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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]
CYP2W1 (Cytochrome P450 Family 2 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2D6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001972 | retinoic acid binding | IDA | 26936974 |
GO:0004497 | monooxygenase activity | IEA | -- |
GO:0005503 | all-trans retinal binding | IDA | 26936974 |
GO:0005506 | iron ion binding | IEA | -- |
GO:0008395 | steroid hydroxylase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005788 | endoplasmic reticulum lumen | IEA,IDA | 20805301 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005886 | plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
2 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006082 | organic acid metabolic process | IBA | 21873635 |
GO:0006644 | phospholipid metabolic process | IDA | 22591743 |
GO:0006805 | xenobiotic metabolic process | IDA | 16551781 |
GO:0034653 | retinoic acid catabolic process | IDA | 26936974 |
GO:0042738 | exogenous drug catabolic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
heme | Pharma | Agonist | 0 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CYP2W1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CYP2W1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LOC618939 30 |
|
||
CYP2W1 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Cyp2w1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cyp2w1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CYP2W1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CYP2W1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CYP2W1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CYP2W1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | cyp2k8 31 |
|
OneToMany | |
cyp2k17 31 |
|
OneToMany | |||
cyp2k16 31 |
|
OneToMany | |||
cyp2k19 31 |
|
OneToMany | |||
cyp2k6 31 |
|
OneToMany | |||
cyp2k22 31 |
|
OneToMany | |||
cyp2k21 31 |
|
OneToMany | |||
cyp2k18 31 |
|
OneToMany | |||
cyp2k31 31 |
|
OneToMany | |||
cyp2k20 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
785204 | Benign: not provided | 986,749(+) | G/A | SYNONYMOUS_VARIANT | |
791281 | Benign: not provided | 987,371(+) | G/A | MISSENSE_VARIANT | |
rs1316523256 | - | p.Glu58Ala | |||
rs3735684 | - | p.Ala181Thr | |||
rs3808348 | - | p.Pro488Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3571557 | CNV | loss | 25503493 |
esv3571559 | CNV | loss | 25503493 |
nsv1024118 | CNV | gain | 25217958 |
nsv1028282 | CNV | gain | 25217958 |
nsv1161477 | CNV | deletion | 26073780 |
nsv464245 | CNV | gain | 19166990 |
nsv477026 | CNV | novel sequence insertion | 20440878 |
nsv482099 | CNV | gain | 20164927 |
nsv509182 | CNV | insertion | 20534489 |
nsv605699 | CNV | loss | 21841781 |
nsv605700 | CNV | gain | 21841781 |
nsv605705 | CNV | loss | 21841781 |
nsv605720 | CNV | loss | 21841781 |
nsv950784 | CNV | deletion | 24416366 |
No disorders were found for CYP2W1 Gene.