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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008] See more...
Aliases for CYP2W1 Gene
Aliases for CYP2W1 Gene
External Ids for CYP2W1 Gene
- HGNC: 20243
- Entrez Gene: 54905
- Ensembl: ENSG00000073067
- OMIM: 615967
- UniProtKB: Q8TAV3
Previous GeneCards Identifiers for CYP2W1 Gene
- GC00U916974
- GC07P000796
- GC07P000989
- GC07P000939
- GC07P001022
- GC07P000980
Summaries for CYP2W1 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2W1 Gene
CYP2W1 (Cytochrome P450 Family 2 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2D6.
UniProtKB/Swiss-Prot Summary for CYP2W1 Gene
-
A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974).
Additional gene information for CYP2W1 Gene
- HGNC(20243)
- Entrez Gene(54905)
- Ensembl(ENSG00000073067)
- OMIM(615967)
- UniProtKB(Q8TAV3)
- Open Targets Platform(ENSG00000073067)
- Search for CYP2W1 at DataMed
- Search for CYP2W1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP2W1 Gene
Genomics for CYP2W1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CYP2W1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYP2W1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2W1
- Top Transcription factor binding sites by QIAGEN in the CYP2W1 gene promoter:
-
- Bach2
- HEN1
- MIF-1
- NF-1
- NF-1/L
- NRSF form 1
- NRSF form 2
- Roaz
- SRY
- Zic1
Genomic Locations for CYP2W1 Gene
Genomic Locations for CYP2W1 Gene
- chr7:983,155-989,640
- (GRCh38/hg38)
- Size:
- 6,486 bases
- Orientation:
- Plus strand
- chr7:1,022,835-1,029,276
- (GRCh37/hg19)
- Size:
- 6,442 bases
- Orientation:
- Plus strand
Genomic View for CYP2W1 Gene
Genes around CYP2W1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3 by HGNC
- 7p22.3 by Entrez Gene
- 7p22.3 by Ensembl
CYP2W1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP2W1 Gene
Proteins for CYP2W1 Gene
-
Protein details for CYP2W1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TAV3-CP2W1_HUMAN
- Recommended name:
- Cytochrome P450 2W1
- Protein Accession:
- Q8TAV3
Protein attributes for CYP2W1 Gene
- Size:
- 490 amino acids
- Molecular mass:
- 53844 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP2W1 Gene
Selected DME Specific Peptides for CYP2W1 Gene
- Q8TAV3:
-
- EAFLPFS
- PGPRPLP
- KIEEVRA
- AGTETTS
Post-translational modifications for CYP2W1 Gene
Other Protein References for CYP2W1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Cytochrome P450 2W1 Antibody and Immunotag™ CYP2W1 Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for CYP2W1
- Novus Biologicals Antibodies for CYP2W1
-
Abcam antibodies for CYP2W1
- Invitrogen Antibodies for CYP2W1 (AFLGC-Cyp2w1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP2W1
Protein Products
-
OriGene Purified Proteins for CYP2W1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP2W1
- Origene Custom Protein Services for CYP2W1
- antibodies-online: Show 4 available CYP2W1 Proteins ranked by validation data
- Compare Top CYP2W1 Proteins
-
Quality Products:
-
Signalway Proteins for CYP2W1
-
Abcam proteins for CYP2W1
Assay Products
-
Signalway ELISA kits for CYP2W1
Domains & Families for CYP2W1 Gene
Gene Families for CYP2W1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CYP2W1 Gene
- InterPro:
- Blocks:
-
- E-class P450 group I signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP2W1 Gene
- GenScript: Design optimal peptide antigens:
-
- CYPIIW1 (CP2W1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TAV3- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP2W1 Gene
Molecular function for CYP2W1 Gene
- UniProtKB/Swiss-Prot Function:
- A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence={ECO:0000269|PubMed:26936974};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50328, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132285; Evidence={ECO:0000269|PubMed:22591743};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50332, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132286; Evidence={ECO:0000269|PubMed:22591743};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50324, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132278; Evidence={ECO:0000269|PubMed:22591743};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50320, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:28610, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132280; Evidence={ECO:0000269|PubMed:22591743};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=5.6 uM for all-trans-retinoate {ECO:0000269|PubMed:26936974}; KM=38 uM for 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (18:1 LPC) (hydroxylation) {ECO:0000269|PubMed:22591743}; KM=34 uM for 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (18:1 LPC) (epoxidation) {ECO:0000269|PubMed:22591743}; KM=14 uM for 16:0 LPC (hydroxylation) {ECO:0000269|PubMed:22591743}; KM=83 uM for hexadecanoate (16:0) (hydroxylation) {ECO:0000269|PubMed:22591743}; KM=101 uM for (9Z)-octadecenoate (18:1) (hydroxylation) {ECO:0000269|PubMed:22591743}; KM=95 uM for (9Z)-octadecenoate (18:1) (epoxidation) {ECO:0000269|PubMed:22591743};
Enzyme Numbers (IUBMB) for CYP2W1 Gene
Phenotypes From GWAS Catalog for CYP2W1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001972 | retinoic acid binding | IDA | 26936974 |
| GO:0004497 | monooxygenase activity | IEA | -- |
| GO:0005503 | all-trans retinal binding | IDA | 26936974 |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0008395 | steroid hydroxylase activity | IBA | 21873635 |
Phenotypes for CYP2W1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP2W1 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for CYP2W1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2W1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2W1
miRNA for CYP2W1 Gene
- miRTarBase miRNAs that target CYP2W1
-
- hsa-miR-6780a-5p (MIRT483792)
- hsa-miR-6779-5p (MIRT483793)
- hsa-miR-3689c (MIRT483794)
- hsa-miR-3689b-3p (MIRT483795)
- hsa-miR-3689a-3p (MIRT483796)
- hsa-miR-30b-3p (MIRT483797)
- hsa-miR-1273h-5p (MIRT483798)
- hsa-miR-6778-5p (MIRT483799)
- hsa-miR-1233-5p (MIRT483800)
- hsa-miR-6766-5p (MIRT483801)
- hsa-miR-6756-5p (MIRT483802)
- hsa-miR-4651 (MIRT483803)
- hsa-miR-608 (MIRT483804)
- hsa-miR-6799-5p (MIRT483805)
- hsa-miR-6883-5p (MIRT483806)
- hsa-miR-6785-5p (MIRT483807)
- hsa-miR-4728-5p (MIRT483808)
- hsa-miR-149-3p (MIRT483809)
- hsa-miR-7106-5p (MIRT483810)
- hsa-miR-765 (MIRT483811)
- hsa-miR-7154-3p (MIRT483812)
- hsa-miR-4644 (MIRT483813)
- hsa-miR-4306 (MIRT483814)
- hsa-miR-185-5p (MIRT483815)
- hsa-miR-6804-5p (MIRT483816)
- hsa-miR-711 (MIRT483817)
- hsa-miR-4784 (MIRT483818)
- hsa-miR-3150b-3p (MIRT483819)
- hsa-miR-4751 (MIRT483820)
- hsa-miR-6856-5p (MIRT483821)
- hsa-miR-6758-5p (MIRT483822)
- hsa-miR-6796-5p (MIRT488940)
- hsa-miR-6812-5p (MIRT488941)
- hsa-miR-6819-5p (MIRT488942)
- hsa-miR-6737-5p (MIRT488943)
- hsa-miR-6742-5p (MIRT488944)
- hsa-miR-4472 (MIRT488945)
- hsa-miR-4447 (MIRT488946)
- hsa-miR-3151-5p (MIRT488947)
- hsa-miR-491-5p (MIRT488948)
- hsa-miR-6747-5p (MIRT488949)
- hsa-miR-4664-5p (MIRT488950)
- hsa-miR-342-5p (MIRT488951)
- hsa-miR-134-3p (MIRT488952)
- hsa-miR-5096 (MIRT646965)
- hsa-miR-197-3p (MIRT646966)
- hsa-miR-411-5p (MIRT646967)
- hsa-miR-3147 (MIRT646968)
- hsa-miR-4425 (MIRT646969)
- hsa-miR-6832-5p (MIRT646970)
- hsa-miR-6721-5p (MIRT646971)
- hsa-miR-4524a-3p (MIRT646972)
- hsa-miR-4716-5p (MIRT646973)
- hsa-miR-6823-5p (MIRT646974)
- hsa-miR-4781-3p (MIRT646975)
- hsa-miR-4524b-3p (MIRT646976)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP2W1
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Clone Products
- Applied Biological Materials (abm): Clones for CYP2W1 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for CYP2W1
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Cell Line Products
-
Horizon Cell Lines for CYP2W1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2W1 Gene
Localization for CYP2W1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP2W1 Gene
- Endoplasmic reticulum lumen. Cell membrane. Microsome membrane. Note=About 8% are expressed on the cell surface. {ECO:0000269 PubMed:20805301}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | IEA,IDA | 20805301 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2W1 Gene
Pathways & Interactions for CYP2W1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
| 2 | Metabolism |
.40
|
|
Pathways by source for CYP2W1 Gene
2 BioSystems pathways for CYP2W1 Gene
6 Reactome pathways for CYP2W1 Gene
Interacting Proteins for CYP2W1 Gene
GPS-Prot Interaction Network for CYP2W1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | IBA | 21873635 |
| GO:0006644 | phospholipid metabolic process | IDA | 22591743 |
| GO:0006805 | xenobiotic metabolic process | IDA | 16551781 |
| GO:0034653 | retinoic acid catabolic process | IDA | 26936974 |
| GO:0042738 | exogenous drug catabolic process | IBA | 21873635 |
No data available for SIGNOR curated interactions for CYP2W1 Gene
Drugs & Compounds for CYP2W1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
Transcripts for CYP2W1 Gene
mRNA/cDNA for CYP2W1 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000308919 2322 nts (view in UCSC)
- ENST00000340150 2361 nts (view in UCSC)
- ENST00000462453 566 nts (view in UCSC)
- ENST00000468456 557 nts (view in UCSC)
- ENST00000415893 890 nts (view in UCSC)
CRISPR Products
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-
OriGene CRISPR knockouts for CYP2W1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2W1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2W1
miRNA Products
Inhibitory RNA Products
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Clone Products
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| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for CYP2W1 Gene
- GeneLoc Exon Structure for
- CYP2W1
Expression for CYP2W1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CYP2W1 Gene
This gene is overexpressed in Adrenal Gland (x17.2), Skin - Not Sun Exposed (Suprapubic) (x9.4), Skin - Sun Exposed (Lower leg) (x7.3), and Nerve - Tibial (x6.7).
This gene is overexpressed in Fetal gut (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP2W1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2W1
SOURCE GeneReport for Unigene cluster for CYP2W1 Gene:
Hs.272795mRNA Expression by UniProt/SwissProt for CYP2W1 Gene:
Q8TAV3-CP2W1_HUMAN
Tissue specificity:
Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors.
Evidence on tissue expression from TISSUES for CYP2W1 Gene
- Lung(4.4)
- Adrenal gland(2.1)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for CYP2W1
-
OriGene qPCR primer pairs and template standards for CYP2W1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2W1 Gene
Orthologs for CYP2W1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CYP2W1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CYP2W1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LOC618939 30 |
|
||
| CYP2W1 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Cyp2w1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cyp2w1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CYP2W1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CYP2W1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CYP2W1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CYP2W1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | cyp2k8 31 |
|
OneToMany | |
| cyp2k17 31 |
|
OneToMany | |||
| cyp2k16 31 |
|
OneToMany | |||
| cyp2k19 31 |
|
OneToMany | |||
| cyp2k6 31 |
|
OneToMany | |||
| cyp2k22 31 |
|
OneToMany | |||
| cyp2k21 31 |
|
OneToMany | |||
| cyp2k18 31 |
|
OneToMany | |||
| cyp2k31 31 |
|
OneToMany | |||
| cyp2k20 31 |
|
OneToMany |
- Species where no ortholog for CYP2W1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CYP2W1 Gene
- ENSEMBL:
- Gene Tree for CYP2W1 (if available)
- TreeFam:
- Gene Tree for CYP2W1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP2W1: view image
Paralogs for CYP2W1 Gene
Paralogs for CYP2W1 Gene
(26) SIMAP similar genes for CYP2W1 Gene using alignment to 3 proteins:
- CP2W1_HUMAN
- A6NJ10_HUMAN
- H7C015_HUMAN
Variants for CYP2W1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2W1 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 785204 | Benign: not provided | 986,749(+) | G/A | SYNONYMOUS_VARIANT | |
| 791281 | Benign: not provided | 987,371(+) | G/A | MISSENSE_VARIANT | |
| rs1316523256 | - | p.Glu58Ala | |||
| rs3735684 | - | p.Ala181Thr | |||
| rs3808348 | - | p.Pro488Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3571557 | CNV | loss | 25503493 |
| esv3571559 | CNV | loss | 25503493 |
| nsv1024118 | CNV | gain | 25217958 |
| nsv1028282 | CNV | gain | 25217958 |
| nsv1161477 | CNV | deletion | 26073780 |
| nsv464245 | CNV | gain | 19166990 |
| nsv477026 | CNV | novel sequence insertion | 20440878 |
| nsv482099 | CNV | gain | 20164927 |
| nsv509182 | CNV | insertion | 20534489 |
| nsv605699 | CNV | loss | 21841781 |
| nsv605700 | CNV | gain | 21841781 |
| nsv605705 | CNV | loss | 21841781 |
| nsv605720 | CNV | loss | 21841781 |
| nsv950784 | CNV | deletion | 24416366 |
Gene Damage Index Score:
6.66;
78.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP2W1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2W1 Gene
Disorders for CYP2W1 Gene
Additional Disease Information for CYP2W1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CYP2W1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2W1 Gene
Publications for CYP2W1 Gene
- CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk. (PMID: 20602611) Gervasini G … Agúndez JA (Pharmacogenomics 2010) 3 4 41
- Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. (PMID: 16551781) Wu ZL … Guengerich FP (Molecular pharmacology 2006) 3 4 23
- Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates. (PMID: 26936974) Zhao Y … Ortiz de Montellano PR (Drug metabolism and disposition: the biological fate of chemicals 2016) 3 4
- Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. (PMID: 22591743) Xiao Y … Guengerich FP (Journal of lipid research 2012) 3 4
- Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity. (PMID: 20805301) Gomez A … Ingelman-Sundberg M (Molecular pharmacology 2010) 3 4
ExternalLinks
Products for CYP2W1 Gene
- Custom Antibody ServicesOriGene Antibodies for CYP2W1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CYP2W1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP2W1
- Origene Custom Protein Services for CYP2W1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP2W1
- Browse OriGene Inhibitory RNA Products For CYP2W1
- OriGene qPCR primer pairs for CYP2W1
- OriGene qPCR primer pairs and template standards for CYP2W1
- OriGene CRISPR knockouts for CYP2W1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYP2W1
- Sino Biological Human cDNA Clone for CYP2W1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CYP2W1
- Novus Biologicals proteins and lysates for CYP2W1
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse ELISA Kits
- Abcam antibodies for CYP2W1
- Abcam proteins for CYP2W1
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for CYP2W1 (AFLGC-Cyp2w1)
- VectorBuilder Custom and pre-made DNA vectors for CYP2W1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CYP2W1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CYP2W1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CYP2W1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CYP2W1
- antibodies-online: Show 9 available CYP2W1 Antibodies ranked by validation data
- Compare Top CYP2W1 Antibodies
- antibodies-online: Search results for available CYP2W1 related products ranked by validation data
- antibodies-online: Show 4 available CYP2W1 Proteins ranked by validation data
- Compare Top CYP2W1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CYP2W1
- Search Santa Cruz Biotechnology (SCBT) for CYP2W1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYP2W1
- Horizon Cell Lines for CYP2W1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2W1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP2W1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CYP2W1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2W1
Sources for CYP2W1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB