -- 99,785,778(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP3A4 Gene

Variant ID Type Subtype PubMed ID
nsv482109 CNV gain 20164927
nsv970558 CNV duplication 23825009
nsv981555 CNV duplication 23825009

Variation tolerance for CYP3A4 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP3A4 Gene

Human Gene Mutation Database (HGMD)
CYP3A4
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP3A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A4 Gene

Disorders for CYP3A4 Gene

MalaCards: The human disease database

(22) MalaCards diseases for CYP3A4 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acetaminophen metabolism
tacrolimus dose selection
hemangioma of liver
  • angioma of liver
koro
  • genital retraction syndrome
methemoglobinemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP3A4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP3A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP3A4 Gene

Publications for CYP3A4 Gene

  1. A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan. (PMID: 20068078) van der Bol JM … de Jong FA (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 22 44 58
  2. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V … Schuetz EG (The Journal of pharmacology and experimental therapeutics 2010) 3 22 44 58
  3. Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. (PMID: 19802823) Becker ML … Stricker BH (Pharmacoepidemiology and drug safety 2010) 3 22 44 58
  4. CYP3A4*1G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients. (PMID: 19784640) Zhang W … Zhang J (European journal of clinical pharmacology 2010) 3 22 44 58
  5. [Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients]. (PMID: 20038391) Isla Tejera B … Suárez García A (Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2009) 3 22 44 58

Products for CYP3A4 Gene